- Long-term mortality and cardiovascular events of seven angiotensin receptor blockers in hypertensive patients: Analysis of a national real-world database: A retrospective cohort study. [Journal Article]Health Sci Rep. 2023 Feb; 6(2):e1056.HS
- CONCLUSIONS: In a Korean population of patients with hypertension without CVD, six different ARBs showed similar efficacy to losartan in terms of long-term mortality and MACEs. Further well-designed prospective studies are required to confirm our findings.
- PMC Free PDF
- Development and validation of an analytical method for trace level quantification of genotoxic nitrosamine impurities in Losartan and Hydrochlorothiazide fixed dose combination tablets using UPLC-TQ-MS/MS. [Journal Article]Rapid Commun Mass Spectrom. 2023 Feb 05 [Online ahead of print]RC
- Since June of 2018, thousands of pharmaceuticals from all over the world have been recalled due to the unexpected presence of nitrosamines. Beginning with the class of pharmaceuticals known as sartans, subsequent lines of inquiry included antidiabetic medicines, antihistamines, and antibiotics. A critical review of FDA database reveals that the highest number of product recalls due to the presenc…
- Publisher Full Text (DOI)
- Utility of a Systematic Approach to Selecting Candidate Prodrugs: A Case Study Using Candesartan Ester Analogues. [Journal Article]J Pharm Sci. 2023 Feb 01 [Online ahead of print]JP
- Development of prodrugs is a useful strategy to overcome some disadvantages of candidate drugs. Recently, we established a systematic approach to selecting appropriate prodrugs, and validated the utility of this approach using oseltamivir analogues. In this study, the utility of the approach was further examined using candesartan cilexetil and 20 kinds of its analogues having various types of sid…
- Publisher Full Text (DOI)
- Chemometric Methods for Simultaneous Determination of Candesartan Cilexetil and Hydrochlorothiazide in Binary Combinations. [Journal Article]
- Simple, accurate, precise, and cost-effective chemometric techniques for the measurement of candesartan cilexetil and hydrochlorothiazide in synthetic mixtures were improved and validated. H-point standard addition, Q-absorption ratio, and correction absorbance spectrophotometric techniques were utilized for the simultaneous determination of both medicines in real pharmaceutical formulations. A n…
- PMC Free PDF
- Single-Pill Combination with Three Antihypertensive Agents to Improve Blood Pressure Control in Hypertension: Focus on Olmesartan-Based Combinations. [Review]High Blood Press Cardiovasc Prev. 2023 Jan 25 [Online ahead of print]HB
- Blood pressure control remains an unmet clinical need. Only about half of patients achieve their blood pressure (BP) targets and of these, the majority require combination and double or triple therapies. International guidelines recommend the association of drugs with complementary mechanisms of action and, in particular, the combination of renin-angiotensin system (RAS) inhibitors, calcium chann…
- Publisher Full Text (DOI)
- Congenital nephrogenic diabetes insipidus arginine vasopressin receptor 2 gene mutation at new site: A case report. [Case Reports]
- CONCLUSIONS: AVPR2 gene mutations in new loci and new clinical symptoms help clinicians understand this disease and shorten the diagnosis cycle.
- PMC Free PDF
- Investigation of Carcinogenic Impurities of N-Nitrosamines in Sartan Pharmaceutical Products Marketed in Brazil: Development and Validation of Method Based on High-Performance Liquid Chromatography-Tandem Mass Spectrometry. [Journal Article]J Pharm Sci. 2023 Jan 16 [Online ahead of print]JP
- N-nitrosamines (NA) impurities have unexpectedly been found in sartan products, angiotensin II receptor antagonists that are used to control hypertension, representing an urgent concern for industry, global regulators and for the patients. In this study, an HPLC-MS/MS method was developed and validated for the quantification of six NA (N-nitrosodimethylamine, N-Nitroso-N-methyl-4-aminobutyric aci…
- Publisher Full Text (DOI)
- Role of angiotensin receptor blockers in the context of Alzheimer's disease. [Review]Fundam Clin Pharmacol. 2023 Jan 18 [Online ahead of print]FC
- As the world's population ages, the prevalence of age-related neurological disorders such as Alzheimer's disease (AD) is increasing. There is currently no treatment for Alzheimer's disease, and the few approved medications have a low success rate in lowering symptoms. As a result, several attempts are underway worldwide to identify new targets for the therapy of Alzheimer's disease. In preclinica…
- Publisher Full Text (DOI)
- Sulphonamide inhibition studies of the β-carbonic anhydrase GsaCAβ present in the salmon platyhelminth parasite Gyrodactylus salaris. [Journal Article]
- A β-class carbonic anhydrase (CA, EC 4.2.1.1) present in the genome of the Monogenean platyhelminth Gyrodactylus salaris, a fish parasite, GsaCAβ, has been investigated for its inhibitory effects with a panel of sulphonamides and sulfamates, some of which in clinical use. Several effective GsaCAβ inhibitors were identified, belonging to simple heterocyclic sulphonamides, the deacetylated precurso…
- PMC Free PDF
- Medium-term real-world data for erenumab in 177 treatment resistant or difficult to treat chronic migraine patients: persistence and patient reported outcome measures after 17-30 months. [Journal Article]
- CONCLUSIONS: Approximately 55% of treatment resistant or difficult to treat CM patients who trialled erenumab in our clinics reported a subjective benefit and were still on treatment after 17-30 months.
