- Rational synthesis, biological screening of azo derivatives of chloro-phenylcarbonyl diazenyl hydroxy dipyrimidines/thioxotetrahydropyrimidines and their metal complexes. [Journal Article]Heliyon. 2023 Jan; 9(1):e12492.H
- Herein, a new series of azo ligands HL-1 (5-(2-chloro-6-(phenylcarbonyl)phenyl)diazenyl)-6-hydroxydihydropyrimidines-2,4dione), HL-2 (5-(2-chloro-6-(phenylcarbonyl)phenyl)diazenyl)-6-hydroxy-2-thioxottetrahydropyrimidin-4one), HL-3 (5-(2,4-dichloro-6-(phenylcarbonyl)phenyl) diazenyl)-6-hydroxydihydropyrimidines-2,4dione), HL-4 (5-(2,4-dichloro-6-(phenylcarbonyl) phenyl)diazenyl)-6-hydroxy-2-thiox…
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- Synthesis and Antioxidant Properties of Novel 1,2,3-Triazole-Containing Nitrones. [Journal Article]
- Herein, we report the synthesis and antioxidant capacity of twelve novel 1,2,3-triazole-containing nitrones such as N-(2-(4-aryl-1H-1,2,3-triazol-1-yl)ethylidene)methanamine oxides 8a-f and N-(2-(4-aryl)-1H-1,2,3-triazol-1-yl)ethylidene)-2-methylpropan-2-amine oxides 9a-f, bearing an N-methyl, and an N-t-butyl substituent, respectively, at the nitrogen of the nitrone motif. Nitrones 8 and 9 were …
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- Inhibition of TRPM8 by the urinary tract analgesic drug phenazopyridine. [Journal Article]Eur J Pharmacol. 2023 Jan 16; 942:175512.EJ
- CONCLUSIONS: PAP inhibits TRPM8 in a concentration range consistent with PAP levels in the urine of treated patients. Since TRPM8 is expressed in bladder afferent neurons and upregulated in patients with painful bladder disorders, TRPM8 inhibition may underlie the analgesic activity of PAP.
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- Deep eutectic solvent-based dispersive liquid-liquid microextraction followed by smartphone digital image colorimetry for the determination of carbofuran in water samples. [Journal Article]Anal Methods. 2023 Jan 18 [Online ahead of print]AM
- A detection method of carbofuran (CBF) in water samples was reported using deep eutectic solvent (DES)-based dispersive liquid-liquid microextraction (DLLME) combined with digital image colorimetry (DIC), which was environmentally friendly, solvent-saving, rapid, and convenient. Under alkaline conditions, the green and multifunctional extractant DESs dissociated into linalool and heptanoic acid, …
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- A Randomized Controlled Trial Comparing a New D-Mannose-based Dietary Supplement to Placebo for the Treatment of Uncomplicated Escherichia coli Urinary Tract Infections. [Journal Article]Eur Urol Focus. 2023 Jan 06 [Online ahead of print]EU
- CONCLUSIONS: The DAPAD complex dietary supplement is effective and safe for treatment of acute uncomplicated E. coli UTIs.
