- Paroxysmal AF Ablation Using a Novel Variable-Loop Biphasic Pulsed Field Ablation Catheter Integrated With a 3D Mapping System: 1-Year Outcomes of the Multicenter inspIRE Study. [Journal Article]Circ Arrhythm Electrophysiol. 2023 Feb 03 [Online ahead of print]CA
- Background - The inspIRE study evaluated safety and effectiveness of a fully integrated biphasic pulsed field ablation (PFA) system with a variable loop circular catheter for the treatment of drug-refractory paroxysmal atrial fibrillation (AF). Methods - Subjects underwent pulmonary vein isolation (PVI) with the PFA system, using at least 12 applications per vein; adenosine/isoproterenol was admi…
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- Atrial Flutter Leads to Diagnosis of Metastatic Melanoma Involving the Heart. [Journal Article]Tex Heart Inst J. 2023 Jan 01; 50(1)TH
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- Ibrutinib in relapsed/refractory patients with Waldenström macroglobulinemia: a real-life, retrospective study on behalf of the "RTL" (regional Tuscan lymphoma network). [Journal Article]Ann Hematol. 2023 Feb 03 [Online ahead of print]AH
- Ibrutinib represents the first approved treatment for patients with Waldenström macroglobulinemia (WM). There are very few published experiences outside of a clinical trial. In this study, we investigated treatment response, survival, and safety in a real life setting. We retrospectively analyzed 49 consecutive R/R WM patients, managed in 8 Tuscan onco-hematological centers, that received ibrutin…
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- Atrial flutter with multilevel atrioventricular block and cyclical occurrence of varying QRS morphologies. [Journal Article]J Arrhythm. 2023 Feb; 39(1):78-81.JA
- An electrocardiogram showing atrial flutter in which varying ratios of AV conduction and the cyclical recurrence of varying QRS morphologies are observed is presented.
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- Identification of undiagnosed atrial fibrillation using a machine learning risk-prediction algorithm and diagnostic testing (PULsE-AI) in primary care: a multi-centre randomized controlled trial in England. [Journal Article]
- CONCLUSIONS: The AF risk-prediction algorithm accurately identified high-risk participants in both arms. While the proportions of AF and related arrhythmia diagnoses were not significantly different between high-risk arms, intervention arm participants who underwent diagnostic testing were twice as likely to receive arrhythmia diagnoses compared with routine care. The algorithm could be a valuable tool to select primary care groups at high risk of undiagnosed AF who may benefit from diagnostic testing.
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- Rate of atrial fibrillation and flutter induced tachycardiomyopathy in a cohort of hospitalized patients with heart failure and detection of indicators for improved diagnosis. [Journal Article]
- CONCLUSIONS: Approximately 5% of all patients hospitalized for HF suffer from AF/AFL induced TCM. Improved discrimination of AF/AFL induced TCM to HFrEF with AF/AFL is possible considering age, NT-pro-BNP level, and resting heart rate >112 beats/minute. Based on these parameters, an earlier diagnosis and improved therapy might be possible.
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- Artificial intelligence-enabled electrocardiogram to distinguish cavotricuspid isthmus dependence from other atrial tachycardia mechanisms. [Journal Article]
- CONCLUSIONS: We describe the first CNN trained to differentiate CTI-dependent AFL from other AT using the ECG. Our model matched and complemented expert electrophysiologist performance. Automated artificial intelligence-enhanced ECG analysis could help guide treatment decisions and plan ablation procedures for patients with organized atrial arrhythmias.
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- Clinical Outcomes, Resource Utilization, and Treatment Over the Disease Course of Symptomatic Obstructive Hypertrophic Cardiomyopathy in the United States. [Journal Article]Am J Cardiol. 2023 Jan 27; 192:16-23.AJ
- We sought to describe the clinical outcomes, resource utilization, and treatment options for patients with symptomatic obstructive hypertrophic cardiomyopathy (HCM) over the course of their disease. Adults with obstructive HCM who were symptomatic were identified from the IBM MarketScan Commercial and Medicare supplemental database (January 2009 to March 2019). The index date was the initial obst…
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- Evolution of and Evidence-Practice Gaps in Antithrombotic Management of Atrial Fibrillation Patients After Percutaneous Coronary Intervention. [Journal Article]CJC Open. 2023 Jan; 5(1):15-23.CO
- CONCLUSIONS: Expert guidance contributed to an increase in OAC prescription following PCI, but up to 2017, substantial further changes in practice patterns would have been required to achieve the recommended rates of OAC prescription.
