- Case report: Peroral endoscopic myotomy for acute pandysautonomia-associated distal esophageal spasm in a child. [Case Reports]Front Pediatr. 2022; 10:935915.FP
- Acute pandysautonomia-associated distal esophageal spasm is a rare disease with an unclear etiology. Here, we describe a 12-year-old boy with an acute pandysautonomia-associated distal esophageal spasm who was treated using a peroral endoscopic myotomy (POEM). The patient's clinical features included recurrent dysphagia, nausea, vomiting, growth retardation, and signs of autonomic nerve dysfuncti…
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- Autonomic dysfunction and postural orthostatic tachycardia syndrome in post-acute COVID-19 syndrome. [Journal Article]Nat Rev Cardiol. 2023 Feb 02 [Online ahead of print]NR
- The post-acute sequelae of COVID-19 present major problems for many patients, their physicians and the health-care system. They are unrelated to the severity of the initial infection, are often highly symptomatic and can occur after vaccination. Many sequelae involve cardiovascular autonomic dysfunction, with postural orthostatic tachycardia syndrome in 30% of individuals. Prognosis is unknown, a…
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- Transcytosis-mediated anterograde transport of TrkA receptors is necessary for sympathetic neuron development and function. [Journal Article]Proc Natl Acad Sci U S A. 2023 Feb 07; 120(6):e2205426120.PN
- In neurons, many membrane proteins, synthesized in cell bodies, must be efficiently delivered to axons to influence neuronal connectivity, synaptic communication, and repair. Previously, we found that axonal targeting of TrkA neurotrophin receptors in sympathetic neurons occurs via an atypical transport mechanism called transcytosis, which relies on TrkA interactions with PTP1B, a protein tyrosin…
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- Vagal cross-sectional area correlates with parasympathetic dysfunction in Parkinson's disease. [Journal Article]
- The aim of this prospective study was to investigate autonomic function in Parkinson's disease with a multidimensional approach including clinical evaluation tools, head-up tilt test and morphological studies of the vagus nerve. Head-up tilt test parameters including high frequency power of the heart frequency interval, the ratio of low frequency power of the distance between two consecutive R wa…
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- Effect of comorbid benign joint hypermobility and juvenile fibromyalgia syndromes on pediatric functional gastrointestinal disorders. [Journal Article]Postgrad Med. 2023 Feb 01 [Online ahead of print]PM
- CONCLUSIONS: Functional GI disorders, JFMS, and BJHS are complex intertwined disorders influenced by emotional distress. Therefore, a multidisciplinary approach is necessary for the diagnosis and treatment process.
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- [Role of NLRP3 inflammasome in diabetic neuropathy and prevention and treatment with traditional Chinese medicine]. [Journal Article]Zhongguo Zhong Yao Za Zhi. 2023 Jan; 48(2):300-310.ZZ
- As one of the most frequent complications of diabetes, diabetic neuropathy often involves peripheral and central nervous systems. Neuroinflammation is the key pathogenic factor of secondary nerve injury in diabetes. NOD-like receptor pyrin domain-containing 3(NLRP3) inflammasome is a group of subcellular multiprotein complexes, including NLRP3, apoptosis associated speck-like protein(ASC), and pr…
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- Phenotypes of Overdiagnosed Long QT Syndrome. [Journal Article]J Am Coll Cardiol. 2023 Feb 07; 81(5):477-486.JACC
- CONCLUSIONS: Knowing the 5 main determinants of discordance between a previously rendered diagnosis of LQTS and full diagnostic reversal or removal (vasovagal syncope, "pseudo"-positive genetic test result in LQTS-causative genes, family history of SCD, transient QT prolongation, and misinterpretation of the QTc interval) increases awareness and provides critical guidance to reduce this burden of overdiagnosed LQTS.
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- Prolactin-Raising and Prolactin-Sparing Antipsychotic Drugs and the Risk of Fracture and Fragility Fracture in Patients With Schizophrenia, Dementia, and Other Disorders. [Meta-Analysis]J Clin Psychiatry. 2023 Jan 30; 84(1)JC
- Patients who require antipsychotic drug treatment are at increased risk of fractures, including osteoporosis-related fragility fractures, for reasons related to demographics, illness-related factors, and treatment-related factors. As examples, patients with dementia may be vulnerable to falls due to cognitive and psychomotor impairment, patients with schizophrenia may be vulnerable to injury rela…
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- Orthostatic Intolerance-Type Events Following Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis. [Meta-Analysis]J Bone Joint Surg Am. 2023 Feb 01; 105(3):239-249.JB
- CONCLUSIONS: OI-type events are common during the acute hospital stay following hip and knee arthroplasty, and 4 risk factors have been reported for OI-type events. High-quality prospective cohort studies are required to systematically and reliably determine the incidence of and risk factors for OI-type events.
