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6,739 results
  • Colon-Targeted Trans-Cinnamic Acid Ameliorates Rat Colitis by Activating GPR109A. [Journal Article]
    Pharmaceutics. 2022 Dec 22; 15(1)Kang C, Kim J, … Jung Y
  • We designed colon-targeted trans-cinnamic acid (tCA) and synthesized its conjugates with glutamic acid (tCA-GA) and aspartic acid (tCA-AA). We evaluated the anti-colitic activity of colon-targeted tCA using a dinitrobenzenesulfonic acid-induced rat colitis model. The conjugates lowered the distribution coefficient and Caco-2 cell permeability of tCA and converted to tCA in the cecum, with higher …
  • Protective effects of lovastatin in a population-based ALS study and mouse model. [Journal Article]
    Ann Neurol. 2023 Jan 10 [Online ahead of print]Kreple CJ, Searles Nielsen S, … Miller TM
  • CONCLUSIONS: Lovastatin reduced risk of ALS in humans, which was confirmed in an ALS mouse model by delayed symptom onset, prolonged survival, and preservation of motor neurons. While further studies to understand the mechanism are required, lovastatin may represent a potential neuroprotective therapy for patients with ALS. These data demonstrate the utility of a combined pharmacoepidemiologic and mouse model approach. This article is protected by copyright. All rights reserved.
  • Sulfasalazine for the treatment of preeclampsia in a nitric oxide synthase antagonist mouse model. [Journal Article]
    Placenta. 2023 Jan 04; 132:20-26.Binder NK, de Alwis N, … Hannan NJ
  • CONCLUSIONS: In this mouse model of preeclampsia, sulfasalazine did not sustain reductions in blood pressure nor affect fetal parameters of size and weight, both desirable attributes of a viable preeclampsia therapeutic. While these data suggest sulfasalazine might improve vasoactivity, murine toxicity considerations limited the dose range of sulfasalazine that could be tested in the current study.
  • A Strong Acid-Induced DNA Hydrogel Based on pH-Reconfigurable A-Motif Duplex. [Journal Article]
    Small. 2023 Jan 01 [Online ahead of print]Hu Y, Ying JY
  • Under a pH value lower than the pKa of adenine (3.5), adenine-rich sequences (A-strand) form a unique parallel A-motif duplex due to the protonation of A-strand. At a pH above 3.5, deprotonation of adenines leads to the dissolution of A-motif duplex to A-strand single coil. This pH-reconfigurable A-motif duplex has been developed as a novel pH-responsive DNA hydrogel, termed A-hydrogel. The hydro…
  • Dual-Site Chemosensor for Monitoring ·OH-Cysteine Redox in Cells and In Vivo. [Journal Article]
    J Am Chem Soc. 2023 Jan 11; 145(1):507-515.Kang Z, Jiang J, … Yuan MS
  • The reaction between hydroxyl radical (·OH) and cysteine (Cys) plays an important role in the redox balance of living cells. A deeper insight into this intracellular reaction modulation and process is necessary and draws great interest. A highly effective technique consists of the real-time visualization of the two bioactive species and the perception of their respective changes by using a fluore…
  • Effect of M2-like macrophages of the injured-kidney cortex on kidney cancer progression. [Journal Article]
    Cell Death Discov. 2022 Dec 05; 8(1):480.Ishii T, Mimura I, … Nangaku M
  • Chronic kidney disease (CKD) affects kidney cancer patients' mortality. However, the underlying mechanism remains unknown. M2-like macrophages have pro-tumor functions, also exist in injured kidney, and promote kidney fibrosis. Thus, it is suspected that M2-like macrophages in injured kidney induce the pro-tumor microenvironment leading to kidney cancer progression. We found that M2-like macropha…
  • Drugs and Lactation Database (LactMed): Sulfasalazine [BOOK]
    Drugs and Lactation Database (LactMed). National Library of Medicine (US): Bethesda (MD)BOOK
  • Sulfasalazine and its active metabolite mesalamine are poorly excreted into breastmilk. However, rather high levels of the mesalamine metabolite N-acetyl-5-ASA appear in breastmilk and its effects on breastfed infants are unknown. Another sulfasalazine metabolite, sulfapyridine, also appears in milk and infant serum and might cause hemolysis, especially in newborn infants and in those with glucos…
  • Is the treatment of inflammatory arthritis different in sickle cell disease? [Journal Article]
    Turk J Med Sci. 2022 Jun; 52(5):1721-1728.Kimyon G, İlhan G
  • CONCLUSIONS: The clinical manifestations of inflammatory arthritis such as rheumatoid arthritis and sickle cell disease may overlap. The use of drugs such as steroids, methotrexate, or anti-TNF in sickle cell patients with rheumatic disease is the same as in patients without sickle cell disease. However, treatment should be individualized in patients with complications such as infection.
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