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(Cholinergic poisoning)
1,395 results
  • Effect of cholinergic crisis on the potency of different emergency anaesthesia protocols in soman-poisoned rats. [Journal Article]
  • CTClin Toxicol (Phila) 2018 Oct 11; :1-7
  • Marquart K, Herbert J, … Wille T
  • CONCLUSIONS: The current in vivo study did not confirm concerns of altered potency of existing anaesthetic protocols for the application of propofol or thiopental with fentanyl due to soman poisoning. Despite severe cholinergic crisis, sufficient anaesthetic depth could be achieved in all animals.Further experiments in in vivo models closer to human pharmaco- and toxicokinetics (e.g., swine) are required for confirmation of the initial findings and for improving extrapolation to humans.
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