- Maternal interactive beliefs and style as predictors of language development in preterm and full term children. [Journal Article]J Child Lang. 2020 Jun 18 [Online ahead of print]JC
- Previous research has shown that the quality of mother-child interactions between pre-term children and their mothers tends to be poorer than that of full-term children and their mothers (Forcada-Guex, Pierrehumbert, Borghini, Moessinger & Muller-Nix, 2006). Mothers of pre-term children are less responsive and more intrusive in interactions with their children than mothers of full-term children (…
Previous research has shown that the quality of mother-child interactions between pre-term children and their mothers tends to be poorer than that of full-term children and their mothers (Forcada-Guex, Pierrehumbert, Borghini, Moessinger & Muller-Nix, 2006). Mothers of pre-term children are less responsive and more intrusive in interactions with their children than mothers of full-term children (Forcada-Guex et al., 2006; Ionio, Lista, Mascheroni, Olivari, Confalonieri, Mastrangelo, Brazzoduro, Balestriero, Banfi, Bonanomi, Bova, Castoldi, Colombo, Introvini & Scelsa, 2017; Laing, McMahon, Ungerer, Taylor, Badawi & Spence, 2010). The current research explored differences between mothers of pre-term and full-term children in terms of interactive beliefs and style, and the potential for language development to be differentially predicted by maternal interactive beliefs and styles in pre-term versus full-term children. Independent t-tests were conducted to compare pre-term and full-term groups in relation to the measures of maternal interactive beliefs and styles. A series of multiple regression analyses were then performed separately for each group to examine the shared and unique contributions of maternal interactive beliefs and styles on full-term versus pre-term children's language development. The results showed that mothers of pre-term children were more intrusive-directive than mothers of full-term children; in contrast, mothers of full-term children were more responsive and supportive-directive in interactions with their children. Moreover, predictors of language development were different in full-term versus pre-term children; in full-term children, maternal supportive beliefs and responsiveness were significant predictors of language development evaluated by both the Bayley Scales of Infant and Toddler Development and the MacArthur Communicative Development Inventory; in the pre-term group, maternal supportive and directive beliefs, as well as supportive and intrusive directiveness, were significant predictors, with the latter being negatively associated with language development indicators. This research can shed light on how to prevent language delay in children and improve mother-child interactions that contribute to language development, which may in turn improve language development in vulnerable children, children born pre-term in particular.
- Developmental outcomes following vaccine-proximate febrile seizures in children. [Journal Article]Neurology. 2020 Jul 01 [Online ahead of print]Neur
- CONCLUSIONS: VP-FS was not associated with an increased risk of developmental or behavioral problems in young children compared to children with NVP-FS or controls. Parents and providers should be reassured by the absence of adverse effects of VP-FS on the development of children.
- Plasma and CSF Candidate Biomarkers of Neonatal Encephalopathy Severity and Neurodevelopmental Outcomes. [Journal Article]J Pediatr. 2020 Jun 28 [Online ahead of print]JPed
- CONCLUSIONS: Plasma candidate biomarkers predicted encephalopathy severity, seizures, MRI abnormalities, and neurodevelopmental outcomes at 15-30 months.
- Validation of the Fine Motor Subtest of the Bayley-III with Children with Sickle Cell Disease Using Rasch Analysis. [Journal Article]Child Care Health Dev. 2020 Jun 29 [Online ahead of print]CC
- CONCLUSIONS: The Bayley-III FM subtest is structured hierarchically, aligning with motor development, and comprehensively evaluates fine motor development in children with SCD. The test could be improved by reordering items, removing overfitting items, and modifying Screening Test items to capture all ranges of development. The Screening Test is comprehensive and has high potential clinical utility among children with SCD.
