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1,434,841 results
  • Transgenic Tumor Models for Evaluating CAR T-Cell Immunotherapies. [Journal Article]
    Curr Protoc Pharmacol 2019; 86(1):e66Aranda F, Barajas M, Huarte E
  • Chimeric antigen receptor (CAR) T-cell therapy against tumor antigens involves a recombinant immunoreceptor that combines an antibody-derived targeting fragment with signaling domains capable of activating T cells and fusion of this receptor domain to a costimulatory domain (typically CD28 or 4-1BB). Clinical trials of CAR T-cell therapeutics targeting CD19 antigens for relapsed or refractory B-c…
  • Spontaneous Model of Sjögren's Syndrome in NOD Mice. [Journal Article]
    Curr Protoc Pharmacol 2019; 86(1):e65Scuron MD, Fay B, … Smith P
  • The non-obese diabetic (NOD) mouse model is the most widely described and validated method for investigating human primary Sjögren's syndrome (SS) and represents a useful model for translational studies. However, the systemic disease manifestation in NOD mice is sensitive to the housing environment, as stress modulates the immune system, so it is essential to confirm that readouts are robust, rep…
  • Characterization of Thyroid Cancer Driven by Known and Novel ALK Fusions. [Journal Article]
    Endocr Relat Cancer 2019Panebianco F, Nikitski AV, … Chiosea SI
  • ALK fusions are found in various tumors, including thyroid cancer, and serve as a diagnostic marker and therapeutic target. Spectrum and outcomes of ALK fusions found in thyroid nodules and cancer are not fully characterized. We report a series of 44 ALK-translocated thyroid neoplasms, including 31 identified preoperatively in thyroid fine-needle aspirates (FNA). The average patients' age was 43 …
  • Early Diagnosis of Gestational Diabetes Mellitus Using Circulating MicroRNAs. [Journal Article]
    Eur J Endocrinol 2019Yoffe L, Polsky A, … Hod M
  • Design Gestational Diabetes Mellitus (GDM) is one of the most common pregnancy complications and its prevalence is constantly rising worldwide. Diagnosis is commonly in the late second or early third trimester of pregnancy, though the development of GDM starts early; hence first-trimester diagnosis is feasible. Our objective was to identify microRNAs that best distinguish GDM samples from those o…
  • Synthesis of Mitomycin C and decarbamoylmitomycin C N6 deoxyadenosine-adducts. [Journal Article]
    Bioorg Chem 2019; 92:103280Zheng M, Hwang S, … Champeil E
  • Mitomycin C (MC), an anti-cancer drug, and its analog, decarbamoylmitomycin C (DMC), are DNA-alkylating agents. MC is currently used in the clinics and its cytotoxicity is mainly due to its ability to form Interstrand Crosslinks (ICLs) which impede DNA replication and, thereby, block cancer cells proliferation. However, both MC and DMC are also able to generate monoadducts with DNA. In particular…
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