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Unbound Medicine.
(Autoimmune hepatitis)
12,684 results
  • Autoimmune Hepatitis Leading to Liver Cirrhosis: A Case Report. [Journal Article]
    JNMA J Nepal Med Assoc. 2022 Dec 01; 60(256):1059-1062.Shrestha M, Subedi SC, … Mehta N
  • Autoimmune hepatitis is a rare form of chronic liver inflammation that begins as acute hepatitis and progresses to chronic liver disease. It presents with varied clinical features from acute hepatitis to chronic liver diseases like chronic viral hepatitis and alcoholic liver disease, making it difficult to diagnose in the absence of a high index of suspicion and adequate laboratory support. Autoi…
  • Curcumae Rhizoma: A botanical drug against infectious diseases. [Review]
    Front Pharmacol. 2022; 13:1015098.Wu YQ, Tong T
  • Curcumae Rhizoma is the dry rhizome coming from Curcuma longa L. which grow widely in tropical south and southwest Asia. It has been used to treat conditions such as dermatoses, infections, stress, and depression. Moreover, in China, Curcumae Rhizoma and its active constituents have been made into different pharmaceutical preparations. Growing evidence suggests that these preparations can exert a…
  • The Preventive and Therapeutic Potential of the Flavonoids in Liver Cirrhosis: Current and Future Perspectives. [Review]
    Chem Biodivers. 2023 Jan 26 [Online ahead of print]Sahu R, Goswami S, … Rawal RK
  • Non-alcoholic fatty liver disease (NAFLD) may vary from moderately mild non-alcohol fatty liver (NAFL) towards the malignant variant known as non-alcoholic steatohepatitis (NASH), which is marked by fatty liver inflammation and may progress to liver cirrhosis (LC), liver cancer, fibrosis, or liver failure. Flavonoids can protect the liver from toxins through their anti-inflammatory, antioxidant, …
  • FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice via activation of CISD3. [Journal Article]
    Int Immunopharmacol. 2023 Jan 24; 116:109762.Jiang H, Fang Y, … Chen Y
  • Autoimmune hepatitis (AIH) is increasingly affecting human health but pharmacotherapies remain to be identified. Growing evidence reveals that ferroptosis, a newly recognized form of programmed cell death, is critical for AIH. However, the exact mechanisms of the ferroptotic cascade remain elusive. Data in this study showed that ferroptosis aggravation was associated with protectively-elevated fi…
  • Facing the Unknown: Idiopathic Giant Cell Hepatitis. [Case Reports]
    ACG Case Rep J. 2023 Jan; 10(1):e00966.McGoldrick M, Castrodad-Rodríguez CA, … Tow C
  • Giant cell hepatitis is a rare infiltrative disease associated with several viruses, drugs, malignancies, and autoimmune conditions. To date, treatment aims at controlling the underlying etiology, and there are limited data on the clinical course and treatment of idiopathic cases. We present a case of idiopathic giant cell hepatitis in an otherwise healthy adult man and review the literature rega…
  • [Thyrotoxicosis in a patient with Turner syndrome: radioactive iodine therapy]. [Case Reports]
    Probl Endokrinol (Mosk). 2022 Jul 25; 68(6):49-58.Guseinova RM, Prosvirnina AA, … Sheremeta MS
  • Turner syndrome (TS) is a chromosomal disorder affecting female and characterized by complete or partial monosomy of the X chromosome. These genetic changes lead to the abnormalities in growth and development and increase the risk of autoimmune diseases, including those affecting the thyroid. Thyroid pathology in TS may include autoimmune thyroiditis, hypothyroidism, thyrotoxicosis (Graves diseas…
  • PPAR agonists for the treatment of primary biliary cholangitis: Old and new tales. [Review]
    J Transl Autoimmun. 2023; 6:100188.Colapietro F, Gershwin ME, Lleo A
  • Primary biliary cholangitis (PBC) is an autoimmune liver disease involving the small intrahepatic bile ducts; when untreated or undertreated, it may evolve to liver fibrosis and cirrhosis. Ursodeoxycholic Acid (UDCA) is the standard of care treatment, Obeticholic Acid (OCA) has been approved as second-line therapy for those non responder or intolerant to UDCA. However, due to moderate rate of UDC…
  • Autoantibodies: are they a clue for liver diseases? [Journal Article]
    Clin Exp Hepatol. 2022 Dec; 8(4):309-314.Nagi SAM, Ayoub BAH, … Rizk MS
  • CONCLUSIONS: Testing for liver-related autoantibodies should be included in the workup of patients with chronic liver diseases. Further studies are needed to explain the cause-effect association of ACL, ab2GPI and antiprothrombin with chronic HCV and vascular liver diseases.