- A randomized trial of parenteral nutrition using a mixed lipid emulsion containing fish oil in infants of extremely low birth weight: Neurodevelopmental outcome at 12 and 24 months corrected age, a secondary outcome analysis. [Journal Article]J Pediatr. 2020 Jun 23 [Online ahead of print]JPed
- CONCLUSIONS: Parenteral nutrition using a mixed lipid emulsion containing fish oil did not improve neurodevelopment of ELBW infants at 12 and 24 months corrected age.
- Severity of nausea and vomiting in pregnancy and early childhood neurobehavioural outcomes: The Growing Up in Singapore Towards Healthy Outcomes study. [Journal Article]Paediatr Perinat Epidemiol. 2020 Jun 23 [Online ahead of print]PP
- CONCLUSIONS: Severe NVP is highly prevalent in this Asian cohort and may be adversely associated with multiple offspring neurobehavioural outcomes.
- Surgery requiring general anesthesia in preterm infants is associated with altered brain volumes at term equivalent age and neurodevelopmental impairment. [Journal Article]Pediatr Res. 2020 Jun 23 [Online ahead of print]PR
- CONCLUSIONS: Very preterm infants who required surgery during the preterm period had lower white mater volumes at TEA and worse neurodevelopmental outcome at age 2 years.In very preterm infants, there is an association between surgery requiring general anesthesia during the preterm period and reduced white mater volume on MRI at TEA and lower cognitive and motor composite scores at age 2 years.It is known that the very preterm infant's brain undergoes rapid growth during the period corresponding to the third trimester.The current study suggests an association between surgery requiring general anesthesia during this period and worse outcomes.
- Disease characteristics of MCT8 deficiency: an international, retrospective, multicentre cohort study. [Journal Article]Lancet Diabetes Endocrinol. 2020 Jul; 8(7):594-605.LD
- CONCLUSIONS: Our description of characteristics of MCT8 deficiency in a large patient cohort reveals poor survival with a high prevalence of treatable underlying risk factors, and provides knowledge that might inform clinical management and future evaluation of therapies.
- Comparison of the neurocognitive outcomes in term infants treated with levetiracetam and phenobarbital monotherapy for neonatal clinical seizures. [Journal Article]Seizure. 2020 Jun 05; 80:71-74.S
- CONCLUSIONS: Our findings suggest that both LEV and PB therapy can be equally safe as monotherapy for neonatal clinical seizures for the neurodevelopmental outcome assessment with BSID-III.
- Associations of Maternal Prenatal Drug Abuse With Measures of Newborn Brain Structure, Tissue Organization, and Metabolite Concentrations. [Journal Article]JAMA Pediatr. 2020 Jun 15 [Online ahead of print]JP
- CONCLUSIONS: The findings suggest that prenatal drug exposure is associated with measures of newborn brain tissue in patterns that may indicate that exposures accelerated normal fetal brain maturation, which in turn mediated the associations with poorer 12-month infant outcomes.
- Relationships between Early Nutrition, Illness, and Later Outcomes among Infants Born Preterm with Hyperglycemia. [Journal Article]J Pediatr. 2020 Jun 09 [Online ahead of print]JPed
- CONCLUSIONS: In infants <32 weeks, ≥5 days of hyperglycemia is associated with decreased lean mass at 4 months' PMA and poorer neurodevelopmental outcome at 12 months' PMA. These associations may be mediated by decreased first week nutrition, potentially related to reduced glucose infusion rate for management of hyperglycemia.
