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Unbound Medicine.
(Autoimmune hemolytic anemia)
8,298 results
  • Evans syndrome as initial presentation of COVID-19 infection: A case report and review of the literature [Journal Article]
    Ann Biol Clin (Paris). 2023 01 31 [Online ahead of print]Ghariani I, Braham NJ, Bekir L
  • Evans syndrome (ES) is a rare and chronic autoimmune disease characterized by the concomitant or sequential association of auto-immune hemolytic anemia (AIHA) with immune thrombocytopenia (ITP), and less frequently autoimmune neutropenia. Coronavirus disease 2019 (Covid-19) may cause various hematologic conditions. COVID-19 may also induce Evans syndrome via immune mechanisms. Here, we describe t…
  • Clinical and Epidemiological Features of Paroxysmal Cold Hemoglobinuria: A Systematic Review. [Journal Article]
    Blood Adv. 2023 Jan 30 [Online ahead of print]Jacobs JW, Figueroa Villalba CA, … Adkins BD
  • Paroxysmal cold hemoglobinuria (PCH) is a rare autoimmune hemolytic anemia often overlooked as a potential etiology of hemolysis, and is challenging to diagnose due to the complicated testing methods required. We performed a systematic review of all reported cases to better assess the clinical, immunohematologic, and therapeutic characteristics of PCH. We systematically analyzed PubMed, Medline, …
    Blood. 2023 Jan 27 [Online ahead of print]Fattizzo B, Bortolotti M, … Barcellini W
  • Relapsing or occurring de novo autoimmune hemolytic anemia (AIHA) during pregnancy or puerperium is a poorly described condition. Here we report 45 pregnancies occurring in 33 women evaluated at 12 centers from 1997 to 2022. Among the 20 women with AIHA diagnosis before pregnancy, 10 had a relapse. Additional 13 patients developed de novo AIHA during gestation/puerperium (two patients had AIHA re…
  • Rise of the planet of rare anemias: An update on emerging treatment strategies. [Review]
    Front Med (Lausanne). 2022; 9:1097426.Fattizzo B, Motta I
  • Therapeutic options for rare congenital (hemoglobinopathies, membrane and enzyme defects, congenital dyserythropoietic anemia) and acquired anemias [warm autoimmune hemolytic anemia (wAIHA), cold agglutinin disease CAD, paroxysmal nocturnal hemoglobinuria (PNH), and aplastic anemia (AA)] are rapidly expanding. The use of luspatercept, mitapivat and etavopivat in beta-thalassemia and pyruvate kina…
  • Chemical- and Drug-Induced Allergic, Inflammatory, and Autoimmune Diseases Via Haptenation. [Review]
    Biology (Basel). 2023 Jan 12; 12(1)Sakamoto E, Katahira Y, … Yoshimoto T
  • Haptens are small molecules that only elicit an immune response when bound to proteins. Haptens initially bind to self-proteins and activate innate immune responses by complex mechanisms via inflammatory cytokines and damage-associated molecular patterns and the subsequent upregulation of costimulatory signals such as cluster of differentiation 86 (CD86) on dendritic cells. Subsequent interaction…
  • Pseudo-thrombotic microangiopathy due to folate deficiency. [Case Reports]
    BMJ Case Rep. 2023 Jan 20; 16(1)Larkin E, Konkol S, Geraghty M
  • Classically, deficiencies of vitamin B12 and folate are associated with megaloblastic anaemia. Additionally, vitamin B12 is able to cause a haemolytic anaemia in the form of pseudo-thrombotic microangiopathy (pseudo-TMA). Here, we present a case of a middle-aged woman with a history of Roux-en-Y gastric bypass who presented with dyspnoea and fatigue and was found to have thrombocytopenia and a no…
  • Cold antibody autoimmune hemolytic anemia following varicella infection. [Case Reports]
    Indian J Pathol Microbiol. 2023 Jan-Mar; 66(1):188-190.Carvalho G, D'silva A, … Basheer A
  • CONCLUSIONS: In patients presenting with acute onset anemia following chicken pox, possibility of cold antibody AIHA must be considered and appropriate testing pursued. Despite lack of empiric evidence, short course of steroids may be beneficial if drop in hemoglobin is rapid with evidence of fulminant hemolysis, showing no abatement after first week.
  • Therapeutic Options in Refractory Evans Syndrome: A Case Report. [Case Reports]
    Cureus. 2022 Dec; 14(12):e32635.Jancar N, Sousa Gonçalves F, … Aguiar P
  • Evans syndrome is a rare autoimmune disease, characterized by at least two immune cytopenias, most frequently anemia and thrombocytopenia and rarely immune neutropenia. It has a variable clinical presentation and is rarely diagnosed in adults. It can be idiopathic or secondary to lymphoproliferative disease, infections, autoimmune diseases, drugs, and immunodeficiencies in about 50% of cases. It …
  • TLR7 and IgM: Dangerous Partners in Autoimmunity. [Review]
    Antibodies (Basel). 2023 Jan 06; 12(1)Amendt T, Yu P
  • The B cell antigen receptor (BCR)-repertoire is capable of recognizing a nearly unlimited number of antigens. Inevitably, the random nature of antibody gene segment rearrangement, needed in order to provide mature B cells, will generate autoreactive specificities. Once tolerance mechanisms fail to block the activation and differentiation of autoreactive B cells, harmful autoantibodies may get sec…
  • GeneReviews®: Wilson Disease [BOOK]
    GeneReviews®. University of Washington, Seattle: Seattle (WA)Adam MP, Everman DB, … Amemiya AWeiss KH, Schilsky MBOOK
  • Wilson disease is a disorder of copper metabolism that, when untreated, can present with hepatic, neurologic, or psychiatric disturbances – or a combination of these – in individuals ages three years to older than 70 years. Manifestations in untreated individuals vary among and within families. Liver disease can include recurrent jaundice, simple acute self-limited hepatitis-like illness, autoimm…
  • Scleroderma Renal Crisis With Thrombotic Microangiopathy Treated With Eculizumab. [Case Reports]
    Cureus. 2022 Nov; 14(11):e31977.Saba L, Kassab J, … Bari M
  • We herein report the unusual case of a 52-year-old female with systemic scleroderma who was admitted to the emergency department (ED) with renal dysfunction and hypertension. Following a decline in hemoglobin (Hb) and platelet (Plt) count, the diagnosis of scleroderma renal crisis (SRC) with associated microangiopathic hemolytic anemia was made. Renal replacement therapy using hemodialysis was re…
  • Use of steroids in the management of low-risk myelodysplastic syndromes with autoimmune features. [Journal Article]
    Blood Transfus. 2022 Dec 22 [Online ahead of print]Fattizzo B, Serpenti F, … Barcellini W
  • CONCLUSIONS: This observation suggests a trial with a short course (2-3 weeks) of standard steroid doses to ascertain efficacy and properly silence the autoimmune pathogenic mechanism. Steroid-related adverse events (16% of cases) should be monitored carefully in this elderly, frail population. In conclusion, features of autoimmunity are present in more than two-thirds of low-risk MDS patients and a trial with prednisone 0.5-1 mg/kg day for 2-3 weeks, with proper monitoring of adverse events, may be useful to improve cytopenias in selected cases.
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