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(Atypical mole)
1,559 results
  • New Insights into Melanoma Tumor Syndromes. [Review]
    JID Innov. 2022 Nov; 2(6):100152.Rashid S, Gupta S, … Tsao H
  • Melanoma tumor syndromes (MTS) represent an important minority of familial melanoma cases. In these patients, the accumulation of sequence alterations in essential genes may prelude the risk of internal malignancies, in addition to melanoma. Although several host and environmental factors have been implicated in familial melanoma, the exact mechanisms of cancer predisposition-particularly in the …
  • A Rare Case of Klippel-Trénaunay Syndrome. [Case Reports]
    Cureus. 2022 Oct; 14(10):e30128.Arasu A, Khalil-Khan A, … Sathiamoorthy R
  • The Klippel-Trénaunay syndrome (KTS) is a rare form of a birth disorder that includes capillary malformation, hypertrophy of bones and soft tissues, and tortuous varicosities, as well as hypertrophy of the capillaries resulting in hemangiomas and port wine discoloration. KTS is also known as angio-osteohypertrophy syndrome and dysplastic angiopathy. In this case report, we describe the case of a …
  • Overview of familial syndromes with increased skin malignancies. [Review]
    Arch Dermatol Res. 2022 Nov 07 [Online ahead of print]Juan HY, Zhou AE, … Khachemoune A
  • The vast majority of skin cancers can be classified into two main types: melanoma and keratinocyte carcinomas. The most common keratinocyte carcinomas include basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Multiple familial syndromes have been identified that can increase the risk of developing SCC, BCC, and/or melanoma. The major syndromes include oculocutaneous albinism for SCC, …
  • StatPearls: Dysplastic Nevi [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)BaigrieDanaDCampbell University School of MedicineTannerLaura S.LSBOOK
  • A dysplastic nevus is also referred to as an atypical or Clark’s nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a “fried-egg” appearance, and are commonly biopsied by provi…
  • Dysplastic nevus part II: Dysplastic nevi: Molecular/genetic profiles and management. [Review]
    J Am Acad Dermatol. 2023 Jan; 88(1):13-20.Spaccarelli N, Drozdowski R, … Grant-Kels JM
  • Dermatologists frequently see patients with clinically atypical nevi and dermatopathologists interpret histologically dysplastic nevi on a near-daily basis, but there is great variability in the definition and management of such lesions. This part of the CME review focuses on information published since the previous comprehensive review (2012), with emphasis on molecular and genetic attributes of…
  • Dysplastic nevus part I: Historical perspective, classification, and epidemiology. [Review]
    J Am Acad Dermatol. 2023 Jan; 88(1):1-10.Drozdowski R, Spaccarelli N, … Grant-Kels JM
  • Since the late 1970s, the diagnosis and management of dysplastic nevi have been areas fraught with controversy in the fields of dermatology and dermatopathology. Diagnostic uncertainty and lack of standardized nomenclature continue to propagate confusion among clinicians, dermatopathologists, and patients. In part I of this CME review article, we summarize the historical context that gave rise to…
  • Handcrafted firearm suicide: About the unusual use of a mole gun. [Case Reports]
    Leg Med (Tokyo). 2022 Nov; 59:102137.Delbreil A, Boyer AL, … Voyer M
  • The body of a man was found in a workshop at the back of his home, a metal pipe embedded in his chest. In the immediate vicinity of the body, among various tools, was a machine containing a holster hit of lead shot evoking a mole-trap-type "taupe gun" (mole gun). The findings at the scene and the presence of a metal tube, sinkers, and a flock in the chest are in favour of the use of a homemade fi…
  • StatPearls: Atypical Mole [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)WensleyKatherine E.KEOxford University Hospitals NHSZitoPatrick M.PMUniversity of Miami; Miller School of MedicineBOOK
  • Atypical moles, or dysplastic nevi, are acquired melanocytic neoplasms with disordered architecture and atypia of melanocytes. Multiple synonyms for atypical moles; they are also known as Clark nevi, B-K moles, or dysplastic nevi, although strictly speaking, the term dysplastic nevus refers only to a specific microscopic appearance, of which, only a minority of atypical moles fulfill the criteria…
  • Dysplastic melanocytic nevus: Are molecular findings the key to the diagnosis? [Review]
    Ann Diagn Pathol. 2022 Oct; 60:152006.Xavier-Junior JCC, Ocanha-Xavier JP
  • The primary differential diagnosis of melanoma is dysplastic nevus. Until now, the final diagnosis is based on histological findings. With modern techniques, pathologists receive very early melanocytic lesions, which do not fit all malignant criteria. In those cases, even the concurrence between specialists and intraobserver agreement is not good. A molecular test could be developed to improve th…
  • [The risks of tanning with the Barbie drug]. [Case Reports]
    Ned Tijdschr Geneeskd. 2022 05 19; 166Eijmael MJPM, Janmaat CJ, Briët-Schipper EMN
  • CONCLUSIONS: This case reports underlines self-administration of Melanotan II is not without potential side effects, although Melanotan II is easily available on the internet and in gyms.
