- A leaky human colon model reveals uncoupled apical/basal cytotoxicity in early Clostridioides difficile toxin exposure. [Journal Article]Am J Physiol Gastrointest Liver Physiol. 2023 Feb 07 [Online ahead of print]AJ
- Clostridioides difficile (C. difficile) toxins A (TcdA) and B (TcdB) cause antibiotic-associated colitis in part by disrupting epithelial barrier function. Accurate in vitro models are necessary to detect early toxicity kinetics, investigate disease etiology, and develop preclinical models for new therapies. Properties of cancer cell lines and organoids inherently limit these efforts. We develope…
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- Could the concomitant use of beta blockers with bevacizumab improve survival in metastatic colon cancer? [Journal Article]Eur J Clin Pharmacol. 2023 Feb 07 [Online ahead of print]EJ
- CONCLUSIONS: This study demonstrated that concomitant usage of beta blockers improved both survival outcomes, irrespective of the kind of beta blocker.
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- Reduced expression of alanyl aminopeptidase is a robust biomarker of non-familial adenomatous polyposis and non-hereditary nonpolyposis colorectal cancer syndrome early-onset colorectal cancer. [Journal Article]Cancer Med. 2023 Feb 07 [Online ahead of print]CM
- CONCLUSIONS: The reduced expression of ANPEP was identified as a novel biomarker of non-FAP and non-HNPCC EOCRC.
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- The other colon cancer: A population-based cohort study of appendix tumours Trends and prognosis of appendix neoplasms. [Journal Article]Colorectal Dis. 2023 Feb 07 [Online ahead of print]CD
- CONCLUSIONS: Appendiceal neoplasia are histologically heterogeneous, however this diversity becomes less relevant compared to the marked difference to cancers of the remaining colon. The previously observed increase in cases appears to be abating, fewer appendicitis and/or appendectomies or changes in histopathological assessment may be behind this trend.
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- YAP regulates intestinal epithelial cell proliferation through activation of STAT3 in DSS-induced colitis and associated cancer. [Journal Article]Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2022 Dec 28; 47(12):1637-1645.ZN
- CONCLUSIONS: YAP activates STAT3 signaling in regulation of epithelial cell proliferation and promotes mucosal regeneration after DSS induced colitis, which may serve as a potential therapeutic target in UC. However, persistent and excessive YAP activation may promote CAC development.
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- Postoperative outcomes of right hemicolectomy for cancer in 11 countries of Latin America: A multicenter retrospective study. [Journal Article]Colorectal Dis. 2023 Feb 07 [Online ahead of print]CD
- CONCLUSIONS: This is the first study in Latin America to show better postoperative outcomes at a regional scale when surgery for right colon cancer is performed in high volume centers. Further studies are needed to validate this data and to identify which are the factors that can explain the present results.
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- Deepfake Histologic Images for Enhancing Digital Pathology. [Journal Article]Lab Invest. 2023 Jan; 103(1):100006.LI
- A pathologist's optical microscopic examination of thinly cut, stained tissue on glass slides prepared from a formalin-fixed paraffin-embedded tissue blocks is the gold standard for tissue diagnostics. In addition, the diagnostic abilities and expertise of pathologists is dependent on their direct experience with common and rarer variant morphologies. Recently, deep learning approaches have been …
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- Cadaveric and CT angiography study of vessels around the transverse colon mesentery. [Journal Article]World J Surg Oncol. 2023 Feb 06; 21(1):36.WJ
- CONCLUSIONS: This study revealed that The MCA branching classifications and relationship between the SMV and MCA. Preoperative CT angiography may be able to reliably identify vessel variation, which may be useful in clinical practice.
