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5,066 results
  • Status Epilepticus in Older Adults: Diagnostic and Treatment Considerations. [Journal Article]
    Drugs Aging. 2023 Feb 06 [Online ahead of print]Osman GM, Hocker SE
  • Status epilepticus (SE) is one of the leading life-threatening neurological emergencies in the elderly population, with significant morbidity and mortality. SE presents unique diagnostic and therapeutic challenges in the older population given overlap with other causes of encephalopathy, complicating diagnosis, and the common occurrence of multiple comorbid diseases complicates treatment. First-l…
  • Seizure Occurring During Baclofen Monotherapy for Phenibut Withdrawal. [Journal Article]
    Clin Neuropharmacol. 2023 Feb 04 [Online ahead of print]Patt A, Fox H, … Feldman R
  • CONCLUSIONS: Phenibut use is rising, and treatment options for PW, such as baclofen, warrant additional study. Potential risks of underdosing baclofen if used as monotherapy in PW may include seizures as withdrawal progresses. Baclofen's role in therapy may be more appropriate as an adjunct than a cornerstone of therapy. Treatment done in consultation with providers experienced in managing withdrawal such as a toxicologist may help reduce this risk.
  • Postpartum Collapse Subsequent to Catatonia in a Female with COVID-19 Infection: a Rare Entity Visited. [Case Reports]
    J Obstet Gynaecol India. 2023 Jan 10 [Online ahead of print]Joshi B, Sahoo S, … Chopra S
  • Postpartum collapse is a life-threatening condition caused by obstetrical and non-obstetrical events. In this case report, we discuss a case of postpartum collapse in COVID-19-positive woman who required intensive care and mechanical ventilation for two days. After confusing collision of many provisional diagnoses soldiering for three days, she was ultimately diagnosed with malignant catatonia. T…
  • Recurrent Catatonia: Infection and Immunity in an Idiopathic Illness. [Case Reports]
    J Psychiatr Pract. 2023 01 01; 29(1):82-89.Tiwari S, Akyuz E, Das A
  • Catatonia can be associated with multiple physical and mental illnesses, and idiopathic catatonia is a well-recognized clinical entity. Here we report a case of recurrent idiopathic catatonia with underlying immunologic abnormalities, with an emphasis on etiological hypotheses. An 18-year-old female with mild learning disability, dyspraxia, autoimmune hypothyroidism, and nonceliac gluten intolera…
  • Evaluation of intravenous lorazepam dosing strategies and the incidence of refractory status epilepticus. [Journal Article]
    Epilepsy Res. 2022 Dec 22; 190:107067.Cetnarowski A, Cunningham B, … Fowler M
  • CONCLUSIONS: The majority of patients in the study received less than the recommended dose of IV lorazepam for SE. Patients who received less than 4 mg experienced an increased progression to RSE, which supports current guideline recommended dosing. While there was an increased rate of mortality in patients who received 4 mg compared to less than 4 mg, time in SE was prolonged in the patient population and severity of illness was only available for a limited number of patients included.
  • Pain, Nausea, and Hospital Admission after Uterine Fibroid Embolization: A Comparison of 2 Protocols. [Journal Article]
    J Vasc Interv Radiol. 2022 Dec 13 [Online ahead of print]Hastings G, Brahler T, … Wrenn SJ
  • Uterine fibroid embolization (UFE) procedures performed from 2013 to 2019 were reviewed. Seventy-two patients were treated with a standard protocol consisting of sedation, ketorolac, ondansetron, and overnight parenteral analgesics and antiemetics. Ninety-six patients were treated with a new protocol, which added transdermal scopolamine, lorazepam, and intravenous acetaminophen. Outpatient uterin…
  • Focal status epilepticus: a review of pharmacological treatment. [Review]
    Neurologia (Engl Ed). 2022 Nov-Dec; 37(9):757-766.Huertas González N, Barros González A, … Díaz Díaz J
  • CONCLUSIONS: The available scientific evidence is insufficient to claim that pharmacological treatment of focal SE should be different from treatment for generalised SE. More studies with a greater number of patients are needed.
  • StatPearls: Lorazepam [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)GhiasiNomanNAmerican Un of the Caribbean School MedBhansaliRakesh KumarRKMarwahaRamanRCase Western Reserve Un/MetroHealth MCBOOK
  • Lorazepam is a benzodiazepine medication commonly used as the sedative and anxiolytic of choice in the inpatient setting owing to its fast (1 to 3 minute) onset of action when administered intravenously. Lorazepam is also one of the few sedative-hypnotics with a relatively clean side effect profile. This activity covers lorazepam, including mechanism of action, pharmacology, adverse event profile…
  • [Acute catatonia]. [Review]
    Nervenarzt. 2023 Feb; 94(2):106-112.Karl S, Schönfeldt-Lecuona C, … Sartorius A
  • CONCLUSIONS: Several factors lead to the underdiagnosis of catatonia. It is problematic that even life-threatening malignant catatonia is often not recognized as such, although there is a mortality of about 50% if untreated. The best treatment outcome is achieved with a combination of benzodiazepines and ECT. The treatment of severe malignant catatonia represents an emergency indication for ECT.
  • Management of Alcohol Withdrawal Syndrome in Patients with Alcoholic Liver Disease. [Review]
    J Clin Exp Hepatol. 2022 Nov-Dec; 12(6):1527-1534.Chand PK, Panda U, … Murthy P
  • Alcohol withdrawal syndrome (AWS) is a common condition that is seen in treatment-seeking patients with Alcohol use disorder (AUD) and alcoholic liver disease (ALD). AWS, which typically starts within 4-6 h of the last alcohol use, can range from mild symptoms such as insomnia, tremors, and autonomic hyperactivity to more severe symptoms such as seizures and delirium tremens. Clinical Institute W…
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