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7 results
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Beta Adrenergic Blocking Agents [BOOK]
    LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • The beta-adrenergic receptor antagonists (beta-blockers) are a family of agents that are widely used to treat hypertension, angina pectoris and cardiac arrhythmias. Beta-blockers are also used for migraine prophylaxis, to treat anxiety, to prevent essential tremor, and to block the side effects of hyperthyroidism. Nonspecific beta-blockers are also recommended for treatment of portal hypertension…
  • Stability of sotalol hydrochloride in extemporaneously prepared oral suspension formulations. [Journal Article]
    Int J Pharm Compd. 2005 Sep-Oct; 9(5):402-6.Sidhom MB, Rivera N, … Kirschenbaum HL
  • The physical, chemical, and microbial stabilities of extemporaneously compounded oral liquid formulations of sotalol hydrochloride were studied. Sotalol hydrochloride oral liquid suspensions (5mg/mL) were prepared from commercially available tablets (Betapace) in a 1:1 mixture of Ora-Plus: Ora-Sweet, a 1:1 mixture of Ora-Plus:Ora-Sweet SF, and a 1:2.4 mixture of simple syrup:methylcellulose vehic…
  • Evaluation of the dofetilide risk-management program. [Journal Article]
    Am Heart J. 2003 Nov; 146(5):894-901.Allen LaPointe NM, Chen A, … Califf RM
  • CONCLUSIONS: Better adherence to several dosing and monitoring recommendations in the dofetilide group may be caused by the presence of the risk-management program. However, low usage of dofetilide during the study period may signify an unintended, negative consequence of the risk-management program.
  • Sotalol hydrochloride (Betapace): a new antiarrhythmic drug. [Review]
    Am J Crit Care. 1993 Sep; 2(5):397-406.Dunnington CS
  • Sotalol hydrochloride (Betapace), recently released by the Food and Drug Administration for general use, is used to treat a variety of ventricular and supraventricular tachyarrhythmias. The drug's dominant action is the result of combined nonselective beta-adrenergic antagonism (Class II effect) and monophasic action potential duration prolongation in all cardiac tissues (Class III effect). It ca…
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