- SREKA-targeted liposomes for highly metastatic breast cancer therapy. [Journal Article]Drug Deliv. 2023 Dec; 30(1):2174210.DD
- Chemotherapy is still a leading therapeutic approach in various tumor types that is often accompanied by a poor prognosis because of metastases. PEGylated liposomes with CREKA targeting moiety are well-known therapeutic agents, especially in highly metastatic experimental models. CREKA specifically targets tumor-associated ECM, which is present at the primary, as well as metastatic tumor sites. T…
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- Awareness and knowledge of risk factors associated with oral cancer among military personnel in Nigeria. [Journal Article]Niger J Clin Pract. 2023 Jan; 26(1):73-80.NJ
- CONCLUSIONS: Oral cancer awareness is low among soldiers in the Nigerian Armed Forces, and strategies to increase awareness should be developed.
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- Polypropylene sulphide coating on magnetic nanoparticles as a novel platform for excellent biocompatible, stimuli-responsive smart magnetic nanocarriers for cancer therapeutics. [Journal Article]Nanoscale. 2023 Feb 08 [Online ahead of print]N
- Magnetic nanoparticle (MNP) delivery systems are promising for targeted drug delivery, imaging, and chemo-hyperthermia of cancer; however, their uses remain limited primarily due to their toxicity associated with reactive oxygen species (ROS) generation, targeted delivery, and biodegradation. Attempts employing polymer coatings to minimize the toxicity, along with other challenges, have had limit…
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- Pertuzumab in Combination with Trastuzumab and Docetaxel in the Neoadjuvant Treatment for HER2-Positive Breast Cancer. [Journal Article]J Immunother Precis Oncol. 2023 Feb; 6(1):1-9.JI
- CONCLUSIONS: Further research with larger samples and longer follow-up is needed to understand the clinical differences. Clinical effectiveness of treatment should also be measured through overall and progression-free survival.
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- The Impact of Travel Distance and Income on Breast Reconstruction after Mastectomy in a Rural Population. [Journal Article]Plast Reconstr Surg Glob Open. 2023 Feb; 11(2):e4802.PR
- CONCLUSIONS: Travel distance did not significantly impact reconstruction rates after mastectomy, while household income did on univariable analysis. Studies at an institutional or regional level remain valuable, especially in populations that may not be accurately represented in larger database studies. Our findings highlight the importance of patient education, resource allocation, and multidisciplinary approach to breast cancer care, especially in the rural setting.
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- Identification and verification of immune-related gene prognostic signature based on ssGSEA for breast cancer. [Journal Article]Cent Eur J Immunol. 2022; 47(2):139-150.CE
- CONCLUSIONS: These results provide a new method to predict the prognosis and survival of BC based on the three genes' features.
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- Radiation-induced morphea of the breast-A case series. [Case Reports]Skin Health Dis. 2023 Feb; 3(1):e148.SH
- Radiation-induced morphea (RIM) is a rare but recognized late complication of radiotherapy. It was first described in 1905, not long after the initial discovery of X-rays by Roentgen. Characterized by the deposition of excess collagen in the dermis, it results in thickening of the skin. Its frequency is approximately 2 in 1000. We present a series of three cases involving patients receiving radio…
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- Long-Term Yogic Intervention Improves Symptomatic Scale and Quality of Life by Reducing Inflammatory Cytokines and Oxidative Stress in Breast Cancer Patients Undergoing Chemotherapy and/or Radiotherapy: A Randomized Control Study. [Journal Article]Cureus. 2023 Jan; 15(1):e33427.C
- CONCLUSIONS: These findings suggest that yoga may reduce levels of inflammatory cytokines and improve QoL and symptomatic scale in breast cancer patients receiving chemotherapy and/or radiotherapy. Yoga can be an important additional therapy during cancer treatments to cope with treatment side effects including fatigue, depression, and immunological profile, which directly affects the patient's quality of life.
