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Unbound Medicine.
(Autonomic insufficiency)
2,218 results
  • Pathophysiology of the Nondipping Blood Pressure Pattern. [Review]
    Hypertension. 2023 Jan 06 [Online ahead of print]Huart J, Persu A, … Stergiou G
  • The nondipping blood pressure (BP) pattern corresponds to a disruption in the circadian BP rhythm with an insufficient decrease in BP levels during night-time sleep as observed using 24-hour ambulatory BP monitoring. Patients with nondipping BP pattern have poorer renal and cardiovascular outcomes, independent of their average 24-hour BP levels. The pathophysiology of nondipping BP is complex and…
  • Trigeminal Sensory Supply Is Essential for Motor Recovery after Facial Nerve Injury. [Review]
    Int J Mol Sci. 2022 Dec 01; 23(23)Rink-Notzon S, Reuscher J, … Angelov DN
  • Recovery of mimic function after facial nerve transection is poor. The successful regrowth of regenerating motor nerve fibers to reinnervate their targets is compromised by (i) poor axonal navigation and excessive collateral branching, (ii) abnormal exchange of nerve impulses between adjacent regrowing axons, namely axonal crosstalk, and (iii) insufficient synaptic input to the axotomized facial …
  • Allgrove syndrome: a case report. [Case Reports]
    Oxf Med Case Reports. 2022 Oct; 2022(10):omac104.Alhalabi M, Alsayd S, Alboushi E
  • Allgrove syndrome (AS), or Triple-A syndrome, is a multi-system disorder characterized by alacrima (a decrease or absence of tear production), adrenal insufficiency and achalasia (absence of esophageal muscle peristalsis and failure to relax the lower esophageal sphincter). This syndrome may affect the autonomic nervous system, in which case it is called a 4A syndrome. It is a rare autosomal rece…
  • StatPearls: Accommodative Insufficiency [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)EnaholoEhimare S.ESCentre for SightZeppieriMarcoMUniversity Hospital of Udine, ItalyBOOK
  • As an optical system, the eyes function in line with the basic principles of refraction. Visual clarity depends on the ability to bring incident light rays to a point focus at the fovea centralis. Schematically, the cornea and crystalline lens provide the requisite total dioptric power (about +60 diopters; the cornea makes up about + 40 to + 48 diopters). Accommodation is the adaptative faculty t…
  • Preferential impairment of parasympathetic autonomic function in type 2 diabetes. [Journal Article]
    Auton Neurosci. 2022 12; 243:103026.Rasmussen TK, Finnerup NB, … Terkelsen AJ
  • CONCLUSIONS: Patients with T2D showed reduced parasympathetic activity but preserved short-term cardiovascular sympathetic function, compared to controls, indicating autonomic dysfunction with predominantly parasympathetic impairment. Despite this, T2D patients reported more symptoms of orthostatic intolerance in COMPASS-31 and had reduced nocturnal BP dipping, indicating that these are not a consequence of cardiovascular sympathetic dysfunction.
