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(Cervical Cancer)
102,760 results
  • A CRISPR Test for Detection of Circulating Nuclei Acids. [Journal Article]
    Transl Oncol 2019; 12(12):1566-1573Tsou JH, Leng Q, Jiang F
  • Emerging CRISPR-based nucleic acid detection shows great promise in molecular diagnosis of diseases. CRISPR-Cas12a can sensitively and specifically detect human papillomavirus (HPV) DNA in anal swabs. However, the current CRISPR-Cas12a system needs auxiliary and expensive equipment, which limit its application as a point-of-care (POC) diagnostic tool. This study aimed to develop CRISPR-Cas12a as …
  • Non-traumatic cervical artery dissection and ischemic stroke: A narrative review of recent research. [Review]
    Clin Neurol Neurosurg 2019; 187:105561Marciniec M, Sapko K, … Rejdak K
  • Cervical artery dissection (CAD) is a leading cause of ischaemic stroke (IS) in young and middle-aged adults. Despite well characterized clinical presentation, the diagnosis of CAD can be quite challenging due to a wide variety of symptoms ranging from minor neck pain to severe neurological symptoms. Invasive diagnostic procedures such as DSA are nowadays being replaced by the sensitive and CAD-s…
  • miR-214 down-regulates MKK3 and suppresses malignant phenotypes of cervical cancer cells. [Journal Article]
    Gene 2019; :144146Peng R, Cheng X, … Hu Z
  • miRNA mediated genetic regulation is widely involved in carcinogenesis of cervical cancer. In this study, miR-214 was confirmed to directly regulate MKK3 via imperfect base-pairing to its 3'UTR, resulting down-regulation of its expression level. Compared to normal tissues, a down-regulated level of miR-214 was observed in cervical cancer, while MKK3 was up-regulated. Next, we demonstrated that ov…
  • Notch signalling in cervical cancer. [Review]
    Exp Cell Res 2019; :111682Rodrigues C, Joy LR, … Krishna S
  • The initial discovery of key developmental signalling pathways, largely using classical genetic approaches in model organisms, was followed by an intense burst of characterisation of the molecular components. Studies also began demonstrating a role for these pathways in oncogenesis. Patterns of mutations in Notch pathway components, such as those reported in sub-sets of hematological malignancies…
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