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- Direct Oral Anticoagulants and Warfarin Safety in Rural Patients with Obesity. [Journal Article]Am J Med Sci. 2023 Jan 21 [Online ahead of print]AJ
- CONCLUSIONS: In patients with atrial fibrillation and class III obesity, regarding safety, DOACs appear to be non-inferior to warfarin during the first six to 12 months of therapy in our rural population - consistent with other analyses; however, the lack of thrombosis events limited the efficacy analysis.
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- Right atrial tachycardia after atrial fibrillation ablation: prevalence, clinical characteristics, electrophysiological mechanisms, and long-term outcomes. [Journal Article]J Interv Card Electrophysiol. 2023 Jan 24 [Online ahead of print]JI
- CONCLUSIONS: Right AT is relatively less common post-AF ablation. The CTI-dependent AFL and the ostium of SVC-derived focal AT constituted the major components of right ATs, suggesting the importance of ablation- and anatomy-related arrhythmogenic effects in the right atrium.
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- [Supraventricular tachycardia]. [Journal Article]Herz. 2023 Feb; 48(1):72-86.HERZ
- Supraventricular tachycardia is a common occurrence in routine clinical practice. As a physician, one can encounter them everywhere, whether as a general practitioner or as an emergency doctor in a hospital. Some tachycardias might have robbed an on-call doctor the night or the last nerve; however, supraventricular tachycardia is usually a benign condition that is easily treatable and, in many ca…
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- Differences in the clinical outcome of Ischemic and Non-Ischemic Cardiomyopathy in Heart Failure with concomitant Opioid Use Disorder. [Review]Curr Probl Cardiol. 2023 Jan 20 [Online ahead of print]CP
- Heart Failure (HF) and Opioid Use Disorder (OUD) independently have significant impact on patients and the United States (US) health system. In the setting of the opioid epidemic, research on the effects of OUD on cardiovascular diseases is rapidly evolving. However, no study exists on differential outcomes of ischemic cardiomyopathy (ICM) and non-ischemic cardiomyopathy (NICM) in patients with H…
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- Real-world comparison of in-hospital complications after catheter ablation for atrial fibrillation between non-antivitamin K anticoagulants and warfarin: A propensity-matched analysis using nation-wide database. [Journal Article]
- CONCLUSIONS: NOACs should be considered as a first-line therapy for periprocedural anticoagulation in patients undergoing CA for AF.
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- Quinine Water-Triggered Atrial Tachyarrhythmia. [Case Reports]
- Quinine is an anti-malarial drug with documented hematologic, dermatologic, and cardiovascular side effects. Tonic water contains a sub-therapeutic amount of quinine and is available over the counter. However, the public is unaware of the risks associated with excessive consumption of tonic water. We present a patient who developed atrial flutter with a rapid ventricular response following the co…
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- Cavotricuspid isthmus ablation for atrial flutter guided by contact force related parameters: A systematic review and meta-analysis. [Systematic Review]
- CONCLUSIONS: CF related parameters guidance improves the efficiency of CTI ablation, with the better catheter-tissue contact, the lower RF duration and the comparable safety as compared with conventional method, but does not improve the acute success rate and long-term outcome.
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- Latest advances in biomimetic nanomaterials for diagnosis and treatment of cardiovascular disease. [Review]
- Cardiovascular disease remains one of the leading causes of death in China, with increasingly serious negative effects on people and society. Despite significant advances in preventing and treating cardiovascular diseases, such as atrial fibrillation/flutter and heart failure over the last few years, much more remains to be done. Therefore, developing innovative methods for identifying and managi…
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- Cardiac arrhythmias and conduction abnormalities in patients with type 2 diabetes. [Journal Article]
- The association between type 2 diabetes (T2D) and the development of cardiac arrhythmias and conduction disturbances has not been extensively studied. Arrhythmia was defined as atrial fibrillation and flutter (AF/AFl), ventricular tachycardia (VT) and ventricular fibrillation (VF), and conduction abnormality as sinus node disease (SND), atrioventricular (AV) block or pacemaker implantation, and i…
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- Atrial Functional Tricuspid Regurgitation: Importance of Atrial Fibrillation and Right Atrial Remodeling and Prognostic Significance. [Journal Article]JACC Cardiovasc Imaging. 2023 Jan 11 [Online ahead of print]JC
- CONCLUSIONS: In patients with mild TR, significant AFTR developed predominantly in patients with AF-AFL, conferring poor prognosis. RA enlargement, especially with increased RA area-to-right ventricle end-systolic area ratio, was a strong risk factor for progression of AFTR.
