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24,000 results
  • Acute Promyelocytic Leukemia with Rare Genetic Aberrations: A Report of Three Cases. [Case Reports]
    Genes (Basel). 2022 Dec 23; 14(1)Liu G, Liu L, … Li X
  • Acute promyelocytic leukemia (APL) is a unique subtype of acute myeloid leukemia (AML) that is characterized by the PML::RARA fusion or, more rarely, a variant RARA translocation. While APL can be clinically suspected, diagnosis of APL requires genetic confirmation. Targeted therapy such as all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) has dramatically improved the prognosis of APL pa…
  • Neuroblastoma Differentiation: The Untapped Potential of Mitochondrial Uncouplers. [Editorial]
    Cancer Res. 2023 Jan 18; 83(2):167-169.Byrne FL, Bell JL
  • While the goal of most anticancer treatments is to kill cancer cells, some therapies halt cancer progression by inducing cancer cell differentiation. For example, retinoic acid induces neuroblastoma cell differentiation in vitro and is used as maintenance therapy for children with high-risk neuroblastoma. A new study by Jiang and colleagues has revealed the mitochondrial uncoupler niclosamide eth…
  • Retinoic acid-induced differentiation of porcine prospermatogonia in vitro. [Journal Article]
    Theriogenology. 2023 Mar 01; 198:344-355.You X, Li T, … Zheng Y
  • Spermatogenesis is an intricate developmental process occurring in testes by which spermatogonial stem cells (SSCs) self-renew and differentiate into mature sperm. The molecular mechanisms for SSC self-renewal and differentiation, while have been well studied in mice, may differ between mice and domestic animals including pigs. To gain knowledge about the molecular mechanisms for porcine SSC self…
  • Tretinoin Review With Newer Formulations: Providing Effective and Tolerable Solutions in Clinical Practice. [Review]
    J Drugs Dermatol. 2023 Jan 01; 22(1):35-40.Baldwin H, Noor O, … Webster G
  • Topical tretinoin has historically been limited by poor tolerability and molecular instability. Research advances have enhanced its efficacy and tolerability, along with reducing oxidation and photodegradation. By overcoming historical limitations, tretinoin use can be extended to patient populations and clinical situations previously not suitable. This review discusses historical limitations of …
  • Acute myeloid leukemia: challenges for diagnosis and treatment in Latin America. [Review]
    Hematology. 2023 Dec; 28(1):2158015.Gómez-De León A, Demichelis-Gómez R, … Rego EM
  • CONCLUSIONS: Disparities in access to technologies, supportive care capacity, and availability of novel agents and HSCT hinder results in our region, reflecting barriers common to other LMICs. Recent developments in the diagnosis and treatment of this disease must be implemented through education, collaborative clinical research, and advocacy to improve outcomes.
  • The Effect of Heterozygous Mutation of Adenylate Kinase 2 Gene on Neutrophil Differentiation. [Journal Article]
    Int J Mol Sci. 2022 Dec 17; 23(24)Horiguchi T, Tanimura A, … Noma T
  • Mitochondrial ATP production plays an important role in most cellular activities, including growth and differentiation. Previously we reported that Adenylate kinase 2 (AK2) is the main ADP supplier in the mitochondrial intermembrane space in hematopoietic cells, especially in the bone marrow. AK2 is crucial for the production of neutrophils and T cells, and its deficiency causes reticular dysgene…
  • A Narrative Review of Current Striae Treatments. [Review]
    Healthcare (Basel). 2022 Dec 17; 10(12)Mendes N, Alves PJ, … Machado J
  • Striae (striae cutis distensae) are a common disfiguring skin condition, characterised by the appearance of linear bands on the skin, with an atrophic look. The striae development is still unknown, being more common in women than in men. The prevalence of this condition ranges from 50% to 90%. Regarding treatment, there are various treatment strategies currently available for stretch marks, inclu…
  • RAR-alpha: Creator, protector, and tormentor. [Comment]
    Neuron. 2022 12 21; 110(24):4033-4035.Harding EK, Ferron L, Zamponi GW
  • Retinoic acid receptors are important for homeostatic synaptic plasticity and have many beneficial effects within the brain. New work by Cao et al.1 uncovers a role for these receptors in driving neuropathic pain development, thus identifying a potential preventative therapeutic target.
  • Remodeling of imbalanced extracellular matrix homeostasis for reversal of pancreatic fibrosis. [Journal Article]
    Biomaterials. 2023 Jan; 292:121945.Qi L, Han H, … Li L
  • Pancreatic fibrosis is mainly manifested by imbalance in extracellular matrix (ECM) homeostasis due to excessive deposition of collagen in pancreas by activated pancreatic stellate cells (PSCs). Recently, some drugs have exhibited therapeutic potentials for the treatment of pancreatic fibrosis; however, currently, no effective clinical strategy is available to remodel imbalanced ECM homeostasis b…
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