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Unbound Medicine.
(Bazin disease)
606 results
  • Cross-sectional evaluation of humoral responses against SARS-CoV-2 Spike. [Preprint]
    bioRxiv. 2020 Jun 10Prévost J, Gasser R, … Finzi A
  • The SARS-CoV-2 virus is responsible for the current worldwide coronavirus disease 2019 (COVID-19) pandemic, infecting millions of people and causing hundreds of thousands of deaths. The Spike glycoprotein of SARS-CoV-2 mediates viral entry and is the main target for neutralizing antibodies. Understanding the antibody response directed against SARS-CoV-2 is crucial for the development of vaccine, …
  • Localization and characterization of thyroid microcalcifications: A histopathological study. [Journal Article]
    PLoS One. 2019; 14(10):e0224138.Guerlain J, Perie S, … Haymann JP
  • Thyroid calcification is frequent in thyroid nodules. The aim of our study was to evaluate the prevalence of calcifications in thyroid tissue samples of patients with various thyroid diseases, and to identify their composition according to their localization. Among 50 thyroid samples included, 56% were malignant (papillary carcinoma) and 44% were benign (adenoma, multinodular goiter, Graves' dise…
  • Vitamin D and Calcium Supplementation Accelerates Randall's Plaque Formation in a Murine Model. [Journal Article]
    Am J Pathol. 2019 11; 189(11):2171-2180.Bouderlique E, Tang E, … Letavernier E
  • Most kidney stones are made of calcium oxalate crystals. Randall's plaque, an apatite deposit at the tip of the renal papilla, is considered to at the origin of these stones. Hypercalciuria may promote Randall's plaque formation and growth. We analyzed whether long-term exposure of Abcc6-/- mice (a murine model of Randall's plaque) to vitamin D supplementation, with or without a calcium-rich diet…
  • Panniculitides of particular interest to the rheumatologist. [Review]
    Adv Rheumatol. 2019 08 01; 59(1):35.Morita TCAB, Trés GFS, … de Carvalho JF
  • The panniculitides remain as one of the most challenging areas for clinicians, as they comprise a heterogeneous group of inflammatory diseases involving the subcutaneous fat with potentially-shared clinical and histopathological features. Clinically, most panniculitides present as red edematous nodules or plaques. Therefore, in addition to a detailed clinical history, a large scalpel biopsy of a …
  • Cobimetinib- and vemurafenib-induced granulomatous dermatitis and erythema induratum: A case report. [Case Reports]
    SAGE Open Med Case Rep. 2019; 7:2050313X19847358.Iafolla MA, Ramsay J, … McWhirter E
  • Metastatic melanoma is an aggressive malignancy. Survival can be increased with the combination of BRAF and MEK inhibition. BRAF inhibitor-induced cutaneous toxicities can be attenuated with MEK inhibition. Here, we describe the first reported case of a patient with metastatic melanoma who developed granulomatous dermatitis and erythema induratum when treated with combination BRAF (vemurafenib) a…
  • Mycosis fungoides: A great imitator. [Review]
    Clin Dermatol. 2019 May - Jun; 37(3):255-267.Hodak E, Amitay-Laish I
  • Mycosis fungoides (MF), the most common cutaneous T-cell lymphoma, typically presents in its early stage as inflammatory erythematous patches or plaques, with epidermotropism as the histopathologic hallmark of the disease. Over the past 30 years, numerous atypical types of MF, which deviate from the classic Alibert-Bazin presentation of the disease, have been described. These variants can simulat…
  • Cutaneous tuberculosis: A great imitator. [Review]
    Clin Dermatol. 2019 May - Jun; 37(3):192-199.Chen Q, Chen W, Hao F
  • Tuberculosis (TB) is still prevalent in many developing countries and can pose a new potential threat to global health due to international migration. As an uncommon form of extrapulmonary TB, cutaneous TB is complicated in its clinical manifestation, pathogenesis, and classification. Cutaneous TB can be divided into two major categories, true cutaneous TB and tuberculid, depending on the source …
  • A unified (but in fact not fully testable) model of preeclampsia triggering. [Journal Article]
    J Reprod Immunol. 2019 04; 132:49-53.Chaouat G
  • In this summary of my presentation in the last Reunion workshop I discuss a few assertions on preeclampsia, then turn on a (not fully testable) model where an embryonic defect in expression of embryo/ placental regulatory proteins results in complement activation, itself responsible for a down regulation of the T regs activity, resulting in a very early lack of complete down regulation of the pre…
  • Correlation Between Clinical Signs and High-resolution Manometry Data in Children. [Journal Article]
    J Pediatr Gastroenterol Nutr. 2019 05; 68(5):642-647.Juzaud M, Lamblin MD, … Vitton V
  • CONCLUSIONS: With nonspecific clinical signs suggesting an esophageal motility disorder, weight loss was a predictive sign of abnormal HRM results. HRM was well tolerated in pediatric patients, and ineffective esophageal motility appears to be the most frequent motility disorder in our cohort, as already observed in adult patient studies.