  • Dysplastic nevi and melanoma: microRNAs tell a divergent story. [Journal Article]
    Pathol Res Pract. 2022 Jul; 235:153942.Durante G, Veronesi G, … Dika E
  • CONCLUSIONS: the hierarchical clustering and principal component analyses of global miRNA expression, independently grouped together DN and their matching congenital nevi and showed a divergence of DN miRNA profile from melanoma. Our study suggests that DN have a peculiar and different miRNA expression profile compared to melanomas developed in the same patient, thus supporting the hypothesis that DN are distinct biological entities and not melanoma precursors.
  • Poly Adenosine Diphosphate-Ribose Polymerase (PARP) Inhibitors in Pancreatic Cancer. [Review]
    Cureus. 2022 Feb; 14(2):e22575.Sunkara T, Bandaru SS, … Chennamadhavuni A
  • Pancreatic cancer is the third most common cause of cancer death in the United States and eleventh worldwide. The majority of patients present with advanced disease with five-year overall survival of less than 10%. Traditional chemotherapy has been the mainstay treatment for years, with limited improvement in survival. Relative success has been achieved with agents targeting the DNA damage repair…
  • Hereditary oral squamous cell carcinoma associated with CDKN2A germline mutation: a case report. [Case Reports]
    J Otolaryngol Head Neck Surg. 2022 Feb 05; 51(1):5.Jeong AR, Forbes K, … Cohen EEW
  • CONCLUSIONS: We report a family with a CDKN2A c.301 G>T mutation who also have significant history of OSCC, adding to the growing body of literature suggesting increased risk of HNSCC, particularly OSCC, in CDKN2A germline mutation carriers. It is important to consider CDKN2A mutation testing in familial HNSCC and young patients without obvious risk factors. Moreover, surveillance for HNSCC should be routine practice in those with a CDKN2A germline mutation.
  • Orthorectification of Skin Nevi Images by Means of 3D Model of the Human Body. [Journal Article]
    Sensors (Basel). 2021 Dec 15; 21(24)Szczypiński PM, Sprawka K
  • Melanoma is the most lethal form of skin cancer, and develops from mutation of pigment-producing cells. As it becomes malignant, it usually grows in size, changes proportions, and develops an irregular border. We introduce a system for early detection of such changes, which enables whole-body screening, especially useful in patients with atypical mole syndrome. The paper proposes a procedure to b…
  • Dermoscopic Nevus Patterns Associated with Melanoma Patients. [Journal Article]
    Dermatology. 2022; 238(4):670-676.Prieto Herman Reinehr C, Marchiori Bakos R
  • CONCLUSIONS: Melanoma patients tend to present a higher number of common reticular nevi on the back and lower limbs, as well as atypical nevi with a complex pattern, especially reticular, reticular-homogeneous, and reticular-globular on the back.
  • Dysplastic nevus syndrome and pancreatic cancer: A case report. [Case Reports]
    Exp Ther Med. 2022 Jan; 23(1):31.Popa LG, Giurcaneanu C, … Mihai MM
  • Multiple primary cancers may occur in the same patient, with a prevalence that follows an ascendant trend. Their development is dictated by a complex interplay between a variety of factors, both patient-dependent and external. The case of a 38-year-old female patient diagnosed and treated for pancreatic cancer (PC) is presented in whom the digital dermoscopic monitoring of melanocytic nevi reveal…
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