- A new perspective: Establishing developmental profiles of premature infants based on Bayley-III scores at age 2. [Journal Article]Appl Neuropsychol Child. 2020 Jun 12 [Online ahead of print]AN
- Longitudinal and cross-sectional studies in early childhood generally focus on different developmental areas separately. The aim of this study is to identify the most common developmental profiles regarding cognitive, language and motor skills among low birthweight (LBW) children. Our sample included 208 LBW children examined at 24-28 months. We used cluster analysis to identify developmental pro…
Longitudinal and cross-sectional studies in early childhood generally focus on different developmental areas separately. The aim of this study is to identify the most common developmental profiles regarding cognitive, language and motor skills among low birthweight (LBW) children. Our sample included 208 LBW children examined at 24-28 months. We used cluster analysis to identify developmental profiles based on the scores of the Bayley-III Cognitive, Language and Motor scales. We found three consistent profiles (High, Mildly Delayed and Severely Delayed) and three inconsistent, average profiles (with High Expressive Language, with Mildly Delayed Expressive Language and with Severely Delayed Language). Socioeconomic status, maternal education, in vitro fertilization, plurality and chronic morbidities were significantly related to the clusters. Cluster analysis might be an effective method to identify developmental profiles of preterm (and other at-risk) children, which might result in a more complex understanding of cognitive and psychomotor development in early childhood.
- Intrauterine total percutaneous fetoscopic repair of myelomeningocele: 30 months follow up data. [Journal Article]Ultrasound Obstet Gynecol. 2020 Jun 08 [Online ahead of print]UO
- CONCLUSIONS: Controlled head to head comparisons of open vs. fetoscopic intrauterine repair investigating long term outcome are lacking. However, concerning mortality, prematurity, shunt placement rates, motor and mental development, and free ambulation, intrauterine repair by percutaneous fetoscopy results in an outcome that seems to lie in range with results reported for open intrauterine repair. This article is protected by copyright. All rights reserved.
- Early inflammatory measures and neurodevelopmental outcomes in preterm infants. [Journal Article]Nurs Res. 2020 Jun 01 [Online ahead of print]NR
- CONCLUSIONS: Although early single-timepoint measures of inflammation may be insufficient to predict neurodevelopment for all preterm infants, the effect of inflammation appears to differ by infant sex and race. These demographic factors may be important considerations for future studies of inflammation and neurodevelopment as well was the development of future interventions to optimize outcomes.
- Time to full enteral feeding after necrotizing enterocolitis in preterm-born children is related to neurodevelopment at 2-3 years of age. [Journal Article]Early Hum Dev. 2020 May 26; 147:105091.EH
- CONCLUSIONS: Prolonged FEFt after NEC in preterm-born children surviving NEC is associated with lower cognitive and lower motor composite scores at the age of 2-3 years. These results show the importance of limiting the duration of the nil per mouth regimen if and when possible.
- General Movement Assessment Predicts Neuro-Developmental Outcome in Very Low Birth Weight Infants at Two Years - A Five-Year Observational Study. [Journal Article]Indian J Pediatr. 2020 Jun 03 [Online ahead of print]IJ
- CONCLUSIONS: GMs assessment at 3 mo post term could be considered as an important screening tool for early identification of VLBW infants who are at risk of neurodevelopmental impairment/cerebral palsy.
- The Interrelationships between Parental Migration, Home Environment, and Early Child Development in Rural China: A Cross-Sectional Study. [Journal Article]Int J Environ Res Public Health. 2020 May 29; 17(11)IJ
- A growing body of literature is providing evidence of a negative association between parental migration and child development. Meanwhile, the chain of relationships between parental migration, home environment, and early child development has not yet been well documented in China. This paper investigates the interrelationships between parental migration, home environment, and early child developm…
A growing body of literature is providing evidence of a negative association between parental migration and child development. Meanwhile, the chain of relationships between parental migration, home environment, and early child development has not yet been well documented in China. This paper investigates the interrelationships between parental migration, home environment, and early child development in an undeveloped area of western rural China. In total, 444 households were included in the study. Bayley Scales of Infant Development version III (BSID-III), Home Observation Measurement of the Environment (HOME), and a socioeconomic questionnaire, were used to measure children's development outcomes, home environment, and socioeconomic characteristics in sample households. A mediation effect model was used to estimate the interrelationships between parental migration, home environment, and child development. The results demonstrate that home environment works as a significant mediator, through which parental migration is associated with a 0.07 standard deviation (SD), 0.13 SD, 0.12 SD, and 0.10 SD decline in the child's cognitive, language, motor, and social-emotional scores, respectively. For future studies, the key findings suggest that interventions aimed at improving the home environments of left-behind children might be necessary in rural China.