  • Nested Polymerase Chain Reaction and Cutaneous Tuberculosis. [Journal Article]
    Am J Dermatopathol. 2019 Jun; 41(6):428-435.Maldonado-Bernal C, Ramos-Garibay A, … Isibasi A
  • The role of Mycobacterium tuberculosis in the etiology and pathogenesis of cutaneous tuberculosis is controversial because of the difficulties associated with demonstrating the presence of these mycobacteria in tuberculid cutaneous lesions by routinely available microbiological and histological techniques. In this study, we aimed to demonstrate the presence of M. tuberculosis in cutaneous tubercu…
  • Nodular vasculitis associated with lung adenocarcinoma. [Case Reports]
    An Bras Dermatol. 2018 Nov/Dec; 93(6):887-889.Borges AS, Brasileiro A, Apetato M
  • Nodular vasculitis is an uncommon type of panniculitis. It was firstly associated to the infection by Mycobacterium tuberculosis and named erythema induratum of Bazin, however nowadays it has been associated with several other underlying disorders and it is better described as nodular vasculitis. Concerning its relationship with malignant conditions, there is only one reported case, in associatio…
  • Urothelium proliferation is a trigger for renal crystal deposits in a murine lithogenesis model. [Journal Article]
    Sci Rep. 2018 11 05; 8(1):16319.Bilbault H, Perez J, … Haymann JP
  • Most mouse kidney stone models induce nephrocalcinosis rather than urolithiasis. The aim of our study was to find an accelerated experimental model in order to study the early events of stone formation, that is, at the time of crystal binding to intrarenal urothelium. C57B6 mice exposed to vitamin D supplements and water containing hydroxyl-L-proline, ammonium chloride and calcium chloride were s…
  • Use of QuantiFERON-TB Gold to determine the aetiology of idiopathic erythema induratum: A case report. [Case Reports]
    SAGE Open Med Case Rep. 2018; 6:2050313X18804076.Brandon A, Mufti A, Sibbald RG
  • Although rare, erythema induratum is the most common entity presenting as lobular panniculitis with vasculitis. It is usually caused by a hypersensitivity reaction to Mycobacterium tuberculosis, although other aetiologies have been reported. We present a case of a 73-year-old male with multiple recurring tender erythematous nodules on the backs of both calves and shins. Prior to arrival in our cl…
  • Preeclampsia and the 20th century: "Le siècle des Lumières". [Historical Article]
    Pregnancy Hypertens. 2018 Jul; 13:107-109.Robillard PY, Dekker G, … Hulsey TC
  • The authors delineate seven quantum leap forward and, or revolutions having occurred during the 20th century in the understanding of the physiopathology of preeclampsia. First the discovery of the inflatable arm band permitting to measure blood pressure in 1896. Second, the discovery that eclamptic (convulsions), and later "pre"eclamptic (proteinuria) women presented hypertension in 1897 and conf…
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