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Unbound Medicine.
(Breast cancer)
484,417 results
  • SREKA-targeted liposomes for highly metastatic breast cancer therapy. [Journal Article]
    Drug Deliv. 2023 Dec; 30(1):2174210.Vári B, Dókus L, … Tóvári J
  • Chemotherapy is still a leading therapeutic approach in various tumor types that is often accompanied by a poor prognosis because of metastases. PEGylated liposomes with CREKA targeting moiety are well-known therapeutic agents, especially in highly metastatic experimental models. CREKA specifically targets tumor-associated ECM, which is present at the primary, as well as metastatic tumor sites. T…
  • The Impact of Travel Distance and Income on Breast Reconstruction after Mastectomy in a Rural Population. [Journal Article]
    Plast Reconstr Surg Glob Open. 2023 Feb; 11(2):e4802.Clegg DJ, Salomon BJ, … Boukovalas S
  • CONCLUSIONS: Travel distance did not significantly impact reconstruction rates after mastectomy, while household income did on univariable analysis. Studies at an institutional or regional level remain valuable, especially in populations that may not be accurately represented in larger database studies. Our findings highlight the importance of patient education, resource allocation, and multidisciplinary approach to breast cancer care, especially in the rural setting.
  • Radiation-induced morphea of the breast-A case series. [Case Reports]
    Skin Health Dis. 2023 Feb; 3(1):e148.Finnegan P, Kiely L, … Murphy LA
  • Radiation-induced morphea (RIM) is a rare but recognized late complication of radiotherapy. It was first described in 1905, not long after the initial discovery of X-rays by Roentgen. Characterized by the deposition of excess collagen in the dermis, it results in thickening of the skin. Its frequency is approximately 2 in 1000. We present a series of three cases involving patients receiving radio…
  • Prognostic role of immune environment in luminal B early breast cancer. [Journal Article]
    Cancer Med. 2023 Feb 07 [Online ahead of print]Chan A, Gill J, … Nelson DJ
  • The importance of the immune microenvironment in triple negative and HER2-amplified breast cancer (BC) is well-established; less is known about the immune environment in luminal breast cancers. We aimed to assess for the impact of immune biomarkers on BC outcome in a group of luminal B patients with archived tissue and annotated clinical information. Patients with early breast cancer (EBC) treate…
  • Shining the light on mesenchymal stem cell-derived exosomes in breast cancer. [Review]
    Stem Cell Res Ther. 2023 Feb 08; 14(1):21.Al-Awsi GRL, Alsaikhan F, … Siahmansouri H
  • In women, breast cancer (BC) is the second most frequently diagnosed cancer and the leading cause of cancer death. Mesenchymal stem cells (MSCs) are a subgroup of heterogeneous non-hematopoietic fibroblast-like cells that have the ability to differentiate into multiple cell types. Recent studies stated that MSCs can migrate into the tumor sites and exert various effect on tumor growth and develop…
  • Cancer in pregnancy: breast cancer. [Review]
    Abdom Radiol (NY). 2023 Feb 08 [Online ahead of print]Fazeli S, Sakala M, … Ojeda-Fournier H
  • Breast cancer is the most common malignancy in women, and for women under 40, it is the leading cause of cancer-related deaths. A specific type of breast cancer is pregnancy-associated breast cancer, which is diagnosed during pregnancy, the first-year postpartum, or during lactation. Pregnancy-associated breast cancer is seen in 3/1000 pregnancies and is increasing in incidence as women delay pre…
  • Ferroptosis, Acyl Starvation, and Breast Cancer. [Review]
    Mol Pharmacol. 2023 Mar; 103(3):132-144.Bobiński R, Dutka M, … Pielesz A
  • To maintain their growth rate, cancer cells must secure a supply of fatty acids, which are necessary for building cell membranes and maintaining energy processes. This is one of the reasons why tissues with intensive fatty acid metabolism, such as the mammary gland, are more likely to develop tumors. One natural or induced defense process against cancer is ferroptosis, which interferes with norma…
  • ECM-targeting bacteria enhance chemotherapeutic drug efficacy by lowering IFP in tumor mouse models. [Journal Article]
    J Control Release. 2023 Feb 05 [Online ahead of print]Kim JS, Park JE, … Park SH
  • Bacterial cancer therapies aim to manipulate bacteria to effectively deploy therapeutic payloads to tumors. Attenuated bacteria alone often cannot eradicate solid tumors. Attenuated Salmonella can be engineered to deliver cytotoxic drugs to either trigger an immune response or increase antitumor efficacy when combined with chemotherapeutic drugs. However, the extracellular matrix (ECM) surroundin…
  • The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain-of-function in cancer. [Journal Article]
    J Clin Invest. 2023 Feb 07 [Online ahead of print]Liu J, Zhang C, … Feng Z
  • Tumor suppressor TP53 is the most frequently mutated gene in human cancers. Mutant p53 (mutp53) proteins often accumulate to very high levels in human cancers to promote cancer progression through the gain-of-function (GOF) mechanism. Currently, the mechanism underlying mutp53 accumulation and GOF is incompletely understood. Here, we identified TRIM21 as a critical E3 ubiquitin ligase of mutp53 b…
  • Variability Among Breast Cancer Risk Classification Models When Applied at the Level of the Individual Woman. [Journal Article]
    J Gen Intern Med. 2023 Feb 07 [Online ahead of print]Paige JS, Lee CI, … Elmore JG
  • CONCLUSIONS: Breast cancer risk estimates for individual women vary substantially, depending on which risk assessment model is used. The choice of cutoff used to define high risk can lead to adverse effects for screening, preventive care, and quality of life for misidentified individuals. Clinicians need to be aware of the high false-positive and false-negative rates and variation between models when talking with patients.
  • Vitamin D metabolism in cancer: potential feasibility of vitamin D metabolism blocking therapy. [Review]
    Med Mol Morphol. 2023 Feb 07 [Online ahead of print]Kamiya S, Nakamori Y, … Osanai M
  • In this review, we discuss the possibility of the vitamin D metabolizing enzyme CYP24A1 being a therapeutic target for various tumors including breast, colorectal and prostate tumors. Given the pleiotropic cellular activity of vitamin D, its deficiency impairs its physiological function in target cells and results in various pathologies including cancer. In addition, accumulated data have shown t…
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