- Characterization of performance on an automated visual recognition memory task in 7.5-month-old infants. [Journal Article]Neurotoxicol Teratol. 2020 May 30 [Online ahead of print]NT
- Infant looking behaviors measured during visual assessment paradigms may be more reliable predictors of long-term cognitive outcomes than standard measures such as the Bayley Scales of Infant Development typically used in environmental epidemiology. Infrared eye tracking technology offers an innovative approach to automate collection and processing of looking behavior data, making it possible to …
Infant looking behaviors measured during visual assessment paradigms may be more reliable predictors of long-term cognitive outcomes than standard measures such as the Bayley Scales of Infant Development typically used in environmental epidemiology. Infrared eye tracking technology offers an innovative approach to automate collection and processing of looking behavior data, making it possible to efficiently assess large numbers of infants. The goals of this study were to characterize infant looking behavior measures including side preference, fixation duration, and novelty preference using eye tracking and an automated version of an established visual recognition memory paradigm that includes both human faces and geometric figures as stimuli. An ancillary goal was to assess the feasibility of obtaining a precise measure of looking to the eye region of faces from the eye-tracking data. In this study, 309 7.5-month-old infants from a prospective birth cohort were assessed using a visual recognition memory (VRM) paradigm. Infrared eye tracking was used to record looking time as infants were shown nine blocks of trials with a pair of identical faces or shapes followed by two trials in which the familiar stimulus was paired with a novel one. Infants were assessed in one of four conditions: in conditions A and B, stimulus set 1 were the familiar stimuli and set 2 were novel; in conditions C and D, set 2 were familiar and set 1 novel. The novel stimuli were presented on the right first in conditions A and C and on the left first in conditions B and D. We observed a significant right side preference, which has not been reported before (57% of looking time spent looking at right side stimulus, p-value < 0.0001). Infants showed a preference for the novel stimuli similar to that published in prior studies (57-60% of looking time spent looking at the novel stimulus, p-value < 0.0001), as well as average fixation durations similar to previous studies. Infants also showed a strong preference for the eyes versus the rest of the face (p-value < 0.0001). Novelty preference was significantly higher when set 2 stimuli were novel (p-value < 0.0001), suggesting a preference among infants for set 2 stimuli compared to set 1 stimuli. The pattern of novelty preference across trials was significantly different between infants who saw the novel stimuli on the left first and those who saw them on the right first (p-value < 0.0001) but the overall mean novelty preference was not significantly different between these groups. There were also significant differences in average fixation duration and eyes preference measures across stimuli (p-values < 0.05). These findings show that VRM assessment can be automated for use in large-scale epidemiological studies using infrared eye tracking with looking behavior measure results similar to those obtained with standard non-automated methods, and that side and stimulus preferences are important modifiers of looking behavior that are critical to consider in this type of assessment.
- Association between Placental Inflammatory Pathology and Offspring Neurodevelopment at 8 Months, 4, and 7 Years of Age. [Journal Article]J Pediatr. 2020 May 29 [Online ahead of print]JPed
- CONCLUSIONS: Placental inflammation was associated with adverse offspring neurodevelopment up to 4 years of age.
- Determinants of motor, language, cognitive, and global developmental delay in children with complicated severe acute malnutrition at the time of discharge: An observational study from Central India. [Journal Article]PLoS One. 2020; 15(6):e0233949.Plos
- CONCLUSIONS: The results indicated that children with SAM exhibit developmental delay across all domains. Identifying multiple modifiable risk factors for developmental delay in children with SAM will be helpful in devising early interventional strategies in low-middle income countries; however, the exact timing of such interventions should be investigated.