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- Management of harlequin syndrome under ECPELLA support: A report of two cases and a proposed approach. [Case Reports]Ann Card Anaesth. 2023 Jan-Mar; 26(1):97-101.AC
- The use of ECPELLA in patients with severe lung disease may result in an unfavorable phenomenon of differential hypoxia. The simultaneous evaluation of three arterial blood samples from different arterial line (right radial artery, left radial artery, ECMO arterial line) in patients at risk of Harlequin syndrome (also called differential hypoxemia (DH)) can localize the "mixing cloud" along the a…
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- Effects of Riceberry Rice Bran Oil Supplementation on Oxidative Stress and Cardiovascular Risk Biomarkers in Older Adults with Prehypertension. [Journal Article]
- We investigated the changes in the oxidative stress and cardiovascular disease risk biomarkers, including the activity of the cardiac autonomic nervous system, in older adults with prehypertension following Riceberry rice bran oil supplementation. A total of 35 women aged 60 to 76 years with prehypertension were randomly allocated to two groups, one of which was supplemented with rice bran oil (n…
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- [Risk factors associated with malignant vasovagal syncope in children]. [Journal Article]Zhonghua Er Ke Za Zhi. 2023 Feb 02; 61(2):131-135.ZE
- Objective: To analyze the clinical characteristics and risk factors of malignant vasovagal syncope (VVS) in children. Methods: This was a case-control study. The data of 368 VVS patients who were treated in the Department of Cardiology, Children's Hospital, Capital Institute of Pediatrics from June 2017 to December 2021 was collected and analyzed. They were divided into malignant VVS group and no…
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- Paroxysmal Sympathetic Hyperactivity After Acquired Brain Injury: An Integrative Literature Review. [Review]Crit Care Nurse. 2023 Feb 01; 43(1):12-19.CC
- CONCLUSIONS: Critical care nurses should be aware of the signs and symptoms of paroxysmal sympathetic hyperactivity in patients with acute brain injury. Early identification is important to ensure timely treatment for patients with paroxysmal sympathetic hyperactivity.
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- [Gut microbiota in patients with relapsing-remitting multiple sclerosis]. [Review]Zh Nevrol Psikhiatr Im S S Korsakova. 2023; 123(1):8-15.ZN
- Microorganisms in human life play a huge role: in particular, those that coexist with the host organism, inhabiting the skin, upper respiratory tract, external genitalia and especially the digestive tract. The intestinal microbiota, including bacteriome, mycobiome and virome, not only takes part in the digestion process, but also provides the synthesis of a number of vitamins. The intestinal micr…
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- Post-acute sequelae of SARS-CoV-2 (PASC) syndrome presenting as postural orthostatic tachycardia syndrome (POTS). [Journal Article]Clin Exp Emerg Med. 2023 Jan 30 [Online ahead of print]CE
- The novel SARS-CoV-2 emerged in 2019, and the global COVID-19 pandemic continues into 2022. It has been known that a subset of patients develops chronic, debilitating symptoms after otherwise complete recovery from acute infection of COVID-19. Multiple terms have been used to describe this constellation of symptoms, including long COVID, long-haul COVID, and post-acute sequelae of SARS-CoV-2 synd…
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- Demonstrating new-onset or worsened sudomotor function post-COVID-19 on comparative analysis of autonomic function pre-and post-SARS-CoV-2 infection. [Journal Article]
- CONCLUSIONS: Sympathetic adrenergic and cholinergic dysautonomia probably account for some of the symptoms of Long COVID-19. Sudomotor dysfunction was demonstrated as consistently worsened or new-sequelae to COVID-19 infection. COVID-19 may be responsible for triggering new-onset or worsened small-fiber neuropathy in this sample, supporting previously reported studies with similar findings. However, the findings in our study are preliminary, and studies with larger sample size are needed to confirm these observations.
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- Syndrome BASCULE chez une jeune femme ayant un syndrome de tachycardie orthostatique posturale. [Case Reports]CMAJ. 2023 Jan 30; 195(4):E166-E167.CMAJ
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- Sympathetic and electrochemical skin responses in the assessment of sudomotor function: a comparative study. [Journal Article]Neurophysiol Clin. 2023 Jan 28; 53(2):102840.NC
- CONCLUSIONS: ESC in palms and soles has a high diagnostic accuracy for sudomotor dysfunction as detected by absent SSR in patients with MSA and PN.
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- The autonomic and nociceptive response to acute exercise is impaired in people with knee osteoarthritis. [Journal Article]
- An acute bout of exercise typically leads to short term exercise induced hypoalgesia (EIH), but this response is more variable in many chronic pain populations, including knee osteoarthritis (OA) and fibromyalgia (FM). There is evidence of autonomic nervous system (ANS) dysfunction in some chronic pain populations that may contribute to impaired EIH, but this has not been investigated in people w…
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- Coherence based graph convolution network for motor imagery-induced EEG after spinal cord injury. [Journal Article]
- CONCLUSIONS: The proposed framework can provide an effective theoretical basis for the rehabilitation treatment of SCI patients.
