- Near-Infrared Ratiometric Hemicyanine-Based pH Fluorescence Probe with Bone Targetability for Monitoring Bone Resorption. [Journal Article]Anal Chem. 2023 Feb 06 [Online ahead of print]AC
- Accurate detection of bone resorption is extremely important in the orthodontic treatment process as it can provide a basis for clinical treatment strategies. Recently, pH-responsive fluorescence probes have received tremendous attention in bone resorption monitoring owing to their high sensitivity, good specificity, and in situ and real-time detection capabilities, but there are still some short…
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- Joint replacement and human immunodeficiency virus. [Review]World J Virol. 2023 Jan 25; 12(1):1-11.WJ
- The incidence of human immunodeficiency virus (HIV)-infected cases that need total joint replacement (TJR) is generally rising. On the other hand, modern management of HIV-infected cases has enabled them to achieve longevity while increasing the need for arthroplasty procedures due to the augmented dege-nerative joint disease and fragility fractures, and the risk of osteonecrosis. Although initia…
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- Age Related Immunosenescence Epstein-Barr Virus-positive Mucocutaneous Ulcer of the Palate Mimicking Medication-related Osteonecrosis of the Jaw. [Journal Article]Indian J Otolaryngol Head Neck Surg. 2022 Dec; 74(Suppl 3):4593-4597.IJ
- Epstein-Barr virus (EBV) -positive mucocutaneous ulcer (EBVMCU) was first described as a lymphoproliferative disorder in 2010. In recent years, EBVMCU has been reported in the field of oral surgery. On the other hand, medication-related osteonecrosis of the jaw (MRONJ) is an osteomyelitis that occurs in patients receiving antiresorptive agents including bisphosphonates (BP) and/or denosumab devel…
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- Augmentation of IFN-γ by bone marrow derived immune cells in the presence of severe suppression of IFN-γ in gingivae induced by zoledronic acid and denosumab in Hu-BLT mice model of ONJ. [Journal Article]Front Endocrinol (Lausanne). 2023; 14:1111627.FE
- The potential mechanisms governing drug induced osteonecrosis of the jaw (ONJ) is not well understood, and is one of the objectives of this study. Thus, we tested the release of IFN-γ within different immune compartments including bone marrow and gingivae upon treatment with zoledronic acid (ZOL) and denosumab which are known to induce ONJ in susceptible individuals.
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- Total Talus Replacements. [Review]Foot Ankle Orthop. 2023 Jan; 8(1):24730114221151068.FA
- CONCLUSIONS: Total talus replacements are a promising alternative to tibiotalocalcaneal fusion for patients with avascular necrosis of the talus; however, further studies are required to ensure reliable outcomes prior to widespread adoption of this technology.
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- Benign osteonecrosis of the external ear canal: case series. [Case Reports]J Surg Case Rep. 2023 Jan; 2023(1):rjad016.JS
- Benign osteonecrosis of the external ear canal is a rare pathology that commonly gets misdiagnosed as cholesteatoma of the external ear canal, keratosis obturans and malignant otitis externa. Each pathology has characteristics that allow for differentiation between them. Careful analysis is required to diagnose properly and determine the best modality of management. This case series presents two …
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- Extensile Anterior and Posterior Knee Exposure for Complete Synovectomy of Diffuse Tenosynovial Giant Cell Tumor (Pigmented Villonodular Synovitis). [Journal Article]JBJS Essent Surg Tech. 2022 Apr-Jun; 12(2)JE
- Diffuse tenosynovial giant cell tumor (TGCT), also known as pigmented villonodular synovitis, is a benign, neoplastic disease of the synovium that can lead to joint destruction, osteoarthritis, and long-term morbidity1,2. Often, there is extra-articular involvement in the intercondylar notch and posterior soft tissues. A complete anterior and posterior synovectomy of the knee is indicated for tre…
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- Revision Amputation with Press-Fit Osseointegration for Transfemoral Amputees. [Journal Article]JBJS Essent Surg Tech. 2022 Apr-Jun; 12(2)JE
- Press-fit transfemoral osseointegration is the technique of inserting an intramedullary metal implant into the residual femur of an amputee; the implant is passed transcutaneously to attach to a standard prosthesis that includes a knee, tibia, ankle, and foot. This allows the prosthesis to be skeletally anchored, eliminating socket-related problems such as tissue compression that can provoke neur…
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- The safety and cost-analysis of simultaneous versus staged bilateral total knee arthroplasty in a Taiwan population. [Journal Article]J Chin Med Assoc. 2023 Feb 06 [Online ahead of print]JC
- CONCLUSIONS: SiTKA is a safe and cost-effective surgery. Both SiTKA and StTKA have similar rates of postoperative complications, readmission and reoperation, but SiTKA significantly reduces medical expenses for both the patient and the NHI.
