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(Colorectal Cancer)
232,123 results
  • Clinical Outcomes of Small Bowel Adenocarcinoma. [Journal Article]
    Clin Colorectal Cancer 2019Akce M, Jiang R, … El-Rayes BF
  • CONCLUSIONS: Most SBA patients present with stage IV disease. D underwent surgery less often than J and I. Stage II and III D received adjuvant chemotherapy less often compared to stage II and III J and I. Adjuvant chemotherapy was associated with improved OS in patients with stage II-III disease. J had the best 5-year OS rate, and D had the worst.
  • Cancer screening in adults with down syndrome, a proposal. [Review]
    Eur J Med Genet 2019; :103783Rethoré MO, Rouëssé J, Satgé D
  • CONCLUSIONS: We propose that adults with DS should participate in colon cancer screening. For women with DS, breast cancer screening is not recommended, but annual clinical monitoring should be conducted, with the option to perform ultrasound or MRI examination in suspect cases. For cervical cancer, screening could be proposed to women who are sexually active beginning at age 25 years. Annual surveillance for testicular cancer via palpation by a health professional is preferable from ages 15 to 45. In case of additional genetic predisposition in a person with DS, a surveillance similar to other family members is recommended.The specific tumor profile in DS warrants an adapted screening program for breast, colon, cervical and testicular neoplasia.
  • The missing heritability of familial colorectal cancer. [Journal Article]
    Mutagenesis 2019Schubert SA, Morreau H, … van Wezel T
  • Pinpointing heritability factors is fundamental for the prevention and early detection of cancer. Up to one-quarter of colorectal cancers (CRCs) occur in the context of familial aggregation of this disease, suggesting a strong genetic component. Currently, only less than half of the heritability of CRC can be attributed to hereditary syndromes or common risk loci. Part of the missing heritability…
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