- PMC Free PDF
- Altered dietary salt intake for preventing diabetic kidney disease and its progression. [Review]
- CONCLUSIONS: This systematic review shows an important reduction in SBP and DBP in people with diabetes with normal GFR during short periods of salt restriction, similar to that obtained with single drug therapy for hypertension. These data support the international recommendations that people with diabetes with or without hypertension or evidence of kidney disease should reduce salt intake to less than 5 g/day (2 g sodium).
- Publisher Full Text (DOI)
- Effects of candesartan on cerebral microvascular function in mild cognitive impairment: Results of two clinical trials. [Journal Article]Int J Stroke. 2023 Jan 30 [Online ahead of print]IJ
- CONCLUSIONS: This study suggests that candesartan is associated with improved microvascular function in MCI, and these findings are independent of its blood pressure effect in these VCI and prodromal AD populations.
- Publisher Full Text (DOI)
- Effect of administration of low-dose irbesartan and hydrochlorothiazide combined with levamlodipine at different times on the circadian rhythm of blood pressure and the levels of MMPs and TIMPs in non-dipper patients with grade 1 and 2 hypertension. [Journal Article]J Clin Hypertens (Greenwich). 2023 Jan 14 [Online ahead of print]JC
- This study aimed to probe the effects of low-dose irbesartan and hydrochlorothiazide in combination with levamlodipine at different times on the circadian rhythm of blood pressure, matrix metalloproteinases (MMPs), and tissue inhibitors of metalloproteinases (TIMPs) levels in patients with non-dipper hypertension (NDH). In this prospective randomized controlled trial, 124 patients with NDH who vi…
- Publisher Full Text (DOI)
- Effect of candesartan treatment on echocardiographic indices of cardiac remodeling in post-myocardial infarction patients. [Journal Article]Rev Assoc Med Bras (1992). 2023 Jan 09 [Online ahead of print]RA
- CONCLUSIONS: Our results suggest that candesartan treatment following myocardial infarction may potentially be useful in terms of improving post-myocardial infarction cardiac remodeling.
- Publisher Full Text (DOI)
- Diuretic and Natriuretic Effects of Hesperidin, a Flavanone Glycoside, in Female and Male Hypertensive Rats. [Journal Article]
- Hesperidin (HSP) is a major flavanone glycoside in citrus fruits, including sweet oranges and lemons. It demonstrates numerous pharmacological activities, such as antihypertensive effects and cardiac and kidney tissue protection. However, its effect on modulating renal function has yet to be properly explored. Female and male Wistar spontaneously hypertensive rats (SHR) were used to test the effe…
- PMC Free PDF
- Highlights of Cardiovascular Disease Prevention Studies Presented at the 2022 American Heart Association Scientific Sessions. [Review]Curr Atheroscler Rep. 2023 Jan; 25(1):31-41.CA
- Summarize selected late-breaking science on cardiovascular (CV) disease prevention presented at the 2022 scientific session of the American Heart Association (AHA).
- Publisher Full Text (DOI)
- Diuretics in pediatrics. [Review]Eur J Pediatr. 2023 Jan 03 [Online ahead of print]EJ
- CONCLUSIONS: This educational review offers a didactical overview of diuretics in Pediatrics.
- Publisher Full Text (DOI)
- Mathematical modeling of antihypertensive therapy. [Journal Article]
- Hypertension is a multifactorial disease arising from complex pathophysiological pathways. Individual characteristics of patients result in different responses to various classes of antihypertensive medications. Therefore, evaluating the efficacy of therapy based on in silico predictions is an important task. This study is a continuation of research on the modular agent-based model of the cardiov…
- PMC Free PDF
- Clinical observation of sacubitril valsartan sodium in the treatment of resistant hypertension: A randomized clinical trial. [Journal Article]
- CONCLUSIONS: Sacubitril valsartan sodium can effectively reduce BP and improve cardiac function in RH.
