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3,248 results
  • Stopping the fat: Repurposing an antidepressant for cancer treatment. [Journal Article]
    J Exp Med. 2023 Mar 06; 220(3)Bhullar D, Commisso C
  • In this issue of JEM, Chu and An et al. (2022. J. Exp. Med. describe the role of the tricyclic antidepressant nortriptyline in inhibition of fatty acid uptake. Nortriptyline promotes cell acidification and suppresses macropinocytosis, providing a link between fatty acid uptake and tumor progression.
  • Refractory Headaches. [Journal Article]
    Semin Neurol. 2022 Aug; 42(4):512-522.Begasse de Dhaem O, Rizzoli P
  • Medication overuse headache (MOH), new daily persistent headache (NDPH), and persistent refractory headache attributed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection represent a significant burden in terms of disability and quality of life, and a challenge in terms of definition, pathophysiology, and treatment. Regarding MOH, prevention without withdrawal is not inferior…
  • Does Smoking Affect OSA? What about Smoking Cessation? [Review]
    J Clin Med. 2022 Aug 31; 11(17)Pataka A, Kotoulas S, … Argyropoulou P
  • The connection between smoking and Obstructive sleep apnea (OSA) is not yet clear. There are studies that have confirmed the effect of smoking on sleep disordered breathing, whereas others did not. Nicotine affects sleep, as smokers have prolonged total sleep and REM latency, reduced sleep efficiency, total sleep time, and slow wave sleep. Smoking cessation has been related with impaired sleep. T…
  • [Drug-repositioning indicates a way to conquest corticosteroid-insensitivity]. [Journal Article]
    Nihon Yakurigaku Zasshi. 2022; 157(5):286-292.To Y
  • Recent advance of medications and devices brings more effective treatment intervention to the patients with asthma. As far as obeying guidelines, approximately 90% of patients with asthma acquire good control. However, there are still small number of patients with asthma who resist conventional treatment. Most of them are corticosteroid-insensitive. It would be thought that there are two ways to …
  • Pharmacological Management of Neuropathic Pain after Radiotherapy in Head and Neck Cancer Patients: A Systematic Review. [Review]
    J Clin Med. 2022 Aug 19; 11(16)Kouri M, Rekatsina M, … Varrassi G
  • CONCLUSIONS: Treatments including pregabalin, methadone, ketamine, and gabapentin were found to provide pain relief against HNC NP. While there is a plethora of pharmacological treatments available for the management of NP, only a few studies have been conducted regarding the pharmacological management of therapy-related NP in HNC patients. More studies should be conducted regarding the pharmacological approaches in HNC therapy-related NP so that specific treatment algorithms can be developed.
  • A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs. [Journal Article]
    J Control Release. 2022 Oct; 350:256-270.Bogaert B, Sauvage F, … Raemdonck K
  • Since the recent clinical approval of siRNA-based drugs and COVID-19 mRNA vaccines, the potential of RNA therapeutics for patient healthcare has become widely accepted. Lipid nanoparticles (LNPs) are currently the most advanced nanocarriers for RNA packaging and delivery. Nevertheless, the intracellular delivery efficiency of state-of-the-art LNPs remains relatively low and safety and immunogenic…
  • StatPearls: Deadly Single Dose Agents [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)EuwemaMichael S.MSOrange Park Medical CenterSwansonTerrell J.TJOrange Park Medical CenterBOOK
  • Although the basics of evaluating and treating most unknown ingestants are well known, many overdoses require very specific treatment if the patient is to have any chance of survival.[1] Countless studies have been published supporting Dr. Gideon Koren's 1993 landmark article "Medications Which Can Kill a Toddler with One Tablet or Teaspoonful" in the Journal of Toxicology.[2][3][4][5] while each…
  • Revised Guidelines for smoking cessation in New Zealand, 2021. [Review]
    N Z Med J. 2022 07 15; 135(1558):54-64.McCormack J, Walker N, … Bullen C
  • CONCLUSIONS: The guidelines will assist healthcare professionals in providing evidence-based smoking cessation support to people who smoke. To be effective and equitable, the ABC model requires organisational commitment, integration into routine practice, and increased attention to the upstream determinants of smoking and quitting.
  • Diabetes: how to manage diabetic peripheral neuropathy. [Review]
    Drugs Context. 2022; 11Gandhi M, Fargo E, … Isaacs D
  • Diabetic peripheral neuropathy (DPN) is a major complication of diabetes mellitus. Tight glycaemic management focused on lowering haemoglobin A1C and increasing time in the target glucose range along with metabolic risk factor management form the cornerstone of DPN prevention. However, there is limited evidence supporting the efficacy of glycaemic and metabolic control in reducing the symptoms an…
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