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24,543 results
  • Botulinum Toxin A Improves Symptoms of Gastroparesis. [Journal Article]
    Dig Dis Sci 2019Reichenbach ZW, Stanek S, … Schey R
  • CONCLUSIONS: BoNT/A therapy to the pylorus provided symptomatic improvement at 1 month in 64% of patients. For those patients initially responding, the improvement can last out to 6 months. The biochemical markers did not serve to predict the outcome of injections.
  • Cannabinoid Receptor Interacting Protein 1a (CRIP1a): Function and Structure. [Review]
    Molecules 2019; 24(20)Booth WT, Walker NB, … Howlett AC
  • Cannabinoid receptor interacting protein 1a (CRIP1a) is an important CB1 cannabinoid receptor-associated protein, first identified from a yeast two-hybrid screen to modulate CB1-mediated N-type Ca2+ currents. In this paper we review studies of CRIP1a function and structure based upon in vitro experiments and computational chemistry, which elucidate the specific mechanisms for the interaction of C…
  • An in-vitro assay using human spermatozoa to detect toxicity of biologically active substances. [Journal Article]
    Sci Rep 2019; 9(1):14525Vollmer T, Ljungberg B, … Stegmayr BG
  • Identifying the key toxic players within an in-vivo toxic syndrome is crucial to develop targeted therapies. Here, we established a novel method that characterizes the effect of single substances by means of an ex-vivo incubation set-up. We found that primary human spermatozoa elicit a distinct motile response on a (uremic) toxic milieu. Specifically, this approach describes the influence of a bu…
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