- Risk factors in the development of gastric adenocarcinoma in the general population: A cross-sectional study of the Wuwei Cohort. [Journal Article]
- Several risk factors have been identified for the development of gastric adenocarcinoma (GAC), where the control group was usually a healthy population. However, it is unclear at what stage known risk factor exert their influence toward the progression to cancer. Based on the Wuwei Cohort, we enrolled 1,739 patients with chronic non-atrophic gastritis (no-CAG), 3,409 patients with chronic atrophi…
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- Helicobacter pylori Infection Promotes Gastric Premalignancies and Malignancies Lesions and Demotes Hyperplastic Polyps: A 5 Year Multicentric Study among Cameroonian Dyspeptic Patients. [Multicenter Study]Asian Pac J Cancer Prev. 2023 Jan 01; 24(1):171-183.AP
- CONCLUSIONS: our finding showed that chronic gastritis, gastric premalignancies and malignancies are positively link to Helicobacter pylori infection and that hyperplastic polyp is inversely associated with H. pylori infection in our milieu.
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- Controlling Gastric Cancer in a World of Heterogeneous Risk. [Journal Article]Gastroenterology. 2023 Jan 24 [Online ahead of print]G
- Gastric cancer (GC) is a leading cause of global mortality, but also a cancer whose footprint is highly unequal. This review aims to define global disease epidemiology, critically appraise strategies of prevention and disease attenuation, and assess how these strategies could be applied to improve outcomes from GC in a world of variable risk and disease burden. Strategies of primary prevention fo…
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- Heptadecanoic acid and pentadecanoic acid crosstalk with fecal-derived gut microbiota are potential non-invasive biomarkers for chronic atrophic gastritis. [Journal Article]
- CONCLUSIONS: Therefore, heptadecanoic acid and pentadecanoic acid, crosstalk with fecal-derived gut microbiota namely Erysipelotrichaceae_UCG-003 and Haemophilus, are potential non-invasive biomarkers for CAG diagnosis.
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- Examining the Diagnosis and Treatment Experiences of People Living With Autoimmune Gastritis and Pernicious Anemia. [Journal Article]J Patient Exp. 2023; 10:23743735231151767.JP
- There is limited research evaluating the diagnosis and treatment of patients with autoimmune gastritis (AIG) and pernicious anemia (PA). We used a 2-phase data collection process to examine the literature and individual patient accounts. Phase one comprised a systematically conducted literature review focusing on diagnosis and treatment, relationships with healthcare practitioners and health-rela…
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- Artificial intelligence-guided discovery of gastric cancer continuum. [Journal Article]
- CONCLUSIONS: A Boolean implication network enabled the identification of hitherto undefined continuum states during GC initiation. The developed model could now serve as a starting point for rationalizing candidate therapeutic targets to intercept GC progression.
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- Do artificial neural networks love sex? How the combination of artificial neural networks with evolutionary algorithms may help to identify gender influence in rheumatic diseases. [Journal Article]Clin Exp Rheumatol. 2023 01; 41(1):1-5.CE
- Although medical research has been performed predominantly on men both in preclinical and clinical studies, continuous efforts have been made to overcome this gender bias. Examining retrospectively 21 data sets containing sex as one of the descriptive variables, it was possible to verify how many times our AI protocol decided to keep gender information in the predictive model. The data sets perta…
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- Serum pepsinogen level as a biomarker for atrophy, reflux esophagitis, and gastric cancer screening in Indonesia. [Journal Article]
- CONCLUSIONS: Serum PG levels, a useful biomarker, represent the endoscopic findings, especially for reflux esophagitis. In addition, the benefits of PG values detecting atrophic gastritis were limited to moderate-severe atrophic gastritis. This usefulness requires careful attention for several ethnic groups in Indonesia.
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- Vitamin B12: For more than just the treatment of megaloblastic anemia? [Review]Rev Clin Esp (Barc). 2023 Jan 18 [Online ahead of print]RC
- Vitamin B12, or cobalamin, belongs to the group of water-soluble vitamins and is ingested through food of animal origin such as eggs, milk, red meat and poultry, fish, and shellfish. Its clinical indication is the treatment of hypovitaminosis B12 administered orally or intramuscularly in the form of hydroxocobalamin. Hypovitaminosis B12 is mainly caused by deficient dietary intake (individuals wi…
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- Application of artificial intelligence in the endoscopic diagnosis of early gastric cancer, atrophic gastritis and H. pylori infection. [Review]J Dig Dis. 2023 Jan 20 [Online ahead of print]JD
- Gastric cancer (GC) is one of the most serious health problems worldwide. Chronic atrophic gastritis (CAG) is a gastric precancerous lesion (GPL), most commonly caused by Helicobacter pylori (H. pylori) infection that may also lead to GC by the direct way such as the translocation of CagA. Presently, the diagnosis of early GC (EGC) and CAG mainly relies on endoscopy, which has always been a chall…
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- Correlation analysis of gastric mucosal lesions with Helicobacter pylori infection and its virulence genotype in Guiyang, Guizhou province, China. [Journal Article]
- CONCLUSIONS: We observed that the positive rate of H. pylori infection was related to the pathological type of patients' gastric mucosal lesions. Isolated H. pylori strains showed a unique genotype, mainly East Asian type cagA (ABD), vacA s1c/m2 genotype, and iceA1. These results provide an important reference for further studies of H. pylori in Guizhou province, China.