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- Broken into pieces: The challenges of determining sulfonated azo dyes in biological reactor effluents using LC-ESI-MS/MS analysis. [Journal Article]Environ Pollut. 2023 Feb 01; 318:120877.EP
- Most studies on the biodegradation of textile azo dyes use color as parameter for measuring the efficiency of degradation. Although widely employed, spectrophotometric methods are susceptible to the interference of metabolites or degradation products from the biological treatment. We propose a method for determination of a model sulfonated azo dye (Direct Black 22, DB22) in wastewater using solid…
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- A novel and simple naphthol azo dye chemosensor as a naked eye detection tool for highly selective, sensitive and accurate determination of thiourea in tap water, juices and fruit skins. [Journal Article]Spectrochim Acta A Mol Biomol Spectrosc. 2023 Mar 15; 289:122194.SA
- In the present study, a highly accurate and sensitive azo-dye-based colorimetric sensor based on Eriochrome Black T (EBT) was proposed to detect and determine thiourea (TU). TU is truly an important toxic and carcinogenic hazardous pollutant as approved by EPA and IARC. This chemosensor shows a distinct color change from blue to pink during interaction with TU in aqueous medium. So EBT is capable…
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- Exhaustive Catalytic ortho-Alkoxylation of Azobenzenes: Flexible Access to Functionally Diverse Yellow-Light-Responsive Photoswitches. [Journal Article]J Org Chem. 2022 12 16; 87(24):16526-16531.JO
- We develop the first method for catalytic, exhaustive ortho-alkoxylation of azobenzene photoswitches. Alkoxylation is known to improve the photoswitch properties that control azobenzenes' success in chemical biology or materials sciences, e.g., better completeness of both E → Z and Z → E photoisomerizations and >100 nm red shift of photoresponse. Our method enables straightforward late-stage dive…
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- Cerium oxide: synthesis, brief characterization, and optimization of the photocatalytic activity against phenazopyridine in an aqueous solution. [Journal Article]Environ Sci Pollut Res Int. 2022 Nov 25 [Online ahead of print]ES
- Water pollution by antibiotics is a global crisis, and its risk is critically more severe due to the explosive use of these drug compounds. A critical effective removal method to diminish this risk is heterogeneous photocatalysis and optimizing the conditions to reach higher mineralization efficiency. CeO2 anoparticles (NPs) were synthesized and characterized by X-ray diffraction (XRD), UV-Vis di…
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- Synthesis, Characterization, DFT Study and Antifungal Activities of Some Novel 2-(Phenyldiazenyl)phenol Based Azo Dyes. [Journal Article]
- In recent decades, there has been an increased interest in azo compounds with special optical and biological properties. In this work, we report the preparation of novel azo-compounds with two and three -N=N- double bonds, using the classical method of synthesis, diazotization and coupling. The compounds were characterized by 1H-NMR, 13C-NMR, FTIR, UV-VIS and fluorescence spectra. DFT calculation…
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- StatPearls: Phenazopyridine [BOOK]StatPearls. StatPearls Publishing: Treasure Island (FL)BOOK
- Phenazopyridine is an azo dye first synthesized in 1914 and adopted by the U.S. Pharmacopoeia in 1928. Phenazopyridine is used as an adjuvant medicine to treat the discomfort, urgency, and frequency associated with lower urinary tract infections (UTIs). It is commonly used and available medication over the counter (OTC) and with a prescription. Phenazopyridine is compatible with concurrent antibi…
- A Case of Severe Hypoxia Caused by Phenazopyridine-Induced Methemoglobinemia: A near Fatal Event from Over-the-Counter Medication Use. [Case Reports]
- Methemoglobinemia is a rare blood disorder characterized by the oxidation of heme iron from ferrous (Fe2+) to ferric (Fe3+) state, which increases oxygen affinity and impairs oxygen release to the tissue causing hypoxia. It can be congenital or acquired; however, most cases are acquired and caused by exogenous substances such as medications, chemicals, and environmental substances. Phenazopyridin…
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- Comparative Two-Dimensional Fluorescence Gel Electrophoresis. [Journal Article]