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- A multi-centre polyp detection and segmentation dataset for generalisability assessment. [Journal Article]Sci Data. 2023 Feb 06; 10(1):75.SD
- Polyps in the colon are widely known cancer precursors identified by colonoscopy. Whilst most polyps are benign, the polyp's number, size and surface structure are linked to the risk of colon cancer. Several methods have been developed to automate polyp detection and segmentation. However, the main issue is that they are not tested rigorously on a large multicentre purpose-built dataset, one reas…
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- Deciphering the modulatory role of apigenin targeting oncogenic pathways in human cancers. [Review]Chem Biol Drug Des. 2023 Feb 06 [Online ahead of print]CB
- Cancer is a complicated malignancy controlled by numerous intrinsic and extrinsic pathways. There has been a significant increase in interest in recent years in the elucidation of cancer treatments based on natural extracts that have fewer side effects. Numerous natural product-derived chemicals have been investigated for their anticancer effects in the search for an efficient chemotherapeutic me…
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- Metal Exposure Promotes Colorectal Tumorigenesis via the Aberrant N6-Methyladenosine Modification of ATP13A3. [Journal Article]Environ Sci Technol. 2023 Feb 06 [Online ahead of print]ES
- Element contamination, including that from heavy metals, is associated with gastrointestinal tumorigenesis, but the effects and mechanisms of crucial element exposure associated with colorectal cancer remain unclear. We profiled 56 elements by ICP-MS and used logistic regression, LASSO, BKMR, and GAM to identify colorectal cancer-relevant elements. A series of biochemical experiments were perform…
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- The usefulness of preoperative CT in colon cancer staging: impact of radiologists' experience. [Journal Article]Abdom Radiol (NY). 2023 Feb 06 [Online ahead of print]AR
- CONCLUSIONS: Reader's experience is one of the most important factors associated with the correct classification of colon cancer. Moreover, CECT can help depict radiological features independently associated with the T and N stages.
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- The Specific Aims Page: A Primer. [Journal Article]Dis Colon Rectum. 2023 Feb 06 [Online ahead of print]DC
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- Myeloid FTH1 Deficiency Protects Mice From Colitis and Colitis-associated Colorectal Cancer via Reducing DMT1-Imported Iron and STAT3 Activation. [Journal Article]Inflamm Bowel Dis. 2023 Feb 06 [Online ahead of print]IB
- CONCLUSIONS: Our study demonstrated that myeloid FTH1 is required for colitis and colitis-associated colorectal cancer via maintaining of DMT1-iron-STAT3 signaling activation under excess iron condition.
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- Two new sarasinosides from marine sponge Petrosia nigricans. [Journal Article]Nat Prod Res. 2023 Feb 06 [Online ahead of print]NP
- Two new sarasinosides designated as 5,8-epoxysarasinoside (1) and 8,9-epoxysarasinoside (2) and four known sarasinosides were isolated from marine sponge Petrosia nigricans, collected off the coast of Lipata, Surigao City, Philippines (9°49' North, 125°27' East). The structures were determined through extensive 2D NMR spectroscopy and HRMS. Both compounds exhibited low cytotoxicity against the HC…
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- Growth hormone and gastrointestinal malignancy: An intriguing link. [Review]
- Growth hormone (GH) excess is associated with several systemic complications, one of which is the increased risk of neoplastic processes particularly of the gastrointestinal (GI) tract. Among the GI neoplasms, the most reported association is with benign and malignant neoplasms of the colon. In the majority of published literature, an increased incidence of GI neoplasms, both colonic adenomas as …
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- Total Neoadjuvant Chemotherapy in Rectal Cancer: Current Facts and Future Strategies. [Review]
- Despite preoperative chemoradiotherapy (CRT) and total mesorectal excision improving the local control for locally advanced rectal cancer (LARC), oncologic outcomes and survival were not significantly improved because the main prognostic factor is distant metastasis. Thus, total neoadjuvant chemotherapy (TNT) as a novel approach has been proposed to improve chemotolerance. Since the first randomi…
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- [Retracted] Inhibiting proliferation and metastasis of osteosarcoma cells by downregulation of long non‑coding RNA colon cancer‑associated transcript 2 targeting microRNA‑143. [Retraction of Publication]
- [This retracts the article DOI: 10.3892/ol.2021.12526.].
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- Significance of logistic regression scoring model based on natural killer cell-mediated cytotoxic pathway in the diagnosis of colon cancer. [Journal Article]
- CONCLUSIONS: The significantly upregulated ULBP2 was a poor prognostic biomarker of colon cancer. The risk score based on the six-feature logistic regression model can effectively predict the 3-year survival time. High-risk score group demonstrated a poorer prognosis, higher TMB, lower M0 macrophage infiltration score, and higher IC50 value of oxaliplatin. The six-feature logistic scoring model has certain clinical significance in colon cancer.
