- Code-free machine learning for classification of central nervous system histopathology images. [Journal Article]J Neuropathol Exp Neurol. 2023 Feb 03 [Online ahead of print]JN
- Machine learning (ML), an application of artificial intelligence, is currently transforming the analysis of biomedical data and specifically of biomedical images including histopathology. The promises of this technology contrast, however, with its currently limited application in routine clinical practice. This discrepancy is in part due to the extent of informatics expertise typically required f…
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- Glioblastoma as a novel drug repositioning target: Updated state. [Journal Article]Anticancer Agents Med Chem. 2023 Feb 02 [Online ahead of print]AA
- Glioblastoma multiforme (GBM) is an aggressive form of adult brain tumor that can arise from a low-grade astrocytoma. In recent decades, several new conventional therapies have been developed that have significantly improved the prognosis of patients with GBM. Nevertheless, most patients have a limited long-term response to these treatments and survive < 1 year. Therefore, innovative anti-cancer …
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- [Report of Multidisciplinary Treatment for Sisters with Li-Fraumeni Syndrome]. [Journal Article]Gan To Kagaku Ryoho. 2022 Dec; 49(13):1947-1949.GT
- Li-Fraumeni syndrome(LFS)is a hereditary cancer disorder caused by germline variant in TP53 and characterized by various malignancies. Multidisciplinary treatment is needed for tumors of LFS, however, radiation therapy is a relative contraindication because of frequent development of secondary malignancy such as sarcoma in the irradiated field. Case 1: A 22- year-old woman who was diagnosed with …
- Qualitative and Quantitative Magnetic Resonance Imaging Phenotypes May Predict CDKN2A/B Homozygous Deletion Status in Isocitrate Dehydrogenase-Mutant Astrocytomas: A Multicenter Study. [Multicenter Study]Korean J Radiol. 2023 Feb; 24(2):133-144.KJ
- CONCLUSIONS: The presence of an infiltrative pattern, larger maximal diameter, and higher 95th percentile of the nCBV may be useful MRI biomarkers for CDKN2A/B homozygous deletion in IDH-mutant astrocytomas.
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- [Effect of Morus alba extract sanggenon C on growth and proliferation of glioblastoma cells]. [Journal Article]Zhongguo Zhong Yao Za Zhi. 2023 Jan; 48(1):211-219.ZZ
- Glioblastoma is the most common primary cranial malignancy, and chemotherapy remains an important tool for its treatment. Sanggenon C(San C), a class of natural flavonoids extracted from Morus plants, is a potential antitumor herbal monomer. In this study, the effect of San C on the growth and proliferation of glioblastoma cells was examined by methyl thiazolyl tetrazolium(MTT) assay and 5-bromod…
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- Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. [Journal Article]Proc Natl Acad Sci U S A. 2023 Feb 07; 120(6):e2219199120.PN
- Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma trials. Here, we found that ICBs induce cerebral edema in some patients and mice with glioblastoma. Through single-cell RNA sequencing, intravital imaging, and CD8+ T cell blocking studies in mice, we demonstrated that this edema results from an inflammatory response following antiprogrammed death 1 (PD1) antibody treatme…
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- Longitudinal study on MRI and neuropathological findings: Neither DSC-perfusion derived rCBVmax nor vessel densities correlate between newly diagnosed and progressive glioblastoma. [Journal Article]
- CONCLUSIONS: Our results suggest that the extent of hyperperfusion in glioblastoma at first diagnosis is not a sustaining tumor characteristic. Hence, the rCBVmax at initial diagnosis should be disregarded when reviewing MRIs for glioblastoma progression.
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- Cervical Lymph Node Metastasis From Recurrent Glioblastoma Detected by MRI and 2-[18F]FDG PET/CT. [Case Reports]Clin Nucl Med. 2023 Mar 01; 48(3):e118-e120.CN
- A 53-year-old man diagnosed with recurrent glioblastoma after multimodal treatment on a follow-up brain MRI. Because of a palpable mass in the neck, the patient underwent a whole-body 2-[18F]FDG PET/CT, which revealed hypermetabolic laterocervical confluent lymphadenopathies. A nodal cervical biopsy indicated distant metastases from glioblastoma. Recent studies have confirmed dural meningeal lymp…
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- Spontaneous Shrinkage of isocitrate dehydrogenase (IDH)-mutant astrocytoma caused by intra-tumoural cyst rupture: a case report. [Journal Article]Br J Neurosurg. 2023 Feb 01 [Online ahead of print]BJ
- CONCLUSIONS: The present case report suggests that IDH-mutant astrocytoma cannot be ruled out even when the lesion shrinks spontaneously.