- Structured Observation of Motor Performance in Infants: level and quality associate to later motor development. [Journal Article]Acta Paediatr. 2020 May 31 [Online ahead of print]AP
- CONCLUSIONS: Both SOMP-I domains, level and quality, are markers to identify motor problems early. Quality became more important with age.
- Low level prenatal exposure to a mixture of Sr, Se and Mn and neurocognitive development of 2-year-old children. [Journal Article]Sci Total Environ. 2020 May 12; 735:139403.ST
- The excess or deficiency of trace metals can cause adverse neurocognitive development. Evidence of health effect of trace metal mixtures on neurocognitive development is limited in children. We evaluated associations of prenatal exposure to trace metals and metal mixtures with neurocognitive development of 2-year-old children. A total of 544 mother-child pairs were included in the study. The conc…
The excess or deficiency of trace metals can cause adverse neurocognitive development. Evidence of health effect of trace metal mixtures on neurocognitive development is limited in children. We evaluated associations of prenatal exposure to trace metals and metal mixtures with neurocognitive development of 2-year-old children. A total of 544 mother-child pairs were included in the study. The concentrations of 10 trace metals in maternal urine were monitored before delivery. Neurocognitive development indexes, including mental development index (MDI) and psychomotor development index (PDI), were assessed using the Bayley Scales of Infant Development. Linear regression analysis was performed to explore the effects of single-metal and multi-metal exposures. Bayesian Kernel Machine regression (BKMR) was used to investigate overall effect of exposure to metal mixtures and potential interactions among mixture components. We found positive associations of urinary strontium (Sr) and Selenium (Se) levels with MDI scores among all children in the single-metal model. Sr was positively related to MDI, while Manganese (Mn) was negatively associated with PDI in the multi-metal model. The results from BKMR model in girls revealed that MDI scores were improved with the increasing concentrations of Sr, Se and Mn mixture until the concentrations reached their 30th percentiles (Sr: 149.49 μg/g creatinine, Se:18.38 μg/g creatinine, Mn:1.96 μg/g creatinine), with no effect after that threshold level. Sr played a positive role in mental development among mixture components, which was consistent with the results of Sr in the multi-metal models. No signification association of mixture with MDI/PDI was found in boys. The study suggested potential sex-specific association of Sr, Se and Mn mixture levels (at or below their 30th percentiles) with improved mental development, and beneficial role of Sr.
- Association between Transport Risk Index of Physiologic Stability (Trips) in Extremely Premature Infants and Mortality or Neurodevelopmental Impairment at 18 to 24 Months. [Journal Article]J Pediatr. 2020 May 19 [Online ahead of print]JPed
- CONCLUSIONS: The TRIPS score on admission to the NICU can be used as an adjunctive, objective tool for counselling the parents of extremely premature infants early after their admission to the NICU.
- Low-Grade Intraventricular Hemorrhage and Neurodevelopmental Outcomes at 24-42 Months of Age. [Journal Article]J Child Neurol. 2020 May 21 [Online ahead of print]JC
- Infants with high-grade (III-IV) intraventricular hemorrhage have been reported to have worse neurodevelopmental outcomes than those without, but outcomes of infants with low-grade (I-II) intraventricular hemorrhage are mixed. We sought to compare neurodevelopmental outcomes of infants with low-grade intraventricular hemorrhage to those with no intraventricular hemorrhage. This is a retrospective…
Infants with high-grade (III-IV) intraventricular hemorrhage have been reported to have worse neurodevelopmental outcomes than those without, but outcomes of infants with low-grade (I-II) intraventricular hemorrhage are mixed. We sought to compare neurodevelopmental outcomes of infants with low-grade intraventricular hemorrhage to those with no intraventricular hemorrhage. This is a retrospective cohort study of very preterm (≤32 weeks' gestation) infants evaluated between 24 and 42 months chronologic age using the Bayley Scales of Infant Development, 3rd edition, to determine neurodevelopmental outcomes. Linear regression was used to control for potential confounders. There was no difference in outcome scores between groups when controlling for confounding variables. Infants with low-grade intraventricular hemorrhage, however, had higher rates of enrollment in early intervention services (64% vs 49%, P = .023). Low-grade intraventricular hemorrhage itself may not significantly increase the risk of neurodevelopmental impairment through the first 3 years of life considering other conditions of prematurity.