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- [Diagnostic Value of Serum Pepsinogen Ⅰ/Pepsinogen Ⅱ Combined with Tumor Markers for Helicobacter pylori-Positive Early-Stage Gastric Cancer]. [Journal Article]Sichuan Da Xue Xue Bao Yi Xue Ban. 2023 Jan; 54(1):186-191.SD
- CONCLUSIONS: Testing PGⅠ/PGⅡ in combination with CEA, CA199, and CA724 results in better diagnostic value for Hp-positive early-stage gastric cancer.
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- Gastric adenocarcinoma of fundic gland type with autoimmune gastritis. [Journal Article]Clin J Gastroenterol. 2023 Jan 16 [Online ahead of print]CJ
- An 87-year-old man with dysphagia presented to our hospital. He was diagnosed with autoimmune gastritis (AIG) with severe atrophy and hypergastrinemia. The patient was positive for parietal cell antibody (PCA) and anti-intrinsic factor antibody (IFA), without evidence of H. pylori infection. A flat elevated tumor was detected in the middle corpus, and therapeutic endoscopic submucosal dissection …
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- Study on tongue coating microbes of bitter taste, sticky and greasy taste in chronic atrophic gastritis. [Journal Article]J Tradit Chin Med. 2023 02; 43(1):160-167.JT
- CONCLUSIONS: and possibly contribute to bitter taste of CAG patients, and and contribute to stick and greasy taste of CAG patients, which is potential for the diagnosis and treatment of CAG.
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- Prevalence of chronic atrophic gastritis worldwide from 2010 to 2020: an updated systematic review and meta-analysis. [Meta-Analysis]Ann Palliat Med. 2022 Dec; 11(12):3697-3703.AP
- CONCLUSIONS: The worldwide prevalence of CAG is still high, and HP infection remains an important risk factor for CAG. Future studies of large-scale are still in urgent need to further control the prevalence of CAG, so as to reduce the burden of gastric cancer.
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- Establishing machine learning models to predict the early risk of gastric cancer based on lifestyle factors. [Multicenter Study]
- CONCLUSIONS: The results suggest that based on simple baseline patient data, the ML techniques have the potential to start the prescreening of gastric cancer and identify high-risk individuals who should proceed with invasive examinations. Our model could also considerably lessen the number of cases that need endoscopic surveillance. Future studies are required to validate the efficacy of the models in a larger and multicenter population.
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- Weikangling capsules combined with omeprazole ameliorates ethanol-induced chronic gastritis by regulating gut microbiota and EGF-EGFR-ERK pathway. [Journal Article]Life Sci. 2023 Feb 15; 315:121368.LS
- CONCLUSIONS: This study elucidated that the effect of WKLCs and its combination with OME in the treatment of chronic gastritis was attributed to regulating the composition of the gut microbiota and inhibiting the EGF-EGFR-ERK pathway. The EA fraction is an inseparable effective substance of WKLCs. This study provides scientific evidence for clinical application.
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- Liquid levothyroxine improves thyroid control in patients with different hypothyroidism aetiology and variable adherence - case series and review. [Journal Article]Endokrynol Pol. 2022; 73(5):893-902.EP
- It is estimated that hypothyroidism treatment may be either suboptimal or excessive in about 32-45% patients treated with L-thyroxine (LT4). There are multiple possible causes of poor control of hypothyroidism, including narrow LT4 therapeutic index, food and drug interactions, comorbidities, and patient non-adherence. Some of these obstacles could possibly be overcome with the novel liquid LT4 f…
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- Microbiota in the stomach and application of probiotics to gastroduodenal diseases. [Review]
- The stomach is a hostile environment for most microbes because strong gastric acid kills indigenous microorganisms. Thus, the mass of indigenous microbes detected by traditional culturing method in a highly acidic stomach is reported to be very small. However, in a stomach with less acidity due to atrophic changes of the gastric mucosa, the number of live gastric microbiota dramatically increases…
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- Involvement of CXCL17 and GPR35 in Gastric Cancer Initiation and Progression. [Journal Article]
- The expression of CXC motif chemokine 17 (CXCL17) and its reported membrane receptor G-protein-coupled receptor 35 (GPR35) in different gastric pathological lesions and their clinical implications are largely unknown. In this study, a total of 860 pathological sections were immune-stained with either anti-CXCL17 or anti-GPR35 antibodies. Their expression was scored within the area of the normal g…
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- Bile acid metabolism involved into the therapeutic action of Xiaojianzhong Tang via gut microbiota to treat chronic atrophic gastritis in rats. [Journal Article]Phytomedicine. 2023 Jan; 109:154557.P
- CONCLUSIONS: The current work indicated that XJZ's therapeutic action was strongly linked to BA-related microorganisms and metabolic processes. These findings provided new insights into the effects of XJZ for the treatment of CAG.
