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11,086 results
  • Scoring the Culture of Care as a key performance indicator in a global pharmaceutical company. [Journal Article]
    Lab Anim. 2023 Feb 03 [Online ahead of print]Turkménian O, Rocua A, Decelle T
  • Culture of Care has been an integral part of Sanofi's policy on animal protection for more than 15 years. Culture of Care goes beyond compliance with regulations and standards, since it relates to the attitudes of staff and to caring for research animals, as well as to the company's commitment to an active animal protection policy. However, the concept of Culture of Care remains subjective. Via t…
  • Management of Type 2 Diabetic Kidney Disease in 2022: A Narrative Review for Specialists and Primary Care. [Review]
    Can J Kidney Health Dis. 2023; 10:20543581221150556.Cherney DZI, Bell A, … Weinstein J
  • Kidney disease is present in almost half of Canadian patients with type 2 diabetes (T2D), and it is also the most common first cardiorenal manifestation of T2D. Despite clear guidelines for testing, opportunities are being missed to identify kidney diseases, and many Canadians are therefore not receiving the best available treatments. This has become even more important given recent clinical tria…
  • Impact of the first wave of the COVID-19 pandemic on non-COVID inpatient care in southern Spain. [Journal Article]
    Sci Rep. 2023 Jan 30; 13(1):1634.Gasch-Illescas A, Calle-Serrano M, … Medrano FJ
  • We assessed the impact of the first wave of COVID-19 pandemic on non-COVID hospital admissions, non-COVID mortality, factors associated with non-COVID mortality, and changes in the profile of non-COVID patients admitted to hospital. We used the Spanish Minimum Basic Data Set with diagnosis grouped according to the Diagnostic Related Groups. A total of 10,594 patients (3% COVID-19; 97% non-COVID) …
  • A2BCD: a concise guide for asthma management. [Review]
    Lancet Respir Med. 2023 Jan 27 [Online ahead of print]Lommatzsch M, Brusselle GG, … Virchow JC
  • The management of asthma has changed fundamentally during the past two decades. Precise assessment and phenotyping are now required to establish individually targeted treatment with disease-modifying anti-asthmatic drugs (DMAADs). Patients with asthma are often managed by primary care doctors or non-respiratory specialists in secondary care. However, the implementation of complex asthma guideline…
  • Gene expression databases for physiologically based pharmacokinetic modeling of humans and animal species. [Journal Article]
    CPT Pharmacometrics Syst Pharmacol. 2023 Jan 30 [Online ahead of print]Cordes H, Rapp H
  • In drug research, developing a sound understanding of the key mechanistic drivers of pharmacokinetics (PK) for new molecular entities is essential for human PK and dose predictions. Here, characterizing the absorption, distribution, metabolism, and excretion (ADME) processes is crucial for a mechanistic understanding of the drug-target and drug-body interactions. Sufficient knowledge on ADME proc…
  • Cancer stem cells in colorectal cancer: Signaling pathways involved in stemness and therapy resistance. [Review]
    Crit Rev Oncol Hematol. 2023 Jan 23; 182:103920.Ebrahimi N, Afshinpour M, … Aref AR
  • Colorectal cancer (CRC) is the third cause of cancer death worldwide. Although, in some cases, treatment can increase patient survival and reduce cancer recurrence, in many cases, tumors can develop resistance to therapy leading to recurrence. One of the main reasons for recurrence and therapy resistance is the presence of cancer stem cells (CSCs). CSCs possess a self-renewal ability, and their s…
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