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- Cudraflavone B induces human glioblastoma cells apoptosis via ER stress-induced autophagy. [Journal Article]
- CONCLUSIONS: Our finding suggests that CUB impaired cell growth and induced cell apoptosis of glioblastoma through ER stress and autophagy-related signaling pathways, and it might be an attractive drug for treatment of GBM.
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- [NMDA receptors expression activity in anaplastic astrocytomas]. [Journal Article]Zh Nevrol Psikhiatr Im S S Korsakova. 2023; 123(1):97-102.ZN
- CONCLUSIONS: We have shown for the first time the significant role of NMDA receptors in the progression of diffuse astrocytomas, which can become the basis for creating new therapeutic and diagnostic tools.
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- Selective Inhibition of PI3K Isoforms in Brain Tumors Suppresses Tumor Growth by Increasing Radiosensitivity. [Journal Article]Yonsei Med J. 2023 Feb; 64(2):139-147.YM
- CONCLUSIONS: This study verified that PI3K-α isoform inhibition improves radiosensitivity, resulting in tumor growth suppression and extended survival in GBM mice.
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- Clinical Outcomes of Moderately Hypofractionated Concurrent Chemoradiotherapy for Newly Diagnosed Glioblastoma. [Journal Article]Yonsei Med J. 2023 Feb; 64(2):94-103.YM
- CONCLUSIONS: HypoRT with 58.5 Gy in 25 fractions could provide comparable oncologic outcomes and significantly reduce the ALC changes. In addition, HypoRT decreased the LDT. Further investigation should be warranted to suggest the significance of reduced LDT through HypoRT affecting survival outcomes.
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- Glioblastom hos voksne. [Journal Article]Tidsskr Nor Laegeforen. 2023 Jan 31; 143(2)TN
- Glioblastoma is the most common form of primary brain cancer in adults, and the disease has a serious prognosis. Although great progress has been made in molecular characteristics, no major breakthroughs in treatment have been achieved for many years. In this article we present a clinical review of current diagnostics and treatment, as well as the challenges and opportunities inherent in developi…
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- Multi-omics analyses of CD276 in pan-cancer reveals its clinical prognostic value in glioblastoma and other major cancer types. [Journal Article]
- CONCLUSIONS: Taken together, based on our systematic analysis, our findings have revealed important roles for CD276 in different types of cancers, especially GBM, and CD276 may potentially serve as a biomarker for cancer.
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- Clinical and genomic features in patients with second primary glioblastoma following first primary renal cell carcinoma. [Journal Article]
- CONCLUSIONS: This is the first study to investigate the pathogenesis and clinical features of spGBM following spRCC. We found that spGBMs are old-age related, highly malignant, and have short survival time. Moreover, they might be misdiagnosed and treated as brain metastases from RCC. Thus, the incidence of spGBMs after fpRCC is underestimated. Further studies are needed to investigate the underlying molecular mechanisms and clinical biomarkers for the development of spGBM following fpRCC.
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- Combined anti-C1-INH and radiotherapy against glioblastoma. [Journal Article]
- CONCLUSIONS: Anti-C1-INH treatment could improve the efficacy of irradiation delivered at sub-therapeutic doses and delay tumor growth in the subcutaneous tumor microenvironment. In the intracranial setting, the doses of anti-C1-INH were not enough to achieve any survival effect in the present setting.
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- Endoscopic Endonasal Transcavernous Posterior Clinoidectomy With Interdural Pituitary Transposition for a Suprasellar Optic Pathway Pilocytic Astrocytoma: 2-Dimensional Operative Video. [Journal Article]Oper Neurosurg (Hagerstown). 2023 Jan 11 [Online ahead of print]ON
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- The incidence and characterization of weight gain associated with MEK inhibitors in pediatric patients. [Journal Article]Pediatr Blood Cancer. 2023 Jan 30 [Online ahead of print]PB
- CONCLUSIONS: Weight gain may be a notable side effect associated with the use of MEK inhibitors in pediatric patients.
