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458 results
  • Pharmacological interventions for prevention of weight gain in people with schizophrenia. [Review]
    Cochrane Database Syst Rev. 2022 10 03; 10:CD013337.Agarwal SM, Stogios N, … Hahn M
  • CONCLUSIONS: There is low-certainty evidence to suggest that metformin may be effective in preventing weight gain. Interpretation of this result and those for other agents, is limited by the small number of studies, small sample size, and short study duration. In future, we need studies that are adequately powered and with longer treatment durations to further evaluate the efficacy and safety of interventions for managing weight gain.
  • Descriptors for some compounds with pharmacological activity; calculation of properties. [Journal Article]
    Int J Pharm. 2022 Apr 05; 617:121597.Liu X, Acree WE, Abraham MH
  • Abraham model solute descriptors have been determined for nisoldipine, nizatidine, loratadine, zonisamide, oxaprozin, rebamipide, domperidone, temozolomide, 'florfenicol', florfenicol A, dapsone, chrysin, benorilate, β-lapachone, and Ipriflavone based on published partition coefficients, molar solubilities and gas chromatographic retention indices. The calculated solute descriptors, combined with…
  • Proton Pump Inhibitors Inhibit PHOSPHO1 Activity and Matrix Mineralisation In Vitro. [Journal Article]
    Calcif Tissue Int. 2021 12; 109(6):696-705.Staines KA, Myers K, … Farquharson C
  • Proton pump inhibitors (PPIs) have been associated with an increased risk of fragility fractures in pharmaco-epidemiological studies. The mechanism is unclear, but it has been speculated that by neutralising gastric acid, they may reduce intestinal calcium absorption, causing secondary hyperparathyroidism and bone loss. Here we investigated that hypothesis that the skeletal effects of PPI might b…
  • Critical Analysis of Drug Product Recalls due to Nitrosamine Impurities. [Journal Article]
    J Med Chem. 2021 03 25; 64(6):2923-2936.Bharate SS
  • A product recall is the outcome of a careful pharmacovigilance; and it is an integral part of drug regulation. Among various reasons for product recall, the detection of unacceptable levels of carcinogenic impurities is one of the most serious concerns. The genotoxic and carcinogenic potential of N-nitrosamines raises a serious safety concern, and in September 2020, the FDA issued guidance for th…
  • Drugs and Lactation Database (LactMed): Nizatidine [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • Because of the low levels of nizatidine in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants. No special precautions are required. Histamine H2-antagonists with more extensive use might be preferred in newborns.
  • Molecular basis for the repurposing of histamine H2-receptor antagonist to treat COVID-19. [Journal Article]
    J Biomol Struct Dyn. 2022 08; 40(13):5785-5802.Ishola AA, Joshi T, … Chandra S
  • With the world threatened by a second surge in the number of Coronavirus cases, there is an urgent need for the development of effective treatment for the novel coronavirus (COVID-19). Recently, global attention has turned to preliminary reports on the promising anti-COVID-19 effect of histamine H2-receptor antagonists (H2RAs), most especially Famotidine. Therefore, this study was designed to exp…
  • Classification of clear cell renal cell carcinoma based on PKM alternative splicing. [Journal Article]
    Heliyon. 2020 Feb; 6(2):e03440.Li X, Turanli B, … Mardinoglu A
  • Clear cell renal cell carcinoma (ccRCC) accounts for 70-80% of kidney cancer diagnoses and displays high molecular and histologic heterogeneity. Hence, it is necessary to reveal the underlying molecular mechanisms involved in progression of ccRCC to better stratify the patients and design effective treatment strategies. Here, we analyzed the survival outcome of ccRCC patients as a consequence of …
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