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12,552 results
  • CTLA4 haploinsufficiency as a predisposition to classical Hodgkin lymphoma. [Journal Article]
    Pediatr Hematol Oncol 2020; :1-8Mahat U, Terzioglu MK, Buhtoiarov I
  • Cytotoxic T-lymphocyte-associated protein 4 (CTLA4) haploinsufficiency (HI) is an immune dysregulation disorder characterized by T lymphocyte hyperactivation, and generalized lymphoproliferative and autoimmune disorders. Patients with CTLA4 haploinsufficiency are also prone to developing various malignancies. Due to the rare nature of this condition, the longitudinal evolution of CTLA4 haploinsuf…
  • Discovery of tumoricidal DNA oligonucleotides by response-directed in vitro evolution. [Journal Article]
    Commun Biol 2020; 3(1):29Mamet N, Amir Y, … Bachelet I
  • Drug discovery is challenged by ineffectiveness of drugs against variable and evolving diseases, and adverse effects due to poor selectivity. We describe a robust platform which potentially addresses these limitations. The platform enables rapid discovery of DNA oligonucleotides evolved in vitro for exerting specific and selective biological responses in target cells. The process operates without…
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