- Awareness and knowledge of risk factors associated with oral cancer among military personnel in Nigeria. [Journal Article]Niger J Clin Pract. 2023 Jan; 26(1):73-80.NJ
- CONCLUSIONS: Oral cancer awareness is low among soldiers in the Nigerian Armed Forces, and strategies to increase awareness should be developed.
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- Cervical Cancer Screening Coverage - China, 2018-2019. [Journal Article]China CDC Wkly. 2022 Dec 02; 4(48):1077-1082.CC
- The World Health Organization set a 2030 target of 70% cervical cancer screening coverage for women aged 35-45 years. Coverage stood at 37% in China in 2015.
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- Awareness of the Adult Population Toward Colorectal Cancer in Qassim Region, Saudi Arabia. [Journal Article]Cureus. 2023 Jan; 15(1):e33477.C
- Introduction Colon and rectal cancer are usually grouped together as they share similar features. They are the third most common cancer in the world and the second most common cancer in the Kingdom of Saudi Arabia (KSA). Awareness and preventive screening programs play a vital role in early diagnosis and improving the survival rate of such patients. This study aimed to assess the awareness and kn…
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- Excess risk of chronic health conditions in Hispanic survivors of adolescent and young adult cancers. [Journal Article]J Cancer Surviv. 2023 Feb 08 [Online ahead of print]JC
- CONCLUSIONS: An AYA cancer diagnosis is associated with poor SES outcomes and increased odds of comorbidities within the Hispanic population.
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- Targeting Cbl-b in cancer immunotherapy. [Review]J Immunother Cancer. 2023 Feb; 11(2)JI
- Cancer immunotherapy with immune-checkpoint blockade has improved the outcomes of patients with various malignancies, yet a majority do not benefit or develop resistance. To address this unmet need, efforts across the field are targeting additional coinhibitory receptors, costimulatory proteins, and intracellular mediators that could prevent or bypass anti-PD1 resistance mechanisms. The CD28 cost…
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- [A comprehensive screening for hepatitis B and C as an effective means of cancer prevention and as a prerequisite for elimination of chronic viral hepatitis - Data and comments on a discussion]. [Journal Article]Dtsch Med Wochenschr. 2023 Feb; 148(4):175-182.DM
- Since October 2021 in Germany all people with a statutory health insurance aged 35 and older have the right to be tested once for hepatitis B and C in a general preventative examination, regardless of specific risk-factors. This is a milestone on the way of eliminating these infections and also a great contribution to cancer prevention.In the USA the Centers of Disease Control and Prevention in A…
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- Variability Among Breast Cancer Risk Classification Models When Applied at the Level of the Individual Woman. [Journal Article]J Gen Intern Med. 2023 Feb 07 [Online ahead of print]JG
- CONCLUSIONS: Breast cancer risk estimates for individual women vary substantially, depending on which risk assessment model is used. The choice of cutoff used to define high risk can lead to adverse effects for screening, preventive care, and quality of life for misidentified individuals. Clinicians need to be aware of the high false-positive and false-negative rates and variation between models when talking with patients.
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- Primary care physician use of patient race and polygenic risk scores in medical decision-making. [Journal Article]Genet Med. 2023 Feb 04 [Online ahead of print]GM
- CONCLUSIONS: Despite advances in precision risk stratification, physicians will likely continue to use patient race implicitly or explicitly in medical decision-making.