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- Limited evidence for sympathetic neural overactivation in older patients with type 2 diabetes mellitus. [Journal Article]
- Mechanistic studies suggested that excess sympathetic activity promotes arterial hypertension while worsening insulin sensitivity. Older patients with type 2 diabetes are at particularly high cardiovascular and metabolic risk. However, data on sympathetic activity in this population is scarce.
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- Cardiovascular Autonomic Dysfunction - a cause of acute Covid-19 complications and persistent post-Covid-19 complaints? [Editorial]Eur J Neurol. 2023 Jan 27 [Online ahead of print]EJ
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- Temporal relationships among changes in the RR-interval and the powers of the low- and high-frequency components of heart rate variability in normal subjects. [Journal Article]
- Spectral analysis of heart rate variability (HRV) is widely used as a non-invasive method to assess the cardiovascular autonomic function. Of the two main frequency components of HRV, namely low-frequency (LF, 0.04-0.15 Hz) and high-frequency (HF, 0.15-0.4 Hz) components, it is generally accepted that the HF power reflects modulation of heart rate which is mediated by cardiac parasympathetic (vag…
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- Postural orthostatic tachycardia syndrome: Recognition and treatment. [Journal Article]Nursing. 2023 Feb 01; 53(2):22-23.N
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- Postural orthostatic tachycardia syndrome: Recognition and treatment. [Journal Article]Nursing. 2023 Feb 01; 53(2):18-22.N
- Postural orthostatic tachycardia syndrome (POTS) affects 3 million in the US and 11 million globally. Signs and symptoms can vary and greatly impact a patient's quality of life. This article focuses on the prevalence, clinical manifestations, diagnosis, treatment, and patient education surrounding POTS.
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- [Orthostatic hypotension: focus on a common pathology sometimes misknowned]. [Journal Article]Geriatr Psychol Neuropsychiatr Vieil. 2022 Dec 01; 20(4):421-428.GP
- Orthostatic hypotension is a frequent pathology especially in older adults and inhospital patients. Prevalence is increasing with age, and is about 30 % of patients older than 65 years. Orthostatic hypotension is defined as a fall in blood pressure of at least 20 mmHg systolic or 10 mmHg diastolic when standing or during head-up tilt testing. Orthostatic hypotension is significantly associated wi…
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- Anti-IgLON5 Disease with Isolated Hemichorea: A Case Report and Review of the Literature. [Review]Mov Disord Clin Pract. 2023 Jan; 10(1):115-119.MD
- CONCLUSIONS: Our results support the diversity of clinical phenotypes in anti-IgLON5 disease, adding isolated hemichorea to the spectrum of presenting symptoms. As sleep-related disorders are often not the leading reason for consultation and only revealed by PSG examination, we suggest that screening for antibodies against IgLON5 should be considered in patients presenting with unexplained movement disorders, including isolated hemichorea.
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- Wireless Self-Powered Optogenetic System for Long-Term Cardiac Neuromodulation to Improve Post-MI Cardiac Remodeling and Malignant Arrhythmia. [Journal Article]Adv Sci (Weinh). 2023 Jan 25 [Online ahead of print]AS
- Autonomic imbalance is an important characteristic of patients after myocardial infarction (MI) and adversely contributes to post-MI cardiac remodeling and ventricular arrhythmias (VAs). A previous study proved that optogenetic modulation could precisely inhibit cardiac sympathetic hyperactivity and prevent acute ischemia-induced VAs. Here, a wireless self-powered optogenetic modulation system is…
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- Lessons of the month: Giant cell arteritis with Horner's syndrome and vertebral dissection. [Case Reports]Clin Med (Lond). 2023 Jan; 23(1):94-96.CM
- We present a case of an 82-year-old woman presenting with left-sided Horner's syndrome and stroke. She also had a 6-week history of intermittent dizziness, reduced appetite, lethargy, muscle stiffness and weight loss. Examination revealed left temporal artery and left posterior auricular artery tenderness. Her ESR showed 62 mm/hr and imaging showed left vertebral artery dissection. Temporal arter…
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- Human pancreatic capillaries and nerve fibers persist in type 1 diabetes despite beta cell loss. [Journal Article]Am J Physiol Endocrinol Metab. 2023 Jan 25 [Online ahead of print]AJ
- The autonomic nervous system regulates pancreatic function. Islet capillaries are essential for the extension of axonal projections into islets, and both of these structures are important for appropriate islet hormone secretion. Because beta cells provide important paracrine cues for islet glucagon secretion and neurovascular development, we postulated that beta cell loss in type 1 diabetes (T1D)…
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