- Analysis of dermoscopic changes of blue nevi on digital follow-up: a 21-year retrospective cohort study. [Journal Article]J Eur Acad Dermatol Venereol. 2023 Jan 25 [Online ahead of print]JE
- CONCLUSIONS: Most blue nevi remain stable during their evolution. Rarely, they can show progressive growth, although histopathological or molecular signs of malignancy have not been identified.
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- Common benign melanocytic and non-melanocytic skin tumors among the elderly. Results of the Graz Study on Health & Aging (GSHA). [Journal Article]Dermatology. 2023 Jan 19 [Online ahead of print]D
- CONCLUSIONS: Our study adds new knowledge about the most frequently occurring benign skin tumors, considering all visible body areas. This research may serve as a reference basis for following epidemiological studies.
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- A Japanese case of familial malignant melanoma with germline CDK4 variant incidentally diagnosed by cancer genome profiling. [Journal Article]J Hum Genet. 2023 Jan 11 [Online ahead of print]JH
- Familial malignant melanoma (FMM) is a hereditary tumor that is quite rare in Japan; to date, the germline CDK4 variant has scarcely been reported around the world. Thus, we report on a woman with FMM who developed salivary gland cancer, for which a germline pathogenic variant of CDK4 was incidentally identified through comprehensive genomic profiling. She had a history of multiple atypical nevi …
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- A Single-Institution Cohort Study With Nevi of Special Site: Recurrence, Progression to Melanoma, and Patterns of Management. [Journal Article]Am J Dermatopathol. 2023 Jan 01; 45(1):28-39.AJ
- Nevi of specialized sites (NOSS) occur on the scalp, ears, flexural, acral, and genital areas and display atypical clinical and histologic features. We assessed NOSS recurrence and progression to melanoma, management patterns, and associations between histologic features and treatment recommendations. We queried all histologic diagnoses of NOSS (n = 275) from 2012 to 2017 from a large U.S. academ…
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- Performance of PRAME immunohistochemistry compared with that of c-Kit, c-Myc, or cyclin D1 for the diagnosis of acral melanocytic tumors. [Journal Article]Pathol Int. 2022 Dec 05 [Online ahead of print]PI
- The diagnostic role of preferentially expressed antigen in melanoma (PRAME) immunohistochemistry has not been thoroughly evaluated for acral melanocytic tumors. The objective of this study was to evaluate the utility of this modality for the diagnosis of acral melanocytic tumors compared with other potential markers. Melanocytic tumors were classified as either acral nevi, challenging melanocytic…
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- Computer Aided Diagnosis of Melanoma Using Deep Neural Networks and Game Theory: Application on Dermoscopic Images of Skin Lesions. [Journal Article]
- Early detection of melanoma remains a daily challenge due to the increasing number of cases and the lack of dermatologists. Thus, AI-assisted diagnosis is considered as a possible solution for this issue. Despite the great advances brought by deep learning and especially convolutional neural networks (CNNs), computer-aided diagnosis (CAD) systems are still not used in clinical practice. This may …
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- Approach of Multiple Endocrine Neoplasia Type 1 (MEN1) Syndrome-Related Skin Tumors. [Review]
- Non-endocrine findings in patients with MEN1 (multiple endocrine neoplasia) syndrome also include skin lesions, especially tumor-type lesions. This is a narrative review of the English-language medical literature including original studies concerning MEN1 and dermatological issues (apart from dermatologic features of each endocrine tumor/neuroendocrine neoplasia), identified through a PubMed-base…
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- Recurrence of a Cellular Blue Nevus with Satellitosis-A Diagnostic Pitfall with Clinical Consequences. [Journal Article]
- Blue nevus is a benign melanocytic lesion, typically asymptomatic and of unknown etiology. Several histologic and clinical variants have been distinguished, the most frequent being common blue nevus, cellular blue nevus, and combined blue nevus. Although melanocytic nevi with a satellite lesion are usually suggestive of locally advanced malignant melanoma, very few cases of blue nevi with satelli…
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- A Rare Case of Klippel-Trénaunay Syndrome. [Case Reports]
- The Klippel-Trénaunay syndrome (KTS) is a rare form of a birth disorder that includes capillary malformation, hypertrophy of bones and soft tissues, and tortuous varicosities, as well as hypertrophy of the capillaries resulting in hemangiomas and port wine discoloration. KTS is also known as angio-osteohypertrophy syndrome and dysplastic angiopathy. In this case report, we describe the case of a …
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- Histopathologic reassessment of melanoma and other melanocytic skin lesions excised in 2009 and 2018-2019. [Journal Article]
- Histopathological assessment of melanoma and other melanocytic skin lesions can be difficult and can vary between pathologists.
