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178 results
  • Emerging Role of Targeted Therapy in Metastatic Pancreatic Adenocarcinoma. [Review]
    Cancers (Basel). 2022 Dec 16; 14(24)Huffman BM, Ellis H, … Cleary JM
  • The aggressive biology of pancreatic ductal adenocarcinoma (PDAC), along with its limited sensitivity to many systemic therapies, presents a major challenge in the management of patients with metastatic PDAC. Over the past decade, the incorporation of combinatorial cytotoxic chemotherapy regimens has improved patient outcomes. Despite these advances, resistance to cytotoxic chemotherapy inevitabl…
  • Mechanism of Astrin in Head and Neck Squamous Cell Carcinoma. [Journal Article]
    Cell Mol Biol (Noisy-le-grand). 2022 Jul 31; 68(7):141-147.Wang J, Liu C, Wei M
  • Head and neck squamous cell carcinoma(HNSCC) is a malignant epidermal tumor that seriously threatens human life and health. The main factors affecting the death of patients are local recurrence and lymph node metastasis. Astrin antibody is the basic component of the mitotic spindle required for normal chromosome separation and later development. There are few domestic studies on the mechanism of …
  • The Astrin-SKAP complex reduces friction at the kinetochore-microtubule interface. [Journal Article]
    Curr Biol. 2022 06 20; 32(12):2621-2631.e3.Rosas-Salvans M, Sutanto R, … Dumont S
  • The kinetochore links chromosomes to spindle microtubules to drive chromosome segregation at cell division. While we know nearly all mammalian kinetochore proteins, how these give rise to the strong yet dynamic microtubule attachments required for function remains poorly understood. Here, we focus on the Astrin-SKAP complex, which localizes to bioriented kinetochores and is essential for chromoso…
  • YAP1 and PRDM14 converge to promote cell survival and tumorigenesis. [Journal Article]
    Dev Cell. 2022 01 24; 57(2):212-227.e8.Kim M, Ly SH, … Hahn WC
  • The transcriptional co-activator YAP1 oncogene is the downstream effector of the Hippo pathway, which regulates tissue homeostasis, organ size, regeneration, and tumorigenesis. Multiple cancers are dependent on sustained expression of YAP1 for cell proliferation, survival, and tumorigenesis, but the molecular basis of this oncogene dependency is not well understood. To identify genes that can fun…
  • The Aurora B gradient sustains kinetochore stability in anaphase. [Journal Article]
    Cell Rep. 2021 11 09; 37(6):109818.Papini D, Levasseur MD, Higgins JMG
  • Kinetochores assemble on chromosomes in mitosis to allow microtubules to attach and bring about accurate chromosome segregation. The kinases Cyclin B-Cdk1 and Aurora B are crucial for the formation of stable kinetochores. However, the activity of these two kinases appears to decline dramatically at centromeres during anaphase onset, precisely when microtubule attachments are required to move chro…
  • Astrin: A Key Player in Mitosis and Cancer. [Review]
    Front Cell Dev Biol. 2020; 8:866.Ying Z, Yang J, … Sha O
  • Astrin, which is a spindle-associated protein, was found to be closely related to mitotic spindle formation and maintenance. It interacts with other spindle-related proteins to play a key role in maintaining the attachment of the kinetochore-microtubule and integrity of centrosomes and promoting the centriole duplication. In addition, Astrin was quite recently found to be abnormally highly expres…
  • SPAG5: An Emerging Oncogene. [Journal Article]
    Trends Cancer. 2020 07; 6(7):543-547.He J, Green AR, … Liu DX
  • Sperm-associated Antigen 5 (SPAG5) is a mitotic spindle protein. Recent studies have found that it is overexpressed in many human cancers and functions as an oncogene. Here, we summarize the current underlying mechanisms for its oncogenic roles in regulating cellular behaviors of cancer cells and discuss the possibility of targeting SPAG5 for cancer treatment.
  • Loss of Kif18A Results in Spindle Assembly Checkpoint Activation at Microtubule-Attached Kinetochores. [Journal Article]
    Curr Biol. 2018 09 10; 28(17):2685-2696.e4.Janssen LME, Averink TV, … Raaijmakers JA
  • The spindle assembly checkpoint (SAC) halts anaphase progression until all kinetochores have obtained bipolar, stable attachments to the mitotic spindle. Upon initial attachment, chromosomes undergo oscillatory movements to reach metaphase. Once a chromosome is correctly attached and positioned, these oscillatory movements are reduced by the motor protein Kif18A, and loss of Kif18A results in chr…
  • Critical roles of Astrin in the mitosis of immature rat Sertoli cells. [Journal Article]
    Biochem Biophys Res Commun. 2017 05 13; 486(4):958-964.Tochigi Y, Iwasaki Y, … Suzuki H
  • Male hypogonadism (hgn/hgn) rats show testicular hypoplasia accompanied by dysplastic development of seminiferous tubules due to loss-of-function mutation of the gene encoding Astrin, which is required for mitotic progression in the division cycle of HeLa cells. In the present study, we examined the cytological base leading to the decrease of Sertoli cells in hgn/hgn testes. In hgn/hgn testes on …
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