- Pathophysiology of the Nondipping Blood Pressure Pattern. [Review]Hypertension. 2023 Jan 06 [Online ahead of print]H
- The nondipping blood pressure (BP) pattern corresponds to a disruption in the circadian BP rhythm with an insufficient decrease in BP levels during night-time sleep as observed using 24-hour ambulatory BP monitoring. Patients with nondipping BP pattern have poorer renal and cardiovascular outcomes, independent of their average 24-hour BP levels. The pathophysiology of nondipping BP is complex and…
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- Baroreceptor Sensitivity in Individuals with CKD and Heart Failure. [Journal Article]
- CONCLUSIONS: Cardiac BRS is depressed in patients with mild to moderate CKD and HF and associated with cardiovascular mortality. Additional study to confirm its contribution to cardiovascular mortality, particularly in advanced CKD, is warranted.
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- Trigeminal Sensory Supply Is Essential for Motor Recovery after Facial Nerve Injury. [Review]
- Recovery of mimic function after facial nerve transection is poor. The successful regrowth of regenerating motor nerve fibers to reinnervate their targets is compromised by (i) poor axonal navigation and excessive collateral branching, (ii) abnormal exchange of nerve impulses between adjacent regrowing axons, namely axonal crosstalk, and (iii) insufficient synaptic input to the axotomized facial …
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- Neural mechanisms underlying peripheral facial nerve palsy: A protocol for systematic review and meta-analysis of neuroimaging studies. [Journal Article]
- CONCLUSIONS: The aim of this study is to investigate functional reorganization of brain alterations in patients with BP. This review will improve the understanding of the neural mechanisms of BP based on the most recent publications through extensive data retrieval. If sufficient data are collected, a sensitivity analysis is performed to verify the robustness of the conclusions.
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- [Posture-dependent left ventricular outflow tract obstruction in a case of Lewy body dementia that presented with transient loss of consciousness]. [Case Reports]Nihon Ronen Igakkai Zasshi. 2022; 59(4):559-564.NR
- An 80-year-old woman with a history of hypertrophic obstructive cardiomyopathy and Lewy body dementia was admitted to our hospital with a first episode of syncope while walking. The pressure gradient of left ventricular outflow tract (LVOT) had been stable at nearly 10 mmHg for 3 years before the admission. We evaluated the cause of syncope. Echocardiography showed that the pressure gradient of L…
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- Living with small fiber neuropathy: insights from qualitative focus group interviews. [Journal Article]
- CONCLUSIONS: Given the results, it can be concluded that an optimal treatment should include biological, psychological, and social components.
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- Characterizing the effect of demographics, cardiorespiratory factors, and inter-subject variation on maternal heart rate variability in pregnancy with statistical modeling: a retrospective observational analysis. [Journal Article]
- Pregnancy complications are associated with insufficient adaptation of the maternal autonomic nervous system to the physiological demands of pregnancy. Consequently, assessing maternal heart rate variability (mHRV)-which reflects autonomic regulation-is a promising tool for detecting early deterioration in maternal health. However, before mHRV can be used to screen for complications, an understan…
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- Does Exercise Training Improve Cardiac-Parasympathetic Nervous System Activity in Sedentary People? A Systematic Review with Meta-Analysis. [Review]
- The aim of this study was to investigate the training-induced effect on cardiac parasympathetic nervous system (PNS) activity, assessed by resting heart rate variability (HRV) and post-exercise heart rate recovery (HRR), in sedentary healthy people. Electronic searches were carried out in PubMed, Embase, and Web of Science. Random-effects models of between-group standardised mean difference (SMD)…
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- Mortality patterns of soft-tissue sarcomas worldwide up to 2018, with predictions for 2025. [Journal Article]Eur J Cancer Prev. 2023 Jan 01; 32(1):71-80.EJ
- CONCLUSIONS: In addition to improvements in STSs registration, unfavourable mortality rates reported in this study reflect inadequate referral of patients with STSs to high-volume multidisciplinary centres, as well as insufficient advancements in STS prevention, diagnosis, and treatments.
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- Synergistic effect of chronic kidney disease, neuropathy, and retinopathy on all-cause mortality in type 1 and type 2 diabetes: a 21-year longitudinal study. [Journal Article]
- CONCLUSIONS: Our study demonstrates the long-term, synergistic, negative effects of single and concomitant diabetic MVC on all-cause mortality, which should encourage comprehensive screenings for MCV in both T1D and T2D to improve risk stratification and treatment.