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- The association of initiating HPV vaccination at ages 9-10 years and up-to-date status among adolescents ages 13-17 years, 2016-2020. [Journal Article]Hum Vaccin Immunother. 2023 Feb 07 [Online ahead of print]HV
- Recent guidelines from the American Cancer Society stress HPV vaccination series initiation at the youngest opportunity, i.e., age 9 years. There are limited data on the association between initiating HPV vaccination at ages 9-10 years and up-to-date (UTD) status. In this study, we compare nationally representative UTD HPV vaccination rates between adolescents who initiated the series younger (ag…
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- Prevalence and founder effect of DRC1 exon 1-4 deletion in Korean patients with primary ciliary dyskinesia. [Journal Article]J Hum Genet. 2023 Feb 07 [Online ahead of print]JH
- Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder affecting ciliary structure and function. PCD exhibiting dynein regulatory complex subunit 1 (DRC1) exon 1-4 deletion has been reported in several Japanese PCD patients; however, no large scale studies have been performed. Here, we aimed to determine the prevalence and founder effect of this variant in the Korean population.…
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- Establishment and validation of a plasma oncofetal chondroitin sulfated proteoglycan for pan-cancer detection. [Journal Article]Nat Commun. 2023 Feb 06; 14(1):645.NC
- Various biomarkers targeting cell-free DNA (cfDNA) and circulating proteins have been tested for pan-cancer detection. Oncofetal chondroitin sulfate (ofCS), which distinctively modifies proteoglycans (PGs) of most cancer cells and binds specifically to the recombinant Plasmodium falciparum VAR2CSA proteins (rVAR2), is explored for its potential as a plasma biomarker in pan-cancer detection. To qu…
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- Scoping review protocol on the impact of antimicrobial resistance on cancer management and outcomes. [Journal Article]BMJ Open. 2023 Feb 06; 13(2):e068122.BO
- Antimicrobial resistance (AMR) is a growing global public health concern and is becoming a significant challenge in the management of patients with cancer. Due to the immunosuppressive nature of cancer treatment, infection is a common complication and the necessary high usage of antibiotics increases the risk of AMR. Failure to adequately prevent and treat infection in patients with cancer as a r…
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- [Pancreatic cancer screening in a clinical practice setting: it is the moment of Prevention]. [Journal Article]Rev Gastroenterol Peru. 2022 Oct-Dec; 42(4):234-241.RG
- Pancreatic cancer surveillance can improve outcomes in high-risk individuals. However, little is known about its applicability and findings in routine clinical practice. Our aim was to evaluate findings on screening tests in high-risk individuals in a clinical practice setting and to analyze factors associated with the presence of relevant pancreatic lesions. We developed a prospective observatio…
- Risk Model-Based Lung Cancer Screening : A Cost-Effectiveness Analysis. [Journal Article]Ann Intern Med. 2023 Feb 07 [Online ahead of print]AIM
- CONCLUSIONS: Risk model-based screening is more cost-effective than the USPSTF recommendation, thus warranting further consideration.
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- Early cervical cancer screening: The influence of culture and religion. [Journal Article]Afr J Prim Health Care Fam Med. 2023 Jan 25; 15(1):e1-e6.AJ
- CONCLUSIONS: According to the study findings, culture and religion constitute impediments to early cervical cancer screening for rural women. Interventions that encourage screening, such as targeted health education and health promotion materials, must consider cultural and religious views if behaviour change in diverse groups is to be accomplished.Contribution: The study has the potential to inform Zimbabwean health policy and contribute to prospective interventions or health education that encourage women to attend early cancer screening.
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- Cervical HPV infection in Guangzhou, China: an epidemiological study of 198,111 women from 2015 to 2021. [Journal Article]Emerg Microbes Infect. 2023 Feb 06 [Online ahead of print]EM
- Persistent high-risk human papillomavirus (HPV) infection is the pivotal cause of cervical carcinogenesis. HPV types distribution varies greatly by region, and its long-term changes of prevalence remain to be fully characterized in China. Here, the largest population of 198,111 consecutive women who underwent routine cervical screening were investigated from 2015 to 2021 in Guangzhou, south China…
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- HPV-based Cervical Cancer Screening on Self-samples in the Netherlands: Challenges to Reach Women and Test Performance Questions. [Editorial]
- In 2017, cervical cancer screening in the Netherlands switched from cytology to human papillomavirus (HPV) testing using the validated PCR-based cobas 4800. Women could order and subsequently received a free self-sampling kit (Evalyn Brush) at their home address instead of clinician sampling. In the laboratory, the shipped brush was placed into 20 mL of PreservCyt fluid, before testing. In the fi…
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- Elucidating the Drivers for the Rising Incidence of Early-Onset Colorectal Cancer: How Ecologic Studies Could Help and What Is Next. [Editorial]
- The incidence of colorectal cancer diagnosed before age 50, often referred to as early-onset colorectal cancer, has been increasing, whereas the overall colorectal cancer incidence has declined. Elucidating the drivers for the rising burden of early-onset colorectal cancer is a priority in cancer epidemiology and prevention. In this issue of Cancer Epidemiology, Biomarkers & Prevention, Chen and …
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- Association of job stress, FK506 binding protein 51 (FKBP5) gene polymorphisms and their interaction with sleep disturbance. [Journal Article]
- CONCLUSIONS: The FKBP5 gene may increase susceptibility to job stress and result in sleep disturbance, especially in the presence of negative work-related events. These findings contribute to the field of sleep disturbance prevention and treatment.
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- Development of a multivariable prediction model for anal high-grade squamous intraepithelial lesions in persons living with HIV in Puerto Rico: a cross-sectional study. [Journal Article]
- Persons living with HIV (PLWH) are at high risk of developing anal high-grade squamous intraepithelial lesions (HSIL). We aimed to develop a prediction model for anal HSIL based on individual characteristics of PLWH.
