- Potentiation of skin TSLP production by a cosmetic colorant leads to aggravation of dermatitis symptoms. [Journal Article]
- CBChem Biol Interact 2018 Feb 17
- Certain cosmetic colorants are irritant to skin or aggravate dermatitis. Thymic stromal lymphopoietin (TSLP) plays an important role in the initiation and progress of skin inflammation and atopic der...
Certain cosmetic colorants are irritant to skin or aggravate dermatitis. Thymic stromal lymphopoietin (TSLP) plays an important role in the initiation and progress of skin inflammation and atopic dermatitis by triggering Th2 immune responses. However, the effects of cosmetic colorants on TSLP production are unknown yet. Therefore, we investigated whether cosmetic colorants regulated TSLP production and dermatitis. Lithol Rubine B (LR-B, Pigment Red 57) and its calcium salt (LR-BCA), commonly used cosmetic colorants, potentiated phorbol-12-myristate-13-acetate-induced TSLP production in keratinocytes. In addition, the topical exposure to LR-B or LR-BCA on mouse ear upregulated a TSLP inducer (MC903)-induced TSLP production and Th2 cytokine expression. Dermatitis symptoms and serum IgE and histamine levels were also aggravated by LR-B or LR-BCA, implicating the role of increased TSLP expression in acute dermatitis. LR-B or LR-BCA induced IκBα degradation and NF-κB activation in keratinocytes, leading to TSLP expression. Collectively, our results demonstrate that LR-B and LR-BCA increase TSLP expression and Th2 immune responses, thereby aggravating acute dermatitis in the compromised skin. The results further suggest that certain cosmetic colorants such as LR-B may aggravate dermatitis under pro-inflammatory conditions by upregulating TSLP production.
- Trends in Atopic Dermatitis Management: Comparison of 1990-1997 to 2003-2012. [Journal Article]
- JDJ Drugs Dermatol 2018 Feb 01; 17(2):135-140
- CONCLUSIONS: The NAMCS does not follow individual patients over time.TCI use has been decreasing. New topical AD treatments may provide an alternative to TCS, better treatment outcomes for moderate-to-severe atopic dermatitis, and an alternative to systemic antihistamines whose efficacy in AD is unproven and whose general use in AD management is discouraged by the American Academy of Dermatology. J Drugs Dermatol. 2018;17(2):135-140.
- Are skin equipment for assessing childhood eczema any good? [Journal Article]
- JDJ Dermatolog Treat 2018 Feb 20; :1-15
- CONCLUSIONS: Skin pH (using Mettler Toledo), SH and TEWL (using Delfin equipment) correlated well with various clinical symptomatology scores. Less acidic pH appears to be associated with worse clinical scores of symptomatology, and increase usage of topical antibiotics, These findings not only support the supplementary usage of equipment in aiding objective documentation of clinical symptomatology in eczema therapeutic research but also the advocacy of maintaining more acidic skin and avoiding alkaline soap and emollient products.
- Major role for TRPV1 and InsP3R in PAR-2-elicited inflammatory mediator production in differentiated human keratinocytes. [Journal Article]
- JIJ Invest Dermatol 2018 Feb 16
- Proteinase-activated receptor-2 (PAR-2) activation in basal keratinocytes stimulates inflammation via the Ca2+-dependent production of mediators such as interleukin (IL)-1β, tumor necrosis factor (TN...
Proteinase-activated receptor-2 (PAR-2) activation in basal keratinocytes stimulates inflammation via the Ca2+-dependent production of mediators such as interleukin (IL)-1β, tumor necrosis factor (TNF)-α and thymic stromal lymphopoietin (TSLP). In this study, we investigated PAR-2 calcium signaling and the consequent production of inflammatory mediators in differentiated human primary keratinocytes (DhPKs). Stimulation with the PAR-2 activating peptide SLIGKV promoted Ca2+store depletion in both undifferentiated human primary keratinocytes (UhPKs) and DhPKs. SLIGKV-evoked Ca2+store depletion did not trigger the store-operated Ca2+entry (SOCE) through ORAI1 in DhPK when compared with UhPK. The inhibition of phospholipase C (PLC) and the concomitant inhibition of transient receptor potential vanilloid 1 (TRPV1) and inositol triphosphate receptor (InsP3R) in DhPKs abrogated the SLIGKV-evoked Ca2+store depletion, NF-κB activity and the production of inflammatory mediators, such as IL-1β, TNF-α and TSLP. Taken together, these results indicate a key role for both InsP3R and TRPV1 in Ca2+internal stores in the PAR-2-evoked Ca2+release and consequent skin inflammation in DhPKs. These findings may provide clues to understanding the pathological role of DhPKs in skin disorders in which PAR-2 is known to be involved, such as atopic dermatitis (AD), Netherton syndrome (NS) and psoriasis.