  • Hypertension Management in Patients with Chronic Kidney Disease. [Review]
    Methodist Debakey Cardiovasc J. 2022; 18(4):41-49.Hebert SA, Ibrahim HN
  • Hypertension and chronic kidney disease are closely linked. Patients with chronic kidney disease have hypertension almost universally and uncontrolled hypertension accelerates the decline in kidney function. The pathophysiology of hypertension in chronic kidney disease is complex, but is largely related to reduced nephron mass, sympathetic nervous system overactivation, involvement of the renin-a…
  • Brachial artery responses to acute hypercapnia: The roles of shear stress and adrenergic tone. [Randomized Controlled Trial]
    Exp Physiol. 2022 12; 107(12):1440-1453.Carr JMJR, Ainslie PN, … Tremblay JC
  • What is the central question of this study? What are the contributions of shear stress and adrenergic tone to brachial artery vasodilatation during hypercapnia? What is the main finding and its importance? In healthy young adults, shear-mediated vasodilatation does not occur in the brachial artery during hypercapnia, as elevated α₁-adrenergic activity typically maintains vascular tone and offsets…
  • Fatigue in older persons: the role of nutrition. [Review]
    Proc Nutr Soc. 2022 Aug 23 [Online ahead of print]Azzolino D, Coelho-Junior HJ, … Cesari M
  • Fatigue is defined as a symptom leading to the inability to continue functioning at the expected activity level. It is a highly prevalent symptom, challenging to frame into monodimensional pathophysiological mechanisms. As a result, fatigue is often underestimated in the clinical setting and is wrongly considered an unavoidable consequence of ageing. Several potential mechanisms responsible for f…
  • Affective video recommender systems: A survey. [Review]
    Front Neurosci. 2022; 16:984404.Wang D, Zhao X
  • Traditional video recommendation provides the viewers with customized media content according to their historical records (e.g., ratings, reviews). However, such systems tend to generate terrible results if the data is insufficient, which leads to a cold-start problem. An affective video recommender system (AVRS) is a multidiscipline and multimodal human-robot interaction (HRI) system, and it inc…
  • Enteric nervous system and intestinal epithelial regulation of the gut-brain axis. [Review]
    J Allergy Clin Immunol. 2022 09; 150(3):513-522.Dowling LR, Strazzari MR, … Kaiko GE
  • The gut-brain axis describes a bidirectional interplay within the enteric environment between the intestinal epithelium, the mucosal immune system, and the microbiota with the enteric nervous system. This interplay provides a link between exogenous environmental stimuli such as nutrient sensing, and nervous system function, as well as a mechanism of feedback from cortical and sensory centers of t…
  • StatPearls: Lumbar Sympathetic Block [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)AlexanderChristopher E.CEDartmouth-Hitchcock Medical CenterDe JesusOrlandoOUniversity of Puerto Rico, Medical Sciences Campus, Neurosurgery SectionVaracalloMatthewMPenn Highlands Healthcare SystemBOOK
  • The autonomic nervous system consists of the sympathetic and parasympathetic divisions. As the name implies, the lumbar sympathetic block can be utilized to disrupt the nerve supply from the sympathetic chain to the lower extremities. This is useful in treating sympathetic mediators of pain. Specifically, lumbar sympathetic blocks can be used for the treatment of painful conditions such as comple…
  • [A case of triple A syndrome with c.463C>T mutation in the AAAS gene]. [Case Reports]
    Rinsho Shinkeigaku. 2022 Sep 28; 62(9):740-743.Hirosawa H, Konishi H, … Nakatsuji Y
  • A 47-year-old woman was admitted to our hospital for scrutiny of limb weakness and orthostatic hypotension that had progressed from childhood. She had been treated for alacrima and esophageal achalasia from childhood. On admission, she had hyperreflexia of upper and lower extremities, distal predominant muscle atrophy in the lower extremities, decreased sensation of the distal extremities, and au…
  • The complex interplay between diabetes mellitus and atrial fibrillation. [Review]
    Expert Rev Cardiovasc Ther. 2022 Sep; 20(9):707-717.Yildiz M, Lavie CJ, … Oktay AA
  • A growing body of evidence suggests that diabetes mellitus (DM) is associated with an increased risk of new-onset atrial fibrillation (AF) and contributes to suboptimal arrhythmia control and poor prognosis in patients with AF. The high prevalence of AF among patients with DM is primarily attributed to common risk factors, shared pathophysiological mechanisms, and associated atrial remodeling and…
  • Stellate ganglion block rectifies excessive daytime sleepiness: a case report. [Case Reports]
    J Int Med Res. 2022 Aug; 50(8):3000605221118681.Xu J, Liu Q, … Zhang Y
  • Excessive daytime sleepiness (EDS) is classified as a neurofunctional disorder that manifests as uncontrolled sleeping propensity in the daytime. Currently, consistent and effective therapeutic approaches for EDS are lacking. Stellate ganglion block (SGB) has a clear effect in various complicated pain syndromes, vascular insufficiency, hyperhidrosis, and posttraumatic stress syndrome. We report a…
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