- Linking whole-body angular momentum and step placement during perturbed walking. [Journal Article]J Exp Biol. 2023 Feb 08 [Online ahead of print]JE
- Human locomotion is remarkably robust to environmental disturbances. Previous studies have thoroughly investigated how perturbations influence body dynamics and what recovery strategies are used to regain balance. Fewer studies have attempted to establish formal links between balance and the recovery strategies that are executed to regain stability. We hypothesized that there would be a strong re…
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- Photoswitchable semiconducting polymer dots for pattern encoding and superresolution imaging. [Journal Article]Chem Commun (Camb). 2023 Feb 08 [Online ahead of print]CC
- Two photoswitchable semiconducting polymers were synthesized by covalently incorporating photochromic dithienylethene (DTE) into the main chains. Small size polymer dots (Pdots) were prepared and showed dynamic photoswitching upon alternate light irradiation. By virtue of the tunable photoswitching properties, effective pattern encoding and superresolution imaging with a resolution of up to about…
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- Effects of oral HPΒCD-angiotensin-(1-7) supplementation on recreational mountain bike athletes: A crossover study. [Journal Article]Phys Sportsmed. 2023 Feb 08 [Online ahead of print]PS
- CONCLUSIONS: Supplementation with HPβCD-Ang-(1-7) did not improve physical performance in time trial or in repeated sprints; however, it promoted the maintenance of plasma glucose and lactate levels after the sprint protocol and at rest, respectively. In addition, HPβCD-Ang-(1-7) also increased resting plasma nitrite levels and reduced diastolic blood pressure in the time trial protocol.
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- Combining sensors and actuators with electrowetting-on-dielectric (EWOD): advanced digital microfluidic systems for biomedical applications. [Review]Analyst. 2023 Feb 08 [Online ahead of print]A
- The concept of digital microfluidics (DMF) enables highly flexible and precise droplet manipulation at a picoliter scale, making DMF a promising approach to realize integrated, miniaturized "lab-on-a-chip" (LOC) systems for research and clinical purposes. Owing to its simplicity and effectiveness, electrowetting-on-dielectric (EWOD) is one of the most commonly studied and applied effects to imple…
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- Capillary responses to functional and pathological activations rely on the capillary states at rest. [Journal Article]J Cereb Blood Flow Metab. 2023 Feb 08 [Online ahead of print]JC
- Brain capillaries play a crucial role in maintaining cellular viability and thus preventing neurodegeneration. The aim of this study was to characterize the brain capillary morphology at rest and during neural activation based on a big data analysis from three-dimensional microangiography. Neurovascular responses were measured using a genetic calcium sensor expressed in neurons and microangiograp…
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- Microglia and astrocytes mediate synapse engulfment in a MER tyrosine kinase-dependent manner after traumatic brain injury. [Journal Article]Neural Regen Res. 2023 Aug; 18(8):1770-1776.NR
- Recent studies have shown that microglia/macrophages and astrocytes can mediate synaptic phagocytosis through the MER proto-oncokinase in developmental or stroke models, but it is unclear whether the same mechanism is also active in traumatic brain injury. In this study, we established a mouse model of traumatic brain injury and found that both microglia/macrophages and astrocytes phagocytosed sy…
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- In vitro microglia models: the era of engineered cell microenvironments. [Journal Article]Neural Regen Res. 2023 Aug; 18(8):1709-1710.NR
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- Polypropylene sulphide coating on magnetic nanoparticles as a novel platform for excellent biocompatible, stimuli-responsive smart magnetic nanocarriers for cancer therapeutics. [Journal Article]Nanoscale. 2023 Feb 08 [Online ahead of print]N
- Magnetic nanoparticle (MNP) delivery systems are promising for targeted drug delivery, imaging, and chemo-hyperthermia of cancer; however, their uses remain limited primarily due to their toxicity associated with reactive oxygen species (ROS) generation, targeted delivery, and biodegradation. Attempts employing polymer coatings to minimize the toxicity, along with other challenges, have had limit…
