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11,041 results
  • Effects of Statin Combinations on Zika Virus Infection in Vero Cells. [Journal Article]
    Pharmaceutics. 2022 Dec 23; 15(1)Españo E, Kim JK
  • The Zika virus (ZIKV) remains a global health concern. Thus far, no antiviral or vaccine has been approved to prevent or treat ZIKV infection. In a previous study, we found that lipophilic statins can inhibit ZIKV production in Vero cells. These statins appear to have different potencies against ZIKV infection. Here, we determined whether combinations of statins would have synergistic effects to …
  • Atorvastatin ameliorated PM2.5-induced atherosclerosis in rats. [Journal Article]
    Arch Environ Occup Health. 2023 Jan 20 [Online ahead of print]Yao H, Zhao X, … Ren Y
  • PM2.5 provokes atherosclerotic events. Atorvastatin presents anti-inflammatory and antioxidant activities, and may ameliorate PM2.5-induced atherosclerosis development. The purpose of this study was to investigate the cardiotoxic effect of fine particulate matter (PM2.5) on atherosclerosis (AS) in rats, and the intervention effects of atorvastatin (ATO) on PM2.5-induced AS development. AS model w…
  • Evaluation of Caralluma edulis for its Potential Against Obesity, Atherosclerosis and Hypertension. [Journal Article]
    Dose Response. 2023 Jan-Mar; 21(1):15593258231152112.Akram A, Jamshed A, … Jabeen Q
  • Obesity, a chronic metabolic condition, is an increase in fat mass and blood lipid levels mainly causing atherosclerosis and hypertension, which further lead to cardiovascular complications. The objective of the study was to investigate the crude extract of Caralluma edulis (CE.Cr) for its potential against high-fat diet (HFD)-induced obesity and its related complications. Hyperlipidemia was indu…
  • HILIC-UV determination of lysine and chloride counterions in active pharmaceutical ingredients. [Journal Article]
    J Pharm Biomed Anal. 2023 Jan 11; 226:115245.Szabovik G, Béni Z
  • A rapid, robust, and routinely applicable HILIC based HPLC-UV assay was developed for the quantitative determination of the L-Lysine content of Atorvastatin lysine active substance. During the method validation it turned out that with UV detection at 200 nm, the method is also capable for the direct determination of chloride ions. To the best of our knowledge, the phenomenon of chloride determina…
  • Hair analysis as a new tool to monitor adherence to long-term therapy to statins. [Journal Article]
    Electrophoresis. 2023 Jan 14 [Online ahead of print]Ballotari M, Taus F, … Bortolotti F
  • Statins are cholesterol-lowering medications which are widely prescribed as first-line treatment for hyperlipidemia, against high blood cholesterol aimed at reducing the risk of atherosclerotic diseases. Notwithstanding their undoubted efficacy, the needed long-term treatment with these drugs is characterized by a high percentage of dropout. Consequently, an effective tool to verify the patients'…
  • Treatment of Ischemic Stroke by Atorvastatin-Loaded PEGylated Liposome. [Journal Article]
    Transl Stroke Res. 2023 Jan 14 [Online ahead of print]Thomas RG, Kim JH, … Jeong YY
  • There is insufficient evidence on the effect of nanoparticles, particularly liposomes loaded with a statin, on acute ischemic stroke. We investigated the impact of atorvastatin-loaded PEG (polyethylene glycol) conjugated liposomes (LipoStatin) on the outcomes in rats with cerebral ischemia-reperfusion. PEGylated liposome loaded with atorvastatin was developed as a nanoparticle to specifically acc…
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