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- Allgrove syndrome: a case report. [Case Reports]
- Allgrove syndrome (AS), or Triple-A syndrome, is a multi-system disorder characterized by alacrima (a decrease or absence of tear production), adrenal insufficiency and achalasia (absence of esophageal muscle peristalsis and failure to relax the lower esophageal sphincter). This syndrome may affect the autonomic nervous system, in which case it is called a 4A syndrome. It is a rare autosomal rece…
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- [Characteristic of disorders of motor-evacuator activities of the stomach and intestinal in chronic duodenal insufficiency]. [Journal Article]Ter Arkh. 2022 Feb 15; 94(2):166-171.TA
- CONCLUSIONS: In patients with CDI, changes in the functional state of the stomach and duodenum are of a systemic nature, which is due to stimulating (parasympathetic) and inhibitory (sympathetic) effects. The relationship between the motor-evacuation activity of the stomach and duodenum and the psychoemotional state in patients with CDI was revealed.
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- StatPearls: Accommodative Insufficiency [BOOK]StatPearls. StatPearls Publishing: Treasure Island (FL)BOOK
- As an optical system, the eyes function in line with the basic principles of refraction. Visual clarity depends on the ability to bring incident light rays to a point focus at the fovea centralis. Schematically, the cornea and crystalline lens provide the requisite total dioptric power (about +60 diopters; the cornea makes up about + 40 to + 48 diopters). Accommodation is the adaptative faculty t…
- Normative values of short-term heart rate variability in a cross-sectional study of a Danish population. The DanFunD study. [Journal Article]Scand J Public Health. 2022 Oct 16 [Online ahead of print]SJ
- CONCLUSIONS: Both sex and age influence the heart rate variability in this adult Danish population. Therefore, our age- and sex-related reference values of heart rate variability in the time and frequency domain should be used in further epidemiological and clinical research.
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- Impact of direct laryngoscopy vs. videolaryngoscopy on signal quality of recurrent laryngeal nerve monitoring in thyroid surgery: a randomised parallel group trial. [Randomized Controlled Trial]Anaesthesia. 2023 01; 78(1):55-63.A
- In thyroid surgery, intra-operative neuromonitoring signals of the recurrent laryngeal nerve can be detected by surface electrodes on a tracheal tube positioned at the vocal fold level. The incidence of difficult tracheal intubation in patients undergoing thyroidectomy for nodular goitre ranges from 5.3% to 20.5%. The aim of this study was to compare videolaryngoscopy with conventional direct lar…
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- Perceived Anxiety, Coping, and Autonomic Function in Takotsubo Syndrome Long after the Acute Event. [Journal Article]
- CONCLUSIONS: Long after the acute event, TS patients are characterized by elevated anxiety, high tension, and a specific religious coping strategy.
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- Preferential impairment of parasympathetic autonomic function in type 2 diabetes. [Journal Article]Auton Neurosci. 2022 12; 243:103026.AN
- CONCLUSIONS: Patients with T2D showed reduced parasympathetic activity but preserved short-term cardiovascular sympathetic function, compared to controls, indicating autonomic dysfunction with predominantly parasympathetic impairment. Despite this, T2D patients reported more symptoms of orthostatic intolerance in COMPASS-31 and had reduced nocturnal BP dipping, indicating that these are not a consequence of cardiovascular sympathetic dysfunction.
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- Hypertension Management in Patients with Chronic Kidney Disease. [Review]
- Hypertension and chronic kidney disease are closely linked. Patients with chronic kidney disease have hypertension almost universally and uncontrolled hypertension accelerates the decline in kidney function. The pathophysiology of hypertension in chronic kidney disease is complex, but is largely related to reduced nephron mass, sympathetic nervous system overactivation, involvement of the renin-a…
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- Systemic Metabolic Alteration Dependent on the Thyroid-Liver Axis in Early PD. [Journal Article]Ann Neurol. 2023 Feb; 93(2):303-316.AN
- CONCLUSIONS: Our findings suggest that interorgan communications between the thyroid and liver are disorganized in the early stage of PD, which would be a sensitive diagnostic biomarker for PD. ANN NEUROL 2023;93:303-316.