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- Polymorphisms in TPT1 Pathways in Pediatric Astrocytomas. [Journal Article]ASN Neuro. 2023 Jan-Dec; 15:17590914231153481.AN
- Central nervous system tumors, especially astrocytomas, are the solid neoplasms with the highest incidence and mortality rates in childhood. The diagnosis is based on histopathological characteristics, but molecular methods have been increasingly used. Translationally controlled tumor protein (TCTP) protein, encoded by the tumor protein, translationally controlled 1 (TPT1) gene, is a multifunctio…
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- TREM2 is associated with tumor immunity and implies poor prognosis in glioma. [Journal Article]
- Triggering receptor expressed on myeloid cells 2 (TREM2) is expressed in myeloid cells of the central nervous system (CNS), which mediate the immunological response in a variety of diseases. Uncertain is the function of TREM2 in glioma and tumor immune responses. In this research, the expression patterns of TREM2 in glioma were analyzed, along with its prognostic value and functional roles. TREM2…
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- Glioma features and seizure control during long-term follow-up. [Journal Article]
- CONCLUSIONS: There are differences in seizure-free times in patients with grade 2-4 glioma and epilepsy. The results suggest that the prognosis of glioma may be the most important factor influencing the prognosis of epilepsy.
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- Astrocytoma and IDH1-Wildtype Glioblastoma (GBM) Cells Colonize Tumor Vessels and Deploy Vascular Mimicry. [Preprint]Res Sq. 2023 Jan 17RS
- Gliomas are the most prevalent type of malignant brain tumors with a very dismal prognosis. Angiogenesis in glioma has recently gotten more attention and its molecular aspects have been published; however, these were not complemented with ultrastructural evidence. Our ultrastructural examination of glioma vessels reveals several unique and critical features related to their mechanisms of progress…
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- G2 checkpoint targeting via Wee1 inhibition radiosensitizes EGFRvIII-positive glioblastoma cells. [Journal Article]
- CONCLUSIONS: We conclude that the inhibition of Wee1 is an effective targeting approach for the radiosensitization of both EGFRvIII- and EGFRvIII+ GBM cells and may therefore represent a promising new therapeutic option to increase response to radiotherapy.
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- Cellular senescence in malignant cells promotes tumor progression in mouse and patient Glioblastoma. [Journal Article]
- Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, yet it remains refractory to systemic therapy. Elimination of senescent cells has emerged as a promising new treatment approach against cancer. Here, we investigated the contribution of senescent cells to GBM progression. Senescent cells are identified in patient and mouse GBMs. Partial removal of p16Ink4a-expressing m…
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- Genomic and epigenomic re-categorization of congenital glioblastoma and desmoplastic infantile ganglioglioma. [Journal Article]Childs Nerv Syst. 2023 Jan 28 [Online ahead of print]CN
- CONCLUSIONS: In conclusion, histology alone is insufficient to distinguish IHG from DIG, necessitating epigenomic and genomic testing for the diagnosis of early-life gliomas.
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- Methylphenidate Reversal of Executive Dysfunction in a Patient with Bi-Frontal Lobe Glioblastoma. [Journal Article]R I Med J (2013). 2023 Feb 01; 106(1):7-10.RI
- An elderly man with advanced glioblastoma developed neuro-cognitive deficits that were reversed by methylphenidate. After tumor resection from the right frontal lobe, he received cranial irradiation, temozolomide and Tumor Treating Fields (TTFields). MRI afterwards showed enhancements near the resection cavity and the contralateral frontal lobe. The patient experienced mild executive dysfunction …
- Posterior C1-C2 fusion for atlantoaxial rotatory fixation after posterior fossa craniotomy in a 4-year old: a case report. [Journal Article]Childs Nerv Syst. 2023 Jan 27 [Online ahead of print]CN
- CONCLUSIONS: Herein, we report a case in which AARF can be developed after neurosurgical procedure. Surgical techniques used for atlantoaxial subluxation should be carefully selected. In our case, the Harms technique after cranial traction was an excellent option for correcting and stabilizing the abnormal neck position. However, further studies are required to determine the best technique to use in the pediatric population.
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- Cytoprotective effects of low-frequency pulsed electromagnetic field against oxidative stress in glioblastoma cells. [Journal Article]Gen Physiol Biophys. 2023 Jan; 42(1):97-106.GP
- The low-frequency pulsed electromagnetic field (PEMF) may have possible cytoprotective effects against the destructive effects of oxidative stress. The goal was to investigate if shortterm low-frequency PEMF has cytoprotective effects in glioblastoma cell line following high-dose hydrogen peroxide (H2O2) treatment. U87-MG cells were divided into four groups: Sham-control group; PEMF group (cells …
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- Natural killer cell therapy potentially enhances the antitumor effects of bevacizumab plus irinotecan in a glioblastoma mouse model. [Journal Article]
- Various combination treatments have been considered to attain the effective therapy threshold by combining independent antitumor mechanisms against the heterogeneous characteristics of tumor cells in malignant brain tumors. In this study, the natural killer (NK) cells associated with bevacizumab (Bev) plus irinotecan (Iri) against glioblastoma multiforme (GBM) were investigated. For the experimen…
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