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3,577 results
  • mycoCSM: using graph-based signatures to identify safe potent hits against Mycobacteria. [Journal Article]
    J Chem Inf Model. 2020 Jul 02 [Online ahead of print]Pires D, Ascher DB
  • Development of new potent, safe drugs to treat Mycobacteria has proven to be challenging, with limited hit rates of initial screens restricting subsequent development efforts. Despite significant efforts and evolution of Quantitative Structure-Activity Relationship (QSAR) as well as machine learning-based models for computationally predicting molecule bioactivity, there is an unmet need for effic…
  • [Observational study of the handover with the SBAR method at Bari Polyclinic complex]. [Journal Article]
    Prof Inferm. 2020 Jan-Mar; 73(1):27-32.Vitale E, Cannito G
  • CONCLUSIONS: From the results obtained, the transmission of deliveries has not been shown to be effective, resulting in prolonged times and a low percentage of information provided for all color codes. It follows that the use of the SBAR method in the handing over of deliveries could improve the effectiveness of the intervention and make the delivery.
  • SIX1 and SIX4 homeoproteins regulate PAX7+ progenitor cell properties during fetal epaxial myogenesis. [Journal Article]
    Development. 2020 Jun 26 [Online ahead of print]Wurmser M, Chaverot N, … Maire P
  • Pax7 expression marks stem cells in developing skeletal muscles and adult satellite cells during homeostasis and muscle regeneration. The genetic determinants that control the entrance into the myogenic program and the appearance of PAX7+ cells during embryogenesis are poorly understood. SIX homeoproteins are encoded by the Sine oculis homeobox related Six1-Six6 genes in vertebrates. Six1, Six2, …
  • Cavernous sinus meningioma. [Journal Article]
    Handb Clin Neurol. 2020; 170:69-85.Raheja A, Couldwell WT
  • Cavernous sinus meningioma (CSM) presents a management challenge to present-day neurosurgeons. Lack of adequate understanding of the natural history of these lesions, the early involvement of vital neurovascular structures, the absence of clear tissue planes with normal surrounding structures, and a high rate of aggressive surgery-related morbidity each pose management dilemmas for neurosurgeons.…
  • Surgical Outcomes in Patients with Congenital Cervical Spinal Stenosis. [Journal Article]
    World Neurosurg. 2020 Jun 06 [Online ahead of print]Atli K, Chakravarthy V, … Mroz TE
  • CONCLUSIONS: Postoperatively, compared to non-CCSS patients, patients with congenital cervical stenosis reported equal quality of life for all markers. Our findings suggest that in patients with CCSS and relatively mild symptoms of myelopathy, equal consideration should be given for surgical intervention. The findings of this study warrant further large-scale, multi-institutional investigation to further understand the generalizability of these surgical outcomes results.
  • A probabilistic approach for cross-spectral matrix denoising: Benchmarking with some recent methods. [Journal Article]
    J Acoust Soc Am. 2020 May; 147(5):3108.Dinsenmeyer A, Antoni J, … Pereira A
  • Array measurements can be contaminated by strong noise, especially when dealing with microphones located near or in a flow. The denoising of these measurements is crucial to allow efficient data analysis or source imaging. In this paper, a denoising approach based on a Probabilistic Factor Analysis is proposed. It relies on a decomposition of the measured cross-spectral matrix (CSM) using the inh…
  • Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death. [Review]
    Front Oncol. 2020; 10:723.Daher B, Vučetić M, Pouysségur J
  • Cancer cells are characterized as highly proliferative at the expense of enhancement of metabolic rate. Consequently, cancer cells rely on antioxidant defenses to overcome the associated increased production of reactive oxygen species (ROS). The reliance of tumor metabolism on amino acids, especially amino acid transport systems, has been extensively studied over the past decade. Although cystein…
  • Tumor Cell Associated Hyaluronan-CD44 Signaling Promotes Pro-Tumor Inflammation in Breast Cancer. [Journal Article]
    Cancers (Basel). 2020 May 22; 12(5)Witschen PM, Chaffee TS, … Schwertfeger KL
  • Cancer has been conceptualized as a chronic wound with a predominance of tumor promoting inflammation. Given the accumulating evidence that the microenvironment supports tumor growth, we investigated hyaluronan (HA)-CD44 interactions within breast cancer cells, to determine whether this axis directly impacts the formation of an inflammatory microenvironment. Our results demonstrate that breast ca…
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