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- Brachial artery responses to acute hypercapnia: The roles of shear stress and adrenergic tone. [Randomized Controlled Trial]Exp Physiol. 2022 12; 107(12):1440-1453.EP
- What is the central question of this study? What are the contributions of shear stress and adrenergic tone to brachial artery vasodilatation during hypercapnia? What is the main finding and its importance? In healthy young adults, shear-mediated vasodilatation does not occur in the brachial artery during hypercapnia, as elevated α₁-adrenergic activity typically maintains vascular tone and offsets…
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- Fatigue in older persons: the role of nutrition. [Review]
- Fatigue is defined as a symptom leading to the inability to continue functioning at the expected activity level. It is a highly prevalent symptom, challenging to frame into monodimensional pathophysiological mechanisms. As a result, fatigue is often underestimated in the clinical setting and is wrongly considered an unavoidable consequence of ageing. Several potential mechanisms responsible for f…
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- Affective video recommender systems: A survey. [Review]
- Traditional video recommendation provides the viewers with customized media content according to their historical records (e.g., ratings, reviews). However, such systems tend to generate terrible results if the data is insufficient, which leads to a cold-start problem. An affective video recommender system (AVRS) is a multidiscipline and multimodal human-robot interaction (HRI) system, and it inc…
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- Enteric nervous system and intestinal epithelial regulation of the gut-brain axis. [Review]
- The gut-brain axis describes a bidirectional interplay within the enteric environment between the intestinal epithelium, the mucosal immune system, and the microbiota with the enteric nervous system. This interplay provides a link between exogenous environmental stimuli such as nutrient sensing, and nervous system function, as well as a mechanism of feedback from cortical and sensory centers of t…
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- Association Between Gait and Dysautonomia in Patients With De Novo Parkinson's Disease: Forward Gait Versus Backward Gait. [Journal Article]J Mov Disord. 2023 Jan; 16(1):59-67.JM
- CONCLUSIONS: Our findings suggest that alteration in gait dynamics, especially backward gait, is highly associated with autonomic dysfunction in patients with de novo PD.
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- StatPearls: Lumbar Sympathetic Block [BOOK]StatPearls. StatPearls Publishing: Treasure Island (FL)BOOK
- The autonomic nervous system consists of the sympathetic and parasympathetic divisions. As the name implies, the lumbar sympathetic block can be utilized to disrupt the nerve supply from the sympathetic chain to the lower extremities. This is useful in treating sympathetic mediators of pain. Specifically, lumbar sympathetic blocks can be used for the treatment of painful conditions such as comple…
- [A case of triple A syndrome with c.463C>T mutation in the AAAS gene]. [Case Reports]Rinsho Shinkeigaku. 2022 Sep 28; 62(9):740-743.RS
- A 47-year-old woman was admitted to our hospital for scrutiny of limb weakness and orthostatic hypotension that had progressed from childhood. She had been treated for alacrima and esophageal achalasia from childhood. On admission, she had hyperreflexia of upper and lower extremities, distal predominant muscle atrophy in the lower extremities, decreased sensation of the distal extremities, and au…
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- Burden of caregiving for cardiovascular dysautonomia in Parkinson's disease. [Journal Article]
- CONCLUSIONS: These results highlight the significant impact of cAN on PD caregivers and the need for targeted interventions addressing this frequently overlooked and insufficiently treated source of nonmotor disability in PD.
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- The complex interplay between diabetes mellitus and atrial fibrillation. [Review]Expert Rev Cardiovasc Ther. 2022 Sep; 20(9):707-717.ER
- A growing body of evidence suggests that diabetes mellitus (DM) is associated with an increased risk of new-onset atrial fibrillation (AF) and contributes to suboptimal arrhythmia control and poor prognosis in patients with AF. The high prevalence of AF among patients with DM is primarily attributed to common risk factors, shared pathophysiological mechanisms, and associated atrial remodeling and…
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- Stellate ganglion block rectifies excessive daytime sleepiness: a case report. [Case Reports]
- Excessive daytime sleepiness (EDS) is classified as a neurofunctional disorder that manifests as uncontrolled sleeping propensity in the daytime. Currently, consistent and effective therapeutic approaches for EDS are lacking. Stellate ganglion block (SGB) has a clear effect in various complicated pain syndromes, vascular insufficiency, hyperhidrosis, and posttraumatic stress syndrome. We report a…
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