- Development and validation of UPLC-MS/MS assay for quantification of cladrin: Absolute bioavailability and dose proportionality study in rats. [Journal Article]
- JPJ Pharm Biomed Anal 2018 Jan 31; 152:289-297
- Cladrin, an isoflavone is a major bioactive constituent found in stem bark of Butea monosperma with remarkable osteogenic activity. A speedy and sensitive UPLC coupled tandem mass spectrometry (UPLC-...
Cladrin, an isoflavone is a major bioactive constituent found in stem bark of Butea monosperma with remarkable osteogenic activity. A speedy and sensitive UPLC coupled tandem mass spectrometry (UPLC-MS/MS) method was developed, validated and successfully applied to bioavailability, blood partitioning, plasma protein binding, intravenous and multiple-dose oral pharmacokinetics of cladrin in rats. Separation was done on C18 column (5.0 μm, 4.6 × 50 mm) using mobile phase containing acetonitrile and 0.10% formic acid in the ratio of 65:35 (v/v) with 0.60 mL/min flow rate. The method was highly sensitive and has a short run time of 2.50 min with an excellent linearity (R2 > 0.99) in the range of 0.20-200 μg/L. Absolute bioavailability was found to be 16.58, 19.04 and 6.76% at oral doses of 5, 10, and 20 mg/Kg, respectively. Cladrin was rapidly absorbed (Tmax3.0 h) with a high apparent volume of distribution (15.03 ± 1.79L/Kg), high clearance (2.27 ± 0.30L/h/Kg) and high plasma protein binding. The present study is a first comprehensive in-vitro as well as the in-vivo preclinical pharmacokinetic report of cladrin giving insights about its drug-likeness and further development as a potential therapeutic agent.
- Phenol separation from phenol-laden saline wastewater by membrane aromatic recovery system-like membrane contactor using superhydrophobic/organophilic electrospun PDMS/PMMA membrane. [Journal Article]
- WRWater Res 2018 Feb 10; 135:31-43
- Phenol recovery from phenol-laden saline wastewater plays an important role in the waste reclamation and pollution control. A membrane aromatic recovery system-like membrane contactor (MARS-like memb...
Phenol recovery from phenol-laden saline wastewater plays an important role in the waste reclamation and pollution control. A membrane aromatic recovery system-like membrane contactor (MARS-like membrane contactor) was set up in this study using electrospun polydimethylsiloxane/polymethyl methacrylate (PDMS/PMMA) membrane with 0.0048 m2effective area to separate phenol from saline wastewater. Phenol and water contact angles of 0° and 162° were achieved on this membrane surface simultaneously, indicating its potential in the separation of phenol and water-soluble salt. Feed solution (500 mL) of 0.90 L/h and receiving solution (500 mL) of 1.26 L/h were investigated to be the optimum conditions for phenol separation, which corresponds to the employed Reynolds number of 14.6 and 20.5. During 108-h continuous separation for feed solution (2.0 g/L phenol, 10.0 g/L NaCl) under room temperature (20 °C), 42.6% of phenol was recycled in receiving solution with a salt rejection of 99.95%. Meanwhile, the mean phenol mass transfer coefficient (Kov) was 6.7 × 10-7 m s-1. As a membrane-based process, though the permeated phenol increased with the increase of phenol concentration in feed solution, the phenol recovery ratio was determined by the membrane properties rather than the pollutant concentrations. Phenol was found to permeate this membrane via adsorption, diffusion and desorption, and therefore, the membrane fouling generated from pore blockage in other membrane separation processes was totally avoided.
- Transformations of dissolved organic matter induced by UV photolysis, Hydroxyl radicals, chlorine radicals, and sulfate radicals in aqueous-phase UV-Based advanced oxidation processes. [Journal Article]
- WRWater Res 2018 Feb 08; 135:22-30
- Considering the increasing identification of trace organic contaminants in natural aquatic environments, the removal of trace organic contaminants from water or wastewater discharge is an urgent task...
Considering the increasing identification of trace organic contaminants in natural aquatic environments, the removal of trace organic contaminants from water or wastewater discharge is an urgent task. Ultraviolet (UV) and UV-based advanced oxidation processes (AOPs), such as UV/hydrogen peroxide (UV/H2O2), UV/free chlorine and UV/persulfate, are attractive and promising approaches for the removal of these contaminants due to the high reactivity of active radical species produced in these UV-AOPs with a wide variety of organic contaminants. However, the removal efficiency of trace contaminants is greatly affected by the presence of background dissolved organic matter (DOM). In this study, we use ultrahigh resolution mass spectrometry to evaluate the transformation of a standard Suwanee River fulvic acid DOM isolate in UV photolysis and UV-AOPs. The use of probe compounds allows for the determination of the steady-state concentrations of active radical species in each UV-AOP. The changes in the H/C and O/C elemental ratios, double bond equivalents, and the low-molecular-weight transformation product concentrations of organic acids reveal that different DOM transformation patterns are induced by each UV-AOP. By comparison with the known reactivities of each radical species with specific organic compounds, we mechanistically and systematically elucidate the molecular-level DOM transformation pathways induced by hydroxyl, chlorine, and sulfate radicals in UV-AOPs. We find that there is a distinct transformation in the aliphatic components of DOM due to HO• in UV/H2O2and UV/free chlorine. Cl• induced transformation of olefinic species is also observed in the UV/free chlorine system. Transformation of aromatic and olefinic moieties by SO4•-are the predominant pathways in the UV/persulfate system.
- Pancreatic cancer presenting as colonic disease. A rare case report. [Journal Article]
- IJInt J Surg Case Rep 2018 Feb 09; 44:4-7
- CONCLUSIONS: Pancreatic metastasis to the colon is a very rare entity. Care should be taken when addressing these patients.Although rare, a sigmoid tumor in a patient with known pancreatic adenocarcinoma must raise the suspicion of metastasis.
