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6,852 results
  • Deletion of Spinophilin Promotes White Adipocyte Browning. [Journal Article]
    Pharmaceuticals (Basel). 2023 Jan 08; 16(1)Gou W, Wei H, … Wang H
  • Browning of white adipose tissue (WAT) is suggested as a promising therapeutic approach to induce energy expenditure and counteract obesity and its associated complications. Systemic depletion of spinophilin (SPL) increases metabolism and improves energy balance in mice. In this study, we explored the mechanistic insight of SPL action in WAT browning. Gene expression and mitochondria tracker stai…
  • A simplified and defined serum-free medium for cultivating fat across species. [Journal Article]
    iScience. 2023 Jan 20; 26(1):105822.Mitić R, Cantoni F, … Jackisch L
  • Cultivated meat is a promising technology with the potential to mitigate the ethical and environmental issues associated with traditional meat. Fat plays a key role in the meat flavor; therefore, development of suitable adipogenic protocols for livestock is essential. The traditional adipogenic cocktail containing IBMX, dexamethasone, insulin and rosiglitazone is not food-compatible. Here, we dem…
  • Anti-ageing effects of FDA-approved medicines: a focused review. [Review]
    J Basic Clin Physiol Pharmacol. 2023 Jan 13 [Online ahead of print]Thanapairoje K, Junsiritrakhoon S, … Supharattanasitthi W
  • Ageing is the process generated by senescent cells, free radicals, inflammation and other relevant factors. Ageing contributes to age-related diseases that affect the quality of life. People are interested in anti-ageing intervention and many scientists attempt to search for anti-ageing medicines. This review focused on describing in vivo anti-ageing activity of US-FDA-approved drugs and found th…
  • Peroxisome proliferator-activated receptor gamma agonists for preventing recurrent stroke and other vascular events in people with stroke or transient ischaemic attack. [Review]
    Cochrane Database Syst Rev. 2023 01 10; 1:CD010693.Liu J, Wang LN
  • CONCLUSIONS: Peroxisome proliferator-activated receptor gamma agonists probably reduce recurrent stroke and total events of cardiovascular death, non-fatal myocardial infarction or non-fatal stroke, and may improve insulin sensitivity and the stabilisation of carotid plaques. Their effects on adverse events are uncertain. Our conclusions should be interpreted with caution considering the small number and the quality of the included studies. Further well-designed, double-blind RCTs with large samples are required to assess the efficacy and safety of PPAR-γ agonists in the secondary prevention of stroke and related vascular events in people with stroke or TIA.
  • Effects of rosiglitazone, an antidiabetic drug, on Kv3.1 channels. [Journal Article]
    Korean J Physiol Pharmacol. 2023 Jan 01; 27(1):95-103.Lee HM, Yoon SH, … Choi BH
  • Rosiglitazone is a thiazolidinedione-class antidiabetic drug that reduces blood glucose and glycated hemoglobin levels. We here investigated the interaction of rosiglitazone with Kv3.1 expressed in Chinese hamster ovary cells using the whole-cell patch-clamp technique. Rosiglitazone rapidly and reversibly inhibited Kv3.1 currents in a concentration-dependent manner (IC50 = 29.8 μM) and accelerate…
  • Ferroptosis and triple-negative breast cancer: Potential therapeutic targets. [Journal Article]
    Front Oncol. 2022; 12:1017041.Xu N, Li B, … Huang Z
  • CONCLUSIONS: The prognostic model composed of 12 ferroptosis-related genes could predict the prognosis of TNBC patients, and seven genes (ASNS, LAMP2, CAV1, DPP4, HELLS, TF, ZFP69B) could be potential new therapeutic targets for TNBC, and two drugs (1-methyl-3-isobutylxanthine, rosiglitazone) could act as potential therapeutic drugs for the treatment of TNBC.
  • Microscopic image-based classification of adipocyte differentiation by machine learning. [Journal Article]
    Histochem Cell Biol. 2022 Dec 11 [Online ahead of print]Noguchi Y, Murakami M, … Kano F
  • Adipocyte differentiation is a sequential process involving increased expression of peroxisome proliferator-activated receptor gamma (PPARγ), adipocyte-specific gene expression, and accumulation of lipid droplets in the cytoplasm. Expression of the transcription factors involved is usually detected using canonical biochemical or biomolecular procedures such as Western blotting or qPCR of pooled c…
  • A novel therapy for hepatic cholestasis treatment-the combination of rosiglitazone and fenofibrate. [Journal Article]
    Eur J Pharmacol. 2023 Jan 05; 938:175428.Chen Y, Yang S, … Han J
  • Hepatic cholestasis can develop into liver fibrosis and eventually liver failure. Currently, ursodeoxycholic acid (UDCA) or UDCA combined with fenofibrate is used for cholestasis treatment. Rosiglitazone inhibited α-naphthyl isothiocyanate (ANIT)-induced cholestasis in mice. In this study, we compared the effect of rosiglitazone, UDCA, fenofibrate, combined rosiglitazone and fenofibrate or UDCA a…
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