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(Azathioprine in breast feeding women)
32 results
  • Antirheumatic medications in pregnancy and breastfeeding. [Review]
    Curr Opin Rheumatol. 2020 05; 32(3):238-246.Birru Talabi M, Clowse MEB
  • As active rheumatic and musculoskeletal disease during pregnancy increases the risk for pregnancy loss, preterm birth, and maternal illness, ongoing management with pregnancy-compatible medications can improve these outcomes. Selecting and taking these medications can be challenging for rheumatologists and patients due to limited knowledge about potential risks and benefits.
  • Immunosuppression and Reproductive Health After Kidney Transplantation. [Review]
    Transplantation. 2019 11; 103(11):e325-e333.Chandra A, Midtvedt K, … Eide IA
  • Following successful kidney transplantation, recipients usually regain fertility. Post-engraftment pregnancies should be planned and the teratogenic mycophenolic acid should be replaced with azathioprine before conception. To avoid unintentional pregnancies, pre-conception counseling is mandatory in women of reproductive age who are scheduled for a kidney transplant. Counseling should be repeated…
  • Overview of Pregnancy in Renal Transplant Patients. [Review]
    Int J Nephrol. 2016; 2016:4539342.Shah S, Verma P
  • Kidney transplantation offers best hope to women with end-stage renal disease who wish to become pregnant. Pregnancy in a kidney transplant recipient continues to remain challenging due to side effects of immunosuppressive medication, risk of deterioration of allograft function, risk of adverse maternal complications of preeclampsia and hypertension, and risk of adverse fetal outcomes of prematur…
  • Rheumatoid arthritis medications and lactation. [Review]
    Curr Opin Rheumatol. 2014 May; 26(3):354-60.Sammaritano LR, Bermas BL
  • CONCLUSIONS: Many but not all RA medications may be used during lactation with low risk to the nursing infant; this review summarizes the available data for commonly used medications in order to help guide therapy during the postpartum period.
  • Update on pregnancy and breastfeeding in the era of biologics. [Review]
    Dig Liver Dis. 2013 Oct; 45(10):787-94.Yarur A, Kane SV
  • Inflammatory bowel diseases are chronic conditions that frequently affect patients during their childbearing years. Considering the characteristics of disease and the medications used to treat it, several issues arise in the care of these patients when they attempt or achieve conception. We review the most current evidence concerning fertility and pregnancy outcomes in patients with inflammatory …
  • Rheumatoid arthritis and pregnancy: safety considerations in pharmacological management. [Review]
    Drugs. 2011 Oct 22; 71(15):1973-87.Makol A, Wright K, Amin S
  • Pregnancy can pose a challenge to the physician caring for women with rheumatoid arthritis (RA). While many women with RA experience a spontaneous improvement in joint pain and inflammation during pregnancy, in others it remains active and they continue to need ongoing therapy. It is important to tailor the treatment regimen so that the disease is stabilized prior to conception and to use medicat…
  • [Liver transplantation and pregnancy]. [Journal Article]
    Presse Med. 2010 Nov; 39(11):1143-9.Revaux A, Bernuau J, … Ducarme G
  • Patients with liver failure have menstrual cycle irregularities or amenorrhea. Liver transplantation restores menstrual pattern among women with cirrhosis in childbearing years. It is now accepted that a planned pregnancy is possible among liver transplant recipients at least 1 year after liver transplantation, with stable allograft function and under immunosuppressive regimens, to minimize the r…
  • Inflammatory bowel diseases and management considerations: fertility and pregnancy. [Review]
    Curr Gastroenterol Rep. 2009 Oct; 11(5):395-9.Moscandrew M, Kane S
  • Young women with inflammatory bowel disease (IBD) pose a unique set of challenges. These women and their treating physicians must make difficult choices in matters regarding conception, pregnancy, and breastfeeding. This review highlights recent evidence and management issues that arise when taking care of women with IBD in terms of fertility, outcomes, and medication safety in pregnancy and brea…
  • Azathioprine treatment during lactation. [Journal Article]
    Aliment Pharmacol Ther. 2008 Nov 15; 28(10):1209-13.Christensen LA, Dahlerup JF, … Schmiegelow K
  • CONCLUSIONS: The major part of 6-mercaptopurine in breast milk is excreted within the first 4 h after drug intake. On the basis of maximum concentration measured, the infant ingests mercaptopurine of <0.008 mg/kg bodyweight/24 h. The findings confirm that breastfeeding during treatment with azathioprine seems safe and should be recommended, considering the extensive beneficial effects.
