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4,289 results
  • Comparison of automated interval measurements by widely used algorithms in digital electrocardiographs. [Journal Article]
  • AHAm Heart J 2018; 200:1-10
  • Kligfield P, Badilini F, … Green CL
  • CONCLUSIONS: Among current-generation computer-based electrocardiographs, clinically small but statistically significant differences exist between ECG interval measurements by individual algorithms. Measurement differences between algorithms for QRS duration and for QT interval are larger in long QT interval subjects than in normal subjects. Comparisons of population study norms should be aware of small systematic differences in interval measurements due to different algorithm methodologies, within-individual interval measurement comparisons should use comparable methods, and further attempts to harmonize interval measurement methodologies are warranted.
  • Challenges in implementing and obtaining acceptance for J-Tpeak assessment as the clinical component of CiPA. [Journal Article]
  • JPJ Pharmacol Toxicol Methods 2018 Jun 04
  • Darpo B, Couderc JP
  • CONCLUSIONS: In this limited analysis performed on the IQ-CSRC study waveforms using FDA's automated algorithm, J-Tpeak prolongation was observed on moxifloxacin, but not on dolasetron, despite clinical observations of proarrhythmias with both drugs. Challenges for the implementation of the J-Tpeak interval as a replacement or complement to the QTc interval, include to demonstrate that the proposed clinical algorithm using a J-Tpeak threshold of 10 ms, can be used to categorize drugs with a QT effect up to ~20 ms as having low pro-arrhythmic risk.
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