- Higher maternal plasma β-cryptoxanthin concentration is associated with better cognitive and motor development in offspring at 2 years of age. [Journal Article]Eur J Nutr. 2020 May 20 [Online ahead of print]EJ
- CONCLUSIONS: Our study provides novel data suggesting a potential role of prenatal carotenoids, particularly β-cryptoxanthin, on early offspring cognitive and motor development. Whether the prenatal influences sustain beyond early childhood requires further investigation in longer term studies.
- Validity of the Early Years Check-In (EYCI) in a Cross-Sectional Sample of Families. [Journal Article]Front Pediatr. 2020; 8:157.FP
- CONCLUSIONS: While further research is required, the EYCI shows promise as a parent-completed tool, particularly to identify more-severe cases of delay. Results with educators were poor overall. Future research investigating accuracy of educators in different types of early childcare centres is needed.
- Adaptive Behavioral, Social-Emotional, and Neurodevelopmental Outcomes at 2 Years of Age in Hungarian Preterm Infants Based on Bayley III. [Journal Article]Dev Neurorehabil. 2020 May 18 [Online ahead of print]DN
- CONCLUSIONS: Additionally, the screening for developmental delays, monitoring the adaptive behavior skills may also be useful - especially among ELBW children - in order to identify the specific areas, situations, and functions that are most in need of interventions.Abbreviations AB: Adaptive Behavior; ABAS-II: Adaptive Behavior Assessment System-II; BPD: Bronchopulmonary Dysplasia; BSID-III: Bayley Scales of Infant Development 3rd Edition; BW: Birthweight; CI: Confidence Interval; CS: Composite Score; ELBW: Extremely Low Birthweight; GA: Gestational Age; IVF: In Vitro Fertilization; IVH: Intraventricular Hemorrhage; LBW: Low Birthweight; NEC: Necrotizing Enterocolitis; OR: Odds Ratio; ROP: Retinopathy of Prematurity; SE: Social-Emotional Development; VLBW: Very Low Birthweight.
- Supratentorial Brain Metrics Predict Neurodevelopmental Outcome in Very Preterm Infants without Brain Injury at Age 2 Years. [Journal Article]Neonatology. 2020 May 12 [Online ahead of print]N
- CONCLUSIONS: Supratentorial brain metrics are predictive for neurodevelopmental outcome in infants with ostensibly normal MRI. A combination of supratentorial brain metrics is most meaningful for identifying infants at risk for long-term sequelae.
- Association of Neurodevelopmental Outcomes With Environmental Exposure to Cyclohexanone During Neonatal Congenital Cardiac Operations: A Secondary Analysis of a Randomized Clinical Trial. [Journal Article]JAMA Netw Open. 2020 May 01; 3(5):e204070.JN
- CONCLUSIONS: The findings of this secondary analysis of a randomized clinical trial suggest that infants who underwent neonatal cardiac surgical treatment with cardiopulmonary bypass had substantial cyclohexanone levels, which were associated with adverse neurodevelopmental function at age 12 months.
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- Developmental Outcomes Among Young Children With Congenital Zika Syndrome in Brazil. [Journal Article]JAMA Netw Open. 2020 May 01; 3(5):e204096.JN
- CONCLUSIONS: The findings of this study provide important information regarding the severity of disability that these children and their families will experience. The findings also establish an initial point from which to monitor developmental trajectories, medical comorbidities (eg, seizures), effectiveness of interventions, and cumulative consequences on families.