- PMC Free PDF
- The impact of different diuretics on regression of myocardial reperfusion injury in spontaneously hypertensive rats. [Journal Article]Mol Cell Biochem. 2022 Dec 27 [Online ahead of print]MC
- The study's objective was to ascertain the results of sub-chronic therapy of various diuretics on the ischemia/reperfusion dysfunction of the heart in hypertensive rats by a global ischemia in an isolated rat heart model. The research included 40 spontaneously hypertensive male rats (Wistar Kyoto strain, body mass 250 ± 30 g, 8 weeks old) grouped into four groups. The animals were treated for 4 w…
- Publisher Full Text (DOI)
- The removal of micropollutants from treated effluent by batch-operated pilot-scale constructed wetlands. [Journal Article]Water Res. 2023 Feb 15; 230:119494.WR
- Micropollutants (MPs), such as pharmaceuticals and antibiotics, are present in the environment at low concentrations (ng/L-μg/L). A constructed wetland (CW) is a nature-based wastewater treatment technology, which can be used to remove MPs from wastewater treatment plant effluent. This study aimed to improve MP removal of CWs by optimizing the design of batch-operated CW. Three pilot-scale CWs we…
- Publisher Full Text (DOI)
- [Role of polypills in cardiovascular risk reduction in primary prevention]. [Review]Medicina (B Aires). 2022; 82(6):904-913.M
- Unlike medications that contain fixed-dose combinations, such as those recommended by clinical guidelines for treating high blood pressure, the so-called polypills contain several drugs that simultaneously treat two or more cardiovascular conditions or risk factors. They were proposed 2 decades ago, both for primary and secondary prevention with the hypothesis that they could have wide disseminat…
- The role of environmental salinity on Na+-dependent intestinal amino acid uptake in rainbow trout (Oncorhynchus mykiss). [Journal Article]
- Na+/K+-ATPases (NKA) in the basolateral membrane of the intestinal enterocytes create a Na+-gradient that drives both ion-coupled fluid uptake and nutrient transport. Being dependent on the same gradient as well as on the environmental salinity, these processes have the potential to affect each other. In salmonids, L-lysine absorption has been shown to be higher in freshwater (FW) than in seawate…
- PMC Free PDF
- New Approach to Hyponatremia: High Prevalence of Cerebral/Renal Salt Wasting, Identification of Natriuretic Protein That Causes Salt Wasting. [Review]
- Our understanding of hyponatremic conditions has undergone major alterations. There is a tendency to treat all patients with hyponatremia because of common subtle symptoms that include unsteady gait that lead to increased falls and bone fractures and can progress to mental confusion, irritability, seizures, coma and even death. We describe a new approach that is superior to the ineffectual volume…
- PMC Free PDF
- Heart failure: an update from the last years and a look at the near future. [Review]
- In the last years, major progress occurred in heart failure (HF) management. Quadruple therapy is now mandatory for all the patients with HF with reduced ejection fraction. Whilst verciguat is becoming available across several countries, omecamtiv mecarbil is waiting to be released for clinical use. Concurrent use of potassium-lowering agents may counteract hyperkalaemia and facilitate renin-angi…
- PMC Free PDF
- Evaluation of Ameliorative Effect of Quercetin and Candesartan in Doxorubicin-Induced Cardiotoxicity. [Journal Article]
- CONCLUSIONS: The overall result depicts more beneficial and cardioprotective effect of quercetin and candesartan combination as compared to their individual effects in doxorubicin treated animals. Therefore, this combination might be a suitable option to treat the cardiotoxic effect of doxorubicin.
- PMC Free PDF
- Chlorthalidone vs. Hydrochlorothiazide for Hypertension-Cardiovascular Events. [Randomized Controlled Trial]N Engl J Med. 2022 12 29; 387(26):2401-2410.NEJM
- CONCLUSIONS: In this large pragmatic trial of thiazide diuretics at doses commonly used in clinical practice, patients who received chlorthalidone did not have a lower occurrence of major cardiovascular outcome events or non-cancer-related deaths than patients who received hydrochlorothiazide. (Funded by the Veterans Affairs Cooperative Studies Program; ClinicalTrials.gov number, NCT02185417.).
- Publisher Full Text (DOI)
- Thymol-Based Hydrophobic Deep Eutectic Solvents as a Green Approach for Screening Polar Nitrosamines in Sartans Pharmaceutical Products by Ultrasound-Assisted Dispersive Liquid-Liquid Microextraction Combined with HPLC-DAD. [Journal Article]J Pharm Sci. 2022 Dec 05 [Online ahead of print]JP
- Nitrosamines are carcinogens substances firstly detected in sartans drugs in 2018, leading to new regulations and monitoring programmes that raised the costs and challenges to the pharmaceutical industry. Therefore, reliable and cost-effective methods for screening nitrosamines in medicines are highly desirable. Hydrophobic deep eutectic solvents (HDES), a novel "eco-friendly" alternative to solv…
- Publisher Full Text (DOI)
- Cardiological Monitoring - A Cornerstone for Pediatric Inflammatory Multisystem Syndrome Temporally Associated with COVID-19 Outcome: A Case Report and a Review from the Literature. [Journal Article]
- CONCLUSIONS: Echocardiographic monitoring might be a lifesaving diagnostic tool in the management of PIMS-TS.
- PMC Free PDF
- Measuring copeptin, a surrogate for vasopressin in patients with hypertension - Can it identify those who are volume Responsive? [Journal Article]Clin Biochem. 2023 Feb; 112:48-52.CB
- CONCLUSIONS: The current study suggests differences in ADH physiology between hypertensive Black and White patients. However, the use of copeptin to identify volume responsive patients could not be confirmed.
- Publisher Full Text (DOI)