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Unbound Medicine.
(Atropine poisoning)
4,794 results
  • Suicidal attempt with eliglustat overdose. [Case Reports]
    JIMD Rep. 2023 Jan; 64(1):23-26.Nadler J, Hermanns-Clausen M, Dilger K
  • Eliglustat is an orphan medicine used for long-term treatment of Gaucher disease type 1 (GD1) in adults. GD1 is a genetic condition, in which glucosylceramide builds up in the body, typically in liver, spleen, and bone. Clinical signs and symptoms of the disease are anemia, tiredness, easy bruising, hepatosplenomegaly, bone pain, and fractures. Eliglustat works by blocking glucosylceramide syntha…
  • Inhaled Organophosphorus Poisoning Presenting as Superior Laryngeal Nerve Palsy: A Rare Case. [Case Reports]
    Cureus. 2022 Nov; 14(11):e31589.Patel S, Patel M, … Acharya S
  • Poisoning by organophosphorus (OP) is a major clinical issue affecting many nations worldwide, especially developing nations. In this case report, we have highlighted organophosphate poisoning syndrome that resulted in paralysis of the vocal cords. A 28-year-old male patient with a history of accidental inhalation of the OP compound reported to our hospital with symptoms of vomiting and hoarsenes…
  • A Rare Presentation of Severe Organophosphate Poisoning: A Case Report and Review of Literature. [Case Reports]
    Cureus. 2022 Nov; 14(11):e31497.Ibrahim AE, Ghantarchyan H, … Arabian S
  • Organophosphates are chemicals commonly used as pesticides and work to inhibit acetylcholinesterase, leading to acetylcholine build up at muscarinic and nicotinic receptors throughout the body. Poisonings are often seen as small volume, chronic cases due to agricultural exposures, but can present as suicide attempts via organophosphate ingestion. Organophosphate poisonings, particularly when larg…
  • [A case of intramuscular injection of methomyl poisoning]. [Case Reports]
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2022 Nov 20; 40(11):865-866.Liao GH, Cheng B, … Chen J
  • Methomyl is a carbamate insecticide widely used in pesticides. Most of the poisoning methods are through digestive tract, respiratory tract and skin contact. At present, there is no report of poisoning caused by intramuscular injection. A case of poisoning caused by intramuscular injection of methomyl was analyzed retrospectively. About 4 minutes later, cholinergic crisis and central inhibition o…
  • Poisoning by Organophosphate Pesticides: A Case Report. [Case Reports]
    Cureus. 2022 Oct; 14(10):e29842.Bereda G
  • In many parts of the world, particularly in impoverished nations like Ethiopia, organophosphate compounds operate as suicide agents, are frequently employed as pesticides, and are strong inhibitors of the acetylcholinesterase enzyme. A 21-year-old Ethiopian female, a university student, was admitted to an emergency department on June 22, 2022, with a two-hour history of nausea and elevated secret…
  • Veratrum parviflorum poisoning: identification of steroidal alkaloids in patient blood and breast milk. [Journal Article]
    Clin Toxicol (Phila). 2022 Dec; 60(12):1309-1317.Seale JT, Carpenter JE, … McDougal OM
  • CONCLUSIONS: V. parviflorum toxicity was observed to cause nausea, vomiting, hypotension, bradycardia, abdominal pain, light-headedness, blurred vision, and tingling in the arms. Patients experiencing mild symptoms improved with supportive care, IV fluids, and antiemetics, but hemodynamically unstable patients required atropine and vasopressors. This study demonstrated that more lipophilic Veratrum alkaloids can be passed along in breast milk, which suggests additional precautions may be critical to limit further poisonings.
