- FLG mutations, eczema control, and respiratory symptom at one-year-old in early-onset atopic dermatitis infants (PACI-ON cohort study). [Letter]J Dermatol Sci. 2023 Jan 25 [Online ahead of print]JD
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- Dupilumab treatment for atopic dermatitis is associated with decreased utilization of psychostimulants for attention deficit hyperactivity disorder: a retrospective cohort study. [Journal Article]J Am Acad Dermatol. 2023 Jan 31 [Online ahead of print]JA
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- Oral JAK Inhibitors for Atopic Dermatitis. [Review]Ann Allergy Asthma Immunol. 2023 Jan 31 [Online ahead of print]AA
- Atopic dermatitis (AD) is one of the most common inflammatory skin conditions. The pathogenesis of AD involves skin barrier disruption and immune activation of T-helper (Th)2 and Th22, as well as varying degrees of Th1 and Th17 activation in various patient subtypes. Although AD is mainly driven by Th2, the molecular and clinical heterogeneity of AD underscores the need for more efficacious treat…
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- Skin colonization with S. aureus can lead to increased NLRP1 inflammasome activation in patients with atopic dermatitis. [Journal Article]J Invest Dermatol. 2023 Jan 31 [Online ahead of print]JI
- The role of NLRP1 inflammasome activation and subsequent production of IL-1 family cytokines in the development of atopic dermatitis (AD) is not clearly understood. S. aureus is known to be associated with increased mRNA levels of IL-1 family cytokines in the skin and more severe AD. In this study, the altered expression of IL-1 family cytokines and inflammasome-related genes was confirmed and po…
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- Janus Kinase Inhibitors in the Treatment of Atopic Dermatitis: Military Considerations. [Journal Article]Cutis. 2022 Dec; 110(6):316-320.C
- Janus kinase (JAK) inhibitors represent one of the newest and most promising additions to the available treatments of atopic dermatitis (AD). Janus kinase inhibitors offer several key benefits over injectable biologics to include more predictable pharmacokinetics, nonimmunogenicity, and flexible dosing, in addition to their oral and topical bioavailability. Recommended laboratory assessments befo…
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- Biologics for pediatric atopic dermatitis: A protocol of a systematic review and meta-analysis. [Journal Article]PLoS One. 2023; 18(2):e0271712.Plos
- CONCLUSIONS: We aim to evaluate the efficacy and safety of biologics in pediatric atopic dermatitis cases and provide evidence-based data for easy clinical application.
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- Pimecrolimus for the Treatment of Atopic Dermatitis in Infants: An Asian Perspective. [Review]Dermatol Ther (Heidelb). 2023 Feb 03 [Online ahead of print]DT
- Atopic dermatitis (AD) is a common chronic, multisystem inflammatory skin disease in pediatric patients. There has been an increase in the incidence of AD in the pediatric population of the Asia-Pacific region. Studies have shown that genetic, epigenetic, environmental and cultural factors may lead to differences in the clinical manifestation and prevalence of AD between races. Early treatment of…
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- Hochuekkito exerts the anti-allergic effects via activating regulatory T cells in a murine model of contact hypersensitivity. [Journal Article]J Nat Med. 2023 Feb 03 [Online ahead of print]JN
- Hochuekkito (HET) is a Kampo prescription, used for the clinical treatment of skin diseases such as atopic dermatitis (AD), in Japan. Oral administration of HET exerts anti-allergic effects in an experimental dermatitis mice model and in patients with atopic dermatitis; however, the mechanism underlying the anti-allergic effects of HET is still unclear. Therefore, we investigated the immunopharma…
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- Skin manifestations of inborn errors of NF-κB. [Review]Front Pediatr. 2022; 10:1098426.FP
- More than 400 single gene defects have been identified as inborn errors of immunity, including many arising from genes encoding proteins that affect NF-κB activity. We summarise the skin phenotypes in this subset of disorders and provide an overview of pathogenic mechanisms. NF-κB acts cell-intrinsically in basal epithelial cells during differentiation of skin appendages, influences keratinocyte …
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- Incorporating genetics in identifying peanut allergy risk and tailoring allergen immunotherapy: A perspective on the genetic findings from the LEAP trial. [Review]J Allergy Clin Immunol. 2023 Jan 31 [Online ahead of print]JA
- Examining the genetics of peanut allergy (PA) in the context of clinical trial interventions and outcomes provides an opportunity to not only understand gene-environment interactions for PA risk but to also understand the benefit of allergen immunotherapy. A consistent theme in the genetics of food allergy is that in keeping with the dual allergen exposure hypothesis, barrier- and immune-related …
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- Multicenter prospective observational study of dupilumab-induced ocular events in atopic dermatitis patients. [Journal Article]J Eur Acad Dermatol Venereol. 2023 Feb 02 [Online ahead of print]JE
- CONCLUSIONS: This study showed that most dupilumab-induced blepharoconjunctivitis cases are de novo. AD severity and conjunctivitis at baseline were not found to be associated risk factors in this study.