  • Emerging Methods in Biosensing of Immunoglobin G-A Review. [Review]
    Sensors (Basel). 2023 Jan 06; 23(2)Azam T, Bukhari SH, … Miran W
  • Human antibodies are produced due to the activation of immune system components upon exposure to an external agent or antigen. Human antibody G, or immunoglobin G (IgG), accounts for 75% of total serum antibody content. IgG controls several infections by eradicating disease-causing pathogens from the body through complementary interactions with toxins. Additionally, IgG is an important diagnostic…
  • Burden, Outcome, and Comorbidities of Extrahepatic Manifestations in Hepatitis C Virus Infection. [Review]
    Biology (Basel). 2022 Dec 22; 12(1)Songtanin B, Nugent K
  • Hepatitis C virus (HCV) is a significant cause of chronic liver diseases worldwide and is associated with negative consequences, including cirrhosis, hepatic decompensation, hepatocellular carcinoma, and increased risk of mortality. In addition to liver-related morbidities, HCV is also associated with several extrahepatic manifestations, including mixed cryoglobulinemia, diabetes mellitus, cardio…
  • Lymphocyte disturbance and functional assessment of the [Asp521Asn] ZAP70 mutation. [Journal Article]
    Clin Immunol. 2023 Jan 17; 247:109236.Lin YF, Lee WI, … Tsai SF
  • Activated zeta-chain-associated protein kinase 70 (ZAP70) phosphorylates the TCRαβ:CD3:zeta complex to diversify and amplify TCR signaling. Patients with ZAP70 mutations can present with phenotypes of immune dysregulation as well as infection. We identified the first Taiwanese boy with the [Asp521Asn] ZAP70 mutation who presented with recurrent pneumonia, inflammatory bowel disease-like diarrhea,…
  • Liver kidney microsome antibodies. Analysis of a laboratory series. [Journal Article]
    Pract Lab Med. 2023 Jan; 33:e00307.Sanchez S, Fang D, … Cihakova D
  • CONCLUSIONS: Overall, LKM antibodies are rare. They contribute to establish a diagnosis of autoimmune hepatitis, although they are also found in other liver diseases. The cytochrome P450 2D6 is one of the antigens recognized by LKM antibodies, but other antigens are likely targeted considering that 2D6 is minimally expressed in the kidney and yet LKM antibodies bind to kidney tubuli.
  • Efficacy and Safety of Glycyrrhizic Acid in Treatment of Autoimmune Hepatitis. [Journal Article]
    Am J Chin Med. 2023 Jan 18 [Online ahead of print]Bi X, Yang L, … Li M
  • To compare the long-term efficacy and safety of glycyrrhizic acid preparation and hormone treatment in patients with autoimmune hepatitis, we enrolled 377 patients in a study that lasted from January 2009 to January 2020. After performing propensity score matching, we included 58 patients in the hormone group and 58 in the glycyrrhizic acid preparation group in statistical analysis. We then compa…
  • The Curious Case of the Black Buboes. [Case Reports]
    Cureus. 2022 Dec; 14(12):e32495.Saha A, Kanamgode SS, Mitra S
  • Anthracosis is an environmental lung disease caused by carbon deposition and pigmentation in the airways. However, in rare instances, it can also have systemic involvement. We present a patient with B-symptoms and diffuse lymphadenopathy who was diagnosed with the infrequently described nodal anthracosis. A 64-year-old Vietnamese gentleman with a 50-pack-year smoking history who was recently diag…
  • Thyroid gland and direct-acting antivirals (DAAs) used to treat chronic hepatitis C. Is it a safe regimen? [Review]
    Pol Merkur Lekarski. 2022 Dec 22; 50(300):388-390.Dyrka K, Borowska M, Czarnywojtek A
  • Hepatitis C virus (HCV) infection is widespread in the world and it has a diverse clinical manifestation. As a result of chronic infection, a patient may experience many health complications. Autoimmune thyroid disorders (AITD) occur more often among HCV-infected patients compared with healthy population. HCV treatment has changed over the years. It results from discovering of more and more new d…
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