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3,475 results
  • Role of angiotensin receptor blockers in the context of Alzheimer's disease. [Review]
    Fundam Clin Pharmacol. 2023 Jan 18 [Online ahead of print]Kuber B, Fadnavis M, Chatterjee B
  • As the world's population ages, the prevalence of age-related neurological disorders such as Alzheimer's disease (AD) is increasing. There is currently no treatment for Alzheimer's disease, and the few approved medications have a low success rate in lowering symptoms. As a result, several attempts are underway worldwide to identify new targets for the therapy of Alzheimer's disease. In preclinica…
  • [Role of polypills in cardiovascular risk reduction in primary prevention]. [Review]
    Medicina (B Aires). 2022; 82(6):904-913.Botto F, Tajer C, … Sosa Liprandi Á
  • Unlike medications that contain fixed-dose combinations, such as those recommended by clinical guidelines for treating high blood pressure, the so-called polypills contain several drugs that simultaneously treat two or more cardiovascular conditions or risk factors. They were proposed 2 decades ago, both for primary and secondary prevention with the hypothesis that they could have wide disseminat…
  • Candesartan-the next anti-amyloid drug? [Journal Article]
    Brain Commun. 2022; 4(6):fcac293.Yasar S
  • This scientific commentary refers to 'Safety and biomarker effects of candesartan in non-hypertensive adults with prodromal Alzheimer's disease' by Hajjar et al. (https://doi.org/10.1093/braincomms/fcac270).
  • Assessment of Urinary Exosomal NHE3 as a Biomarker of Acute Kidney Injury. [Journal Article]
    Diagnostics (Basel). 2022 Oct 30; 12(11)Yu Y, Ren Z, … Wang X
  • The diagnosis of acute kidney injury (AKI) traditionally depends on the serum creatinine (Scr) and urine output, which lack sufficient sensitivity and specificity. Using urinary exosomes as a biomarker has unique advantages. To assess whether urinary exosomal Na+/H+ exchanger isoform 3 (NHE3) protein could serve as a biomarker of AKI, we constructed four AKI rat models: cisplatin (7.5 mg/kg) inje…
  • Treatment of Hypertension: A Review. [Review]
    JAMA. 2022 11 08; 328(18):1849-1861.Carey RM, Moran AE, Whelton PK
  • CONCLUSIONS: Hypertension affects approximately 116 million adults in the US and more than 1 billion adults worldwide and is a leading cause of CVD morbidity and mortality. First-line therapy for hypertension is lifestyle modification, consisting of weight loss, dietary sodium reduction and potassium supplementation, healthy dietary pattern, physical activity, and limited alcohol consumption. When drug therapy is required, first-line therapies are thiazide or thiazidelike diuretics, angiotensin-converting enzyme inhibitor or angiotensin receptor blockers, and calcium channel blockers.
  • Candesartan Does Not Activate PPARγ and Its Target Genes in Early Gestation Trophoblasts. [Journal Article]
    Int J Mol Sci. 2022 Oct 14; 23(20)Neuper L, Kummer D, … Gauster M
  • Angiotensin II receptor 1 blockers are commonly used to treat hypertension in women of childbearing age. While the fetotoxic effects of these drugs in the second and third trimesters of pregnancy are well documented, their possible impacts on placenta development in early gestation are unknown. Candesartan, a member of this group, also acts as a peroxisome proliferator-activated receptor gamma (P…
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