- Atopy Associated With Positive Patch Test and Possible Allergic Contact Dermatitis. [Journal Article]
- JCJ Cutan Med Surg 2018 Feb 01; :1203475418758988
- CONCLUSIONS: We conclude from our study that patients with a personal or family history of atopy have an increased risk of allergic contact dermatitis (ACD). These results provide further evidence for the link between atopy and ACD and suggest that children of atopic parents should avoid potential contact allergens and would likely benefit from prophylactic emollient use.
- Atopic Dermatitis in Diverse Racial and Ethnic Groups - Variations in Epidemiology, Genetics, Clinical Presentation, and Treatment. [Review]
- EDExp Dermatol 2018 Feb 19
- Atopic dermatitis (AD) is a chronic inflammatory skin condition that affects diverse ethnic groups with varying prevalence. Despite a predominance of studies in individuals of European ancestry, AD h...
Atopic dermatitis (AD) is a chronic inflammatory skin condition that affects diverse ethnic groups with varying prevalence. Despite a predominance of studies in individuals of European ancestry, AD has been found to occur more frequently in Asian and black individuals than whites. Therefore, an understanding of the unique clinical features of AD in diverse ethnic groups, as well as the differences in genetic polymorphisms that influence susceptibility to AD and response to current therapies, is paramount for management of an increasingly diverse patient population. In this article, we review key nuances in the epidemiology, pathophysiology, clinical presentation, and treatment of AD in non-white ethnic groups, which are largely under-appreciated in the literature. We highlight the need for studies evaluating the tissue molecular and cellular phenotypes of AD in non-white patients, as well as greater inclusion of minority groups in clinical trials, in order to develop targeted treatments for a multi-ethnic population. This article is protected by copyright. All rights reserved.
- Influence of topical steroids on intraocular pressure in patients with atopic dermatitis. [Journal Article]
- AIAllergol Int 2018 Feb 15
- CONCLUSIONS: Our study suggests that TCS might not cause increases in IOP at the abovementioned doses. However, the IOP of steroid responders is known to be highly responsive to steroids. Therefore, patients who have steroids applied to their eyelids had better undergo regular IOP measurements at ophthalmological clinics.
- Exposure to dogs but not cats is associated to a decrease in the prevalence in atopic dermatitis amongst school-children. [Journal Article]
- AIAllergol Immunopathol (Madr) 2018 Feb 15
- CONCLUSIONS: Our findings suggest that exposure to dogs, whether they be indoor or outdoor pets, is associated to a decreased prevalence in atopic dermatitis.
- Pathophysiology and Management of Mild to Moderate Pediatric Atopic Dermatitis. [Journal Article]
- JPJ Pediatr Health Care 2018 Mar - Apr; 32(2):S2-S12
- Atopic dermatitis (AD), or eczema, is a chronic inflammatory skin condition characterized by relapsing pruritic and dry, scaly lesions. AD affects 10% to 20% of children in the United States and sign...
Atopic dermatitis (AD), or eczema, is a chronic inflammatory skin condition characterized by relapsing pruritic and dry, scaly lesions. AD affects 10% to 20% of children in the United States and significantly affects the quality of life of patients and their families. Primary care providers (PCPs) are often the first point of contact for the management of AD symptoms. As many as 70% of patients with mild to moderate disease can be managed by a PCP, underscoring the need for these providers to understand basic AD pathophysiology and current standards of care. This article will discuss the basic principles of AD diagnosis and management that PCPs need to optimize patient care, including AD pathogenesis, appropriate use of currently available topical therapies, basic skin care practices, and patient/caregiver counseling points. This article is sponsored by Spire Learning and supported by an educational grant from Pfizer Inc.
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- Bamboo salt suppresses skin inflammation in mice with 2, 4-dinitrofluorobenzene-induced atopic dermatitis. [Journal Article]
- CJChin J Nat Med 2018; 16(2):97-104
- Bamboo salt (BS) is a traditional Korean food, and has been reported to have anti-cancer, anti-inflammatory, and anti-metastatic effects. However, the anti-atopic dermatitis (AD) activity of BS has n...
Bamboo salt (BS) is a traditional Korean food, and has been reported to have anti-cancer, anti-inflammatory, and anti-metastatic effects. However, the anti-atopic dermatitis (AD) activity of BS has not been described yet. In the present study, we examined the preventive effect of BS on AD. The effect of oral administration of BS was tested in a 2, 4-dinitrofluorobenzene (DNFB)-induced AD animal model, by histological analysis, enzyme-linked immunosorbent assay, reverse transcription-polymerase chain reaction, caspase-1 assay, and Western blotting analysis. BS administration reduced the total clinical severity and scratching frequencies, compared with the AD group. In the serum of DNFB-induced AD mice, the levels of IgE, histamine, thymic stromal lymphopoietin (TSLP), interleukin (IL)-5, and IL-13 were significantly reduced by BS treatment. BS significantly reduced the protein and mRNA expression of TSLP, IL-6, and tumor necrosis factor-α in the AD skin lesions. BS markedly reduced the infiltration of inflammatory cells. Furthermore, the activation of caspase-1 was reduced by BS in the AD skin lesions. Our results suggested that BS should be considered as a candidate treatment for allergic inflammatory diseases including AD.