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11,883 results
  • Bioimaging of alloantigen-stimulated regulatory T cells in rat vascularized composite allotransplantation. [Journal Article]
  • PlosPLoS One 2018; 13(9):e0203624
  • Cheng HY, Tay SKL, … Wei FC
  • CONCLUSIONS: Sorted Tregs induced donor-specific tolerance to VCA in rats. Live cell tracking demonstrated that activated CD4+CD25+FoxP3+ Tregs targeted primarily to the lymph nodes and VCA. The Tregs migrated to the secondary grafted donor skin and contributed to the maintenance of donor-specific tolerance. These behaviors were associated with phenotypic changes induced by donor antigen stimulation. Increased expression of CCR4 and CCL22 in VCA skin may also be relevant.
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