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(Chronic Kidney Disease)
160,672 results
  • Orai1: CRACing the Th17 response in AKI. [Journal Article]
    J Clin Invest 2019Noel S
  • A strong Th17 inflammatory response aggravates ischemia reperfusion-induced (IR-induced) acute kidney injury (AKI), tissue fibrosis, and AKI-to-chronic kidney disease (CKD) progression. However, the underlying mechanisms of sustained Th17 activation following AKI and during AKI-to-CKD progression are unclear. In this issue of the JCI, Mehrotra et al. present compelling evidence that the store-ope…
  • Salvia officinalis attenuates bleomycin-induced oxidative stress and lung fibrosis in rats. [Journal Article]
    Nutr Cancer 2019; :1-11Bahri S, Ben Ali R, … Jameleddine S
  • Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by progressive and irreversible fibroblasts proliferation leading to significant respiratory insufficiency. This study was designed to investigate the effect of sage infusion against bleomycin (BLM)-induced lung fibrosis in rats. Male Wistar rats were given a single dose of BLM (4 mg/kg, intratracheal), while sage infusio…
  • Molecular Targets for Improving Arteriovenous Fistula Maturation and Patency. [Journal Article]
    Vasc Investig Ther 2019 Apr-Jun; 2(2):33-41Gorecka J, Fereydooni A, … Dardik A
  • The increasing prevalence of chronic and end-stage renal disease creates an increased need for reliable vascular access, and although arteriovenous fistulae (AVF) are the preferred mode of hemodialysis access, 60% fail to mature and only 50% remain patent at one year. Fistulae mature by diameter expansion and wall thickening; this outward remodeling of the venous wall in the fistula environment r…
  • Evidence of epigenetic alterations in thrombosis and coagulation: A systematic review. [Review]
    J Autoimmun 2019; :102347Patsouras MD, Vlachoyiannopoulos PG
  • Thrombosis in the context of Cardiovascular disease (CVD) affects mainly the blood vessels supplying the heart, brain and peripheries and it is the leading cause of death worldwide. The pathophysiological thrombotic mechanisms are largely unknown. Heritability contributes to a 30% of the incidence of CVD. The remaining variation can be explained by life style factors such as smoking, dietary and …
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