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- Prognostic role of immune environment in luminal B early breast cancer. [Journal Article]Cancer Med. 2023 Feb 07 [Online ahead of print]CM
- The importance of the immune microenvironment in triple negative and HER2-amplified breast cancer (BC) is well-established; less is known about the immune environment in luminal breast cancers. We aimed to assess for the impact of immune biomarkers on BC outcome in a group of luminal B patients with archived tissue and annotated clinical information. Patients with early breast cancer (EBC) treate…
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- Breakthroughs in the Systemic Treatment of HER2-Positive Advanced/Metastatic Gastric Cancer: From Singlet Chemotherapy to Triple Combination. [Review]J Gastric Cancer. 2023 Jan; 23(1):224-249.JG
- Gastric cancer is heterogeneous in morphology, biology, genomics, and treatment response. Alterations in human epidermal growth factor receptor 2 (HER2) overexpression, microsatellite instability (MSI) status, programmed death-ligand 1 (PD-L1) levels, and fibroblast growth factor receptor 2 (FGFR2) can be used as biomarkers. Since the combination of fluoropyrimidine/platinum plus trastuzumab that…
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- Correction: Changes in the tumor oxygenation but not in the tumor volume and tumor vascularization reflect early response of breast cancer to neoadjuvant chemotherapy. [Published Erratum]Breast Cancer Res. 2023 Feb 07; 25(1):16.BC
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- Shining the light on mesenchymal stem cell-derived exosomes in breast cancer. [Review]Stem Cell Res Ther. 2023 Feb 08; 14(1):21.SC
- In women, breast cancer (BC) is the second most frequently diagnosed cancer and the leading cause of cancer death. Mesenchymal stem cells (MSCs) are a subgroup of heterogeneous non-hematopoietic fibroblast-like cells that have the ability to differentiate into multiple cell types. Recent studies stated that MSCs can migrate into the tumor sites and exert various effect on tumor growth and develop…
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- Solubility of palbociclib in supercritical carbon dioxide from experimental measurement and Peng-Robinson equation of state. [Journal Article]Sci Rep. 2023 Feb 07; 13(1):2172.SR
- Palbociclib is a poorly water-soluble medicine which acts against metastatic breast cancer cells. Among various techniques to improve the solubility of this medicine, applying supercritical technologies to produce micro- and nano-sized particles is a possible option. For this purpose, extraction of solubility data is required. In this research, the solubility of palbociclib in supercritical carbo…
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- Cancer in pregnancy: breast cancer. [Review]Abdom Radiol (NY). 2023 Feb 08 [Online ahead of print]AR
- Breast cancer is the most common malignancy in women, and for women under 40, it is the leading cause of cancer-related deaths. A specific type of breast cancer is pregnancy-associated breast cancer, which is diagnosed during pregnancy, the first-year postpartum, or during lactation. Pregnancy-associated breast cancer is seen in 3/1000 pregnancies and is increasing in incidence as women delay pre…
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- Ferroptosis, Acyl Starvation, and Breast Cancer. [Review]Mol Pharmacol. 2023 Mar; 103(3):132-144.MP
- To maintain their growth rate, cancer cells must secure a supply of fatty acids, which are necessary for building cell membranes and maintaining energy processes. This is one of the reasons why tissues with intensive fatty acid metabolism, such as the mammary gland, are more likely to develop tumors. One natural or induced defense process against cancer is ferroptosis, which interferes with norma…
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- Effects of self-disclosure and resilience on reproductive concern in patients of childbearing age with breast cancer: a cross-sectional survey study. [Journal Article]BMJ Open. 2023 Feb 07; 13(2):e068126.BO
- CONCLUSIONS: The findings suggest that self-disclosure and resilience may ease reproductive concern. Therefore, self-disclosure education and resilience-oriented interventions should be provided to patients of childbearing age with breast cancer, to reduce reproductive concerns.
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- miRNA-874-3p inhibits the migration, invasion and proliferation of breast cancer cells by targeting VDAC1. [Journal Article]Aging (Albany NY). 2023 Jan 10; 15A
- Breast cancer is an important cause of crisis for women's life and health. Voltage-dependent anion channel 1 (VDAC1) is mainly localized in the outer mitochondrial membrane of all eukaryotes, and it plays a crucial role in the cell as the main interface between mitochondria and cellular metabolism. Through bioinformatics, we found that VDAC1 is abnormally highly expressed in breast cancer, and th…
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- ECM-targeting bacteria enhance chemotherapeutic drug efficacy by lowering IFP in tumor mouse models. [Journal Article]J Control Release. 2023 Feb 05 [Online ahead of print]JC
- Bacterial cancer therapies aim to manipulate bacteria to effectively deploy therapeutic payloads to tumors. Attenuated bacteria alone often cannot eradicate solid tumors. Attenuated Salmonella can be engineered to deliver cytotoxic drugs to either trigger an immune response or increase antitumor efficacy when combined with chemotherapeutic drugs. However, the extracellular matrix (ECM) surroundin…
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- Associations of body fat mass and fat-free mass with breast cancer incidence in postmenopausal women: A Danish prospective cohort study. [Journal Article]Ann Epidemiol. 2023 Feb 05 [Online ahead of print]AE
- CONCLUSIONS: Among postmenopausal women who never used HRT, BFMI was associated with breast cancer in women older than 65 years. FFMI was found to be more strongly associated with postmenopausal breast cancer incidence than BFMI independently of age in never users of HRT.
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- Circulating glypican-4 is a predictor of 24-month overall survival in metastatic breast cancer. [Journal Article]Oncol Res Treat. 2023 Feb 07 [Online ahead of print]OR
- CONCLUSIONS: In conclusion, our study suggests circulating GPC4 as a significant predictor of poor survival in metastatic breast cancer patients.
