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Unbound Medicine.
(Atopic dermatitis)
33,930 results
  • Oral JAK Inhibitors for Atopic Dermatitis. [Review]
    Ann Allergy Asthma Immunol. 2023 Jan 31 [Online ahead of print]Mikhaylov D, Ungar B, … Guttman-Yassky E
  • Atopic dermatitis (AD) is one of the most common inflammatory skin conditions. The pathogenesis of AD involves skin barrier disruption and immune activation of T-helper (Th)2 and Th22, as well as varying degrees of Th1 and Th17 activation in various patient subtypes. Although AD is mainly driven by Th2, the molecular and clinical heterogeneity of AD underscores the need for more efficacious treat…
  • Janus Kinase Inhibitors in the Treatment of Atopic Dermatitis: Military Considerations. [Journal Article]
    Cutis. 2022 Dec; 110(6):316-320.Nolan CF
  • Janus kinase (JAK) inhibitors represent one of the newest and most promising additions to the available treatments of atopic dermatitis (AD). Janus kinase inhibitors offer several key benefits over injectable biologics to include more predictable pharmacokinetics, nonimmunogenicity, and flexible dosing, in addition to their oral and topical bioavailability. Recommended laboratory assessments befo…
  • Pimecrolimus for the Treatment of Atopic Dermatitis in Infants: An Asian Perspective. [Review]
    Dermatol Ther (Heidelb). 2023 Feb 03 [Online ahead of print]Chu CY, Yao TC, … Luger T
  • Atopic dermatitis (AD) is a common chronic, multisystem inflammatory skin disease in pediatric patients. There has been an increase in the incidence of AD in the pediatric population of the Asia-Pacific region. Studies have shown that genetic, epigenetic, environmental and cultural factors may lead to differences in the clinical manifestation and prevalence of AD between races. Early treatment of…
  • Skin manifestations of inborn errors of NF-κB. [Review]
    Front Pediatr. 2022; 10:1098426.Shen Y, Boulton APR, … Cook MC
  • More than 400 single gene defects have been identified as inborn errors of immunity, including many arising from genes encoding proteins that affect NF-κB activity. We summarise the skin phenotypes in this subset of disorders and provide an overview of pathogenic mechanisms. NF-κB acts cell-intrinsically in basal epithelial cells during differentiation of skin appendages, influences keratinocyte …
  • Relationship Between Atopic Dermatitis and Food Allergy in Children. [Review]
    Cureus. 2022 Dec; 14(12):e33160.Mehta Y, Fulmali DG
  • Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by a compromised skin barrier due to a variety of reasons, such as hereditary predisposition, immunological overactivity, and skin microbiome disruption. There is strong evidence linking food allergies (FA) with AD in some children, and many children with AD develop asymptomatic food sensitivity. FA and AD are two frequ…
  • The Association Between Fatigue and Adult Atopic Dermatitis: A Cross-Sectional Study. [Journal Article]
    Dermatitis. 2023 Feb 01 [Online ahead of print]Thyssen JP, Nymand LK, … Egeberg A
  • Background: There is currently limited insight into the broader impact of atopic dermatitis (AD) on mental health. Although studies indicate that AD patients may experience fatigue, no study has so far examined fatigue in more granular detail, for example, occurrence of general fatigue, physical fatigue, reduced activity, reduced motivation, and mental fatigue, or correlated fatigue measures with…
  • Atopic Dermatitis and Self-Image Design: A Real-Life Study in Children Using Drawings. [Journal Article]
    Dermatitis. 2023 Feb 01 [Online ahead of print]Braun C, Bourrel-Bouttaz M, … Nosbaum A
  • Background: Atopic dermatitis (AD) induces alterations of external appearance and self-esteem, with impact on the personal development of the children. However, tools for estimating such suffering are lacking. We aimed to assess how children with AD represent themselves through their drawings. Methods: In this retrospective study, we included children (<18 years) suffering from AD who followed th…
  • Prevalence and risk factors for atopic dermatitis in Greenlandic children. [Journal Article]
    Clin Exp Dermatol. 2022 Dec 22 [Online ahead of print]Andersson AM, Kaiser H, … Thyssen JP
  • CONCLUSIONS: The overall prevalence of AD in children in Greenland is high and has likely increased over the past 20 years. The point prevalence was highest in the youngest children indicating early onset of disease. Inuit descent, family atopy predisposition and having a higher socioeconomic status (based on parental educational level and housing) increased the risk of AD. Insight into possible Inuit-specific genetic predisposition is needed.
  • Quality of life of pediatric patients with atopic dermatitis and their caregivers. [Journal Article]
    Arch Dermatol Res. 2023 Feb 01 [Online ahead of print]El Achkar Mello ME, Simoni AG, … de Souza Pires MM
  • To compare the quality of life (QoL) of children with and without atopic dermatitis (AD) and that of their caregivers and to assess their QoL according to different degrees of AD. This is a cross-sectional, case-control study conducted with patients aged between 4 and 12 years with and without AD and their caregivers. Patients were treated at the Pediatric Dermatology Outpatient Center and the Ch…
  • Nagashima-type palmoplantar keratoderma: Case series and two novel variants. [Case Reports]
    Pediatr Dermatol. 2023 Jan 31 [Online ahead of print]Braun M, Choate KA, Mathes EF
  • Nagashima-type palmoplantar keratoderma (PPK) is an autosomal recessive PPK. We report four patients, highlight two new genetic variants, and emphasize the possibility of misdiagnosing the condition. Concomitant atopic dermatitis, specifically, may make correct diagnosis challenging. Clinicians should consider the diagnosis of Nagashima-type PPK in patients presenting with mild PPK with transgred…
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