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35,845 results
  • Human Aging Alters the Spatial Organization between CD34+ Hematopoietic Cells and Adipocytes in Bone Marrow. [Journal Article]
    Stem Cell Reports. 2020 Jun 26 [Online ahead of print]Aguilar-Navarro AG, Meza-León B, … Flores-Figueroa E
  • Age-related clonal hematopoiesis is a major risk factor for myeloid malignancy and myeloid skewing is a hallmark of aging. However, while it is known that non-cell-autonomous components of the microenvironment can also influence this risk, there have been few studies of how the spatial architecture of human bone marrow (BM) changes with aging. Here, we show that BM adiposity increases with age, w…
  • A novel homozygous GFI1B variant in 2 sisters with thrombocytopenia and severe bleeding tendency. [Journal Article]
    Platelets. 2020 Jul 07 [Online ahead of print]Brøns N, Zaninetti C, … Leinøe E
  • Genetic variants in growth factor-independent 1B (GFI1B), encoding transcription factor GFI1B, are causative of platelet-type bleeding disorder-17. Presently, 53 cases of GFI1B associated inherited thrombocytopenia (IT) have been published, however only three were homozygous. The bleeding- and platelet phenotypes of these patients depend on location and inheritance pattern of the GFI1B variant. W…
  • Mesenchymal stem cell-derived microvesicles mediate BMP2 gene delivery and enhance bone regeneration. [Journal Article]
    J Mater Chem B. 2020 Jul 07 [Online ahead of print]Liang Z, Luo Y, Lv Y
  • A demineralized bone matrix (DBM) scaffold has good biocompatibility, low antigenicity, a natural porous structure and no cytotoxicity, and so it is an appropriate material for bone regeneration. However, osteoinductive growth factors are often removed during preparation, which destroys the osteoinductive capacity of the DBM scaffold. Biomaterials combined with gene therapy is a promising approac…
  • [New immunohistochemistry markers to determine presence of vas deferens in vasectomy specimen.] [Journal Article]
    Arch Esp Urol. 2020 Jul; 73(6):534-540.Ortiz-Rey JA, Domínguez-de Dios J, … Gómez-de María C
  • CONCLUSIONS: PAX8 is a useful antibody to confirm the presence of vas deferens in artifacted vasectomy specimens. CD34 and ERG are negative in the epithelium,and, otherwise, they are expressed by vascular endothelium, with the advantage of nuclear staining pattern for ERG. CD31, a classic endothelial marker, is not so specific as it had been stated as it shows weak or moderate expression in the vas deferens epithelium.
  • Morphological diversity in H3G34-mutant high-grade gliomas: Ganglionic and epithelioid features. [Journal Article]
    Clin Neuropathol. 2020 Jul 07 [Online ahead of print]Gilani A, Kleinschmidt-DeMasters BK
  • Although increasing numbers of central nervous system (CNS) tumors with stereotypic morphological, molecular, and/or site-specific features have been recently reported, morphological diversity is often recognized within a tumor category as more cases are encountered. Such was the case with diffuse midline gliomas, H3K27M-mutant. Therefore, it is not surprising that two cases of H3G34-mutant. CNS …
  • Markers of Regenerative Processes in Patients with Bipolar Disorder: A Case-control Study. [Journal Article]
    Brain Sci. 2020 Jun 30; 10(7)Reginia A, Samochowiec J, … Kucharska-Mazur J
  • Progress in medical science has allowed the discovery of many factors affecting the pathogenesis of bipolar disorder, and among the most recent research directions are found regenerative and inflammatory processes. The role of regenerative processes remains particularly poorly explored, but available data encourage further research, which may explain the pathogenesis of bipolar disorder (BD). The…
  • Increased expression of RBMS3 predicts a favorable prognosis in human gallbladder carcinoma. [Journal Article]
    Oncol Rep. 2020 Jul; 44(1):55-68.Wu Y, Meng D, … Sun D