- Two-dimensional comparative fluorescence gel electrophoresis (CoFGE) uses an internal standard to increase the reproducibility of coordinate assignment for protein spots visualized on 2D polyacrylamide gels. This is particularly important for samples that need to be compared without the availability of replicates and thus cannot be studied using differential gel electrophoresis (DIGE). CoFGE corr…
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- Dynamic modulation and epoxy functionalization of protein-mediated enoate ester-based hybrid cryogels. [Journal Article]Int J Biol Macromol. 2022 Dec 31; 223(Pt A):1158-1179.IJ
- The current work is focused on the preparation of protein-mediated poly(hydroxyethyl methacrylate-co-glycidyl methacrylate) copolymer as a self-template for in situ synthesis of hybrid gels. Gelatin, collagen, biotin, and l-arginine were used to create hybrid materials with adjustable swelling and elastic properties. Hybrid cryogels tended to swell more than hybrid hydrogels due to their porous n…
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- Optical chemical sensor of Gd(iii) based on 5-(2'-bromophenyl- azo)-6-hydroxypyrimidine-2,4-dione immobilized on poly(methyl methacrylate) and 2-nitrophenyloctylether matrix. [Journal Article]
- A novel optical chemical sensor (optode) was fabricated for the determination of Gadolinium ions. The optical sensor was prepared by incorporating a recently synthesized ionophore, 5-(2'-bromophenylazo)-6-hydroxy pyrimidine-2,4-dione (BPAHPD), and 2-nitrophenyloctylether (NPOE) as a plasticizer in poly(methyl methacrylate) (PMMA) membrane. The color of the sensing membrane in contact with Gd(iii)…
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- Colorimetric analysis based on solid-phase extraction with sedimentable dispersed particulates: demonstration of concept and application for on-site environmental water analysis. [Journal Article]
- A novel simple and functional colorimetric methodology for on-site environmental water analysis was proposed. This method combines coloration of the analyte and extraction of the colored species on dispersed particulates during their sedimentation in the same container. The whole analysis can be performed within 15 min by comprising the addition of 1 mL of sample solution into a 1.5-mL microtube …
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- Decolorization of Direct Black 22 by Photo Fenton like Method Using UV Light and Zeolite Modified Zinc Ferrite: Kinetics and Thermodynamics. [Journal Article]Acta Chim Slov. 2022 Sep 26; 69(3):552-563.AC
- In this study, a heterogeneous catalyst was prepared to enhance photo-Fenton like oxidation of Direct Black-22 (DB-22). Zeolite modified with zinc ferrite was used as a catalyst. The prepared catalyst was characterized using FTIR, SEM, EDS and XRD. The effect of various parameters like catalyst modification with HCl, H2O2 amount, catalyst amount, CaCl2 amount, initial pH, initial concentration an…
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- ROS/JNK-mediated lysosomal injury in rat intestinal epithelial-6 cells during heat stress. [Journal Article]J Therm Biol. 2022 Oct; 109:103326.JT
- Injury to the intestinal epithelial cells and loss of the intestinal barrier are critical to heatstroke. To reveal the mechanism through which heatstroke leads to intestinal epithelial injury, the relationship between reactive oxygen species (ROS), c-Jun NH2-terminal kinase (JNK), and lysosomes were studied in intestinal epithelial cells subjected to heat stress. Cells of heat stress groups were …
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- StatPearls: Glucose 6 Phosphate Dehydrogenase Deficiency [BOOK]StatPearls. StatPearls Publishing: Treasure Island (FL)BOOK
- Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme found in the cytoplasm of all cells in the body. It is a housekeeping enzyme that plays a vital role in the prevention of cellular damage from reactive oxygen species (ROS). It does this by providing substrates to prevent oxidative damage. Erythrocytes are particularly vulnerable to ROS due to their role in oxygen transport and inability to re…
- Skin ulcers as a complication of short-term use of phenazopyridine in an old man: A case report. [Case Reports]J Infect Chemother. 2022 Dec; 28(12):1654-1657.JI
- CONCLUSIONS: Phenazopyridine severe skin changes are hardly reported. We described a case who experienced severe skin reactions and ulcers following phenazopyridine use not related to other complications including renal dysfunction, methemoglobinemia, and hemolytic anemia.
