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Unbound Medicine.
(Colon cancer)
158,748 results
  • Deepfake Histologic Images for Enhancing Digital Pathology. [Journal Article]
    Lab Invest. 2023 Jan; 103(1):100006.Falahkheirkhah K, Tiwari S, … Bhargava R
  • A pathologist's optical microscopic examination of thinly cut, stained tissue on glass slides prepared from a formalin-fixed paraffin-embedded tissue blocks is the gold standard for tissue diagnostics. In addition, the diagnostic abilities and expertise of pathologists is dependent on their direct experience with common and rarer variant morphologies. Recently, deep learning approaches have been …
  • A multi-centre polyp detection and segmentation dataset for generalisability assessment. [Journal Article]
    Sci Data. 2023 Feb 06; 10(1):75.Ali S, Jha D, … East JE
  • Polyps in the colon are widely known cancer precursors identified by colonoscopy. Whilst most polyps are benign, the polyp's number, size and surface structure are linked to the risk of colon cancer. Several methods have been developed to automate polyp detection and segmentation. However, the main issue is that they are not tested rigorously on a large multicentre purpose-built dataset, one reas…
  • Deciphering the modulatory role of apigenin targeting oncogenic pathways in human cancers. [Review]
    Chem Biol Drug Des. 2023 Feb 06 [Online ahead of print]Pandey P, Khan F, Upadhyay TK
  • Cancer is a complicated malignancy controlled by numerous intrinsic and extrinsic pathways. There has been a significant increase in interest in recent years in the elucidation of cancer treatments based on natural extracts that have fewer side effects. Numerous natural product-derived chemicals have been investigated for their anticancer effects in the search for an efficient chemotherapeutic me…
  • Two new sarasinosides from marine sponge Petrosia nigricans. [Journal Article]
    Nat Prod Res. 2023 Feb 06 [Online ahead of print]Mama RL, Gelani CD, … Ohta S
  • Two new sarasinosides designated as 5,8-epoxysarasinoside (1) and 8,9-epoxysarasinoside (2) and four known sarasinosides were isolated from marine sponge Petrosia nigricans, collected off the coast of Lipata, Surigao City, Philippines (9°49' North, 125°27' East). The structures were determined through extensive 2D NMR spectroscopy and HRMS. Both compounds exhibited low cytotoxicity against the HC…
  • Growth hormone and gastrointestinal malignancy: An intriguing link. [Review]
    World J Gastrointest Pathophysiol. 2023 Jan 22; 14(1):1-11.Palui R, Sridharan K, … Naik D
  • Growth hormone (GH) excess is associated with several systemic complications, one of which is the increased risk of neoplastic processes particularly of the gastrointestinal (GI) tract. Among the GI neoplasms, the most reported association is with benign and malignant neoplasms of the colon. In the majority of published literature, an increased incidence of GI neoplasms, both colonic adenomas as …
  • Total Neoadjuvant Chemotherapy in Rectal Cancer: Current Facts and Future Strategies. [Review]
    J Anus Rectum Colon. 2023; 7(1):1-7.Beppu N, Ikeda M, … Yanagi H
  • Despite preoperative chemoradiotherapy (CRT) and total mesorectal excision improving the local control for locally advanced rectal cancer (LARC), oncologic outcomes and survival were not significantly improved because the main prognostic factor is distant metastasis. Thus, total neoadjuvant chemotherapy (TNT) as a novel approach has been proposed to improve chemotolerance. Since the first randomi…
  • Nanomedicine-based multimodal therapies: Recent progress and perspectives in colon cancer. [Review]
    World J Gastroenterol. 2023 Jan 28; 29(4):670-681.He YC, Hao ZN, … Gao DW
  • Colon cancer has attracted much attention due to its annually increasing incidence. Conventional chemotherapeutic drugs are unsatisfactory in clinical application because of their lack of targeting and severe toxic side effects. In the past decade, nanomedicines with multimodal therapeutic strategies have shown potential for colon cancer because of their enhanced permeability and retention, high …
  • Signet ring cell carcinoma of the rectal stump in a known ulcerative colitis patient. [Case Reports]
    Autops Case Rep. 2023; 13:e2023418.Nadaf A, Al Haddabi IH, … Al Moundhri MS
  • Colorectal carcinoma (CRC) is the third most commonly diagnosed cancer worldwide and is the second most common cause of cancer-related deaths. However, the Omani population shares the major burden as the most prevalent carcinoma. The disease is comparatively higher in males than females. Patients with pre-existing risk factors, including inflammatory bowel disease, are at increased risk of develo…
  • Identifying colon cancer stage related genes and their cellular pathways. [Journal Article]
    Front Genet. 2023; 14:1120185.Chen B, Chakrobortty N, … Shang X
  • In the world, colon cancer is regarded as one of the most common deadly cancer. Due to the lack of a better understanding of its prognosis system, this prevailing cancer has the second-highest morbidity and mortality rate compared with other cancers. A variety of genes are responsible to participate in colon cancer and the molecular mechanism is almost unsure. In addition, various studies have be…
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