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- StatPearls: Dysplastic Nevi [BOOK]StatPearls. StatPearls Publishing: Treasure Island (FL)BOOK
- A dysplastic nevus is also referred to as an atypical or Clark’s nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a “fried-egg” appearance, and are commonly biopsied by provi…
- Reflectance confocal microscopy in paediatric patients: Applications and limits. [Journal Article]Exp Dermatol. 2022 Oct 20 [Online ahead of print]ED
- Reflectance confocal microscopy (RCM) is a non-invasive diagnostic tool extensively studied for adult patients. In this retrospective case series conducted at the Dermatology Unit of the University of Campania, Naples, Italy, all patients under 19 years old who were submitted to RCM from January 2011 to December 2021 where evaluated. The aim of the study was to review the most usual indications a…
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- Dysplastic nevus part II: Dysplastic nevi: Molecular/genetic profiles and management. [Review]J Am Acad Dermatol. 2023 Jan; 88(1):13-20.JA
- Dermatologists frequently see patients with clinically atypical nevi and dermatopathologists interpret histologically dysplastic nevi on a near-daily basis, but there is great variability in the definition and management of such lesions. This part of the CME review focuses on information published since the previous comprehensive review (2012), with emphasis on molecular and genetic attributes of…
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- Differences in Nomenclature Usage and Preference Among Dermatopathologists for "Dysplastic" Nevi: A National Survey. [Journal Article]J Cutan Pathol. 2022 Oct 14 [Online ahead of print]JC
- CONCLUSIONS: Little has changed with the wide variation in terminology for atypical melanocytic nevi. There continues to be no one dominant terminology in use. However, there is enthusiasm for standardization. A new attempt at updated consensus nomenclature may be fruitful.
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- Electrical impedance spectroscopy significantly enhances correct biopsy choice for pigmented skin lesions beyond clinical evaluation and dermoscopy. [Journal Article]Melanoma Res. 2023 Feb 01; 33(1):80-83.MR
- The purpose of this study was to investigate whether EIS technology can further improve correct biopsy choices beyond clinical and dermoscopic evaluation for melanoma (MM), severe dysplastic nevi (SDN) and benign PSLs. Images of 49 MMs, SDNs and benign PSLs were randomly selected from a prior study and were provided in a reader-type survey study to dermatologists to evaluate for biopsy. A total o…
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- An Updated Algorithm Integrated With Patient Data for the Differentiation of Atypical Nevi From Early Melanomas: the idScore 2021. [Journal Article]
- CONCLUSIONS: An integrated checklist combining multiple anamnestic data with selected relevant dermoscopic features can be useful in the differential diagnosis and management of eMM and aN exhibiting with equivocal features.
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- A Scoping Review and Population Study Regarding Prevalence and Histopathology of Juvenile Vulvar Melanocytic Lesions. A Recommendation. [Journal Article]
- Cases of vulvar melanocytic lesions in juveniles are rarely reported. We analyze the evidence regarding vulvar melanocytic lesions in juveniles with or without vulvar lichen sclerosus to help decision making by clinicians and pathologists. A scoping review on vulvar melanocytic lesions with or without vulvar lichen sclerosus, including malignant vulvar melanomas, in females up to age 18 years was…
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- Dysplastic nevus part I: Historical perspective, classification, and epidemiology. [Review]J Am Acad Dermatol. 2023 Jan; 88(1):1-10.JA
- Since the late 1970s, the diagnosis and management of dysplastic nevi have been areas fraught with controversy in the fields of dermatology and dermatopathology. Diagnostic uncertainty and lack of standardized nomenclature continue to propagate confusion among clinicians, dermatopathologists, and patients. In part I of this CME review article, we summarize the historical context that gave rise to…
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- StatPearls: Atypical Mole [BOOK]StatPearls. StatPearls Publishing: Treasure Island (FL)BOOK
- Atypical moles, or dysplastic nevi, are acquired melanocytic neoplasms with disordered architecture and atypia of melanocytes. Multiple synonyms for atypical moles; they are also known as Clark nevi, B-K moles, or dysplastic nevi, although strictly speaking, the term dysplastic nevus refers only to a specific microscopic appearance, of which, only a minority of atypical moles fulfill the criteria…
- Noninvasive detection of the endogenous free radical melanin in human skin melanomas using electron paramagnetic resonance (EPR). [Journal Article]