  • A fatal case involving the highest ever reported 4-CMC concentration. [Case Reports]
    J Forensic Sci. 2023 Jan; 68(1):349-354.Tusiewicz K, Chłopaś-Konowałek A, … Szpot P
  • Synthetic cathinones comprise a large amount of substances present on the dark market, which creates an undeniably worldwide problem and still is posing a threat. A 22-year-old man was brought to the Emergency Room from a party, where he had ingested orally 20 g of mephedrone. The man exhibited a disorder of consciousness with no logical verbal contact and dilated pupils. Moreover, a metabolic ac…
  • StatPearls: Atropine [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)McLendonKevinKMerit Health WesleyPreussCharles V.CVUniversity of South FloridaBOOK
  • Atropine or atropine sulfate carries FDA indications for anti-sialagogue/anti-vagal effect, organophosphate/muscarinic poisoning, and bradycardia. Atropine acts as a competitive, reversible antagonist of muscarinic receptors: an anticholinergic drug. This activity outlines the indications, mechanism of action, safe administration, adverse effects, contraindications, toxicology, and monitoring of …
  • 6-NitroDopamine is an endogenous modulator of rat heart chronotropism. [Journal Article]
    Life Sci. 2022 Oct 15; 307:120879.Britto-Júnior J, de Oliveira MG, … De Nucci G
  • 6-Nitrodopamine (6-ND) is released by rat vas deferens and exerts a potent contractile response that is antagonized by tricyclic antidepressants and α1-, β1- and β1/β2-adrenoceptor antagonists. The release of 6-ND, noradrenaline, adrenaline and dopamine from rat isolated right atria was assessed by tandem mass spectrometry. The effects of the catecholamines were evaluated in both rat isolated rig…
  • StatPearls: Deadly Single Dose Agents [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)EuwemaMichael S.MSOrange Park Medical CenterSwansonTerrell J.TJOrange Park Medical CenterBOOK
  • Although the basics of evaluating and treating most unknown ingestants are well known, many overdoses require very specific treatment if the patient is to have any chance of survival.[1] Countless studies have been published supporting Dr. Gideon Koren's 1993 landmark article "Medications Which Can Kill a Toddler with One Tablet or Teaspoonful" in the Journal of Toxicology.[2][3][4][5] while each…
  • Functional expression of NaV1.7 channels in freshly dispersed mouse bronchial smooth muscle cells. [Journal Article]
    Am J Physiol Cell Physiol. 2022 09 01; 323(3):C749-C762.Matthews RM, Bradley E, … Thornbury KD
  • Isolated smooth muscle cells (SMCs) from mouse bronchus were studied using the whole cell patch-clamp technique at ∼21°C. Stepping from -100 mV to -20 mV evoked inward currents of mean amplitude -275 pA. These inactivated (tau = 1.1 ms) and were abolished when external Na+ was substituted with N-Methyl-d-glucamine. In current-voltage protocols, current peaked at -10 mV and reversed between +20 an…
  • Life-threatening pediatric poisoning due to ingestion of Bufo bufo toad eggs: A case report. [Case Reports]
    Toxicon. 2022 Oct 15; 217:13-16.Gambassi F, Lanzi C, … Occupati B
  • Bufo parotid glands and eggs contain cardiac glycosides also known as bufadienolides. This class of molecules can cause digoxin-like cardiac toxicity, as they can block the sodium potassium-adenosine triphosphatase (Na/K-ATPase) pump. Poisoning with these toxins is rare but carries a high mortality risk. There are only a few cases of toad poisoning that have been reported worldwide, mainly in the…
  • Dose-Dependency of Toxic Signs and Outcomes of Paraoxon Poisoning in Rats. [Journal Article]
    Acta Medica (Hradec Kralove). 2022; 65(1):8-17.Maksimović ŽM, Škrbić R, Stojiljković MP
  • Organophosphorus compounds induce irreversible inhibition of acetylcholinesterase, which then produces clinically manifested muscarinic, nicotinic and central effects. The aim of the study was to analyse the clinical signs of acute paraoxon poisoning in rats and to determine the relationship between the intensity of signs of poisoning and the dose of paraoxon and/or the outcome of poisoning in ra…
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