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(Atopic dermatitis)
24,866 results
  • Baseline IL22 expression in atopic dermatitis patients stratifies tissue responses to fezakinumab. [Journal Article]
  • JAJ Allergy Clin Immunol 2018 Aug 16
  • Brunner PM, Pavel AB, … Guttman-Yassky E
  • CONCLUSIONS: This is the first report showing a profound effect of IL-22 blockade on multiple inflammatory pathways in AD. These data, supported by the robust effects in patients with high IL22 baseline expression, suggest a central role for IL-22 in AD, indicating the need for a precision medicine approach for improving therapeutic outcomes in AD.Stratification of cytokine expression at baseline might help future precision medicine approaches to effectively treat atopic dermatitis patient subsets that might benefit from IL-22 antagonism or other specific blockers.
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