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- A new colorimetric method for determining antioxidant levels using 3,5-dibromo-4-nitrosobenzene sulfonate (DBNBS). [Journal Article]
- We describe here a novel assay that determines the total a+ntioxidative activities of known antioxidants and antioxidants in beverages. The method employs the substrate 3,5-dibromo-4-nitrosobenzene sulfonate (DBNBS) that yields the colored product 3,5,3',5'-tetrabromoazobenzene sulfate sodium salt (azo-TBBS). The amounts of azo-TBBS are measured using HPLC and then used to calculate total antioxi…
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- A simple and safe approach for simultaneous spectrophotometric determination of nitroglycerin and nitrocellulose in double base solid propellants. [Journal Article]
- An accurate, simple and safe method was developed for simultaneous determination of nitroglycerine (NG) and nitrocellulose (NC) in double base solid propellants (DB propellants). The proposed method is based on alkaline hydrolysis of NG and NC, and followed by colored reaction of released nitrite ion with p-nitroaniline in the presence of diphenylamine in acidic media and produce azo dye. The abs…
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- A highly selective bulk optode based on 6-{4-(2,4-dihydroxy-phenyl)diazenyl)phenyl}-2-oxo-4-phenyl-1,2-dihydro-pyridine-3-carbonitrile incorporating chromoionophore V for determination of nano levels of cadmium. [Journal Article]
- A novel optical sensor has been fabricated for highly accurate, simple and selective determination of nanomolar levels of cadmium ions. The sensor depends on the interaction of 6-{4-(2,4-dihydroxyphenyl)diazenyl)phenyl}-2-oxo-4-phenyl-1,2-dihydropyri-dine-3-carbonitrile (DDPODC) with Cd(II) in plasticized (2-nitrophenyloctyl ether) (o-NPOE) polyvinylchloride (PVC) membrane incorporating chromoion…
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- Phenazopyridine promotes RPS23RG1/Rps23rg1 transcription and ameliorates Alzheimer-associated phenotypes in mice. [Journal Article]
- Alzheimer's disease (AD) is the most common form of dementia with no effective treatment options. A complete elucidation of its underlying molecular mechanisms, including the transcription regulation of genes critically involved in AD, may shed light on new therapeutic development. RPS23RG1 is a newly identified AD-associated gene, whose expression is decreased in AD and restoration can attenuate…
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- Development of a simple analytical method for the determination of nitrite in waters using redox reaction and smartphone. [Journal Article]Anal Sci. 2022 Sep; 38(9):1207-1212.AS
- In this study, it was aimed to perform the colorimetric determination of nitrite in waters using the redox reaction of iodide in acidic conditions with smartphone. The simple redox reaction of iodide and nitrite in an acidic medium was used instead of the conventional nitrite methods based on the formation of azo dye. The quantitative relationship between the yellow-colored iodine formed because …
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- Anti-tumor and antioxidant activity of kaempferol-3-O-alpha-L-rhamnoside (Afzelin) isolated from Pithecellobium dulce leaves. [Journal Article]
- CONCLUSIONS: The compound may have a great importance as a therapeutic agent in preventing oxidative damage of biomolecules and therapeutic use in chemotherapy.
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- An up-conversion test paper based on "switch-off" of fluorescence is constructed to sensitively and selectively detect cancer-causing dye Sudan III in lipstick. [Journal Article]Spectrochim Acta A Mol Biomol Spectrosc. 2022 Nov 05; 280:121515.SA
- Cancer-causing dye Sudan III is banned adding to cosmetics, so a method for detecting trace Sudan III in cosmetics is established. A single dispersed up-conversion molecularly imprinted fluorescent nanoprobe is constructed and coated on the filter paper. The mechanism for detecting Sudan III by this composite fluorescent nanoprobes-paper is systematically analyzed. The fluorescent response (max e…
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- Acquired Methemoglobinemia in a Ketamine-induced Ulcerative Cystitis Patient: A Case Report. [Journal Article]
- CONCLUSIONS: This case highlights the need to suspect ketamine-induced ulcerative cystitis in patients who use ketamine chronically and be judicious in the use of phenazopyridine for symptom management to prevent life-threatening complications.
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- Palladium-Catalyzed Three-Component Selective Aminoallylation of Diazo Compounds. [Journal Article]Org Lett. 2022 06 17; 24(23):4160-4164.OL
- We describe a Xantphos-containing dinuclear palladium complex-enabled geminal aminoallylation of diazocarbonyl compounds, which selectively provides a range of quaternary α-amino esters. Direct N-H insertion, allylic alkylation of amino nucleophiles, and diene formation were not observed under standard conditions. Mechanistic studies indicated that a relayed pathway via allylation of the N-H inse…
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- Oral phenazopyridine vs intravesical lidocaine for bladder onabotulinumtoxinA analgesia: a randomized controlled trial. [Randomized Controlled Trial]Am J Obstet Gynecol. 2022 08; 227(2):308.e1-308.e8.AJ
- CONCLUSIONS: In women receiving intradetrusor onabotulinumtoxinA injections for idiopathic overactive bladder, oral phenazopyridine was noninferior to intravesical lidocaine for procedural pain control. Phenazopyridine is well-tolerated by participants, allows for the procedure to be performed with similar ease, and is associated with shorter appointment times.
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