  • Multiple regions in the short arm of chromosome 3 are frequently deleted in a variety of solid tumors including gallbladder carcinoma (GBC). RNA binding motif, single‑stranded interacting protein 3 (RBMS3), a tumor suppressor gene (TSG), is located in this region. However, the role of RBMS3 in GBC remains unclear. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and western …
  • Anti-HIV Activity of Standard cART in Primary Cells Is Intensified by CCR5-Targeting Drugs. [Journal Article]
    AIDS Res Hum Retroviruses. 2020 Jul 05 [Online ahead of print]Weichseldorfer M, Affram Y, … Latinovic OS
  • The efficacy of combined antiretroviral therapy (cART) against HIV-1 is evidenced by reduction of plasma viremia, disease progression, viral transmission and mortality. However, major challenges still remain in HIV-1 management, especially the emergence of resistant strains and the persistence of viral reservoirs, apparent after cART treatment interruption. Efforts are ongoing to explore the most…
  • Effect of delayed cord clamping on stem cell transfusion and hematological parameters in preterm infants with placental insufficiency: a pilot randomized trial. [Journal Article]
    Eur J Pediatr. 2020 Jul 04 [Online ahead of print]Yunis M, Nour I, … Nasef N
  • CONCLUSIONS: In conclusion, DCC compared with ICC increased stem cell transfusion and decreased early- and late-onset anemia in preterm infants with placental insufficiency.Trial registration: NCT03731546 What is Known: • Delayed cord clamping has been recommended by the American Academy of Pediatrics as a standard of care practice during delivery of preterm infants. • The feasibility of DCC in preterm infants with placental insufficiency (PI) is uncertain. What is New: • This randomized controlled trial demonstrated that DCC in the delivery room care of preterm infants born to mothers with placental insufficiency increased stem cell transfusion and decreased early- and late-onset anemia.
  • Nerve Sheath Myxoma Involving the Medial Rectus Muscle: A Case Report. [Journal Article]
    Ophthalmic Plast Reconstr Surg. 2020 Jun 17 [Online ahead of print]Mora-Cantallops A, Won-Kim HR, … Sales-Sanz M
  • A 63-year-old man reported a 2-year history of painless OS proptosis. The first MRI, performed in the institution of origin, resulted in a diagnosis of hemangioma versus orbital pseudotumor. Examination revealed proptosis and mild chemosis. Ancillary tests were normal, and oral prednisone was initiated without remarkable changes. Later, an incisional biopsy identified the lesion as an intramuscul…
  • Lipofibromatosis-Like Neural Tumor: A Case Report and Review of the Literature. [Journal Article]
    Am J Dermatopathol. 2020 Jun 30 [Online ahead of print]Crumbach L, Descotes F, … Harou O
  • Lipofibromatosis-like neural tumors (LPF-NT) are soft tissue tumors characterized by a lipofibromatosis-like pattern, CD34/PS100 positivity, and recurrent NTRK1 gene rearrangement. It occurs mainly in pediatric patients or young adults. We report here, the first case of LPF-NT in a middle-aged adult initially misdiagnosed as a myoepithelial tumor. LPF-NT may have a locally aggressive course but n…
  • Etoposide-mediated interleukin-8 secretion from bone marrow stromal cells induces hematopoietic stem cell mobilization. [Journal Article]
    BMC Cancer. 2020 Jul 02; 20(1):619.Kang KW, Lee SJ, … Kim BS
  • CONCLUSIONS: Collectively, the unique mechanism of etoposide with G-CSF-induced mobilization is associated with IL-8 secretion from the BMSCs, which is responsible for the enhanced proliferation and mobilization of HSCs in the bone marrow; this was not observed with mobilization using cyclophosphamide with G-CSF or G-CSF alone. However, the long-term toxicity of etoposide toward BMSCs emphasizes the need for the development of more efficient and safe chemo-mobilization strategies.
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