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- A Systematic Review of the Use of Commercial Wearable Activity Trackers for Monitoring Recovery in Individuals Undergoing Total Hip Replacement Surgery. [Review]Cyborg Bionic Syst. 2022; 2022:9794641.CB
- The innovation of wearable devices is advancing rapidly. Activity monitors can be used to improve the total hip replacement (THR) patients' recovery process and reduce costs. This systematic review assessed the body-worn accelerometers used in studies to enhance the rehabilitation process and monitor THR patients. Electronic databases such as Cochrane Database of Systematic Reviews library, CINAH…
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- Mobile SARS‑CoV‑2 screening facilities for rapid deployment and university-based diagnostic laboratory. [Journal Article]Eng Life Sci. 2023 Feb; 23(2):2200026.EL
- The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has created a public crisis. Many medical and public institutions and businesses went into isolation in response to the pandemic. Because SARS-CoV-2 can spread irrespective of a patient's course of disease, these institutions' continued operation or reopening based on the assessment and control of virus spread can be suppor…
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- Optical coherence tomography. [Journal Article]Nat Rev Methods Primers. 2022; 2NR
- Optical coherence tomography (OCT) is a non-contact method for imaging the topological and internal microstructure of samples in three dimensions. OCT can be configured as a conventional microscope, as an ophthalmic scanner, or using endoscopes and small diameter catheters for accessing internal biological organs. In this Primer, we describe the principles underpinning the different instrument co…
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- Mechanical Assist Device-Assisted Percutaneous Coronary Intervention: The Use of Impella Versus Extracorporeal Membrane Oxygenation as an Emerging Frontier in Revascularization in Cardiogenic Shock. [Review]Cureus. 2023 Jan; 15(1):e33372.C
- The extracorporeal membrane oxygenation (ECMO) procedure aids in the provision of prolonged cardiopulmonary support, whereas the Impella device (Abiomed, Danvers, MA) is a ventricular assist device that maintains circulation by pumping blood into the aorta from the left ventricle. Blood is circulated in parallel with the heart by Impella. It draws blood straight into the aorta from the left ventr…
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- A Short History of the Consideration of Sex Differences in Biomedical Research - Lessons for the In Vitro Community from Animal Models and Human Clinical Trials. [Journal Article]Altern Lab Anim. 2023 Feb 07 [Online ahead of print]AL
- In recent decades, it has become clear that in many fields - such as drug development, particularly with regard to drug dosage and specific disease treatment - the sex of a patient must be taken into consideration, in view of the fact that male and female physiology and pathophysiology show many differences of practical concern. While, in the last decade or so, considerable efforts have been unde…
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- 2,4-Di-tert-butylphenol Induces Adipogenesis in Human Mesenchymal Stem Cells by Activating Retinoid X Receptors. [Journal Article]Endocrinology. 2023 Feb 08 [Online ahead of print]E
- 2,4-di-tert-butylphenol (2,4-DTBP) is an important commercial antioxidant and a toxic natural secondary metabolite that has been detected in humans. However, there is scant information regarding its toxicological effects. Here we asked whether 2,4-DTBP is a potential obesogen. Using a human mesenchymal stem cell (MSC) adipogenesis assay, we found that exposure to 2,4-DTBP led to increased lipid a…
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- Comprehensive positional and morphological assessments of the temporomandibular joint in adolescents with skeletal Class III malocclusion: a retrospective CBCT study. [Journal Article]BMC Oral Health. 2023 Feb 07; 23(1):78.BO
- CONCLUSIONS: Our findings can be used clinically and radiographically to evaluate the condyle and glenoid fossa features in adolescents with skeletal Class III malocclusion, providing a basis for better TMD diagnosis and orthodontic treatment.
