- The Effect of Metformin on Vestibular Schwannoma Growth: A Systematic Review and Meta-analysis. [Review]Laryngoscope. 2023 Feb 06 [Online ahead of print]L
- CONCLUSIONS: Metformin use may reduce the odds of VS growth. A randomized trial would be ideal to identify an unbiased estimate of metformin's effect on VS growth. Laryngoscope, 2023.
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- A Retrospective Study of the Effect of Metformin on Patients with Metastatic Prostate Cancer. [Journal Article]Clin Med Insights Oncol. 2023; 17:11795549231152073.CM
- CONCLUSIONS: Among patients with mHSPC, use of metformin was not significantly associated with improved OS in the multivariate analysis.
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- International evidence-based guidelines on hypertension and type 2 diabetes mellitus: A systematic review. [Review]J Public Health Res. 2023 Jan; 12(1):22799036221146913.JP
- This systematic review provides a high-quality, comprehensive summary of recommendations on hypertension (HT) and type 2 diabetes mellitus (T2DM), accentuating patient blood pressure, HbA1c levels, patterns of drug treatment, management, and screening of these diseases. The overall objective of the review is to support adapting existing clinical practice guidelines in Indonesia, Vietnam, and Myan…
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- Targeting lipid metabolism in metastatic prostate cancer. [Review]Ther Adv Med Oncol. 2023; 15:17588359231152839.TA
- Despite key advances in the treatment of prostate cancer (PCa), a proportion of men have de novo resistance, and all will develop resistance to current therapeutics over time. Aberrant lipid metabolism has long been associated with prostate carcinogenesis and progression, but more recently there has been an explosion of preclinical and clinical data which is informing new clinical trials. This re…
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- miR-223 Plays A Key Role in Obesogen-Enhanced Adipogenesis in Mesenchymal Stem Cells and in Transgenerational Obesity. [Journal Article]Endocrinology. 2023 Feb 06 [Online ahead of print]E
- Exposure of pregnant F0 mouse dams to the obesogen tributyltin (TBT) predisposes unexposed male descendants to obesity and diverts mesenchymal stem cells (MSCs) toward the adipocytic lineage. TBT promotes adipogenic commitment and differentiation of MSCs, in vitro. To identify TBT-induced factors predisposing MSCs toward the adipocytic fate, we exposed mouse MSCs to TBT, the PPARγ-selective agoni…
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- Urinary excretion of metformin in diabetic patients with and without tuberculosis. [Journal Article]Indian J Tuberc. 2023 Jan; 70(1):37-41.IJ
- CONCLUSIONS: This is the first study to report on the percent dose of MET excretion in urine in patients with DM and DMTB receiving MET along with anti-TB drugs.
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- Myo-Inositol Potentiates the Inhibitory Effect of Metformin on Prolactin Levels. [Journal Article]Pharmacology. 2023 Feb 03 [Online ahead of print]P
- CONCLUSIONS: The obtained results suggest that myo-inositol supplementation potentiates the inhibitory effect of metformin on prolactin levels in women with hyperprolactinemia.
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- Contrast-induced Nephropathy in Kidney Transplant Recipients: A Single-center Experience. [Journal Article]Iran J Kidney Dis. 2023 Jan; 1(1):47-53.IJ
- CONCLUSIONS: CIN is not uncommon in KT recipients receiving CM, especially with ischemic heart disease. Risk stratification, optimizing hemodynamics, and avoiding potential nephrotoxins are essential before performing CM-enhanced studies in KT recipients. DOI: 10.52547/ijkd.7165.
- Co-administration of metformin and/or glibenclamide with losartan reverse NG-nitro-l-arginine-methyl ester-streptozotocin-induced hypertensive diabetes and haemodynamic sequelae in rats. [Journal Article]Microvasc Res. 2023 Feb 02 [Online ahead of print]MR
- Over the years, there have been opinions on whether to reduced blood pressure (BP) to a different levels in patients with diabetes mellitus. Hence, this study investigated the efficacy of the co-administration of losartan (angiotensin receptor blocking antihypertensive agent) with metformin and/or glibenclamide (antidiabetic agents) on hypertensive-diabetic experimental rats induced by NG-nitro-l…
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- Efficacy and safety of the SGLT2 inhibitor empagliflozin versus placebo and the DPP-4 inhibitor linagliptin versus placebo in young people with type 2 diabetes (DINAMO): a multicentre, randomised, double-blind, parallel group, phase 3 trial. [Journal Article]Lancet Diabetes Endocrinol. 2023 Feb 01 [Online ahead of print]LD
- CONCLUSIONS: Empagliflozin provided clinically relevant placebo-corrected reductions in HbA1c, whereas linagliptin did not, and might offer a new treatment option for young people with type 2 diabetes.