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- MRONJ in breast cancer patients under bone modifying agents for cancer treatment-induced bone loss (CTIBL): a multi-hospital-based case series. [Journal Article]
- CONCLUSIONS: This is the first case series that investigated BC patients under BMAs for CTIBL prevention suffering from MRONJ. These patients seem to have similar probabilities of developing MRONJ as osteo-metabolic ones. Breast cancer patients under BMAs for CTIBL prevention need a regular prevention program for MRONJ, since they may develop bone metastases and be treated with higher doses of BMAs, potentially leading to a high-risk of MRONJ.
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- Surgical Trends for Managing Knee Osteonecrosis: a 2010 to 2020 United States Nationwide Study. [Journal Article]J Arthroplasty. 2023 Feb 02 [Online ahead of print]JA
- CONCLUSIONS: To our knowledge, this is the first study to characterize surgical trends in management of knee ON. Overall surgical volume for knee ON has continued to increase, outpacing population growth. Patients who have knee ON are most commonly managed with arthroplasty procedures, specifically TKA. Younger aged patients (<50 years) are more likely to undergo joint-preserving procedures, namely core decompression.
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- Bone marrow mesenchymal stem cells paracrine TGF-β1 to mediate the biological activity of osteoblasts in bone repair. [Journal Article]Cytokine. 2023 Feb 02; 164:156139.C
- CONCLUSIONS: Our findings provide evidence that the biological mechanism of BMSC-produced TGF-β1 promotes bone regeneration and repair, providing a theoretical basis and new directions for the application of BMSC transplantation in the treatment of osteonecrosis and bone injury.
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- Radiographic perception of anatomical structures and bony changes in oncologic patients under antiresorptive therapy. [Journal Article]Support Care Cancer. 2023 Feb 04; 31(2):149.SC
- CONCLUSIONS: Sclerotic bone pattern and thicker mandibular cortices may represent a consequence of ART rather than MRONJ specific findings. Prospective studies on larger patient samples radiographically followed-up during the ART treatment are advised, with specific attention to heterogenous trabecular bone pattern as a possible MRONJ predictor.
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- The influence of diagnoses on patient satisfaction during inpatient stays: A prospective study. [Journal Article]J Craniomaxillofac Surg. 2023 Jan 28 [Online ahead of print]JC
- The aim of this study was to assess patient satisfaction relating to inpatient stays. In this prospective observational study, adult patients with oncological (oral cancer, medication-related osteonecrosis of the jaw) and non-oncological (mandibular fracture) diagnoses, and who had undergone surgery, were contacted 4 weeks after discharge. Two validated questionnaires were used: EORTC QLQ-C30 for…
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- Thermomechanical damage in cortical bone caused by margins of surgical drill bit: A finite element analysis. [Journal Article]Comput Methods Programs Biomed. 2023 Jan 20; 231:107361.CM
- CONCLUSIONS: A surgical drill bit with a margin height of 0.05-0.13 mm and a margin width of 0.22-0.26 mm can produce minimum thermomechanical damage in cortical bone drilling. The insights regarding the suitable ranges for margin height and width from this study could be adopted in future research devoted to optimizing the margin of the existing surgical drill bit.
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- Quantitative analysis of local microcirculation changes in early osteonecrosis of femoral head: DCE-MRI findings. [Journal Article]
- CONCLUSIONS: ONFH is a complex ischemic lesion caused by changes in local microcirculation. It mainly manifests as increased permeability of the vascular wall, blood stasis in the posterior circulation, high intraosseous pressure in the femoral head, and decreased arterial blood flow. The application of DCE-MRI scanning to quantitatively analyze the visual manifestations of microcirculation after early ONFH is an ideal method to study the microcirculation changes of necrotic femoral heads.
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- Treatment of Advanced Kienböck's Disease Using 3D Printing Assisted Autologous Costochondral Transplantation: A Case Report. [Case Reports]JBJS Case Connect. 2022 Oct 01; 12(4)JC
- CONCLUSIONS: This costochondral transplantation strategy may offer a feasible treatment option for patients with severe Kienböck's disease.
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- Episode-of-care costs of total hip arthroplasty: day surgery versus same-day admission. [Journal Article]Can J Surg. 2023 Jan-Feb; 66(1):E59-E65.CJ
- CONCLUSIONS: Day surgery THA is cost-effective in selected patient populations. With the savings identified in this study, every 10 additional DS THA procedures would save sufficient resources to perform an additional THA operation.
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- Zoledronic acid-associated osteonecro sis of the jaw in patients with EGFR-sensitive mutant lung cancer: two case reports. [Journal Article]Anticancer Drugs. 2022 Nov 21 [Online ahead of print]AD
- Bone metastasis from lung cancer predicts a decrease in the quality of life and a shortening of survival for patients. While controlling the primary disease, active prevention and treatment of skeletal-related events (SREs) are crucial. The use of bisphosphonates as a basic drug for bone metastases from lung cancer has been increasing; also, the corresponding adverse effects have emerged. The cas…
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- Long-term Outcomes Following Free Vascularized Fibula Physeal Transfer for Proximal Humerus Oncologic Reconstruction in Children: An International Multi-Institutional Study. [Journal Article]Plast Reconstr Surg. 2022 Dec 06 [Online ahead of print]PR
- CONCLUSIONS: The vascularized fibula epiphysis for proximal humerus reconstruction in children preserves the potential for future growth and an articular surface for motion. Peroneal nerve palsy is common following harvest, although this is often transient. Future efforts should be geared towards reducing post-operative morbidity.