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- The dangers of social media: patients with atopic dermatitis ceasing their basic treatment. [Journal Article]Clin Exp Dermatol. 2023 Feb 02; 48(2):142-143.CE
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- Development and validation of a minimally invasive and image-guided tape stripping method to sample atopic skin in children. [Journal Article]Clin Exp Dermatol. 2023 Feb 02; 48(2):80-88.CE
- CONCLUSIONS: Our minimally invasive method is safe and reliable, and provides reproducible acquisition of cDNA in atopic children. In addition, it enables rapid sample collection, a crucial factor in clinical practice.
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- Malignancy-associated generalised exfoliative dermatitis: A retrospective study in a single-centre Asian cohort. [Journal Article]Australas J Dermatol. 2023 Feb 02 [Online ahead of print]AJ
- CONCLUSIONS: When compared to existing literature, our cohort reflects a higher observed occurrence of malignancy in association with erythroderma. As delays in evaluation for underlying malignancy could result in potentially deleterious outcomes, it is prudent to consider systematic screening for malignancy in high-risk populations such as elderly erythroderma patients.
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- Modulation of allergic contact dermatitis via gut microbiota modified by diet, vitamins, probiotics, prebiotics, and antibiotics. [Review]Pharmacol Rep. 2023 Feb 02 [Online ahead of print]PR
- Allergic contact dermatitis is one of the most common recorded occupational diseases. There are many different substances that the skin comes into contact with on a daily basis and that can cause ACD, e.g., preservatives, surfactants, and antimicrobial agents. The development of a mouse model of ACD has provided insight into the immune mechanisms involved. Drugs used in the treatment of skin dise…
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- Healthcare Provider Experience in Diagnosing and Treating Cutaneous T-Cell Lymphoma. [Journal Article]Dermatol Ther (Heidelb). 2023 Feb 02 [Online ahead of print]DT
- CONCLUSIONS: Given the infrequency of CTCL and its similar presentation to other common dermatologic conditions, increased education of CTCL is needed in the dermatology community to improve patient outcomes.
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- Case report: Primary immunodeficiency due to a novel mutation in CARMIL2 and its response to combined immunomodulatory therapy. [Case Reports]
- Capping protein regulator and myosin 1 linker 2 (CARMIL2) is necessary for invadopodia formation, cell polarity, lamellipodial assembly, membrane ruffling, acropinocytosis, and collective cell migration. CARMIL2 deficiency is a rare autosomal recessive disease characterized by dysfunction in naïve T-cell activation, proliferation, differentiation, and effector function and insufficient responses …
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- Relationship Between Atopic Dermatitis and Food Allergy in Children. [Review]
- Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by a compromised skin barrier due to a variety of reasons, such as hereditary predisposition, immunological overactivity, and skin microbiome disruption. There is strong evidence linking food allergies (FA) with AD in some children, and many children with AD develop asymptomatic food sensitivity. FA and AD are two frequ…
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- bSRWPSO-FKNN: A boosted PSO with fuzzy K-nearest neighbor classifier for predicting atopic dermatitis disease. [Journal Article]
- Atopic dermatitis (AD) is an allergic disease with extreme itching that bothers patients. However, diagnosing AD depends on clinicians' subjective judgment, which may be missed or misdiagnosed sometimes.