- We explored the capability of low-frequency Electron Paramagnetic Resonance (EPR) to noninvasively detect melanin (a stable semiquinone free radical) in the human skin. As previous in vitro studies on biopsies suggested that the EPR signal from melanin was different when measured in skin melanomas or benign nevi, we conducted a prospective first-in-man clinical EPR study in patients with skin les…
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- Recognizing Histopathological Simulators of Melanoma to Avoid Misdiagnosis. [Review]
- Melanocytic lesions have a wide morphological spectrum, ranging from benign nevi to malignant melanoma. In contrast to a diagnosis of a benign nevus, a diagnosis of melanoma could mean intensive treatment, lifetime monitoring, and a worse prognosis. Therefore, melanocytic tumors are notoriously challenging and associated with a high risk of litigation in surgical pathology. After describing the b…
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- Dysplastic melanocytic nevus: Are molecular findings the key to the diagnosis? [Review]
- The primary differential diagnosis of melanoma is dysplastic nevus. Until now, the final diagnosis is based on histological findings. With modern techniques, pathologists receive very early melanocytic lesions, which do not fit all malignant criteria. In those cases, even the concurrence between specialists and intraobserver agreement is not good. A molecular test could be developed to improve th…
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- [Application of immunohistochemical staining of PRAME in differential diagnosis between melanoma and melanocytic nevus]. [Journal Article]
- Objective: To investigate the diagnostic value of preferentially expressed antigen in melanoma (PRAME) in differential diagnosis of benign and malignant cutaneous melanocytic lesions. Methods: Fifty-nine cases of melanoma (50 cases of skin primary melanoma, and 9 cases of metastatic melanoma) and 48 cases of melanocytic nevus (40 cases of common nevus and 8 cases of dysplastic nevus) were subject…
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- The Spectrum of Spitz Melanocytic Lesions: From Morphologic Diagnosis to Molecular Classification. [Review]
- Spitz tumors represent a distinct subtype of melanocytic lesions with characteristic histopathologic features, some of which are overlapping with melanoma. More common in the pediatric and younger population, they can be clinically suspected by recognizing specific patterns on dermatoscopic examination, and several subtypes have been described. We now classify these lesions into benign Spitz nevi…
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- Genetic and methylation profiles distinguish benign, malignant and spitzoid melanocytic tumors. [Journal Article]
- Accurate classification of melanocytic tumors is important for prognostic evaluation, treatment and follow-up protocols of patients. The majority of melanocytic proliferations can be classified solely based on clinical and pathological criteria, however in select cases a definitive diagnostic assessment remains challenging and additional diagnostic biomarkers would be advantageous. We analyzed me…
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- [The risks of tanning with the Barbie drug]. [Case Reports]Ned Tijdschr Geneeskd. 2022 05 19; 166NT
- CONCLUSIONS: This case reports underlines self-administration of Melanotan II is not without potential side effects, although Melanotan II is easily available on the internet and in gyms.
- Rosette-like formations in melanocytic neoplasms: A case report and literature review. [Case Reports]J Cutan Pathol. 2022 Sep; 49(9):818-823.JC
- Homer-Wright-like rosettes are a common finding in neural tumors but seldom seen in melanocytic nevi and melanoma. We report a case of a 23-year-old male with a compound melanocytic nevus with such rosette-like structures and summarize the current literature on this histopathological feature in melanocytic neoplasms. A symmetric, well-circumscribed, compound nevus consisting of aggregations of ep…
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- Conceptual Evolution and Current Approach to Spitz Tumors. [Journal Article]
- Over the past several decades, the study of Spitz neoplasms has flourished, with expanded conceptualization and refined terminology, providing a framework for the assessment and classification of Spitz nevi, atypical Spitz Tumors, and Spitz melanoma. Cancer genomics have generated concepts such as driver and passenger genes and clonal evolution, which can be applied to Spitz tumors. Herein, we pr…
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- The use of digital dermoscopy in the surveillance of melanocytic skin lesions: A real-life retrospective study comparing university hospital and private practices. [Journal Article]Ann Dermatol Venereol. 2022 Dec; 149(4):251-257.AD
- CONCLUSIONS: In both populations in real-life practice, DD seemed to allow the detection of thin melanomas and to decrease the rate of "futile" resections.
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