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- Comparison of Cardiovascular Procedure Rates in Patients With Supplementary vs Basic Insurance in Switzerland. [Journal Article]JAMA Netw Open. 2023 Jan 03; 6(1):e2251965.JN
- CONCLUSIONS: This study found an association between supplementary private insurance and a higher likelihood of receiving nonemergency cardiovascular procedures. Whether this higher rate of procedures in people with supplementary private insurance is based on clinical reasoning or due to financial incentives warrants further exploration.
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- Emerging concepts in heart failure management and treatment: focus on tachycardia-induced cardiomyopathy. [Review]
- Tachycardia-induced cardiomyopathy is an entity characterized by reversible dysfunction of the left ventricle, which can be induced by different types of arrhythmia such as atrial fibrillation, atrial flutter, incessant supraventricular tachycardia and ventricular arrhythmia (more frequent causes). Correct identification of the causative arrhythmia and normalization of the heart rate (e.g through…
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- Cardio-oncology Clinical Assessment and Screening in Patients Undergoing High Toxicity Chemotherapy: A Retrospective Cohort Study. [Journal Article]
- CONCLUSIONS: Despite the recognized CV toxicity of chemotherapeutic drugs, the majority of patients receiving highly toxic regimens at high risk of CV complications are not previously evaluated by a cardiologist and the CV workup was not routinely used in our study. The implementation of cardio-oncology programs will facilitate the identification of high-risk patients, aiming to detect and treat complications early.
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- Atypical atrial flutter catheter ablation in the era of high-density mapping. [Journal Article]J Interv Card Electrophysiol. 2023 Jan 16 [Online ahead of print]JI
- CONCLUSIONS: AAFL catheter ablation can be achieved with high procedural success rate using a contemporary strategy based on high-density mapping alone. Non-conventional circuits are frequent and present unique electrophysiological characteristics.
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- Prior statin use and the incidence of in-hospital arrhythmia in acute coronary syndrome: A systematic review and meta-analysis. [Review]Indian Heart J. 2023 Jan 13 [Online ahead of print]IH
- CONCLUSIONS: Based on aggregate patient data, prior statin use may reduce the incidence of in-hospital arrhythmia during ACS, particularly atrial fibrillation or atrial flutter and ventricular tachycardia or ventricular fibrillation.
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- Anterior mitral line in patients with persistent AF and anterior scar: a multicenter matched comparison. The MiLine Study. [Journal Article]Heart Rhythm. 2023 Jan 11 [Online ahead of print]HR
- CONCLUSIONS: In this retrospective matched analysis of patients with persistent AF and anterior scar, AML on top of standard treatment was associated with improved AF/AT-free survival compared with matched patients treated with standard treatment alone.
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- Implementation of an Intravenous Sotalol Initiation Protocol: Implications for Feasibility, Safety, and Length of Stay. [Journal Article]J Cardiovasc Electrophysiol. 2023 Jan 14 [Online ahead of print]JC
- CONCLUSIONS: Intravenous sotalol loading has a safety profile that is similar to oral sotalol. It significantly shortens hospital LOS, potentially leading to large cost savings. This article is protected by copyright. All rights reserved.
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- Exploring disease comorbidities and temporal disease progression of psoriasis: an observational, retrospective, multi-database, cohort study. [Journal Article]
- CONCLUSIONS: Comorbidity trajectories may support clinicians in conducting disease risk analyses of patients with psoriasis and help plan optimal treatment to prevent future high-risk comorbidities.
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- Infantile-onset Pompe disease with neutropenia: Treatment decisions in the face of a unique phenotype. [Case Reports]
- Infantile-onset Pompe disease manifests with early signs of cardiomyopathy during the first few days to weeks of life. We present the case of a newborn born via emergency cesarean section with atrial flutter and moderate biventricular hypertrophy who was diagnosed with Pompe disease on New York State newborn screen. Diagnosis was confirmed with repeat leukocyte acid alpha-glucosidase (GAA) enzyme…
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- Investigator-reported ventricular arrhythmias and mortality in heart failure with mildly reduced or preserved ejection fraction. [Journal Article]
- CONCLUSIONS: VT/VF was uncommon in patients with HFmrEF and HFpEF. However, such events were strongly associated with mortality and appear to be a marker of disease severity rather than risk of sudden death.
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