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- The efficacy and safety of lebrikizumab monotherapy for the management of moderate-to-severe atopic dermatitis: A systematic review and meta-analysis. [Systematic Review]
- CONCLUSIONS: Overall, lebrikizumab showed a significant improvement in all efficacy outcomes. Additionally, it did not contribute to any significant incidence of SAEs, NSAEs, or mortality. The risk of bias in included RCTs was minor except in the randomization domain. Grading of Recommendations Assessment, Development, and Evaluation (GRADE) assessment of the outcomes ranged from low to high, but predominantly high certainty of evidence.
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- The Association Between Fatigue and Adult Atopic Dermatitis: A Cross-Sectional Study. [Journal Article]Dermatitis. 2023 Feb 01 [Online ahead of print]D
- Background: There is currently limited insight into the broader impact of atopic dermatitis (AD) on mental health. Although studies indicate that AD patients may experience fatigue, no study has so far examined fatigue in more granular detail, for example, occurrence of general fatigue, physical fatigue, reduced activity, reduced motivation, and mental fatigue, or correlated fatigue measures with…
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- Atopic Dermatitis and Self-Image Design: A Real-Life Study in Children Using Drawings. [Journal Article]Dermatitis. 2023 Feb 01 [Online ahead of print]D
- Background: Atopic dermatitis (AD) induces alterations of external appearance and self-esteem, with impact on the personal development of the children. However, tools for estimating such suffering are lacking. We aimed to assess how children with AD represent themselves through their drawings. Methods: In this retrospective study, we included children (<18 years) suffering from AD who followed th…
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- Prevalence and risk factors for atopic dermatitis in Greenlandic children. [Journal Article]Clin Exp Dermatol. 2022 Dec 22 [Online ahead of print]CE
- CONCLUSIONS: The overall prevalence of AD in children in Greenland is high and has likely increased over the past 20 years. The point prevalence was highest in the youngest children indicating early onset of disease. Inuit descent, family atopy predisposition and having a higher socioeconomic status (based on parental educational level and housing) increased the risk of AD. Insight into possible Inuit-specific genetic predisposition is needed.
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- Successful response of upadacitinib in the treatment of atopic dermatitis lesions involving sensitive and visible areas resistant to dupilumab. [Journal Article]Clin Exp Dermatol. 2023 Feb 01 [Online ahead of print]CE
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- Therapeutic Relief for Erythrodermic Atopic Dermatitis. [Journal Article]JAMA Dermatol. 2023 Feb 01 [Online ahead of print]JD
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- Efficacy and Safety of Dupilumab in Patients With Erythrodermic Atopic Dermatitis: A Post Hoc Analysis of 6 Randomized Clinical Trials. [Journal Article]JAMA Dermatol. 2023 Feb 01 [Online ahead of print]JD
- CONCLUSIONS: In this post hoc analysis of 6 randomized clinical trials, treatment with dupilumab resulted in rapid, sustained improvements in AD signs and symptoms with acceptable safety in patients with erythrodermic AD, similar to those in the trials' overall patient population.
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- Quality of life of pediatric patients with atopic dermatitis and their caregivers. [Journal Article]Arch Dermatol Res. 2023 Feb 01 [Online ahead of print]AD
- To compare the quality of life (QoL) of children with and without atopic dermatitis (AD) and that of their caregivers and to assess their QoL according to different degrees of AD. This is a cross-sectional, case-control study conducted with patients aged between 4 and 12 years with and without AD and their caregivers. Patients were treated at the Pediatric Dermatology Outpatient Center and the Ch…
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- Reported Pregnancy Outcomes in Women With Severe Atopic Dermatitis Treated With Dupilumab: A Systematic Review. [Letter]J Cutan Med Surg. 2023 Jan 31 [Online ahead of print]JC
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- Nagashima-type palmoplantar keratoderma: Case series and two novel variants. [Case Reports]Pediatr Dermatol. 2023 Jan 31 [Online ahead of print]PD
- Nagashima-type palmoplantar keratoderma (PPK) is an autosomal recessive PPK. We report four patients, highlight two new genetic variants, and emphasize the possibility of misdiagnosing the condition. Concomitant atopic dermatitis, specifically, may make correct diagnosis challenging. Clinicians should consider the diagnosis of Nagashima-type PPK in patients presenting with mild PPK with transgred…
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