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2,052 results
  • The removal of micropollutants from treated effluent by batch-operated pilot-scale constructed wetlands. [Journal Article]
    Water Res. 2023 Feb 15; 230:119494.Lei Y, Wagner T, … Langenhoff A
  • Micropollutants (MPs), such as pharmaceuticals and antibiotics, are present in the environment at low concentrations (ng/L-μg/L). A constructed wetland (CW) is a nature-based wastewater treatment technology, which can be used to remove MPs from wastewater treatment plant effluent. This study aimed to improve MP removal of CWs by optimizing the design of batch-operated CW. Three pilot-scale CWs we…
  • Rapid Quantitation of Four Nitrosamine Impurities in Angiotensin Receptor Blocker Drug Substances. [Journal Article]
    J Pharm Sci. 2022 Dec 09 [Online ahead of print]Zhang J, Selaya SD, … Faustino PJ
  • Starting in July 2018, the FDA alerted patients and health care professionals to the recall of ARBs such as valsartan by several pharmaceutical companies because of their potential contamination with carcinogenic nitrosamine impurities, including: (1) N-nitrosodimethylamine (NDMA), (2) N-nitrosodiethylamine (NDEA), (3) N-nitrosoethylisopropylamine (NEIPA), (4) N-nitrosodiisopropylamine (NDIPA), (…
  • Influence of AGTR1 and ABCB1 Gene Polymorphism on the Curative Effect of Irbesartan. [Journal Article]
    Int J Hypertens. 2022; 2022:4278675.Wang Q, You L, … Yang X
  • The interindividual heterogeneity in response to the antihypertensive effect of irbesartan has received considerable attention because of gene polymorphism. In this study, we investigated the new combinational influences of AGTR1 and ABCB1 gene polymorphism on the therapeutic effect of irbesartan among Chinese hypertensive patients. A total of 353 samples including 168 normal people and 185 hyper…
  • Determination and pharmacokinetic study of riociguat by UPLC-MS/MS in human plasma. [Journal Article]
    J Chromatogr B Analyt Technol Biomed Life Sci. 2022 Nov 01; 1210:123454.Kocak OF, Albayrak M, … Araz O
  • Pulmonary hypertension (PH) is frequent in the general population and is linked to an increased risk of death. Riociguat is a kind of endothelin receptor antagonist that is often used to treat PH. For pharmacokinetic studies and the determination of riociguat in PH patients, a new, quick, easy, and sensitive UPLC-MS/MS approach was designed and validated. Riociguat and irbesartan (IS) were detect…
  • Methylglyoxal enhances the proliferation of vascular smooth muscle cells via Akt phosphorylation. [Journal Article]
    J Recept Signal Transduct Res. 2022 Dec; 42(6):567-572.Kırça M
  • Methylglyoxal (MGO) is predominantly produced as a by-product of the glycolysis pathway. The glyoxalase system effectively removes it in a healthy organism. However, this process is impaired, and MGO level is elevated in people with diabetes. MGO's effects on proliferation were mostly studied in cancer cells, and the data in other cell types are limited. This study inspected the proliferative cap…
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