- Obesity, dyslipidemia and brain age in first-episode psychosis. [Journal Article]
- JPJ Psychiatr Res 2018 Feb 10; 99:151-158
- CONCLUSIONS: Overweight/obesity may be an independent risk factor for diffuse brain alterations manifesting as advanced brain age already early in the course of psychosis. These findings raise the possibility that targeting metabolic health and intervening already at the level of overweight/obesity could slow brain ageing in FEP.
- Revealing metabolic storage processes in electrode respiring bacteria by differential electrochemical mass spectrometry. [Journal Article]
- BBioelectrochemistry 2018 Feb 08; 121:160-168
- In this work we employ differential electrochemical mass spectrometry (DEMS) in combination with static and dynamic electrochemical techniques for the study of metabolic processes of electrochemicall...
In this work we employ differential electrochemical mass spectrometry (DEMS) in combination with static and dynamic electrochemical techniques for the study of metabolic processes of electrochemically active bacteria. CO2production during acetate oxidation by electrode respiring bacteria was measured, in-vivo and online with a sensitivity of 6.5 ⋅ 10-13mol/s. The correlation of ion current and electrical current provides insight into the interaction of metabolic processes and extra-cellular electron transfer. In low-turnover CVs, two competing potential dependent electron transfer mechanisms were observed and formal potentials of two redox systems that are involved in complete oxidation of acetate to CO2were determined. By balancing charge and carbon flows during dynamic measurements, two significant storage mechanisms in electrochemically active bacteria were identified: 1) a charge storage mechanism that allows substrate oxidation to proceed at a constant rate despite of external current flowing in cathodic direction. 2) a carbon storage mechanism that allows the biofilm to take up acetate at an unchanged rate at very low potentials even though the oxidation to CO2stops. These storage capabilities allow a limited decoupling of electrical current and CO2production rate.
- Photo-assisted electrochemical abatement of trifluralin using a cathode containing a C60-carbon nanotubes composite. [Journal Article]
- CChemosphere 2018 Feb 09; 199:510-523
- This work reports the potential application of modified gas-diffusion electrode (GDE) with C60-CNT composite, as a stable and efficient cathode material for degradation of trifluralin (TRL) pesticide...
This work reports the potential application of modified gas-diffusion electrode (GDE) with C60-CNT composite, as a stable and efficient cathode material for degradation of trifluralin (TRL) pesticide by photo-assisted electrochemical (PE) process. C60-CNT composite was prepared and characterized. Subsequently, a novel C60-CNT composite modified GDE cathode was developed and the electrochemical and physical characteristics of the modified GDEs were studied. C60-CNT composite/GDE showed great efficiencies for electro-generating H2O2, owing to huge surface area and high conductivity. Afterwards, a comparative study of TRL oxidation via photolysis, anodic oxidation (AO) and PE processes using C60-CNT composite/GDE revealed the degradation percentages of 42.2, 48.5 and 93.4%, respectively, after 180 min of treatment. The TRL degradation followed a pseudo-first-order kinetics, being faster in the order: photolysis < AO < PE. The effects of various operational conditions were assessed on the degradation of TRL. From the results, PE process using C60-CNT composite/GDE exhibited great performance for the degradation of TRL (20 mg L-1) under its original pH, Na2SO4electrolyte concentration of 0.05 mol L-1, applied current intensity of 300 mA, and flow rate of 12.5 L h-1. TOC results displayed that 92.8% of TRL was mineralized after 8 h of PE process. In addition, a plausible pathway for mineralization of TRL was proposed according to the identified by-products detected by means of gas chromatography-mass spectroscopy (GC-MS), High-performance liquid chromatography (HPLC) and ion chromatography analyses.
- Delayed post-traumatic subacute lumbar subarachnoid hematoma: Case report and review of the literature. [Journal Article]
- WNWorld Neurosurg 2018 Feb 14
- CONCLUSIONS: Six weeks after surgery, the neurological examination revealed only a slight tactile hypoesthesia of the left thigh. With only 4 reported cases, purely sub-arachnoid spinal hematomas remain widely rarer than epidural hematomas. The reported case possesses a certain number of peculiarities: young age, pure subarachnoid location, lumbar location, occurrence after a car accident, subacute onset and excellent neurological recovery. In our opinion, a symptomatic sub-arachnoid spinal hematoma should be surgically evacuated at the early phase to expect a neurological recovery.
- Optic Nerve Atrophy Due To Long-Standing Compression By Planum Sphenoidale Meningioma. [Journal Article]
- WNWorld Neurosurg 2018 Feb 14
- In this study we report an uncommon endoscopic endonasal image of an atrophic optic nerve as seen after surgical removal of a suprasellar meningioma. The peculiarity of this case is the long-lasting ...
In this study we report an uncommon endoscopic endonasal image of an atrophic optic nerve as seen after surgical removal of a suprasellar meningioma. The peculiarity of this case is the long-lasting underestimated ocular symptomatology of the patient who reported a 15-year history of impairment of vision on her left eye. After making serendipitously the diagnosis of a suprasellar mass, an endoscopic endonasal surgery was performed and, at the end of tumor removal, the impressive left optic nerve atrophy due to enduring local compression was visualized.
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- The factors affecting the difficulty of percutaneous cylindrical electrode placement for spinal cord stimulation. [Journal Article]
- WNWorld Neurosurg 2018 Feb 14
- CONCLUSIONS: This is the first study to evaluate factors affecting the difficulty of percutaneous electrode placement. A history of percutaneous cylindrical electrode placement did not affect the success of current placement, although it lengthened the operation time.