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- Shining the light on mesenchymal stem cell-derived exosomes in breast cancer. [Review]Stem Cell Res Ther. 2023 Feb 08; 14(1):21.SC
- In women, breast cancer (BC) is the second most frequently diagnosed cancer and the leading cause of cancer death. Mesenchymal stem cells (MSCs) are a subgroup of heterogeneous non-hematopoietic fibroblast-like cells that have the ability to differentiate into multiple cell types. Recent studies stated that MSCs can migrate into the tumor sites and exert various effect on tumor growth and develop…
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- Association of plasma lipid metabolism profiles with overall survival for patients with gastric cancer undergoing gastrectomy based on 1H-NMR spectroscopy. [Journal Article]Nutr Metab (Lond). 2023 Feb 07; 20(1):7.NM
- CONCLUSIONS: This study found that the index derived from the LDL-5 Apo-B, LDL-4 Cholesterol, HDL-4 Apo-A2, and HDL-4 Free Cholesterol, was significantly associated with overall survival, suggesting that regulating lipid metabolisms might improve the prognosis for GC patients.
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- LIFTOSCOPE: development of an automated AI-based module for time-effective and contactless analysis and isolation of cells in microtiter plates. [Journal Article]J Biol Eng. 2023 Feb 07; 17(1):10.JB
- CONCLUSIONS: LIFTOSCOPE speeds up cell cultivation and analysis with a target process time of 10 minutes, which can be achieved if the cell transfer is sped up using a more efficient path-finding algorithm. Some challenges remain, like finding a suitable cell transfer medium.
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- Omics analysis of Mycobacterium tuberculosis isolates uncovers Rv3094c, an ethionamide metabolism-associated gene. [Journal Article]Commun Biol. 2023 Feb 07; 6(1):156.CB
- Global control of the tuberculosis epidemic is threatened by increasing prevalence of drug resistant M. tuberculosis isolates. Many genome-wide studies focus on SNP-associated drug resistance mechanisms, but drug resistance in 5-30% of M. tuberculosis isolates (varying with antibiotic) appears unrelated to reported SNPs, and alternative drug resistance mechanisms involving variation in gene/prote…
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- Comparing 2D and 3D representations for face-based genetic syndrome diagnosis. [Journal Article]Eur J Hum Genet. 2023 Feb 07 [Online ahead of print]EJ
- Human genetic syndromes are often challenging to diagnose clinically. Facial phenotype is a key diagnostic indicator for hundreds of genetic syndromes and computer-assisted facial phenotyping is a promising approach to assist diagnosis. Most previous approaches to automated face-based syndrome diagnosis have analyzed different datasets of either 2D images or surface mesh-based 3D facial represent…
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- The role of digital technology in surgical home hospital programs. [Review]NPJ Digit Med. 2023 Feb 07; 6(1):22.ND
- Home hospital (HH), a care delivery model of providing hospital-grade care to patients in their homes, has become increasingly common in medical settings, though surgical uptake has been limited. HH programs have been shown to be safe and effective in a variety of medical contexts, with increased usage of this care pathway during the COVID-19 pandemic. Though surgical patients have unique clinica…
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- Enzyme Translocation-Mediated Signal Amplification for Spatially-Selective Aptasensing of ATP in Inflammatory Cells. [Journal Article]Angew Chem Int Ed Engl. 2023 Feb 07 [Online ahead of print]AC
- Amplified ATP imaging in inflammatory cells is highly desirable. However, the spatial selectivity of current amplification methods is limited, that is, signal amplification is performed systemically and not in a disease site-specific manner. Here we present a versatile strategy, termed enzymatically triggerable, aptamer-based signal amplification (ETA-SA), that enables inflammatory cell-specific …
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- Associations of high-normal blood pressure and impaired fasting glucose with atrial fibrillation. [Journal Article]Heart. 2023 Feb 07 [Online ahead of print]H
- CONCLUSIONS: In healthy individuals, high-normal BP and IFG were important risk factors for AF. When high-normal BP and IFG were combined, the risk of new-onset AF was significantly increased. These findings may suggest that lifestyle interventions for high-normal BP and IFG should be considered to reduce the risk of AF.
