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12,632 results
  • Role of angiotensin receptor blockers in the context of Alzheimer's disease. [Review]
    Fundam Clin Pharmacol. 2023 Jan 18 [Online ahead of print]Kuber B, Fadnavis M, Chatterjee B
  • As the world's population ages, the prevalence of age-related neurological disorders such as Alzheimer's disease (AD) is increasing. There is currently no treatment for Alzheimer's disease, and the few approved medications have a low success rate in lowering symptoms. As a result, several attempts are underway worldwide to identify new targets for the therapy of Alzheimer's disease. In preclinica…
  • Altered dietary salt intake for preventing diabetic kidney disease and its progression. [Review]
    Cochrane Database Syst Rev. 2023 01 16; 1:CD006763.Hodson EM, Cooper TE
  • CONCLUSIONS: This systematic review shows an important reduction in SBP and DBP in people with diabetes with normal GFR during short periods of salt restriction, similar to that obtained with single drug therapy for hypertension. These data support the international recommendations that people with diabetes with or without hypertension or evidence of kidney disease should reduce salt intake to less than 5 g/day (2 g sodium).
  • Diuretics in pediatrics. [Review]
    Eur J Pediatr. 2023 Jan 03 [Online ahead of print]Lava SAG, Zollinger C, … Di Bernardo S
  • CONCLUSIONS: This educational review offers a didactical overview of diuretics in Pediatrics.
  • Mathematical modeling of antihypertensive therapy. [Journal Article]
    Front Physiol. 2022; 13:1070115.Kutumova E, Kiselev I, … Kolpakov F
  • Hypertension is a multifactorial disease arising from complex pathophysiological pathways. Individual characteristics of patients result in different responses to various classes of antihypertensive medications. Therefore, evaluating the efficacy of therapy based on in silico predictions is an important task. This study is a continuation of research on the modular agent-based model of the cardiov…
  • The removal of micropollutants from treated effluent by batch-operated pilot-scale constructed wetlands. [Journal Article]
    Water Res. 2023 Feb 15; 230:119494.Lei Y, Wagner T, … Langenhoff A
  • Micropollutants (MPs), such as pharmaceuticals and antibiotics, are present in the environment at low concentrations (ng/L-μg/L). A constructed wetland (CW) is a nature-based wastewater treatment technology, which can be used to remove MPs from wastewater treatment plant effluent. This study aimed to improve MP removal of CWs by optimizing the design of batch-operated CW. Three pilot-scale CWs we…
  • [Role of polypills in cardiovascular risk reduction in primary prevention]. [Review]
    Medicina (B Aires). 2022; 82(6):904-913.Botto F, Tajer C, … Sosa Liprandi Á
  • Unlike medications that contain fixed-dose combinations, such as those recommended by clinical guidelines for treating high blood pressure, the so-called polypills contain several drugs that simultaneously treat two or more cardiovascular conditions or risk factors. They were proposed 2 decades ago, both for primary and secondary prevention with the hypothesis that they could have wide disseminat…
  • Heart failure: an update from the last years and a look at the near future. [Review]
    ESC Heart Fail. 2022 12; 9(6):3667-3693.Riccardi M, Sammartino AM, … Tomasoni D
  • In the last years, major progress occurred in heart failure (HF) management. Quadruple therapy is now mandatory for all the patients with HF with reduced ejection fraction. Whilst verciguat is becoming available across several countries, omecamtiv mecarbil is waiting to be released for clinical use. Concurrent use of potassium-lowering agents may counteract hyperkalaemia and facilitate renin-angi…
  • Chlorthalidone vs. Hydrochlorothiazide for Hypertension-Cardiovascular Events. [Randomized Controlled Trial]
    N Engl J Med. 2022 12 29; 387(26):2401-2410.Ishani A, Cushman WC, … Diuretic Comparison Project Writing Group
  • CONCLUSIONS: In this large pragmatic trial of thiazide diuretics at doses commonly used in clinical practice, patients who received chlorthalidone did not have a lower occurrence of major cardiovascular outcome events or non-cancer-related deaths than patients who received hydrochlorothiazide. (Funded by the Veterans Affairs Cooperative Studies Program; number, NCT02185417.).
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