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3,162 results
  • Safety of hydroxyzine in the sedation of pediatric dental patients. [Review]
    J Dent Anesth Pain Med. 2022 Dec; 22(6):395-404.Kim T, Kim K, … Kim J
  • Hydroxyzine is one of the most popular oral sedatives used in pediatric dentistry. This study aimed to investigate the safety and possible side effects of sedation using hydroxyzine in pediatric dentistry. "Hydroxyzine," "Dental sedation," "Child," and "Safety" and their associated synonyms were searched using the Cochrane Library, Embase, PubMed, KISS, KMBASE, and KoreaMed databases. Academic in…
  • Association of Benzodiazepine Treatment for Sleep Disorders With Drug Overdose Risk Among Young People. [Journal Article]
    JAMA Netw Open. 2022 Nov 01; 5(11):e2243215.Bushnell GA, Gerhard T, … Olfson M
  • CONCLUSIONS: The findings of this study suggest that benzodiazepines, compared with alternative pharmacologic treatments for common sleep disorders, were associated with an increased risk of drug overdose among young people during the following 6-month period, especially among those with a recent opioid prescription. Drug overdose is an important safety consideration when treating young people with benzodiazepines.
  • Bitten to the Bone: A Case of Anxiety-Induced Osteomyelitis. [Case Reports]
    Cureus. 2022 Nov; 14(11):e31511.Rivera JA, Aragon D, … Hernandez D
  • Onychophagia is a habitual nail-biting disorder, usually associated with mental or emotional diseases. It affects 20-30% of the population in all age groups. Human bites have the potential to become serious injuries due to high virulence in the human oral flora and may often require hospital admission, antibiotics and even debridement in the operating room. Thus, repetitive nail biting has the po…
  • High opioid doses, naloxone, and central nervous system active medications received by Medicare-enrolled adults. [Journal Article]
    J Am Geriatr Soc. 2023 Jan; 71(1):98-108.Silva Almodóvar A, Nahata MC
  • CONCLUSIONS: Nearly one-fourth of patients were prescribed a mean daily opioid therapy of MME ≥50. These patients were more likely to be prescribed hypnotics, SNRIs, and naloxone. Patients receiving chronic high-dose opioid therapy were more likely to be in age groups of persons <85 years. Naloxone may be underprescribed among eligible adults. Targeted medication services may ensure optimal prescribing among Medicare patients with chronic opioid therapies.
  • Cetirizine more potently exerts mast cell-stabilizing property than diphenhydramine. [Journal Article]
    Drug Discov Ther. 2022 Nov 20; 16(5):245-250.Fujimura R, Asada A, … Kazama I
  • Cetirizine, a second-generation antihistamine, and diphenhydramine, a first-generation antihistamine, are among the most widely used anti-allergic drugs. In addition to longer duration of action and less incidence of sedative side effects, recent clinical studies also indicate a higher potency of cetirizine than diphenhydramine in the treatment or prevention of allergic disorders. In the present …
  • An evidence-based approach to psychopharmacology for posttraumatic stress disorder (PTSD) - 2022 update. [Review]
    Psychiatry Res. 2022 11; 317:114840.Bajor LA, Balsara C, Osser DN
  • Algorithms for posttraumatic stress disorder were published by this team in 1999 and 2011. Developments since then warrant revision. New studies and review articles from January 2011 to November 2021 were identified via PubMed and analyzed for evidence supporting changes. Following consideration of variations required by special patient populations, treatment of sleep impairments remains as the f…
  • Shufeng Jiedu capsule ameliorates olfactory dysfunction via the AMPK/mTOR autophagy pathway in a mouse model of allergic rhinitis. [Journal Article]
    Phytomedicine. 2022 Dec; 107:154426.Chen H, Cheng Y, … Chen M
  • CONCLUSIONS: In addition to antibacterial and antiviral activities, SFJDC has marked anti-inflammatory effects in AR mice. Its mechanism of action in the nasal cavity involves inhibition of upregulated anti-inflammatory cytokines, modulation of autophagy and apoptosis levels and regulation of autophagy through the AMPK/mTOR pathway in the OE tissue of AR mice. Hence, SFJDC is a promising drug for AR, and clinical trials should further validate the therapeutic impact of SFJDC on AR with olfactory dysfunction.
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