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- Integrative analyses of biomarkers and pathways for metformin reversing cisplatin resistance in head and neck squamous cell carcinoma cells. [Journal Article]Arch Oral Biol. 2023 Feb 01; 147:105637.AO
- CONCLUSIONS: Our study demonstrates that Fen1 is overexpressed in HNSCC tissues compared with normal tissues and that Fen1 overexpression is a poor prognostic factor in HNSCC patients. Metformin enhances the ability of cisplatin to inhibit HNSCC progression. Further studies are needed to explore the therapeutic value of Fen1 in HNSCC.
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- Metformin induces pyroptosis in leptin receptor-defective hepatocytes via overactivation of the AMPK axis. [Journal Article]Cell Death Dis. 2023 Feb 03; 14(2):82.CD
- Metformin is the biguanide of hepatic insulin sensitizer for patients with non-alcohol fatty liver disease (NAFLD). Findings regarding its efficacy in restoring blood lipids and liver histology have been contradictory. In this study, we explore metformin's preventive effects on NAFLD in leptin-insensitive individuals. We used liver tissue, serum exosomes and isolated hepatocytes from high-fat die…
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- Pioglitazone can improve liver sex hormone-binding globulin levels and lipid metabolism in polycystic ovary syndrome by regulating hepatocyte nuclear factor-4α. [Journal Article]J Steroid Biochem Mol Biol. 2023 Feb 01 [Online ahead of print]JS
- Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic disorder that is closely correlated with insulin resistance. Sex hormone-binding globulin (SHBG) is an important carrier for regulating androgen activity and is affected by insulin level, which is related to metabolic abnormalities and long-term prognosis of PCOS. Insulin sensitizer pioglitazone can improve the SHBG level and…
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- Simultaneous, dual continuous veno-venous haemofiltration for refractory metformin-induced lactic acidosis: a case report. [Letter]Clin Toxicol (Phila). 2023 Feb 03 [Online ahead of print]CT
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- Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity. [Journal Article]Aging (Albany NY). 2023 Feb 02; 15A
- CONCLUSIONS: This study may elucidate metformin's potential role in longevity through epigenetic modifications and other possible mechanisms of action.
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- Metformin use and hospital attendance-related resources utilization among diabetic patients with prostate cancer on androgen deprivation therapy: A population-based cohort study. [Journal Article]Cancer Med. 2023 Feb 03 [Online ahead of print]CM
- CONCLUSIONS: Metformin use was associated with decreased hospital attendances, days of hospitalization, and associated costs, which could help reduce healthcare resource utilization following ADT in the treatment of PCa.
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- [Retracted] Metformin exerts anticancer effects through the inhibition of the Sonic hedgehog signaling pathway in breast cancer. [Retraction of Publication]
- Following the publication of this paper, it was drawn to the Editor's attention by concerned readers that several of the cellular images shown in Figs. 6A and 8A, the scratch‑wound assay images shown in Fig. 5A, the western blotting data in Figs. 2C and 7A and the Matrigel invasion assays in Fig. 5C were strikingly similar to data appearing in different form in other articles by different authors…
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- Metformin, cancer, COVID-19, and longevity. [Journal Article]Int J Clin Pharmacol Ther. 2023 Feb 03 [Online ahead of print]IJ
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- Endocrine disorders and fertility and pregnancy: An update. [Review]
- It is estimated that more and more couples suffer from fertility and pregnancy maintenance disorders. It is associated with impaired androgen secretion, which is influenced by many factors, ranging from genetic to environmental. It is also important to remember that fertility disorders can also result from abnormal anatomy of the reproductive male and female organ (congenital uterine anomalies - …
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- Obesity management: Attitudes and practice of Italian endocrinologists. [Journal Article]
- Obesity is a global pandemic and is cause of serious concern in all regions of the world. It is important to raise the attention of health care professionals in order to provide early treatment of patients with obesity. Obesity management, however, varies greatly amongst endocrinologists with respect to attitudes to diagnosis and treatment. Aim of this study was to identify practices and needs of…
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- Association of metformin exposure with low risks of frailty and adverse outcomes in patients with diabetes. [Journal Article]
- CONCLUSIONS: Metformin use is associated with a reduced risk of frailty. In addition, frailty may attenuate the protective effects of metformin on adverse outcomes in diabetic patients. The early identification and prevention of frailty progression may help enhance the benefits of metformin in patients with diabetes.
