- Epithelial-Mesenchymal Transdifferentiation in Pediatric Lens Epithelial Cells. [Journal Article]
- IOInvest Ophthalmol Vis Sci 2018 Dec 03; 59(15):5785-5794
- CONCLUSIONS: Patient characteristics correlated with growth behavior of pLEC in vitro, paralleling a higher clinical incidence of PCO in younger children. Gene expression profiles of pLEC and HLE-B3 suggest that upregulation of αV-integrin, collagen-Iα2, and fibronectin-1 are involved in EMT.
- Lipid Lowering and Incidence of Cataract, a Role for Fibrates. [Journal Article]
- CPClin Pharmacol Ther 2018 Dec 05
- Cataract is a pathological eye condition with loss of lens transparency. Age-related cataract is the most common type in adults, and opacity is believed to result from oxidative stress. According to ...
Cataract is a pathological eye condition with loss of lens transparency. Age-related cataract is the most common type in adults, and opacity is believed to result from oxidative stress. According to estimates by the World Health Organization, cataract affects ≈100 million people worldwide. There has been discussion on the role of lipid-lowering drugs in inducing cataract. Herein, we comment on an article suggesting a role for fibrates.
- Epithelial ingrowth through venting incision into laser-assisted in situ keratomileusis flap interface after descemet stripping automated endothelial keratoplasty. [Journal Article]
- AJAm J Ophthalmol Case Rep 2019; 13:25-27
- CONCLUSIONS: Epithelial ingrowth is a well-described complication following LASIK but has rarely been described to occur after endothelial keratoplasty (EK). Even rarer, are reports of epithelial ingrowth after EK cases that have been found to result from venting incisions. To the authors' knowledge, this is the first case of the ingrowth into a LASIK flap interface occurring after EK through a venting incision. Although it may be an uncommon occurrence in which a patient with a history of LASIK requires EK, surgeons should take extra precautions to avoid this complication.
- Multimodal imaging in a patient with Prader-Willi syndrome. [Journal Article]
- IJInt J Retina Vitreous 2018; 4:45
- CONCLUSIONS: We report a presumed association of fovea plana and choroidal neovascularization with PWS. The use of multimodal imaging revealed novel findings in a PWS patient that might enrich our current understanding of the overlap between PWS and OCA.
- Off-Label Use of Phakic Intraocular Lens with a "Piggyback" Technique. [Journal Article]
- CRCase Rep Ophthalmol 2018 Sep-Dec; 9(3):465-472
- CONCLUSIONS: This case demonstrates the successful off-label use of a phakic IOL in a pseudophakic, highly myopic patient with a piggyback technique, resulting in improved visual acuity and ultimately allowing IOL placement in the fellow eye for emmetropia. This off-label use of pIOL can offer ophthalmologists an alternative option for pseudophakic patents with severe refractive error.
- Patient-reported outcomes of multifocal and accommodating intraocular lenses: analysis of 117 patients 2-10 years after surgery. [Journal Article]
- COClin Ophthalmol 2018; 12:2297-2304
- CONCLUSIONS: The majority of patients who received either accommodating or multifocal IOLs remain satisfied with their lens of choice more than 5 years after the original surgery. Glare and halos remain more noticeable in patients who received multifocal lenses.
- A novel method to evaluate quality of care from the perspective of cataract patients. [Journal Article]
- EEye (Lond) 2018 Dec 05
- CONCLUSIONS: A valid new method to reliably and holistically evaluate patient's satisfaction related to cataract surgery including a broad range of patient needs is presented, suitable to assess potential lacks in quality of health care in daily ophthalmological clinical practice.
- Corneal endothelial cell loss associated to phacoemulsification and ophthalmologist experience: prospective analysis of individual secondary data. [Journal Article]
- MMedwave 2018 Oct 29; 18(6):e7314
- CONCLUSIONS: Although there were differences in the surgical management regarding the surgeons’ experience in factors known to influence corneal endothelial cell loss, no differences in endothelial cell loss were observed as an outcome.
- A history of prophylaxis in haemophilia. [Journal Article]
- BCBlood Coagul Fibrinolysis 2018 Nov 29
- Prophylaxis entails long-term continuous intravenous administration of concentrates of the deficient factor with a view to preventing spontaneous bleeds and the development of hemophilic arthropathy....
Prophylaxis entails long-term continuous intravenous administration of concentrates of the deficient factor with a view to preventing spontaneous bleeds and the development of hemophilic arthropathy. Initiation of prophylaxis at an early age and continuous uninterrupted factor administration in patients with hemophilia have been hailed as essential by such organizations.The most widely used prophylaxis regimens include the Swedish (Malmö), the Dutch and the Canadian protocols. Different international groups have hailed prophylaxis as the most effective treatment in patients with hemophilia.Prophylaxis is effectiveness in preventing bleeding and arthropathy in children with (particularly early-onset) hemophilia. Although some retrospective trials confirm the benefits of prophylaxis, others point to a lack of conclusive data to support switching adult patients with established hemophilic arthropathy who always received on-demand treatment to prophylactic treatment.The potential effects of prophylaxis on the patients' sex lives, renal status, prostate involvement and cataract must be analyzed before indicating prophylactic treatment in elderly patients.The high efficacy of prophylactic treatment in patients with hemophilia and inhibitors has been widely reported in the literature.
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- [Opacification of hydrophilic intraocular lens after multiple injections of bevacizumab]. [Journal Article]
- OOphthalmologe 2018 Nov 30
- In the literature various causes of opacification of hydrophilic lenses have been described. Pronounced opacity is a complication that must be taken seriously because it can lead to explantation or e...
In the literature various causes of opacification of hydrophilic lenses have been described. Pronounced opacity is a complication that must be taken seriously because it can lead to explantation or exchange of the intraocular lens (IOL). The calcification of hydrophilic IOLs is often made responsible for an explantation. Despite the rapidly increasing number of intravitreal injections, they have so far not been associated with opacification of lenses. This article reports on a female patient where opacification of the hydrophilic lens was obviously associated with multiple intravitreal injections over several years. It involved a secondary calcification with calcium phosphate deposition directly under the surface of the IOL. Possible pathomechanisms are discussed. Due to the increasing number of intravitreal injections the association with IOL opacity should be further evaluated in the future. Generally, with hydrophilic lens materials it must be taken into consideration that these can become opaque following diverse interventions.