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- Effects of Technical Errors on the Outcomes of Operatively Managed Femoral Neck Fractures in Adults Less than 50 Years of Age. [Journal Article]J Orthop Trauma. 2023 Jan 05 [Online ahead of print]JO
- CONCLUSIONS: TEs were found in half of all femoral neck fractures in young adults undergoing operative repair. Both the occurrence and number of TEs were associated with an increased risk for failure of treatment. preoperative planning for thoughtful and well-executed reduction and fixation techniques should lead to improved outcomes for young patients with femoral neck fractures. This study should also highlight the need for educational forums to address this subject.
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- A Retrospective Observational Study to Compare the Outcome of Various Treatment Modalities of Idiopathic Avascular Necrosis of Hip. [Journal Article]
- CONCLUSIONS: In the early stage of disease, core decompression with and without bone grafting produced satisfactory results. In an advanced stage of AVN, THR is an excellent treatment option.
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- Vertebral Body Osteonecrosis Mimicking Malignant Disease on 18F-FDG PET. [Case Reports]Clin Nucl Med. 2023 Mar 01; 48(3):e115-e117.CN
- We report a case of vertebral osteonecrosis after chemotherapy in a 24-year-old man with non-Hodgkin lymphoma, with transient avidity on 18F-FDG PET initially misinterpreted as recurrent extranodal disease. The patient demonstrated a partial metabolic response on midtreatment restaging PET; however, posttreatment PET showed an increase in uptake in T4 and T5 vertebrae, interpreted as recurrent ve…
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- The effect of drug holiday on preventing medication-related osteonecrosis of the jaw in osteoporotic rat model. [Journal Article]
- CONCLUSIONS: Our data provided the first experimental evidence in the osteoporotic animal model that the implementation of a BP holiday in prior to dental extractions could partially recover osteoclastic activity, but could not alleviate the development of MRONJ-like lesion or exacerbate the osteoporotic condition in the femur. Longer-term drug holiday, or combination of drug holiday and other prophylaxes to prevent MRONJ in patients with osteoporosis could be worth exploring in future studies, to pave the way for clinical managements.
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- Is Only Peripheral Hip Arthroscopy Enough for Selected Patients with Femoroacetabular Impingement Syndrome? [Journal Article]
- CONCLUSIONS: OPHA can provide adequate treatment in selected FAI patients as it allows us to avoid critical complications such as damage to the cartilage, avascular necrosis, complications caused by traction and prolonged operation times seen in central compartment arthroscopy.
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- Analysis of the potential biological mechanisms of Danyu Gukang Pill against osteonecrosis of the femoral head based on network pharmacology. [Journal Article]
- CONCLUSIONS: This study is the first to investigate the molecular mechanisms of DGP in the treatment of ONFH based on network pharmacology. The results showed that DGP might up-regulate the expression of HIF-1α and VEGFA by participating in the HIF-1 signaling pathway, thus playing an anti-ONFH role.
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- One in five patients require conversion to arthroplasty after non-vascularized bone grafts in patients with osteonecrosis of the femoral head: a systematic review. [Journal Article]
- CONCLUSIONS: This study preliminarily obtained the general trend of the survival rate of NVBG patients, but these results should be interpreted cautiously. Pooled results from 2599 hips and of these nearly 80% with early stage of osteonecrosis, showed that approximately 21% of patients underwent a THA following NVBG. NVBG treatment for patient with ONFH appears to defer or at least delay the need for THA.
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- The effects of nano-hydroxyapatite/polyamide 66 scaffold on dog femoral head osteonecrosis model: A preclinical study. [Journal Article]Biomed Mater. 2023 Jan 31 [Online ahead of print]BM
- CONCLUSIONS: The n-HA/P66 scaffold implantation can provide mechanical support to the subchondral bone and relieve high stress induced by core decompression. The n-HA/P66 scaffold can treat femoral head necrosis and provide the bone tissue growth scaffold for the femoral head after CD to promote bone tissue regeneration.
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- A Novel Anti-Osteoporosis Mechanism of VK2: Interfering with Ferroptosis via AMPK/SIRT1 Pathway in Type 2 Diabetic Osteoporosis. [Journal Article]J Agric Food Chem. 2023 Jan 31 [Online ahead of print]JA
- Type 2 diabetic osteoporosis (T2DOP) is a chronic bone metabolic disease. Compared with traditional menopausal osteoporosis, the long-term high glucose (HG) microenvironment increases patients' risk of fracture and osteonecrosis. We were accumulating evidence that implicated ferroptosis as a pivotal mechanism of glucolipotoxicity-mediated death of osteocytes and osteoblast, a novel form of progra…
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- [Bisphosphonates: how to proceed in orthodontics]. [Review]Orthod Fr. 2022 Dec 01; 93(4):333-351.OF
- CONCLUSIONS: Research is ongoing to evaluate the value of bisphosphonates as anchorage reinforcement.
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