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- Effects of Systemic Drugs on the Development and Progression of Age-Related Macular Degeneration. [Review]Surv Ophthalmol. 2023 Jan 30 [Online ahead of print]SO
- Age-related macular degeneration (AMD) is the leading cause of severe loss of central vision among people over 50. The pathophysiology of the disease is multifactorial and can be attributed to genetics, aging, inflammation, environmental factors, and lifestyle factors including smoking, diet, obesity, and alcohol consumption. While there is no treatment for dry AMD, the current standard treatment…
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- Postop Complication With Euglycemic Diabetic Ketoacidosis in a Patient Receiving Empagliflozin. [Case Reports]
- Euglycemic diabetic ketoacidosis (EDKA) is an uncommon diabetic complication with increasing prevalence and is associated with the use of sodium-glucose co-transporter 2 inhibitors (SGLT2i). We report the case of a 77-year-old female patient with type 2 diabetes mellitus, treated with metformin/linagliptin and empagliflozin, who initiated a slurred speech and altered level of consciousness in the…
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- AMPK Activation Restores Salivary Function Following Radiation Treatment. [Journal Article]J Dent Res. 2023 Feb 01 [Online ahead of print]JD
- Head and neck cancers represent a significant portion of cancer diagnoses, with head and neck cancer incidence increasing in some parts of the world. Typical treatment of early-stage head and neck cancers includes either surgery or radiotherapy; however, advanced cases often require surgery followed by radiation and chemotherapy. Salivary gland damage following radiotherapy leads to severe and ch…
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- Direct comparison two fixed-ratio combination glucagon-like peptide receptor agonist and basal insulin on glycemic and non glycemic parameters in type 2 diabetes. [Journal Article]
- CONCLUSIONS: Our results showed that more patients with iDegLira had HbA1c less than 7% and these combination had better effect on weight loss. There was no difference observed in FPG and PPG, lipid profile and rate of hypoglycemia.
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- Long-Term High-Fat Diet Decreases Renal Insulin-Degrading Enzyme Expression and Function by Inhibiting the PPARγ Pathway. [Journal Article]Mol Nutr Food Res. 2023 Feb 01 [Online ahead of print]MN
- CONCLUSIONS: Long-term HFD decreases renal IDE expression and activity, and causes insulin resistance, which involves PPARγ. This article is protected by copyright. All rights reserved.
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- [Zuogui Jiangtang Qinggan Prescription promotes recovery of intestinal mucosal barrier in mice with type 2 diabetes mellitus and nonalcoholic fatty liver disease by improving intestinal flora homeostasis]. [Journal Article]Zhongguo Zhong Yao Za Zhi. 2023 Jan; 48(2):525-533.ZZ
- This study aimed to investigate the recovery effect of Zuogui Jiangtang Qinggan Prescription on intestinal flora homeostasis control and intestinal mucosal barrier in type 2 diabetes mellitus(T2DM) with nonalcoholic fatty liver disease(NAFLD) induced by a high-fat diet. NAFLD was established in MKR transgenic mice(T2DM mice) by a high-fat diet(HFD), and subsequently treated for 8 weeks with Zuogu…
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- Metformin mitigates amyloid β1-40-induced cognitive decline via attenuation of oxidative/nitrosative stress and neuroinflammation. [Journal Article]Metab Brain Dis. 2023 Feb 01 [Online ahead of print]MB
- Metformin is an antidiabetic medicine widely used for management of type 2 diabetes with neuroprotective effects and promising potential to attenuate cognitive impairment. The efficacy of metformin in attenuation of Alzheimer's disease (AD) pathology has not been well-documented. Thus, this study was designed to assess protective effect of metformin against Aβ1-40-instigared cognitive impairment.…
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- Sulfonylureas versus metformin and the risk of ventricular arrhythmias among people with type 2 diabetes: a population-based cohort study. [Journal Article]Diabetes Obes Metab. 2023 Feb 01 [Online ahead of print]DO
- CONCLUSIONS: Sulfonylureas are associated with an increased risk of VA when used as first-line therapy for type 2 diabetes relative to metformin use. This increased risk should be considered when prescribing sulfonylureas as an initial treatment for type 2 diabetes. This article is protected by copyright. All rights reserved.
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