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2,800 results
  • Analysis of cocaine adulterants in human brain in cases of drug-related death. [Journal Article]
  • FSForensic Sci Int 2018 Feb 10; 285:86-92
  • Knuth M, Temme O, … Pawlik E
  • CONCLUSIONS: The method was fully validated for cocaine (COC), benzoylecgonine (BZE), ecgonine methyl ester (EME), diltiazem (DIL), hydroxyzine (HYD), and levamisole (LEV) and partly validated for cetirizine (CET), lidocaine (LID), phenacetin (PHE), and procaine (PRO) in brain material. By analyzing post-mortem brain tissue of ten cocaine users, LEV, LID, and HYD as well as PHE were identified in contrast to DIL, PRO, and the HYD metabolite CET. HYD and LEV were found in moderate to high concentrations in some cases. Therefore, it cannot be excluded that they have caused adverse side effects.Because adulterants can potentially affect the central nervous and cardiac systems, it is likely that they enhance COC toxicity.
  • Treating Pediatric Anxiety: Initial Use of SSRIs and Other Antianxiety Prescription Medications. [Journal Article]
  • JCJ Clin Psychiatry 2017 Oct 31
  • Bushnell GA, Compton SN, … Stürmer T
  • CONCLUSIONS: SSRIs are the most commonly used first-line medication for pediatric anxiety disorders, with about half of SSRI initiators continuing treatment for 6 months. Still, a third began therapy on a non-SSRI medication, for which there is limited evidence of effectiveness for pediatric anxiety, and a notable proportion of children initiated with 2 antianxiety medication classes.
  • Chloral hydrate as a sedating agent for neurodiagnostic procedures in children. [Review]
  • CDCochrane Database Syst Rev 2017 11 03; 11:CD011786
  • Fong CY, Tay CG, … Lai NM
  • CONCLUSIONS: The quality of evidence for the comparisons of oral chloral hydrate against several other methods of sedation was very variable. Oral chloral hydrate appears to have a lower sedation failure rate when compared with oral promethazine for children undergoing paediatric neurodiagnostic procedures. The sedation failure was similar for other comparisons such as oral dexmedetomidine, oral hydroxyzine hydrochloride, and oral midazolam. When compared with intravenous pentobarbital and music therapy, oral chloral hydrate had a higher sedation failure rate. However, it must be noted that the evidence for the outcomes for the comparisons of oral chloral hydrate against intravenous pentobarbital and music therapy was of very low to low quality, therefore the corresponding findings should be interpreted with caution.Further research should determine the effects of oral chloral hydrate on major clinical outcomes such as successful completion of procedures, requirements for additional sedative agent, and degree of sedation measured using validated scales, which were rarely assessed in the studies included in this review. The safety profile of chloral hydrate should be studied further, especially the risk of major adverse effects such as bradycardia, hypotension, and oxygen desaturation.
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