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- Discovery of 2-(3-Benzamidopropanamido)thiazole-5-carboxylate Inhibitors of the Kinesin HSET (KIFC1) and the Development of Cellular Target Engagement Probes. [Journal Article]J Med Chem. 2023 Feb 07 [Online ahead of print]JM
- The existence of multiple centrosomes in some cancer cells can lead to cell death through the formation of multipolar mitotic spindles and consequent aberrant cell division. Many cancer cells rely on HSET (KIFC1) to cluster the extra centrosomes into two groups to mimic the bipolar spindle formation of non-centrosome-amplified cells and ensure their survival. Here, we report the discovery of a no…
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- Novel Algorithm for the Estimation of Cancer Incidence Using Claims Data in Japan: A Feasibility Study. [Journal Article]JCO Glob Oncol. 2023 Jan; 9:e2200222.JG
- CONCLUSIONS: The novel algorithms are effective for extracting information about patients with cancer from claims data by using the combined information on diagnosis, procedures, and medicines (algorithm 2), with 2-year cancer-treatment history as an exclusion criterion (extract 2).
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- CCNE1 and PLK1 mediates resistance to palbociclib in HR+/HER2- metastatic breast cancer. [Journal Article]Clin Cancer Res. 2023 Feb 07 [Online ahead of print]CC
- CONCLUSIONS: We confirm the association of non-luminal subtype and CCNE1 with resistance to CDK4/6i+ET in HR+ MBC. High levels of PLK1 mRNA identify patients with poor response to palbociclib, suggesting PLK1 could also play a role in the setting of resistance to CDK4/6i.
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- Patients' Individualized Care Perceptions and Health Literacy Using an Interactive App During Breast and Prostate Cancer Treatment: Two Parallel Randomized Controlled Trials. [Journal Article]Comput Inform Nurs. 2023 Feb 03 [Online ahead of print]CI
- The use of symptom management mobile apps can reduce patients' symptom burden during cancer treatment, but the evidence is lacking about their effect on care. Moreover, if patients' health literacy can be improved, it needs to be more rigorously tested. This study aimed to evaluate patients' perceptions of individualized care and health literacy using an interactive app in two randomized trials. …
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- The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain-of-function in cancer. [Journal Article]J Clin Invest. 2023 Feb 07 [Online ahead of print]JCI
- Tumor suppressor TP53 is the most frequently mutated gene in human cancers. Mutant p53 (mutp53) proteins often accumulate to very high levels in human cancers to promote cancer progression through the gain-of-function (GOF) mechanism. Currently, the mechanism underlying mutp53 accumulation and GOF is incompletely understood. Here, we identified TRIM21 as a critical E3 ubiquitin ligase of mutp53 b…
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- Breast Cancer Screening, Diagnosis, and Surgery during the Pre- and Peri-pandemic: Experience of Patients in a Statewide Health Information Exchange. [Journal Article]Ann Surg Oncol. 2023 Feb 07 [Online ahead of print]AS
- CONCLUSIONS: Breast cancer diagnosis and treatment patterns were interrupted during the lockdown and still altered 1 year after. Screening in primary care should be expanded to mitigate possible longer-term effects of these interruptions.
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- Breast MRI: Clinical Indications, Recommendations, and Future Applications in Breast Cancer Diagnosis. [Review]Curr Oncol Rep. 2023 Feb 07 [Online ahead of print]CO
- This article aims to provide an updated overview of the indications for diagnostic breast magnetic resonance imaging (MRI), discusses the available and novel imaging exams proposed for breast cancer detection, and discusses considerations when performing breast MRI in the clinical setting.
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- Validation of a breast cancer risk prediction model based on the key risk factors: family history, mammographic density and polygenic risk. [Journal Article]Breast Cancer Res Treat. 2023 Feb 07 [Online ahead of print]BC
- CONCLUSIONS: BRISK performs better than two commonly used clinical risk models and no worse compared to a similar model with more risk factors.
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- Variability Among Breast Cancer Risk Classification Models When Applied at the Level of the Individual Woman. [Journal Article]J Gen Intern Med. 2023 Feb 07 [Online ahead of print]JG
- CONCLUSIONS: Breast cancer risk estimates for individual women vary substantially, depending on which risk assessment model is used. The choice of cutoff used to define high risk can lead to adverse effects for screening, preventive care, and quality of life for misidentified individuals. Clinicians need to be aware of the high false-positive and false-negative rates and variation between models when talking with patients.
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- Vitamin D metabolism in cancer: potential feasibility of vitamin D metabolism blocking therapy. [Review]Med Mol Morphol. 2023 Feb 07 [Online ahead of print]MM
- In this review, we discuss the possibility of the vitamin D metabolizing enzyme CYP24A1 being a therapeutic target for various tumors including breast, colorectal and prostate tumors. Given the pleiotropic cellular activity of vitamin D, its deficiency impairs its physiological function in target cells and results in various pathologies including cancer. In addition, accumulated data have shown t…
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