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(Brenner tumor)
2,486 results
  • A network analysis to identify mediators of germline-driven differences in breast cancer prognosis. [Journal Article]
    Nat Commun 2020; 11(1):312Escala-Garcia M, Abraham J, … Schmidt MK
  • Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast canc…
  • Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes. [Journal Article]
    Nat Genet 2020; 52(1):56-73Fachal L, Aschard H, … Dunning AM
  • Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underlying risk remain largely unknown. These regions were explored by combining association analysis with in silico genomic feature annotations. We defined 205 independent risk-associated signals with the set of credible causal variants in each one. In parallel, we used a B…
  • Magnitude of the Age-Advancement Effect of Comorbidities in Colorectal Cancer Prognosis. [Journal Article]
    J Natl Compr Canc Netw 2020; 18(1):59-68Boakye D, Walter V, … Brenner H
  • CONCLUSIONS: Comorbidities advance the commonly observed deterioration of prognosis with age by many years, meaning that at substantially younger ages, comorbid patients with CRC experience survival rates comparable to those of older patients without comorbidity. This first derivation of AAPs may enhance the empirical basis for treatment decisions in patients with comorbidities and highlight the need to incorporate comorbidities into prognostic nomograms for CRC.
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