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- Risk assessment of metachronous gastric cancer development using OLGA and OLGIM systems after endoscopic submucosal dissection for early gastric cancer: a long-term follow-up study. [Journal Article]Gastric Cancer. 2023 Jan 06 [Online ahead of print]GC
- CONCLUSIONS: High OLGA and OLGIM stages are independent risk factors for metachronous gastric cancer, with the OLGIM staging system being a better predictor. Patients with OLGIM stages 0 ~ II are a subgroup that may benefit more from Helicobacter pylori eradication.
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- Potential benefits of one-time gastroscopy in searching for precancerous conditions. [Journal Article]Pol Arch Intern Med. 2023 Jan 05 [Online ahead of print]PA
- CONCLUSIONS: The one-time EGD in searching for precancerous conditions could be potentially applicable in individuals between 40 and 69 years of age.
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- Pernicious Anemia and Vitamin B12 Deficiency Presenting As Pseudothrombotic Microangiopathy and Developing Secondary Thrombocytopenia After Treatment: A Case Report. [Case Reports]
- Pernicious anemia (PA) is an autoimmune disease secondary to chronic atrophic gastritis leading to vitamin B12 deficiency. Rarely, some patients may develop advanced hematological complications that mimic those of thrombotic thrombocytopenic purpura (TTP). Differentiating these conditions is crucial because they require different management. We present a case of a 68-year-old male who presented w…
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- Non-atrophic gastric mucosa is an independently associated factor for superficial non-ampullary duodenal epithelial tumors: a multicenter, matched, case-control study. [Journal Article]Clin Endosc. 2023 Jan; 56(1):75-82.CE
- CONCLUSIONS: Non-atrophic gastric mucosa, regardless of H. pylori infection status, was a factor independently associated with SNADETs.
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- Analysis of Staged Features of Gastritis-Cancer Transformation and Identification of Potential Biomarkers in Gastric Cancer. [Journal Article]
- CONCLUSIONS: There may be a stable development mechanism in the process of gastritis-carcinoma transformation, resulting in the differences in the performance of each stage. The newly discovered staging features and potential biomarkers in this work can provide references for related research.
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- Clinical efficacy of moluodan in the treatment of chronic atrophic gastritis: A protocol for systematic review and meta-analysis. [Journal Article]
- CONCLUSIONS: Moluodan can improve the effective rates of pathological examination, gastroscopy and symptoms in patients with CAG, and play a role in slowing down the disease progression and reducing clinical symptoms. It may be a potential drug for the treatment of CAG and has the value of further exploration.
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- Analysis of high risk factors for chronic atrophic gastritis. [Journal Article]Saudi J Gastroenterol. 2022 Dec 30 [Online ahead of print]SJ
- CONCLUSIONS: CAG screening should be combined with endoscopic evaluation, biopsy, and other non-invasive tests. Non-invasive tests include the combination of serum pepsinogen II protein and pepsinogen I/II ratio and high level of serum testosterone. UBT combined with serum pepsinogen testing may improve the positive rate of CAG and reduce gastric mucosal damage from multiple biopsies.
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- A digital pathology workflow for the segmentation and classification of gastric glands: Study of gastric atrophy and intestinal metaplasia cases. [Journal Article]
- Gastric cancer is one of the most frequent causes of cancer-related deaths worldwide. Gastric atrophy (GA) and gastric intestinal metaplasia (IM) of the mucosa of the stomach have been found to increase the risk of gastric cancer and are considered precancerous lesions. Therefore, the early detection of GA and IM may have a valuable role in histopathological risk assessment. However, GA and IM ar…
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- A novel endoscopic finding of a scratch sign is useful for evaluating the Helicobacter pylori infection status. [Journal Article]
- CONCLUSIONS: A novel endoscopic finding, the scratch sign, was found to be a good endoscopic predictor of H. pylori-negative gastric mucosa. Furthermore, combined with atrophic changes and xanthomas that persisted after eradication, these findings were found to be useful in accurately diagnosing H. pylori past-infected gastric mucosa endoscopically.
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