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- Global health and global governance of emerging biomedical technologies. [Journal Article]J Med Ethics. 2023 Feb 07 [Online ahead of print]JM
- Global governance of emerging, disruptive biomedical technologies presents a multitude of ethical problems. The recent paper by Shozi et al raises some of these problems in the context of a discussion of what could be the most disruptive (and most morally fraught) emerging biomedical technology-human germline genome editing. At the heart of their argument is the claim that, for something like gen…
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- Contribution of the stereoscopic representation of motion-in-depth during visually guided feedback control. [Journal Article]Cereb Cortex. 2023 Feb 07 [Online ahead of print]CC
- Considerable studies have focused on the neural basis of visually guided tracking movement in the frontoparallel plane, whereas the neural process in real-world circumstances regarding the influence of binocular disparity and motion-in-depth (MID) perception is less understood. Although the role of stereoscopic versus monoscopic MID information has been extensively described for visual processing…
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- Microfluidics-enabled Serial Assembly of Lipid-siRNA-sorafenib Nanoparticles for Synergetic Hepatocellular Carcinoma Therapy. [Journal Article]Adv Mater. 2023 Feb 07 [Online ahead of print]AM
- Multi-component nanoparticles (mNPs) hold great potential for disease prevention and treatment. However, a major barrier is the lack of versatile platforms to accommodate steps of assembly processes of mNPs. Here we present the microfluidics-enabled serial assembly (MESA) of mNPs. The microfluidic chip, as a mini-conveyor of initial materials, sequentially enables the assembly of sorafenib supram…
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- Diet-induced obesity alters intestinal monocyte-derived and tissue-resident macrophages and increases intestinal permeability in female mice independent of TNF. [Journal Article]Am J Physiol Gastrointest Liver Physiol. 2023 Feb 07 [Online ahead of print]AJ
- Macrophages are essential for homeostatic maintenance of the anti-inflammatory and tolerogenic intestinal environment, yet monocyte-derived macrophages can promote local inflammation. Pro-inflammatory macrophage accumulation within the intestines may contribute to the development of systemic chronic inflammation and immunometabolic dysfunction in obesity. Using a model of high fat diet-induced ob…
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- Development of Furanopyrimidine-Based Orally Active Third-Generation EGFR Inhibitors for the Treatment of Non-Small Cell Lung Cancer. [Journal Article]J Med Chem. 2023 Feb 07 [Online ahead of print]JM
- The development of orally bioavailable, furanopyrimidine-based double-mutant (L858R/T790M) EGFR inhibitors is described. First, selectivity for mutant EGFR was accomplished by replacing the (S)-2-phenylglycinol moiety of 12 with either an ethanol or an alkyl substituent. Then, the cellular potency and physicochemical properties were optimized through insights from molecular modeling studies by im…
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- Divergent sensory and immune gene evolution in sea turtles with contrasting demographic and life histories. [Journal Article]Proc Natl Acad Sci U S A. 2023 Feb 14; 120(7):e2201076120.PN
- Sea turtles represent an ancient lineage of marine vertebrates that evolved from terrestrial ancestors over 100 Mya. The genomic basis of the unique physiological and ecological traits enabling these species to thrive in diverse marine habitats remains largely unknown. Additionally, many populations have drastically declined due to anthropogenic activities over the past two centuries, and their r…
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- Development of a Slow-Degrading Polymerized Curcumin Coating for Intracortical Microelectrodes. [Journal Article]ACS Appl Bio Mater. 2023 Feb 07 [Online ahead of print]AA
- Intracortical microelectrodes are used with brain-computer interfaces to restore lost limb function following nervous system injury. While promising, recording ability of intracortical microelectrodes diminishes over time due, in part, to neuroinflammation. As curcumin has demonstrated neuroprotection through anti-inflammatory activity, we fabricated a 300 nm-thick intracortical microelectrode co…
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