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Unbound Medicine.
(Brugia malayi)
2,037 results
  • Prediction pipeline for discovery of regulatory motifs associated with Brugia malayi molting. [Journal Article]
    PLoS Negl Trop Dis. 2020 Jun 23; 14(6):e0008275.Grote A, Li Y, … Ghedin E
  • Filarial nematodes can cause debilitating diseases in humans. They have complicated life cycles involving an insect vector and mammalian hosts, and they go through a number of developmental molts. While whole genome sequences of parasitic worms are now available, very little is known about transcription factor (TF) binding sites and their cognate transcription factors that play a role in regulati…
  • Nearly Complete Genome Sequence of Brugia malayi Strain FR3. [Journal Article]
    Microbiol Resour Announc. 2020 Jun 11; 9(24)Tracey A, Foster JM, … Ghedin E
  • Lymphatic filariasis affects ∼120 million people and can result in elephantiasis and hydrocele. Here, we report the nearly complete genome sequence of the best-studied causative agent of lymphatic filariasis, Brugia malayi The assembly contains four autosomes, an X chromosome, and only eight gaps but lacks a contiguous sequence for the known Y chromosome.
  • Genetic and functional diversification of chemosensory pathway receptors in mosquito-borne filarial nematodes. [Journal Article]
    PLoS Biol. 2020 Jun 08; 18(6):e3000723.Wheeler NJ, Heimark ZW, … Zamanian M
  • Lymphatic filariasis (LF) afflicts over 60 million people worldwide and leads to severe pathological outcomes in chronic cases. The nematode parasites (Nematoda: Filarioidea) that cause LF require both arthropod (mosquito) intermediate hosts and mammalian definitive hosts for their propagation. The invasion and migration of filarial worms through host tissues are complex and critical to survival,…
  • Sex chromosome evolution in parasitic nematodes of humans. [Journal Article]
    Nat Commun. 2020 Apr 23; 11(1):1964.Foster JM, Grote A, … Ghedin E
  • Sex determination mechanisms often differ even between related species yet the evolution of sex chromosomes remains poorly understood in all but a few model organisms. Some nematodes such as Caenorhabditis elegans have an XO sex determination system while others, such as the filarial parasite Brugia malayi, have an XY mechanism. We present a complete B. malayi genome assembly and define Nigon ele…
  • In vivo imaging of transgenic Brugia malayi. [Journal Article]
    PLoS Negl Trop Dis. 2020 Apr; 14(4):e0008182.Liu C, De SL, … Unnasch TR
  • CONCLUSIONS: To our knowledge, this represents the first application of IVIS to the study of a human filarial parasite. This method should prove useful in studies of tissue tropism and as an efficient in vivo assay for candidate anti-filarial drugs.
  • Recent advances in functional genomics for parasitic nematodes of mammals. [Review]
    J Exp Biol. 2020 Feb 07; 223(Pt Suppl 1)Castelletto ML, Gang SS, Hallem EA
  • Human-parasitic nematodes infect over a quarter of the world's population and are a major cause of morbidity in low-resource settings. Currently available treatments have not been sufficient to eliminate infections in endemic areas, and drug resistance is an increasing concern, making new treatment options a priority. The development of new treatments requires an improved understanding of the bas…
  • Activation of mosquito immunity blocks the development of transmission-stage filarial nematodes. [Journal Article]
    Proc Natl Acad Sci U S A. 2020 02 18; 117(7):3711-3717.Edgerton EB, McCrea AR, … Povelones M
  • Mosquito-borne helminth infections are responsible for a significant worldwide disease burden in both humans and animals. Accordingly, development of novel strategies to reduce disease transmission by targeting these pathogens in the vector are of paramount importance. We found that a strain of Aedes aegypti that is refractory to infection by Dirofilaria immitis, the agent of canine heartworm dis…
  • Dirofilaria immitis possesses molecules with anticoagulant properties in its excretory/secretory antigens. [Journal Article]
    Parasitology. 2020 Apr; 147(5):559-565.Diosdado A, Simón F, … González-Miguel J
  • Dirofilaria immitis is a parasitic nematode that survives in the circulatory system of suitable hosts for many years, causing the most severe thromboembolisms when simultaneous death of adult worms occurs. The two main mechanisms responsible for thrombus formation in mammals are the activation and aggregation of platelets and the generation of fibrin through the coagulation cascade. The aim of th…
  • De novo Assembly of the Brugia malayi Genome Using Long Reads from a Single MinION Flowcell. [Journal Article]
    Sci Rep. 2019 12 20; 9(1):19521.Fauver JR, Martin J, … Fischer PU
  • Filarial nematode infections cause a substantial global disease burden. Genomic studies of filarial worms can improve our understanding of their biology and epidemiology. However, genomic information from field isolates is limited and available reference genomes are often discontinuous. Single molecule sequencing technologies can reduce the cost of genome sequencing and long reads produced from t…
  • Canine vector-borne pathogens from dogs and ticks from Tamil Nadu, India. [Journal Article]
    Acta Trop. 2020 Mar; 203:105308.Manoj RRS, Iatta R, … Otranto D
  • Canine vector-borne diseases (CVBDs) pose a major health problem in dogs globally, with the potential to cause zoonoses, in particular in developing countries where scientific knowledge on the topic is minimal. Blood samples and ticks were collected from stray dogs in Tamil Nadu, South India to assess the prevalence of CVBD-causing pathogens (Anaplasma spp., Babesia spp., Ehrlichia spp., Hepatozo…
  • The consequences of Brugia malayi infection on the flight and energy resources of Aedes aegypti mosquitoes. [Journal Article]
    Sci Rep. 2019 12 05; 9(1):18449.Somerville AGT, Gleave K, … Reimer LJ
  • Evidence from experimental infection studies has shown that infected mosquitoes exhibit altered host-seeking behaviours, with suppression and activation of behaviours dependent on the parasite's development stage. The mechanisms are poorly characterised; however, infections can impact mosquito energy reserves, thereby influencing key life-history traits and behaviours. In addition, filarial infec…
  • An insight into the discovery of potent antifilarial leads against lymphatic filariasis. [Journal Article]
    Curr Drug Targets. 2019 Dec 04 [Online ahead of print]Boniface PK, Elizabeth FI
  • CONCLUSIONS: With reference to in vitro antifilarial studies, there is evidence that natural and synthetic products can serve as basic scaffolds for the development of antifilarial agents. The optimization of the most potent antifilarial compounds can be further performed, follow by their in vivo studies.
  • Brugia malayi galectin 2 is a tandem-repeat type galectin capable of binding mammalian polysaccharides. [Journal Article]
    Mol Biochem Parasitol. 2020 01; 235:111233.Hertz MI, Glaessner PM, … Budge PJ
  • Galectins are among the most abundant excretory/secretory (ES) products of filarial worms, but their role in filarial biology is poorly understood. Galectin-2 (Lec-2), a major component of Brugia malayi extracellular vesicles, is released by filarial worms, and was recently identified in the serum of persons with loiasis. We therefore sought to clone and characterize Lec-2, and to develop reagent…
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