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- Feasibility and acceptability of self-collection of Human Papillomavirus samples for primary cervical cancer screening on the Caribbean Coast of Nicaragua: A mixed-methods study. [Journal Article]
- CONCLUSIONS: Self-collection of samples for hrHPV testing demonstrated high acceptability and feasibility. Through concerted effort at the local, regional, and national levels, this project supported capacity building in reporting, monitoring, and surveilling cervical cancer screening across the continuum of cervical cancer control.
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- Assessment of Saudi Females' Knowledge Regarding Human Papillomavirus Infection, Screening, and Available Methods for Prevention: A Cross-Sectional Study in Qassim Region. [Journal Article]
- Introduction Human papillomaviruses (HPV) are known to be the main culprit of cervical cancer. It is the fourth most common cancer among women worldwide. In recent years, it has begun to spread more widely in Saudi Arabia. Saudi Arabia's Ministry of Health recently added HPV vaccination for women to the list of recommended vaccinations. Aim This study aimed to assess Saudi females' knowledge rega…
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- Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis. [Journal Article]
- DNA methyltransferases (DNMTs) catalyze methylation at the C5 position of cytosine with S-adenosyl-L-methionine. Methylation regulates gene expression, serving a variety of physiological and pathophysiological roles. The chemical mechanisms regulating DNMT enzymatic activity, however, are not fully elucidated. Here, we show that protein S-nitrosylation of a cysteine residue in DNMT3B attenuates D…
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- Significant outcomes associated with high-risk human papillomavirus negative Papanicolaou tests. [Journal Article]J Am Soc Cytopathol. 2023 Jan 11 [Online ahead of print]JA
- CONCLUSIONS: With widespread adoption of risk-based approach to management, the role of cytology, by itself, will likely diminish in the detection of HPV-associated lesions. Additional data regarding the role of cytology in the screening of patients with no/unknown/limited history and in the detection/management of HPV-independent lesions may be helpful for designing future screening guidelines.
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- Screening Chest CT Prior to Allogenic Hematopoietic Stem Cell Transplantation. [Journal Article]Transplant Cell Ther. 2023 Feb 02 [Online ahead of print]TC
- Pulmonary complications constitute a major cause of morbidity and mortality in the post-allogenic hematopoietic stem cell transplant (alloHSCT) period. While Chest X-ray (CXR) is customarily used for screening, we have utilized chest computed tomography (CT). To characterize the prevalence of abnormalities and explore their impact on alloHSCT eligibility and outcomes post-transplant, we conducted…
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- "There is a God or There is No God-It is in the Hands of God:" Fatalistic Beliefs Among Israeli People About Cancer and Their Impact on Behavioral Outcomes. [Journal Article]J Relig Health. 2023 Feb 04 [Online ahead of print]JR
- This qualitative study examined fatalistic beliefs and cancer causal attributions among people without cancer. Participants were 30 Israeli women and men aged 51-70 from diverse sociocultural backgrounds who participated in four focus groups. Three main themes emerged, referring to the variability in fatalistic beliefs of cancer occurrence and cancer outcome, the duality in attributing causality …
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- Knowledge and awareness of colorectal cancer among a predominantly Indigenous Caribbean community. [Journal Article]
- CONCLUSIONS: Despite limited familiarity with CRC screening, participants broadly believed CRC screening to be important. Health education research is needed to develop patient-centered, culturally appropriate materials about CRC screening and prevention. Future work facilitating productive community partnerships and incorporating prevailing community traditions may align cancer prevention and education initiatives with community priorities.
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- Prostate cancer screening: what work should GPs stop doing so they can do this work instead? [Journal Article]BMJ. 2023 Feb 03; 380:284.BMJ
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- Exploring monitoring strategies for population surveillance of HPV vaccine impact using primary HPV screening. [Journal Article]Tumour Virus Res. 2023 Jan 31 [Online ahead of print]TV
- Australia's cervical screening program transitioned from cytology to HPV-testing with genotyping for HPV16/18 in Dec'2017. We investigated whether program data could be used to monitor HPV vaccination program impact (commenced 2007) on HPV16/18 prevalence and compared estimates with pre-vaccination benchmark prevalence. Pre-vaccination samples (2005-2008) (n = 1933; WHINURS), from 25 to 64-year-o…
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- A comparison of patient and provider practices between bone marrow and solid organ transplant programs for patient education on increased risk of skin cancer. [Journal Article]Transplant Cell Ther. 2023 Jan 31 [Online ahead of print]TC
- CONCLUSIONS: Despite results indicating patient knowledge of skin cancer risk, patients do not practice adequate prevention. Incorporation of a transplant dermatologist in the care team or use of risk-stratification tools by providers may assist in streamlining timely referrals to dermatology.
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