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50,927 results
  • Code-free machine learning for classification of central nervous system histopathology images. [Journal Article]
    J Neuropathol Exp Neurol. 2023 Feb 03 [Online ahead of print]Jungo P, Hewer E
  • Machine learning (ML), an application of artificial intelligence, is currently transforming the analysis of biomedical data and specifically of biomedical images including histopathology. The promises of this technology contrast, however, with its currently limited application in routine clinical practice. This discrepancy is in part due to the extent of informatics expertise typically required f…
  • Glioblastoma as a novel drug repositioning target: Updated state. [Journal Article]
    Anticancer Agents Med Chem. 2023 Feb 02 [Online ahead of print]Hosseinalizadeh H, Ebrahimi A, … Monavari SH
  • Glioblastoma multiforme (GBM) is an aggressive form of adult brain tumor that can arise from a low-grade astrocytoma. In recent decades, several new conventional therapies have been developed that have significantly improved the prognosis of patients with GBM. Nevertheless, most patients have a limited long-term response to these treatments and survive < 1 year. Therefore, innovative anti-cancer …
  • [Report of Multidisciplinary Treatment for Sisters with Li-Fraumeni Syndrome]. [Journal Article]
    Gan To Kagaku Ryoho. 2022 Dec; 49(13):1947-1949.Suzuki O, Amano K, … Ishida H
  • Li-Fraumeni syndrome(LFS)is a hereditary cancer disorder caused by germline variant in TP53 and characterized by various malignancies. Multidisciplinary treatment is needed for tumors of LFS, however, radiation therapy is a relative contraindication because of frequent development of secondary malignancy such as sarcoma in the irradiated field. Case 1: A 22- year-old woman who was diagnosed with …
  • [Effect of Morus alba extract sanggenon C on growth and proliferation of glioblastoma cells]. [Journal Article]
    Zhongguo Zhong Yao Za Zhi. 2023 Jan; 48(1):211-219.Tang WH, Zhang ZN, … Cui HJ
  • Glioblastoma is the most common primary cranial malignancy, and chemotherapy remains an important tool for its treatment. Sanggenon C(San C), a class of natural flavonoids extracted from Morus plants, is a potential antitumor herbal monomer. In this study, the effect of San C on the growth and proliferation of glioblastoma cells was examined by methyl thiazolyl tetrazolium(MTT) assay and 5-bromod…
  • Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. [Journal Article]
    Proc Natl Acad Sci U S A. 2023 Feb 07; 120(6):e2219199120.Datta M, Chatterjee S, … Jain RK
  • Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma trials. Here, we found that ICBs induce cerebral edema in some patients and mice with glioblastoma. Through single-cell RNA sequencing, intravital imaging, and CD8+ T cell blocking studies in mice, we demonstrated that this edema results from an inflammatory response following antiprogrammed death 1 (PD1) antibody treatme…
  • Cervical Lymph Node Metastasis From Recurrent Glioblastoma Detected by MRI and 2-[18F]FDG PET/CT. [Case Reports]
    Clin Nucl Med. 2023 Mar 01; 48(3):e118-e120.Suárez-Piñera M, Pudis M, … Torró CM
  • A 53-year-old man diagnosed with recurrent glioblastoma after multimodal treatment on a follow-up brain MRI. Because of a palpable mass in the neck, the patient underwent a whole-body 2-[18F]FDG PET/CT, which revealed hypermetabolic laterocervical confluent lymphadenopathies. A nodal cervical biopsy indicated distant metastases from glioblastoma. Recent studies have confirmed dural meningeal lymp…
  • Glioblastom hos voksne. [Journal Article]
    Tidsskr Nor Laegeforen. 2023 Jan 31; 143(2)Schipmann-Miletic S, Sivakanesan S, … Sundstrøm T
  • Glioblastoma is the most common form of primary brain cancer in adults, and the disease has a serious prognosis. Although great progress has been made in molecular characteristics, no major breakthroughs in treatment have been achieved for many years. In this article we present a clinical review of current diagnostics and treatment, as well as the challenges and opportunities inherent in developi…
  • Combined anti-C1-INH and radiotherapy against glioblastoma. [Journal Article]
    BMC Cancer. 2023 Jan 30; 23(1):106.Liljedahl E, Konradsson E, … Redebrandt HN
  • CONCLUSIONS: Anti-C1-INH treatment could improve the efficacy of irradiation delivered at sub-therapeutic doses and delay tumor growth in the subcutaneous tumor microenvironment. In the intracranial setting, the doses of anti-C1-INH were not enough to achieve any survival effect in the present setting.
  • Polymorphisms in TPT1 Pathways in Pediatric Astrocytomas. [Journal Article]
    ASN Neuro. 2023 Jan-Dec; 15:17590914231153481.Morais de Castro E, Barbosa LV, … Machado-Souza C
  • Central nervous system tumors, especially astrocytomas, are the solid neoplasms with the highest incidence and mortality rates in childhood. The diagnosis is based on histopathological characteristics, but molecular methods have been increasingly used. Translationally controlled tumor protein (TCTP) protein, encoded by the tumor protein, translationally controlled 1 (TPT1) gene, is a multifunctio…
  • TREM2 is associated with tumor immunity and implies poor prognosis in glioma. [Journal Article]
    Front Immunol. 2022; 13:1089266.Yu M, Chang Y, … Zeng F
  • Triggering receptor expressed on myeloid cells 2 (TREM2) is expressed in myeloid cells of the central nervous system (CNS), which mediate the immunological response in a variety of diseases. Uncertain is the function of TREM2 in glioma and tumor immune responses. In this research, the expression patterns of TREM2 in glioma were analyzed, along with its prognostic value and functional roles. TREM2…
  • Methylphenidate Reversal of Executive Dysfunction in a Patient with Bi-Frontal Lobe Glioblastoma. [Journal Article]
    R I Med J (2013). 2023 Feb 01; 106(1):7-10.McGillion-Moore J, Sampath P, Wong ET
  • An elderly man with advanced glioblastoma developed neuro-cognitive deficits that were reversed by methylphenidate. After tumor resection from the right frontal lobe, he received cranial irradiation, temozolomide and Tumor Treating Fields (TTFields). MRI afterwards showed enhancements near the resection cavity and the contralateral frontal lobe. The patient experienced mild executive dysfunction …
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