  • Pregnancy and breastfeeding in patients with Crohn's disease. [Review]
    Digestion. 2007; 76(2):149-60.Mottet C, Juillerat P, … Felley C
  • Crohn's disease commonly affects women of childbearing age. Available data on Crohn's disease and pregnancy show that women with Crohn's disease can expect to conceive successfully, carry to term and deliver a healthy baby. Control of disease activity before conception and during pregnancy is critical, to optimize both maternal and fetal health. Generally speaking, pharmacological therapy for Cro…
  • Therapy insight: the use of antirheumatic drugs during nursing. [Review]
    Nat Clin Pract Rheumatol. 2007 Jul; 3(7):400-6.Østensen M, Motta M
  • In 90% of cases, women with rheumatoid arthritis suffer a disease flare within 3 months of delivery of their baby. Drug treatment is, therefore, required; however, such therapies have implications for mothers who decide to nurse their infants. Unfortunately, because of a paucity of data, little is known about the transfer of antirheumatic drugs into breast milk, and even less is known about wheth…
  • Azathioprine and breastfeeding: is it safe? [Multicenter Study]
    BJOG. 2007 Apr; 114(4):498-501.Sau A, Clarke S, … Nelson-Piercy C
  • Traditionally, women receiving azathioprine have been discouraged from breastfeeding because of theoretical potential risks of neonatal bone marrow suppression, susceptibility to infection, and pancreatitis. The aims of this study were to measure the concentration of 6-mercaptopurine (6-MP) in breast milk of mothers receiving azathioprine and in the blood of their babies and to investigate any im…
  • Breast-feeding during maternal use of azathioprine. [Case Reports]
    Ann Pharmacother. 2006 Dec; 40(12):2269-72.Moretti ME, Verjee Z, … Koren G
  • CONCLUSIONS: Maternal azathioprine use during lactation does not appear to pose a significant immediate clinical risk to the suckling infant. Continued monitoring and long-term assessment of these infants are warranted.
  • The use of medications for inflammatory bowel disease during pregnancy and nursing. [Review]
    Expert Opin Pharmacother. 2005 Sep; 6(11):1833-9.Sauk J, Kane S
  • Inflammatory bowel disease includes two primary disorders, ulcerative colitis and Crohn's disease. These diseases mainly affect young adults, with a peak occurrence between 15 and 25 years of age. The causes of these diseases are largely unknown, with current treatments targeted against the heightened inflammatory response witnessed in the intestinal mucosa of both conditions. With the peak age r…
  • Multiple sclerosis: management issues during pregnancy. [Review]
    Eur J Obstet Gynecol Reprod Biol. 2004 Jul 15; 115(1):3-9.Ferrero S, Pretta S, Ragni N
  • Care of pregnant women with multiple sclerosis (MS) is challenging because of the multiple physiological changes associated with pregnancy and the need to consider the impact of any intervention on the foetus. Pregnancy is associated with clinical MS stability or improvement, while the rate of relapse rises significantly during the first three months post-partum before coming back to its level pr…
  • Inflammatory bowel disease: management issues during pregnancy. [Review]
    Arch Gynecol Obstet. 2004 Sep; 270(2):79-85.Ferrero S, Ragni N
  • CONCLUSIONS: Pregnancy should be avoided in women treated with methotrexate because of its known abortifacient effects and risk of causing typical malformations. There is no actual evidence of adverse effect in pregnant women receiving Infliximab but the amount of clinical information is small. The treatment with metronidazole or ciprofloxacin for short durations appear to be safe, but there is no data about the effects of increased length of treatment as required in Crohn's disease remains unknown. Control of disease activity before conception and during pregnancy is critical to optimise both maternal and foetal health. A multidisciplined approach involving both obstetrician and gastroenterologist and education about pregnancy are essential components of the treatment of any young women with IBD.
  • Connective tissue disorders and pregnancy. Recommendations for prescribing. [Review]
    J Reprod Med. 1998 Apr; 43(4):341-9.Rayburn WF
  • This report summarizes experience with drugs prescribed for women with connective tissue disorders who either are anticipating childbearing, are pregnant or are breast-feeding. Principles of maintenance therapy are the same as when nonpregnant. Comparative trials of drugs during gestation are uncommon because of a lack of sufficient case numbers. It is difficult to distinguish between any additio…
  • Breast-feeding during treatment with cyclosporine. [Journal Article]
    Transplantation. 1998 Jan 27; 65(2):253-5.Nyberg G, Haljamäe U, … Kjellmer I
  • CONCLUSIONS: Breast-fed infants of mothers treated with CsA received less than 300 microg per day of CsA and absorbed undetectable amounts. There were no demonstrable nephrotoxic effects or other side effects. Thus, women with kidney transplants could be allowed to breast-feed.
  • Drug therapy for ulcerative colitis during pregnancy. [Review]
    Eur J Gastroenterol Hepatol. 1997 Sep; 9(9):854-7.Modigliani R
  • Women with ulcerative colitis (UC) are usually young and thus likely to undergo pregnancy. They should be advised to conceive when the disease is quiescent. Steroids and salicylates may be used normally during pregnancy, possibly without exceeding a dose of 2g/day for mesalazine. Azathioprine can be maintained if its indication is clear cut. Cyclosporin seems to be without additional risk in the …
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