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- Identification of gene signatures associated with ulcerative colitis and the association with immune infiltrates in colon cancer. [Journal Article]
- CONCLUSIONS: Study results show the involvement of hub genes like CCL3, MMP3, and TIMP1 in the pathogenesis of UC. These genes could serve as a novel pharmacological regulator of UC. These could be used as a therapeutic target for treating patients with UC and may serve as biomarkers for immune cell infiltration in colon cancer.
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- Experience and Attitude of Colorectal Screening Pilot Program Participants Regarding Screening and Screening Programs in Hungary. [Journal Article]
- CONCLUSIONS: The respondents were satisfied with the screening program. Awareness raising of men, lower educated patients, those living in major cities, and recommendation of the family physician may increase the participation rate in the future.
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- Nanomedicine-based multimodal therapies: Recent progress and perspectives in colon cancer. [Review]
- Colon cancer has attracted much attention due to its annually increasing incidence. Conventional chemotherapeutic drugs are unsatisfactory in clinical application because of their lack of targeting and severe toxic side effects. In the past decade, nanomedicines with multimodal therapeutic strategies have shown potential for colon cancer because of their enhanced permeability and retention, high …
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- High-efficient synthesis of carbon quantum dots from orange pericarp as fluorescence turn-on probes for Ca2+ and Zn2+ ion detection and their application in trypsin activity characterization. [Journal Article]
- CONCLUSIONS: The obtained NCQDs contain high photo-stability, excellent PL activity, and efficient fluorescent emission based on excitation. The results of kinetic studies revealed the ability of NCQDs to inhibit trypsin activity in a non-competitive model, which qualifies them as potent inhibitors and quenchers of trypsin. It can be suggested that the synthesized NCQDs have the potential of functioning as a sustainable and eco-friendly source for various applications such as sensors for detecting Ca2+ and Zn2+ and trypsin biosensor for determining enzyme activity.
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- A Patient with Transverse Colon Cancer Complicated by Cowden Syndrome Administered FOLFOXIRI + Bevacizumab Therapy. [Case Reports]
- Cowden syndrome is characterized by several clinical features related to tumorous lesions primarily consisting of systemic hamartomas. The mutation of a tumor suppressor gene, the PTEN gene, is etiologically involved. As gastrointestinal lesions, polyps of all digestive tracts involving the esophagus to rectum develop. In patients with Cowden syndrome, the risk of colorectal cancer may increase. …
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- Downregulation of ITGβ3 in colon adenocarcinoma reveals poor prognosis by affecting genome stability, cell cycle, and the tumor immune microenvironment. [Journal Article]
- Abnormal expression of integrin subunit beta 3 (ITGβ3), a gene-encoding protein, is related to the occurrence and development of cancers; however, the biological role of ITGβ3 in colon adenocarcinoma (COAD) remains unclear.
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- Signet ring cell carcinoma of the rectal stump in a known ulcerative colitis patient. [Case Reports]
- Colorectal carcinoma (CRC) is the third most commonly diagnosed cancer worldwide and is the second most common cause of cancer-related deaths. However, the Omani population shares the major burden as the most prevalent carcinoma. The disease is comparatively higher in males than females. Patients with pre-existing risk factors, including inflammatory bowel disease, are at increased risk of develo…
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- The genetic and epigenetic regulation of CD55 and its pathway analysis in colon cancer. [Journal Article]
- CONCLUSIONS: Our results indicated that CD55 is regulated by TFCP2, NF-κB, miR-27a-3p, and several immune-related genes, which in turn affects colon cancer.
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- Identifying colon cancer stage related genes and their cellular pathways. [Journal Article]
- In the world, colon cancer is regarded as one of the most common deadly cancer. Due to the lack of a better understanding of its prognosis system, this prevailing cancer has the second-highest morbidity and mortality rate compared with other cancers. A variety of genes are responsible to participate in colon cancer and the molecular mechanism is almost unsure. In addition, various studies have be…
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- Pyroptosis-Related Signature Predicts the Progression of Ulcerative Colitis and Colitis-Associated Colorectal Cancer as well as the Anti-TNF Therapeutic Response. [Journal Article]
- Ulcerative colitis (UC) is a complex intestinal inflammation with an increasing risk of colitis-associated colorectal cancer (CAC). However, the pathogenesis is still unclear between active UC and inactive UC. Recently, it has been reported that pyroptosis-related genes (PRGs) are closely associated with inflammatory disease activity. Nevertheless, the specific roles of PRGs in the progression an…
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