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1,005 results
  • Synthesis and Antioxidant Properties of Novel 1,2,3-Triazole-Containing Nitrones. [Journal Article]
    Antioxidants (Basel). 2022 Dec 24; 12(1)Hadjipavlou-Litina D, Głowacka IE, … Piotrowska DG
  • Herein, we report the synthesis and antioxidant capacity of twelve novel 1,2,3-triazole-containing nitrones such as N-(2-(4-aryl-1H-1,2,3-triazol-1-yl)ethylidene)methanamine oxides 8a-f and N-(2-(4-aryl)-1H-1,2,3-triazol-1-yl)ethylidene)-2-methylpropan-2-amine oxides 9a-f, bearing an N-methyl, and an N-t-butyl substituent, respectively, at the nitrogen of the nitrone motif. Nitrones 8 and 9 were …
  • Inhibition of TRPM8 by the urinary tract analgesic drug phenazopyridine. [Journal Article]
    Eur J Pharmacol. 2023 Jan 16; 942:175512.Luyts N, Daniluk J, … Voets T
  • CONCLUSIONS: PAP inhibits TRPM8 in a concentration range consistent with PAP levels in the urine of treated patients. Since TRPM8 is expressed in bladder afferent neurons and upregulated in patients with painful bladder disorders, TRPM8 inhibition may underlie the analgesic activity of PAP.
  • StatPearls: Phenazopyridine [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)EasthamJohn H.JHUniversity of the Pacific, Stockton, CaliforniaPatelPreetiPBOOK
  • Phenazopyridine is an azo dye first synthesized in 1914 and adopted by the U.S. Pharmacopoeia in 1928. Phenazopyridine is used as an adjuvant medicine to treat the discomfort, urgency, and frequency associated with lower urinary tract infections (UTIs). It is commonly used and available medication over the counter (OTC) and with a prescription. Phenazopyridine is compatible with concurrent antibi…
  • Comparative Two-Dimensional Fluorescence Gel Electrophoresis. [Journal Article]
    Methods Mol Biol. 2023; 2596:71-81.Ackermann D, König S
  • Two-dimensional comparative fluorescence gel electrophoresis (CoFGE) uses an internal standard to increase the reproducibility of coordinate assignment for protein spots visualized on 2D polyacrylamide gels. This is particularly important for samples that need to be compared without the availability of replicates and thus cannot be studied using differential gel electrophoresis (DIGE). CoFGE corr…
  • Dynamic modulation and epoxy functionalization of protein-mediated enoate ester-based hybrid cryogels. [Journal Article]
    Int J Biol Macromol. 2022 Dec 31; 223(Pt A):1158-1179.Er M, Orakdogen N
  • The current work is focused on the preparation of protein-mediated poly(hydroxyethyl methacrylate-co-glycidyl methacrylate) copolymer as a self-template for in situ synthesis of hybrid gels. Gelatin, collagen, biotin, and l-arginine were used to create hybrid materials with adjustable swelling and elastic properties. Hybrid cryogels tended to swell more than hybrid hydrogels due to their porous n…
  • ROS/JNK-mediated lysosomal injury in rat intestinal epithelial-6 cells during heat stress. [Journal Article]
    J Therm Biol. 2022 Oct; 109:103326.Pan Z, He X, … Fang B
  • Injury to the intestinal epithelial cells and loss of the intestinal barrier are critical to heatstroke. To reveal the mechanism through which heatstroke leads to intestinal epithelial injury, the relationship between reactive oxygen species (ROS), c-Jun NH2-terminal kinase (JNK), and lysosomes were studied in intestinal epithelial cells subjected to heat stress. Cells of heat stress groups were …
  • StatPearls: Glucose 6 Phosphate Dehydrogenase Deficiency [BOOK]
    StatPearls. StatPearls Publishing: Treasure Island (FL)RichardsonS. RussSRGrand Strand Medical CenterO'MalleyGerald F.GFGrand Strand Regional Medical CenterBOOK
  • Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme found in the cytoplasm of all cells in the body. It is a housekeeping enzyme that plays a vital role in the prevention of cellular damage from reactive oxygen species (ROS). It does this by providing substrates to prevent oxidative damage. Erythrocytes are particularly vulnerable to ROS due to their role in oxygen transport and inability to re…
  • Palladium-Catalyzed Three-Component Selective Aminoallylation of Diazo Compounds. [Journal Article]
    Org Lett. 2022 06 17; 24(23):4160-4164.Ou P, Zhu L, … Huang X
  • We describe a Xantphos-containing dinuclear palladium complex-enabled geminal aminoallylation of diazocarbonyl compounds, which selectively provides a range of quaternary α-amino esters. Direct N-H insertion, allylic alkylation of amino nucleophiles, and diene formation were not observed under standard conditions. Mechanistic studies indicated that a relayed pathway via allylation of the N-H inse…
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